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Closes #107, #132, #134 pharmaverseadam updates for pk/pd #140

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merged 9 commits into from
Jun 4, 2024
Merged

Closes #107, #132, #134 pharmaverseadam updates for pk/pd #140

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4d76a6d
add upstream dependency
zdz2101 May 24, 2024
aadaa03
adopt new data for listings
zdz2101 May 24, 2024
08c2ab6
add tables
zdz2101 May 29, 2024
58b2d48
[skip style] [skip vbump] Restyle files
github-actions[bot] May 29, 2024
08cc360
address errors, use staged dependencies
zdz2101 May 30, 2024
6410ce4
data changed
zdz2101 May 31, 2024
35020f6
Update tests/testthat/test-listing_pkcl02.R
zdz2101 May 31, 2024
60a9612
Update tests/testthat/test-listing_pkpl02.R
zdz2101 May 31, 2024
b4f2300
Merge branch 'main' into 132_134_pharmaverseadam_updates@adpp_adpc_up…
zdz2101 Jun 4, 2024
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3 changes: 3 additions & 0 deletions staged_dependencies.yaml
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Original file line number Diff line number Diff line change
Expand Up @@ -19,4 +19,7 @@ upstream_repos:
insightsengineering/rlistings:
repo: insightsengineering/rlistings
host: https://github.com
pharmaverse/pharmaverseadam:
repo: pharmaverse/pharmaverseadam
host: https://github.com
downstream_repos:
116 changes: 58 additions & 58 deletions tests/testthat/_snaps/listing_pkcl02.md
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110 changes: 55 additions & 55 deletions tests/testthat/_snaps/listing_pkpl02.md
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Expand Up @@ -3,61 +3,61 @@
Code
result
Output
Listing of Plasma Drug X Urine PK Parameters, PK Population
Listing of XANOMELINE URINE PK Parameters, PK Population
Protocol: xxnnnnn
Analyte: Plasma Drug X
Analyte: XANOMELINE

———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
Treatment Group Subject ID Visit Renal CL (L/hr) Renal CL Norm by Dose (L/hr/mg) Amt Rec from T1 to T2 (mg) Pct Rec from T1 to T2 (%)
———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————
A: Drug X AB12345-BRA-1-id-105 SCREENING 0.0538423152160391 0.00441769893771616 2.15210785813109 17.8220657702531
CYCLE 1 DAY 1 0.0480828455497337 0.00418360874479016 1.77968465488986 13.4821873677008
CYCLE 1 DAY 2 0.0524191320174391 0.00574562025709617 1.7751362634173 11.7748899262287
AB12345-BRA-1-id-134 SCREENING 0.054828756388858 0.00489378524965625 1.69069405572207 14.6782255303037
CYCLE 1 DAY 1 0.0463628883891636 0.00281388401660215 1.03364773182262 15.2049132671477
CYCLE 1 DAY 2 0.0542853013687975 0.00480239019141706 2.07978470495693 16.6499332185177
AB12345-BRA-1-id-42 SCREENING 0.0479776607513692 0.00620670551445586 1.49259200502984 12.4632371401908
CYCLE 1 DAY 1 0.060136833920038 0.00423749524975822 2.002399829348 16.1228873656652
CYCLE 1 DAY 2 0.0222050225259149 0.0041513339034891 1.65173021070619 10.129985981426
AB12345-BRA-1-id-93 SCREENING 0.0429283028076499 0.00450841008626937 0.882348047230192 19.8088728992851
CYCLE 1 DAY 1 0.0343747382858835 0.00495342578722049 1.73500915591676 14.8733500411057
CYCLE 1 DAY 2 0.0474831008867497 0.00415970555107753 1.30298887256052 14.9616973312841
AB12345-BRA-11-id-217 SCREENING 0.0524432563610182 0.00439177770746837 1.16344390767412 16.584779611686
CYCLE 1 DAY 1 0.0411628011374518 0.00567801310981526 1.11763922430636 19.3000982041101
CYCLE 1 DAY 2 0.0672581292323284 0.00400060865194939 1.45655867480937 10.1596117673893
AB12345-BRA-11-id-345 SCREENING 0.044070189259969 0.00561835429596993 1.43739076299198 15.4875095868721
CYCLE 1 DAY 1 0.0362275034574886 0.0038765297501434 0.96604915921 17.1567306808389
CYCLE 1 DAY 2 0.0416331541840018 0.00462187415243145 1.27070193721417 19.2547757988484
AB12345-BRA-11-id-397 SCREENING 0.0379747899730378 0.0047876948377162 1.67729762147252 11.6015615292251
CYCLE 1 DAY 1 0.0430467407701829 0.00463308440642305 1.1695965192594 12.5511219923965
CYCLE 1 DAY 2 0.0530275699526593 0.00602824936236151 1.16951935869462 9.3792062123841
AB12345-BRA-11-id-50 SCREENING 0.0490899843603453 0.00433904660682343 1.51662375506863 15.1874519747015
CYCLE 1 DAY 1 0.0672184411834178 0.00456991448716558 1.73703640920242 16.5948637732063
CYCLE 1 DAY 2 0.0408411675307402 0.00494112531418564 1.33731817886724 17.4222650292624
AB12345-BRA-13-id-177 SCREENING 0.047220210221337 0.0064503185110655 1.67258875483346 17.4280023779494
CYCLE 1 DAY 1 0.0489373754070362 0.00671542529332243 1.93690522649455 14.3501519027283
CYCLE 1 DAY 2 0.0476235035173541 0.00591546136689979 1.58365865060925 13.2957559043989
AB12345-BRA-14-id-23 SCREENING 0.0495814933133832 0.00617948401359631 1.03444255220443 13.0571967102206
CYCLE 1 DAY 1 0.0455377758301445 0.00416716143750013 1.56728483899209 8.14687917618995
CYCLE 1 DAY 2 0.0597234964090954 0.00576708040948061 1.03841982256427 15.7297767486961
AB12345-BRA-15-id-36 SCREENING 0.0398530524430873 0.00576796951997663 1.44039115712981 14.9495531914984
CYCLE 1 DAY 1 0.0631198664734805 0.0054539578118663 2.0190939818875 15.5142069508071
CYCLE 1 DAY 2 0.038679043889048 0.00502496029365965 1.71180290425847 12.0432693355435
AB12345-BRA-2-id-296 SCREENING 0.0571285385821894 0.00404181186257367 1.25389235120619 13.6995575905696
CYCLE 1 DAY 1 0.0465486658818343 0.0046153997039265 1.24333604201248 15.5963377687228
CYCLE 1 DAY 2 0.0246355131297949 0.00581779485158459 1.37709625369746 19.2298219073723
AB12345-BRA-6-id-369 SCREENING 0.0519755297020007 0.00430804631825859 1.69712447775344 14.8978371441706
CYCLE 1 DAY 1 0.0524201202040517 0.00384205611457903 1.64411514985229 16.8525317500937
CYCLE 1 DAY 2 0.0573691635100109 0.0060043554490695 1.24660015101016 12.2942732423123
AB12345-CAN-1-id-18 SCREENING 0.0420893473716153 0.00370165882084242 1.78373846143053 14.998695764624
CYCLE 1 DAY 1 0.0498766468005559 0.00421427186841228 1.88918675337134 23.6013393964935
CYCLE 1 DAY 2 0.0531659989184035 0.0047996283911874 1.90944129380272 18.1642741952931
AB12345-CAN-11-id-139 SCREENING 0.057867905674068 0.00351064249092922 1.4234768880846 20.7247433268497
CYCLE 1 DAY 1 0.0514130901286956 0.00515695212612405 1.23457064862642 16.764629078951
CYCLE 1 DAY 2 0.046471320158638 0.00475110812326987 1.78421633194994 19.435931090301
AB12345-CAN-14-id-104 SCREENING 0.0464544159245633 0.00620207698621864 1.71948940594064 12.8317528976335
CYCLE 1 DAY 1 0.0400829371347404 0.00529445498185962 1.1407644493182 13.8393948453127
CYCLE 1 DAY 2 0.0326813911909074 0.00504264297283436 1.27500039606452 11.5234045604907
AB12345-CHN-1-id-119 SCREENING 0.0359049114863373 0.0060141782673535 1.18304750443328 13.0170409934116
CYCLE 1 DAY 1 0.0498801340825785 0.00576979837396612 0.702117462322584 21.3990567973093
————————————————————————————————————————————————————————————————————————————————
Treatment Group Subject ID Visit Ae (mg) CLR (mL/min)
————————————————————————————————————————————————————————————————————————————————
Xanomeline High Dose 01-701-1028 Day 1 57.1686321209494 52.6778016500772
01-701-1034 Day 1 61.6324956170209 52.7033978058332
01-701-1133 Day 1 68.5626755916635 59.5314937639222
01-701-1146 Day 1 66.2718322300181 60.845367631265
01-701-1148 Day 1 64.6202505077946 54.0155370632339
01-701-1180 Day 1 59.283127942342 50.827469125046
01-701-1239 Day 1 69.1394283654332 59.9929255703251
01-701-1275 Day 1 59.0658856860667 52.9445554448263
01-701-1287 Day 1 57.1376323292053 48.9217471528443
01-701-1302 Day 1 63.5102740219449 55.3675149364335
01-701-1383 Day 1 71.8372518973587 62.0164991360124
01-701-1444 Day 1 62.4963953872185 57.1515269729303
01-703-1076 Day 1 66.2848212245528 58.1558846107899
01-703-1258 Day 1 58.4920648676619 53.5962262898658
01-703-1295 Day 1 57.8648679687882 52.763708718869
01-703-1335 Day 1 63.8531331699272 58.6037765743557
01-703-1439 Day 1 70.7755000786901 59.6696375811495
01-704-1008 Day 1 55.9990798466281 47.2514948189056
01-704-1017 Day 1 72.6847847018819 60.5525819296715
01-704-1065 Day 1 69.152244946338 60.352526521024
01-704-1074 Day 1 62.7313317385175 53.1967632164635
01-704-1093 Day 1 56.251557699656 48.0085629690869
01-704-1241 Day 1 56.1253172057378 51.2668638995274
01-704-1266 Day 1 71.5040958601842 62.4132167266334
01-704-1332 Day 1 57.9689177871063 52.1765497001733
01-705-1280 Day 1 61.6693630759244 53.6603880162113
01-705-1281 Day 1 57.3815204069199 52.1842532977695
01-705-1303 Day 1 63.0419436494928 55.3339980130265
01-705-1310 Day 1 57.162715069113 52.2864311537116
01-705-1377 Day 1 65.1416632033625 57.064976921407
01-706-1049 Day 1 71.056979970562 63.4199682800638
01-708-1178 Day 1 58.8831359412451 50.8650082456469
01-708-1216 Day 1 66.4437289199898 60.5447192270224
01-708-1336 Day 1 60.2132807404654 51.1195462917555
01-708-1347 Day 1 64.7170946238724 54.8022359425916
01-708-1406 Day 1 68.7670150275877 60.2674235422186
01-709-1029 Day 1 69.3065645322237 61.1301972053892
01-709-1099 Day 1 67.4604957624351 61.7216628440754
01-709-1168 Day 1 55.8628177647489 50.4750006505934
01-709-1238 Day 1 60.3626150459332 53.4291912533151
01-709-1309 Day 1 72.4015709005017 64.034822453722
01-710-1006 Day 1 60.2081198996999 50.9911487369642
01-710-1021 Day 1 57.7615141523578 53.6088163626131
01-710-1070 Day 1 71.9000395982654 60.670072986372
01-710-1137 Day 1 58.2393035699699 51.9021410806068
01-710-1142 Day 1 67.9365391653132 61.7392711691635
01-710-1187 Day 1 64.7050790826768 58.9932513850946
01-710-1249 Day 1 61.2239482544055 54.6833922081462
01-710-1278 Day 1 73.6444387849105 64.6665271959921
01-710-1354 Day 1 70.97572435018 60.8000829476732

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