From 10ca8f11433759a76f602f4f30357d4541b8eadb Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Wed, 16 Aug 2023 17:39:31 -0400 Subject: [PATCH 01/15] oncoprint color config for mutations testing --- src/pages/resultsView/ResultsViewPageStore.ts | 56 ++++++ src/shared/components/oncoprint/DeltaUtils.ts | 59 ++++-- src/shared/components/oncoprint/Oncoprint.tsx | 6 +- .../oncoprint/ResultsViewOncoprint.tsx | 81 +++++++- .../oncoprint/controls/OncoprintColors.tsx | 181 ++++++++++++++++++ .../oncoprint/controls/OncoprintControls.tsx | 96 +++++++++- 6 files changed, 455 insertions(+), 24 deletions(-) create mode 100644 src/shared/components/oncoprint/controls/OncoprintColors.tsx diff --git a/src/pages/resultsView/ResultsViewPageStore.ts b/src/pages/resultsView/ResultsViewPageStore.ts index 42e6e8f635f..204530f996c 100644 --- a/src/pages/resultsView/ResultsViewPageStore.ts +++ b/src/pages/resultsView/ResultsViewPageStore.ts @@ -304,6 +304,7 @@ import { ONCOKB_DEFAULT_INFO, USE_DEFAULT_PUBLIC_INSTANCE_FOR_ONCOKB, } from 'react-mutation-mapper'; +import { RGBAColor } from 'oncoprintjs'; type Optional = | { isApplicable: true; value: T } @@ -573,6 +574,15 @@ export class ResultsViewPageStore extends AnalysisStore @observable queryFormVisible: boolean = false; + @observable userAlterationColors: { + [alteration: string]: string | undefined; + } = {}; + + private _selectedComparisonGroupsWarningSigns = observable.map< + string, + boolean + >({}, { deep: false }); + @computed get doNonSelectedDownloadableMolecularProfilesExist() { return ( this.nonSelectedDownloadableMolecularProfilesGroupByName.result && @@ -586,6 +596,52 @@ export class ResultsViewPageStore extends AnalysisStore | ModifyQueryParams | undefined = undefined; + @action.bound + public onAlterationColorChange( + alteration: string, + color: string | undefined + ) { + if (color == undefined && this.userAlterationColors[alteration]) { + delete this.userAlterationColors[alteration]; + } else this.userAlterationColors[alteration] = color; + } + + @action public showAlterationWarningSign( + alteration: string, + markedValue: boolean + ) { + this._selectedComparisonGroupsWarningSigns.set(alteration, markedValue); + } + + public flagDuplicateColorsForAlterations( + alteration: string, + color: string | undefined + ) { + let colors: { [color: string]: number } = {}; + + Object.keys(this.userAlterationColors).forEach( + (a: string, i: number) => { + let alterationColor = + a === alteration ? color : this.userAlterationColors[a]; + if ( + alterationColor == undefined || + colors[alterationColor] == undefined + ) { + if (alterationColor != undefined) + colors[alterationColor] = 1; + this.showAlterationWarningSign(alteration, false); + } else { + colors[alterationColor] = colors[alterationColor] + 1; + this.showAlterationWarningSign(alteration, true); + } + } + ); + } + + public isAlterationMarkedWithWarningSign(alteration: string): boolean { + return !!this._selectedComparisonGroupsWarningSigns.get(alteration); + } + @action.bound public setOncoprintAnalysisCaseType(e: OncoprintAnalysisCaseType) { this.urlWrapper.updateURL({ diff --git a/src/shared/components/oncoprint/DeltaUtils.ts b/src/shared/components/oncoprint/DeltaUtils.ts index c4225c5b9bd..0f53eb589e4 100644 --- a/src/shared/components/oncoprint/DeltaUtils.ts +++ b/src/shared/components/oncoprint/DeltaUtils.ts @@ -15,6 +15,7 @@ import { SortConfig, TrackId, UserTrackSpec, + IGeneticAlterationRuleSetParams, } from 'oncoprintjs'; import _ from 'lodash'; import { @@ -60,7 +61,8 @@ export function transition( getTrackSpecKeyToTrackId: () => { [key: string]: TrackId }, getMolecularProfileMap: () => | { [molecularProfileId: string]: MolecularProfile } - | undefined + | undefined, + customRule?: IGeneticAlterationRuleSetParams ) { const notKeepingSorted = shouldNotKeepSortedForTransition( nextProps, @@ -90,7 +92,8 @@ export function transition( prevProps, oncoprint, getTrackSpecKeyToTrackId, - getMolecularProfileMap + getMolecularProfileMap, + customRule ); transitionSortConfig(nextProps, prevProps, oncoprint); transitionTrackGroupSortPriority(nextProps, prevProps, oncoprint); @@ -587,7 +590,8 @@ function hasGeneticTrackRuleSetChanged( prevProps.distinguishMutationType || nextProps.distinguishDrivers !== prevProps.distinguishDrivers || nextProps.distinguishGermlineMutations !== - prevProps.distinguishGermlineMutations + prevProps.distinguishGermlineMutations || + nextProps.test !== prevProps.test ); } @@ -598,7 +602,8 @@ function transitionTracks( getTrackSpecKeyToTrackId: () => { [key: string]: TrackId }, getMolecularProfileMap: () => | { [molecularProfileId: string]: MolecularProfile } - | undefined + | undefined, + customRule?: IGeneticAlterationRuleSetParams ) { // Initialize tracks for rule set sharing const trackIdForRuleSetSharing = { @@ -740,7 +745,9 @@ function transitionTracks( oncoprint, nextProps, prevProps, - trackIdForRuleSetSharing + trackIdForRuleSetSharing, + undefined, + customRule ); delete prevGeneticTracks[track.key]; } @@ -756,7 +763,9 @@ function transitionTracks( oncoprint, nextProps, prevProps, - trackIdForRuleSetSharing + trackIdForRuleSetSharing, + undefined, + customRule ); } } @@ -1093,13 +1102,26 @@ function transitionGeneticTrack( nextProps: IOncoprintProps, prevProps: Partial, trackIdForRuleSetSharing: { genetic?: TrackId }, - expansionParentKey?: string + expansionParentKey?: string, + customRule?: IGeneticAlterationRuleSetParams ) { const trackSpecKeyToTrackId = getTrackSpecKeyToTrackId(); if (tryRemoveTrack(nextSpec, prevSpec, trackSpecKeyToTrackId, oncoprint)) { // Remove track return; } else if (nextSpec && !prevSpec) { + let rule = customRule + ? customRule + : getGeneticTrackRuleSetParams( + nextProps.distinguishMutationType, + nextProps.distinguishDrivers, + nextProps.distinguishGermlineMutations + ); + console.log(rule); + // if (rule.rule_params.conditional.disp_mut.inframe) { + // console.log('hi') + // rule.rule_params.conditional.disp_mut.inframe.shapes[0].fill = [153, 52, 4, 1] + // } // Add track const createCustomOncoprintTooltip = getCustomJsFunctions() .createCustomOncoprintTooltip; @@ -1115,11 +1137,7 @@ function transitionGeneticTrack( ); } const geneticTrackParams: UserTrackSpec = { - rule_set_params: getGeneticTrackRuleSetParams( - nextProps.distinguishMutationType, - nextProps.distinguishDrivers, - nextProps.distinguishGermlineMutations - ), + rule_set_params: rule, label: nextSpec.label, sublabel: nextSpec.sublabel, track_label_color: nextSpec.labelColor || undefined, @@ -1211,15 +1229,16 @@ function transitionGeneticTrack( trackId ); } else { + let rule = customRule + ? customRule + : getGeneticTrackRuleSetParams( + nextProps.distinguishMutationType, + nextProps.distinguishDrivers, + nextProps.distinguishGermlineMutations + ); + console.log(rule); // otherwise, update ruleset - oncoprint.setRuleSet( - trackId, - getGeneticTrackRuleSetParams( - nextProps.distinguishMutationType, - nextProps.distinguishDrivers, - nextProps.distinguishGermlineMutations - ) - ); + oncoprint.setRuleSet(trackId, rule); } } // either way, use this one now diff --git a/src/shared/components/oncoprint/Oncoprint.tsx b/src/shared/components/oncoprint/Oncoprint.tsx index 25a7fd6059d..95e82776165 100644 --- a/src/shared/components/oncoprint/Oncoprint.tsx +++ b/src/shared/components/oncoprint/Oncoprint.tsx @@ -7,6 +7,7 @@ import { TrackSortDirection, InitParams, ColumnLabel, + IGeneticAlterationRuleSetParams, } from 'oncoprintjs'; import { GenePanelData, MolecularProfile } from 'cbioportal-ts-api-client'; import { observer } from 'mobx-react'; @@ -275,6 +276,8 @@ export interface IOncoprintProps { alterationTypesInQuery?: string[]; distinguishMutationType?: boolean; + test?: boolean; + rule?: IGeneticAlterationRuleSetParams; distinguishDrivers?: boolean; distinguishGermlineMutations?: boolean; @@ -386,7 +389,8 @@ export default class Oncoprint extends React.Component { () => this.trackSpecKeyToTrackId, () => { return this.props.molecularProfileIdToMolecularProfile; - } + }, + this.props.rule ); this.lastTransitionProps = _.clone(props); } diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index b3ccc60fac7..fa47d1a0909 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -42,6 +42,7 @@ import { AlterationTypeConstants } from 'shared/constants'; import { ResultsViewPageStore } from '../../../pages/resultsView/ResultsViewPageStore'; import { getAlteredUids, + getGeneticTrackRuleSetParams, getUnalteredUids, makeClinicalTracksMobxPromise, makeGenericAssayProfileCategoricalTracksMobxPromise, @@ -55,7 +56,13 @@ import _ from 'lodash'; import { onMobxPromise, toPromise } from 'cbioportal-frontend-commons'; import { getServerConfig } from 'config/config'; import LoadingIndicator from 'shared/components/loadingIndicator/LoadingIndicator'; -import { OncoprintJS, TrackGroupIndex, TrackId } from 'oncoprintjs'; +import { + IGeneticAlterationRuleSetParams, + OncoprintJS, + RGBAColor, + TrackGroupIndex, + TrackId, +} from 'oncoprintjs'; import fileDownload from 'react-file-download'; import tabularDownload from './tabularDownload'; import classNames from 'classnames'; @@ -90,6 +97,7 @@ import '../../../globalStyles/oncoprintStyles.scss'; import { GenericAssayTrackInfo } from 'pages/studyView/addChartButton/genericAssaySelection/GenericAssaySelection'; import { toDirectionString } from './SortUtils'; import { RestoreClinicalTracksMenu } from 'pages/resultsView/oncoprint/RestoreClinicalTracksMenu'; +import { hexToRGBA } from 'shared/lib/Colors'; interface IResultsViewOncoprintProps { divId: string; @@ -254,6 +262,15 @@ export default class ResultsViewOncoprint extends React.Component< @observable renderingComplete = false; + @observable + rule: IGeneticAlterationRuleSetParams = getGeneticTrackRuleSetParams( + this.distinguishMutationType, + this.distinguishDrivers, + this.distinguishGermlineMutations + ); + + @observable test: boolean = false; + private heatmapGeneInputValueUpdater: IReactionDisposer; private molecularProfileIdToTrackGroupIndex: { @@ -486,9 +503,15 @@ export default class ResultsViewOncoprint extends React.Component< get sortByCaseListDisabled() { return !self.caseListSortPossible; }, + get rule() { + return self.rule; + }, get distinguishMutationType() { return self.distinguishMutationType; }, + get test() { + return self.test; + }, get distinguishDrivers() { return self.distinguishDrivers; }, @@ -706,6 +729,12 @@ export default class ResultsViewOncoprint extends React.Component< onSelectDistinguishMutationType: (s: boolean) => { this.distinguishMutationType = s; }, + onSelectTest: (s: boolean) => { + this.test = s; + }, + onSetRule: (rule: IGeneticAlterationRuleSetParams) => { + this.rule = rule; + }, onSelectDistinguishDrivers: action((s: boolean) => { if (!s) { this.props.store.driverAnnotationSettings.oncoKb = false; @@ -1691,6 +1720,7 @@ export default class ResultsViewOncoprint extends React.Component< this .selectedGenericAssayEntitiesGroupedByGenericAssayTypeFromUrl } + setRules={this.setRules} /> ); @@ -1794,6 +1824,53 @@ export default class ResultsViewOncoprint extends React.Component< return WindowStore.size.width - 75; } + @action.bound + public setRules(alteration: string, color: RGBAColor | undefined) { + if (color == undefined) { + this.rule = getGeneticTrackRuleSetParams( + this.distinguishMutationType, + this.distinguishDrivers, + this.distinguishGermlineMutations + ); + for (alteration in this.props.store.userAlterationColors) { + if ( + this.props.store.userAlterationColors[alteration] !== + undefined + ) { + this.rule.rule_params.conditional.disp_mut[ + alteration + ].shapes[0].fill = hexToRGBA( + this.props.store.userAlterationColors[alteration]! + ); + } + } + } else { + // const rules = getGeneticTrackRuleSetParams(this.distinguishMutationType, + // this.distinguishDrivers, + // this.distinguishGermlineMutations + // ); + // if (rules.rule_params.conditional.disp_mut.missense && this.test) { + // rules.rule_params.conditional.disp_mut.missense.shapes[0].fill = [0, 128, 0, 1] + // } + // else if (rules.rule_params.conditional.disp_mut.missense && !this.test) { + // rules.rule_params.conditional.disp_mut.missense.shapes[0].fill = [83, 212, 0, 1] + // } + if (this.rule.rule_params.conditional.disp_mut[alteration]) { + this.rule.rule_params.conditional.disp_mut[ + alteration + ].shapes[0].fill = color; + } + // else if (rules.rule_params.conditional.disp_mut['splice,missense,inframe,trunc,promoter,other'] && this.test) { + // rules.rule_params.conditional.disp_mut['splice,missense,inframe,trunc,promoter,other'].shapes[0].fill = [0, 128, 0, 1] + // } + // else if (rules.rule_params.conditional.disp_mut['splice,missense,inframe,trunc,promoter,other'] && !this.test) { + // rules.rule_params.conditional.disp_mut['splice,missense,inframe,trunc,promoter,other'].shapes[0].fill = [83, 212, 0, 1] + // } + // this.rule = rules; + } + console.log(this.rule); + } + public render() { getBrowserWindow().donk = this; return ( @@ -1895,6 +1972,7 @@ export default class ResultsViewOncoprint extends React.Component< distinguishMutationType={ this.distinguishMutationType } + test={this.test} distinguishDrivers={this.distinguishDrivers} distinguishGermlineMutations={ this.distinguishGermlineMutations @@ -1918,6 +1996,7 @@ export default class ResultsViewOncoprint extends React.Component< initParams={{ max_height: Number.POSITIVE_INFINITY, }} + rule={this.rule} /> diff --git a/src/shared/components/oncoprint/controls/OncoprintColors.tsx b/src/shared/components/oncoprint/controls/OncoprintColors.tsx new file mode 100644 index 00000000000..8cd23a2c4eb --- /dev/null +++ b/src/shared/components/oncoprint/controls/OncoprintColors.tsx @@ -0,0 +1,181 @@ +import * as React from 'react'; +import { observer } from 'mobx-react'; +import autobind from 'autobind-decorator'; +import { action, computed, makeObservable, observable } from 'mobx'; +import styles from '../styles.module.scss'; +import { CirclePicker, CirclePickerProps } from 'react-color'; +import { OverlayTrigger, Popover } from 'react-bootstrap'; +import { DefaultTooltip } from 'cbioportal-frontend-commons'; +import { ColorPickerIcon } from 'pages/groupComparison/comparisonGroupManager/ColorPickerIcon'; +import { + CLI_FEMALE_COLOR, + CLI_NO_COLOR, + CLI_YES_COLOR, + DARK_GREY, +} from 'shared/lib/Colors'; +import { COLORS } from 'pages/studyView/StudyViewUtils'; +import { ResultsViewPageStore } from 'pages/resultsView/ResultsViewPageStore'; +import { + IOncoprintControlsHandlers, + IOncoprintControlsState, +} from './OncoprintControls'; +import { RGBAColor } from 'oncoprintjs'; + +export interface IGroupCheckboxProps { + alteration: string; + store?: ResultsViewPageStore; + handlers: IOncoprintControlsHandlers; + state: IOncoprintControlsState; + setRules?: (alteration: string, color: RGBAColor | undefined) => void; + color?: string; + markedWithWarningSign: boolean; +} + +const COLOR_UNDEFINED = '#FFFFFF'; + +const alterationToLabel: { [alteration: string]: string } = { + missense: 'Missense Mutation (unknown significance)', + missense_rec: 'Missense Mutation (putative driver)', + trunc: 'Truncating Mutation (unknown significance)', + trunc_rec: 'Truncating Mutation (putative driver)', + inframe: 'Inframe Mutation (unknown significance)', + inframe_rec: 'Inframe Mutation (putative driver)', + splice: 'Splice Mutation (unknown significance)', + splice_rec: 'Splice Mutation (putative driver)', + promoter: 'Promoter Mutation (unknown significance)', + promoter_rec: 'Promoter Mutation (putative driver)', + other: 'Other Mutation (unknown significance)', + other_rec: 'Other Mutation (putative driver)', +}; + +@observer +export default class OncoprintColors extends React.Component< + IGroupCheckboxProps, + {} +> { + constructor(props: IGroupCheckboxProps) { + super(props); + makeObservable(this); + } + + @action.bound + handleChangeComplete = (color: any, event: any) => { + // if same color is select, unselect it (go back to no color) + if (color.hex === this.props.color) { + this.props.store?.onAlterationColorChange( + this.props.alteration, + undefined + ); + this.props.setRules && + this.props.setRules(this.props.alteration, undefined); + this.props.store!.flagDuplicateColorsForAlterations( + this.props.alteration, + undefined + ); + } else { + this.props.store?.onAlterationColorChange( + this.props.alteration, + color.hex + ); + this.props.setRules && + this.props.setRules(this.props.alteration, [ + color.rgb.r, + color.rgb.g, + color.rgb.b, + color.rgb.a, + ]); + this.props.store!.flagDuplicateColorsForAlterations( + this.props.alteration, + color.hex + ); + } + this.props.handlers.onSelectTest && + this.props.handlers.onSelectTest(!this.props.state.test!); + this.props.handlers.onSetRule && + this.props.handlers.onSetRule(this.props.state.rule!); + }; + + @computed get colorList() { + let colors: string[] = COLORS.slice(0, 20); + colors.push(CLI_YES_COLOR); + colors.push(CLI_NO_COLOR); + colors.push(CLI_FEMALE_COLOR); + colors.push(DARK_GREY); + return colors; + } + + buildColorChooserWidget = () => ( + +
{ + e.nativeEvent.stopImmediatePropagation(); + }} + onClick={e => { + e.nativeEvent.stopImmediatePropagation(); + }} + > + +
+ + ); + + render() { + return ( +
+ {alterationToLabel[this.props.alteration]} + + + {this.props.markedWithWarningSign && ( + + )} + + + + + + + + + +
+ ); + } +} diff --git a/src/shared/components/oncoprint/controls/OncoprintControls.tsx b/src/shared/components/oncoprint/controls/OncoprintControls.tsx index f08855e191a..d31bb002a55 100644 --- a/src/shared/components/oncoprint/controls/OncoprintControls.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintControls.tsx @@ -1,6 +1,6 @@ import * as React from 'react'; import { observer } from 'mobx-react'; -import { Button, ButtonGroup } from 'react-bootstrap'; +import { Button, ButtonGroup, OverlayTrigger, Popover } from 'react-bootstrap'; import CustomDropdown from './CustomDropdown'; import ConfirmNgchmModal from './ConfirmNgchmModal'; import ReactSelect from 'react-select1'; @@ -32,7 +32,9 @@ import { import OQLTextArea, { GeneBoxType } from '../../GeneSelectionBox/OQLTextArea'; import autobind from 'autobind-decorator'; import { SingleGeneQuery } from '../../../lib/oql/oql-parser'; -import TracksMenu from 'pages/resultsView/oncoprint/TracksMenu'; +import TracksMenu, { + MIN_DROPDOWN_WIDTH, +} from 'pages/resultsView/oncoprint/TracksMenu'; import { GenericAssayTrackInfo } from 'pages/studyView/addChartButton/genericAssaySelection/GenericAssaySelection'; import { IDriverAnnotationControlsHandlers, @@ -44,6 +46,8 @@ import { ClinicalTrackConfigMap, } from 'shared/components/oncoprint/Oncoprint'; import { getServerConfig } from 'config/config'; +import { IGeneticAlterationRuleSetParams, RGBAColor } from 'oncoprintjs'; +import OncoprintColors from './OncoprintColors'; export interface IOncoprintControlsHandlers extends IDriverAnnotationControlsHandlers { @@ -58,6 +62,8 @@ export interface IOncoprintControlsHandlers onSelectShowMinimap: (showMinimap: boolean) => void; onSelectDistinguishMutationType: (distinguish: boolean) => void; onSelectDistinguishGermlineMutations: (distinguish: boolean) => void; + onSelectTest?: (distinguish: boolean) => void; + onSetRule?: (rule: IGeneticAlterationRuleSetParams) => void; onSelectHideVUS: (hide: boolean) => void; onSelectHideGermlineMutations: (hide: boolean) => void; @@ -101,6 +107,8 @@ export interface IOncoprintControlsState sortByCaseListDisabled: boolean; hidePutativePassengers: boolean; hideGermlineMutations: boolean; + test?: boolean; + rule?: IGeneticAlterationRuleSetParams; sortMode?: SortMode; clinicalAttributesPromise?: MobxPromise; @@ -136,6 +144,7 @@ export interface IOncoprintControlsProps { selectedGenericAssayEntitiesGroupedByGenericAssayTypeFromUrl?: { [genericAssayType: string]: string[]; }; + setRules?: (alteration: string, color: RGBAColor | undefined) => void; } export interface ISelectOption { @@ -178,6 +187,8 @@ const EVENT_KEY = { downloadOncoprinter: '29.1', horzZoomSlider: '30', viewNGCHM: '31', + test: '32', + rule: '33', }; @observer @@ -319,7 +330,23 @@ export default class OncoprintControls extends React.Component< this.props.handlers.onSelectDistinguishMutationType( !this.props.state.distinguishMutationType ); + // this.props.test && this.props.test(); + // this.props.handlers.onSetRule && + // this.props.handlers.onSetRule( + // this.props.state.rule + // ); break; + // case EVENT_KEY.rule: + // this.props.handlers.onSelectTest && + // this.props.handlers.onSelectTest( + // !this.props.state.test + // ); + // this.props.test && this.props.test(); + // this.props.handlers.onSetRule && + // this.props.handlers.onSetRule( + // this.props.state.rule + // ); + // break; case EVENT_KEY.distinguishGermlineMutations: this.props.handlers.onSelectDistinguishGermlineMutations( !this.props.state.distinguishGermlineMutations @@ -830,6 +857,70 @@ export default class OncoprintControls extends React.Component< } } + private ColorsMenuOncoprint = observer(() => { + return ( + +
+ {[ + 'missense', + 'missense_rec', + 'trunc', + 'trunc_rec', + 'inframe', + 'inframe_rec', + 'splice', + 'splice_rec', + 'promoter', + 'promoter_rec', + 'other', + 'other_rec', + ].map(alteration => ( + + ))} + {/*
Color by Alteration
+
+
+ +
+
*/} +
+ + ); + }); + private MutationColorMenu = observer(() => { return ( + From bdab324f879a808789eb9a4cb5df766a33c38e6c Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Fri, 18 Aug 2023 16:18:24 -0400 Subject: [PATCH 02/15] add color config for all alterations --- src/pages/resultsView/ResultsViewPageStore.ts | 85 +++++++++----- .../oncoprint/ResultsViewOncoprint.tsx | 81 +++++++------ .../oncoprint/controls/OncoprintColors.tsx | 110 +++++++++++------- .../oncoprint/controls/OncoprintControls.tsx | 91 +++++---------- src/shared/lib/Colors.ts | 17 +++ 5 files changed, 214 insertions(+), 170 deletions(-) diff --git a/src/pages/resultsView/ResultsViewPageStore.ts b/src/pages/resultsView/ResultsViewPageStore.ts index 204530f996c..4e58c6f2f7f 100644 --- a/src/pages/resultsView/ResultsViewPageStore.ts +++ b/src/pages/resultsView/ResultsViewPageStore.ts @@ -304,7 +304,7 @@ import { ONCOKB_DEFAULT_INFO, USE_DEFAULT_PUBLIC_INSTANCE_FOR_ONCOKB, } from 'react-mutation-mapper'; -import { RGBAColor } from 'oncoprintjs'; +import { IGeneticAlterationRuleSetParams, RGBAColor } from 'oncoprintjs'; type Optional = | { isApplicable: true; value: T } @@ -575,7 +575,9 @@ export class ResultsViewPageStore extends AnalysisStore @observable queryFormVisible: boolean = false; @observable userAlterationColors: { - [alteration: string]: string | undefined; + [alteration: string]: { + [type: string]: RGBAColor | undefined; + }; } = {}; private _selectedComparisonGroupsWarningSigns = observable.map< @@ -599,45 +601,64 @@ export class ResultsViewPageStore extends AnalysisStore @action.bound public onAlterationColorChange( alteration: string, - color: string | undefined + type: string, + color: RGBAColor ) { - if (color == undefined && this.userAlterationColors[alteration]) { - delete this.userAlterationColors[alteration]; - } else this.userAlterationColors[alteration] = color; + this.userAlterationColors[alteration][type] = color; } - @action public showAlterationWarningSign( - alteration: string, - markedValue: boolean - ) { - this._selectedComparisonGroupsWarningSigns.set(alteration, markedValue); - } - - public flagDuplicateColorsForAlterations( - alteration: string, - color: string | undefined + @action.bound + public setDefaultUserAlterationColors( + rule: IGeneticAlterationRuleSetParams ) { - let colors: { [color: string]: number } = {}; - - Object.keys(this.userAlterationColors).forEach( - (a: string, i: number) => { - let alterationColor = - a === alteration ? color : this.userAlterationColors[a]; - if ( - alterationColor == undefined || - colors[alterationColor] == undefined - ) { - if (alterationColor != undefined) - colors[alterationColor] = 1; - this.showAlterationWarningSign(alteration, false); + for (let alteration in rule.rule_params.conditional) { + this.userAlterationColors[alteration] = {}; + for (let type in rule.rule_params.conditional[alteration]) { + if (alteration === 'disp_mrna') { + this.userAlterationColors[alteration][type] = rule + .rule_params.conditional[alteration][type].shapes[0] + .stroke as RGBAColor; } else { - colors[alterationColor] = colors[alterationColor] + 1; - this.showAlterationWarningSign(alteration, true); + this.userAlterationColors[alteration][type] = rule + .rule_params.conditional[alteration][type].shapes[0] + .fill as RGBAColor; } } - ); + } } + // @action public showAlterationWarningSign( + // alteration: string, + // markedValue: boolean + // ) { + // this._selectedComparisonGroupsWarningSigns.set(alteration, markedValue); + // } + + // public flagDuplicateColorsForAlterations( + // alteration: string, + // color: string | undefined + // ) { + // let colors: { [color: string]: number } = {}; + + // Object.keys(this.userAlterationColors).forEach( + // (a: string, i: number) => { + // let alterationColor = + // a === alteration ? color : this.userAlterationColors[a]; + // if ( + // alterationColor == undefined || + // colors[alterationColor] == undefined + // ) { + // if (alterationColor != undefined) + // colors[alterationColor] = 1; + // this.showAlterationWarningSign(alteration, false); + // } else { + // colors[alterationColor] = colors[alterationColor] + 1; + // this.showAlterationWarningSign(alteration, true); + // } + // } + // ); + // } + public isAlterationMarkedWithWarningSign(alteration: string): boolean { return !!this._selectedComparisonGroupsWarningSigns.get(alteration); } diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index fa47d1a0909..ee0661bf7f3 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -97,7 +97,6 @@ import '../../../globalStyles/oncoprintStyles.scss'; import { GenericAssayTrackInfo } from 'pages/studyView/addChartButton/genericAssaySelection/GenericAssaySelection'; import { toDirectionString } from './SortUtils'; import { RestoreClinicalTracksMenu } from 'pages/resultsView/oncoprint/RestoreClinicalTracksMenu'; -import { hexToRGBA } from 'shared/lib/Colors'; interface IResultsViewOncoprintProps { divId: string; @@ -424,6 +423,7 @@ export default class ResultsViewOncoprint extends React.Component< super(props); makeObservable(this); + this.props.store.setDefaultUserAlterationColors(this.rule); this.showOqlInLabels = props.store.queryContainsOql; (window as any).resultsViewOncoprint = this; @@ -1825,50 +1825,65 @@ export default class ResultsViewOncoprint extends React.Component< } @action.bound - public setRules(alteration: string, color: RGBAColor | undefined) { + public setRules( + alteration: string, + type: string, + color: RGBAColor | undefined + ) { if (color == undefined) { this.rule = getGeneticTrackRuleSetParams( this.distinguishMutationType, this.distinguishDrivers, this.distinguishGermlineMutations ); - for (alteration in this.props.store.userAlterationColors) { - if ( - this.props.store.userAlterationColors[alteration] !== - undefined - ) { - this.rule.rule_params.conditional.disp_mut[ - alteration - ].shapes[0].fill = hexToRGBA( - this.props.store.userAlterationColors[alteration]! - ); + for (let a in this.props.store.userAlterationColors) { + for (let t in this.props.store.userAlterationColors[a]) { + if (a === 'disp_mrna') { + if (a !== alteration && t !== type) { + this.rule.rule_params.conditional[a][ + t + ].shapes[0].stroke = this.props.store.userAlterationColors[ + a + ][t]; + } else { + this.props.store.onAlterationColorChange( + alteration, + type, + this.rule.rule_params.conditional[a][t] + .shapes[0].stroke as RGBAColor + ); + } + } else { + if (a !== alteration || t !== type) { + this.rule.rule_params.conditional[a][ + t + ].shapes[0].fill = this.props.store.userAlterationColors[ + a + ][t]; + } else { + this.props.store.onAlterationColorChange( + alteration, + type, + this.rule.rule_params.conditional[a][t] + .shapes[0].fill as RGBAColor + ); + } + } } } } else { - // const rules = getGeneticTrackRuleSetParams(this.distinguishMutationType, - // this.distinguishDrivers, - // this.distinguishGermlineMutations - // ); - // if (rules.rule_params.conditional.disp_mut.missense && this.test) { - // rules.rule_params.conditional.disp_mut.missense.shapes[0].fill = [0, 128, 0, 1] - // } - // else if (rules.rule_params.conditional.disp_mut.missense && !this.test) { - // rules.rule_params.conditional.disp_mut.missense.shapes[0].fill = [83, 212, 0, 1] - // } - if (this.rule.rule_params.conditional.disp_mut[alteration]) { - this.rule.rule_params.conditional.disp_mut[ - alteration + if (alteration === 'disp_mrna') { + this.rule.rule_params.conditional[alteration][ + type + ].shapes[0].stroke = color; + } else { + this.rule.rule_params.conditional[alteration][ + type ].shapes[0].fill = color; } - // else if (rules.rule_params.conditional.disp_mut['splice,missense,inframe,trunc,promoter,other'] && this.test) { - // rules.rule_params.conditional.disp_mut['splice,missense,inframe,trunc,promoter,other'].shapes[0].fill = [0, 128, 0, 1] - // } - // else if (rules.rule_params.conditional.disp_mut['splice,missense,inframe,trunc,promoter,other'] && !this.test) { - // rules.rule_params.conditional.disp_mut['splice,missense,inframe,trunc,promoter,other'].shapes[0].fill = [83, 212, 0, 1] - // } - // this.rule = rules; + this.props.store.onAlterationColorChange(alteration, type, color); } - console.log(this.rule); + // console.log(this.rule); } public render() { diff --git a/src/shared/components/oncoprint/controls/OncoprintColors.tsx b/src/shared/components/oncoprint/controls/OncoprintColors.tsx index 8cd23a2c4eb..0d0a5bd1ec6 100644 --- a/src/shared/components/oncoprint/controls/OncoprintColors.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintColors.tsx @@ -12,6 +12,7 @@ import { CLI_NO_COLOR, CLI_YES_COLOR, DARK_GREY, + rgbaToHex, } from 'shared/lib/Colors'; import { COLORS } from 'pages/studyView/StudyViewUtils'; import { ResultsViewPageStore } from 'pages/resultsView/ResultsViewPageStore'; @@ -23,29 +24,65 @@ import { RGBAColor } from 'oncoprintjs'; export interface IGroupCheckboxProps { alteration: string; + type: string; store?: ResultsViewPageStore; handlers: IOncoprintControlsHandlers; state: IOncoprintControlsState; - setRules?: (alteration: string, color: RGBAColor | undefined) => void; - color?: string; + setRules?: ( + alteration: string, + type: string, + color: RGBAColor | undefined + ) => void; + color: RGBAColor; markedWithWarningSign: boolean; } const COLOR_UNDEFINED = '#FFFFFF'; -const alterationToLabel: { [alteration: string]: string } = { - missense: 'Missense Mutation (unknown significance)', - missense_rec: 'Missense Mutation (putative driver)', - trunc: 'Truncating Mutation (unknown significance)', - trunc_rec: 'Truncating Mutation (putative driver)', - inframe: 'Inframe Mutation (unknown significance)', - inframe_rec: 'Inframe Mutation (putative driver)', - splice: 'Splice Mutation (unknown significance)', - splice_rec: 'Splice Mutation (putative driver)', - promoter: 'Promoter Mutation (unknown significance)', - promoter_rec: 'Promoter Mutation (putative driver)', - other: 'Other Mutation (unknown significance)', - other_rec: 'Other Mutation (putative driver)', +export const alterationToTypeToLabel: { + [alteration: string]: { [type: string]: string }; +} = { + // disp_cna + disp_cna: { + 'amp_rec,amp': 'Amplification', + 'gain_rec,gain': 'Gain', + 'hetloss_rec,hetloss': 'Shallow Deletion', + 'homdel_rec,homdel': 'Deep Deletion', + }, + // disp_germ + disp_germ: { + true: 'Germline Mutation', + }, + // disp_mrna + disp_mrna: { + high: 'mRNA High', + low: 'mRNA Low', + }, + // disp_mut + disp_mut: { + missense: 'Missense Mutation (unknown significance)', + missense_rec: 'Missense Mutation (putative driver)', + trunc: 'Truncating Mutation (unknown significance)', + trunc_rec: 'Truncating Mutation (putative driver)', + inframe: 'Inframe Mutation (unknown significance)', + inframe_rec: 'Inframe Mutation (putative driver)', + splice: 'Splice Mutation (unknown significance)', + splice_rec: 'Splice Mutation (putative driver)', + promoter: 'Promoter Mutation (unknown significance)', + promoter_rec: 'Promoter Mutation (putative driver)', + other: 'Other Mutation (unknown significance)', + other_rec: 'Other Mutation (putative driver)', + }, + // disp_prot + disp_prot: { + high: 'Protein High', + low: 'Protein Low', + }, + // disp_structuralVariant + disp_structuralVariant: { + sv: 'Structural Variant (unknown significance)', + sv_rec: 'Structural Variant (putative driver)', + }, }; @observer @@ -61,38 +98,24 @@ export default class OncoprintColors extends React.Component< @action.bound handleChangeComplete = (color: any, event: any) => { // if same color is select, unselect it (go back to no color) - if (color.hex === this.props.color) { - this.props.store?.onAlterationColorChange( - this.props.alteration, - undefined - ); + if (color.hex === rgbaToHex(this.props.color)) { this.props.setRules && - this.props.setRules(this.props.alteration, undefined); - this.props.store!.flagDuplicateColorsForAlterations( - this.props.alteration, - undefined - ); + this.props.setRules( + this.props.alteration, + this.props.type, + undefined + ); } else { - this.props.store?.onAlterationColorChange( - this.props.alteration, - color.hex - ); this.props.setRules && - this.props.setRules(this.props.alteration, [ + this.props.setRules(this.props.alteration, this.props.type, [ color.rgb.r, color.rgb.g, color.rgb.b, color.rgb.a, ]); - this.props.store!.flagDuplicateColorsForAlterations( - this.props.alteration, - color.hex - ); } this.props.handlers.onSelectTest && this.props.handlers.onSelectTest(!this.props.state.test!); - this.props.handlers.onSetRule && - this.props.handlers.onSetRule(this.props.state.rule!); }; @computed get colorList() { @@ -119,7 +142,7 @@ export default class OncoprintColors extends React.Component< circleSize={20} circleSpacing={3} onChangeComplete={this.handleChangeComplete} - color={this.props.color} + color={rgbaToHex(this.props.color)} width="140px" /> @@ -129,7 +152,11 @@ export default class OncoprintColors extends React.Component< render() { return (
- {alterationToLabel[this.props.alteration]} + { + alterationToTypeToLabel[this.props.alteration][ + this.props.type + ] + } diff --git a/src/shared/components/oncoprint/controls/OncoprintControls.tsx b/src/shared/components/oncoprint/controls/OncoprintControls.tsx index d31bb002a55..8703a996a4e 100644 --- a/src/shared/components/oncoprint/controls/OncoprintControls.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintControls.tsx @@ -47,7 +47,7 @@ import { } from 'shared/components/oncoprint/Oncoprint'; import { getServerConfig } from 'config/config'; import { IGeneticAlterationRuleSetParams, RGBAColor } from 'oncoprintjs'; -import OncoprintColors from './OncoprintColors'; +import OncoprintColors, { alterationToTypeToLabel } from './OncoprintColors'; export interface IOncoprintControlsHandlers extends IDriverAnnotationControlsHandlers { @@ -144,7 +144,11 @@ export interface IOncoprintControlsProps { selectedGenericAssayEntitiesGroupedByGenericAssayTypeFromUrl?: { [genericAssayType: string]: string[]; }; - setRules?: (alteration: string, color: RGBAColor | undefined) => void; + setRules?: ( + alteration: string, + type: string, + color: RGBAColor | undefined + ) => void; } export interface ISelectOption { @@ -330,23 +334,7 @@ export default class OncoprintControls extends React.Component< this.props.handlers.onSelectDistinguishMutationType( !this.props.state.distinguishMutationType ); - // this.props.test && this.props.test(); - // this.props.handlers.onSetRule && - // this.props.handlers.onSetRule( - // this.props.state.rule - // ); break; - // case EVENT_KEY.rule: - // this.props.handlers.onSelectTest && - // this.props.handlers.onSelectTest( - // !this.props.state.test - // ); - // this.props.test && this.props.test(); - // this.props.handlers.onSetRule && - // this.props.handlers.onSetRule( - // this.props.state.rule - // ); - // break; case EVENT_KEY.distinguishGermlineMutations: this.props.handlers.onSelectDistinguishGermlineMutations( !this.props.state.distinguishGermlineMutations @@ -869,53 +857,28 @@ export default class OncoprintControls extends React.Component< className="oncoprint__controls__color_menu" data-test="oncoprintColorDropdownMenu" > - {[ - 'missense', - 'missense_rec', - 'trunc', - 'trunc_rec', - 'inframe', - 'inframe_rec', - 'splice', - 'splice_rec', - 'promoter', - 'promoter_rec', - 'other', - 'other_rec', - ].map(alteration => ( - + Object.keys( + alterationToTypeToLabel[alteration] + ).map(type => ( + - ))} - {/*
Color by Alteration
-
-
- -
-
*/} + )} + /> + )) + )}
); diff --git a/src/shared/lib/Colors.ts b/src/shared/lib/Colors.ts index 9546100ae7d..4913e3dce63 100644 --- a/src/shared/lib/Colors.ts +++ b/src/shared/lib/Colors.ts @@ -13,6 +13,7 @@ import { STRUCTURAL_VARIANT_COLOR, } from 'cbioportal-frontend-commons'; import { MUT_PROFILE_COUNT_NOT_MUTATED } from 'pages/resultsView/plots/PlotsTabUtils'; +import { RGBAColor } from 'oncoprintjs'; // Default grey export const BLACK = '#000000'; export const LIGHT_GREY = '#D3D3D3'; @@ -178,3 +179,19 @@ export function hexToRGBA(str: string): [number, number, number, number] { const b = parseInt(str[5] + str[6], 16); return [r, g, b, 1]; } + +export function rgbaToHex(rgba: RGBAColor): string { + let hexR = rgba[0].toString(16); + let hexG = rgba[1].toString(16); + let hexB = rgba[2].toString(16); + if (hexR.length === 1) { + hexR = '0' + hexR; + } + if (hexG.length === 1) { + hexG = '0' + hexG; + } + if (hexB.length === 1) { + hexB = '0' + hexB; + } + return `#${hexR}${hexG}${hexB}`; +} From 17ac47c0ec0b0b38580ac3ef3e32065fa590436a Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Thu, 7 Sep 2023 16:49:15 -0400 Subject: [PATCH 03/15] use default colors as computed and refactor --- src/pages/resultsView/ResultsViewPageStore.ts | 76 ++++++++---- src/shared/components/oncoprint/DeltaUtils.ts | 7 +- src/shared/components/oncoprint/Oncoprint.tsx | 2 +- .../oncoprint/ResultsViewOncoprint.tsx | 113 ++++++++---------- .../oncoprint/controls/OncoprintColors.tsx | 14 +-- .../oncoprint/controls/OncoprintControls.tsx | 37 +++--- 6 files changed, 133 insertions(+), 116 deletions(-) diff --git a/src/pages/resultsView/ResultsViewPageStore.ts b/src/pages/resultsView/ResultsViewPageStore.ts index 4e58c6f2f7f..1e3e173689d 100644 --- a/src/pages/resultsView/ResultsViewPageStore.ts +++ b/src/pages/resultsView/ResultsViewPageStore.ts @@ -574,9 +574,15 @@ export class ResultsViewPageStore extends AnalysisStore @observable queryFormVisible: boolean = false; - @observable userAlterationColors: { - [alteration: string]: { - [type: string]: RGBAColor | undefined; + @observable userSelectedAlterationColors: { + [alterationType: string]: { + [type: string]: RGBAColor; + }; + } = {}; + + @observable _defaultAlterationColors: { + [alterationType: string]: { + [type: string]: RGBAColor; }; } = {}; @@ -600,31 +606,57 @@ export class ResultsViewPageStore extends AnalysisStore @action.bound public onAlterationColorChange( - alteration: string, + alterationType: string, type: string, - color: RGBAColor + color: RGBAColor | undefined ) { - this.userAlterationColors[alteration][type] = color; + if ( + !color && + this.userSelectedAlterationColors[alterationType] && + this.userSelectedAlterationColors[alterationType][type] + ) { + delete this.userSelectedAlterationColors[alterationType][type]; + } else if (color) { + if (!this.userSelectedAlterationColors[alterationType]) { + this.userSelectedAlterationColors[alterationType] = {}; + } + this.userSelectedAlterationColors[alterationType][type] = color; + } + } + + @computed get defaultAlterationColors() { + return this._defaultAlterationColors; } @action.bound - public setDefaultUserAlterationColors( - rule: IGeneticAlterationRuleSetParams - ) { - for (let alteration in rule.rule_params.conditional) { - this.userAlterationColors[alteration] = {}; - for (let type in rule.rule_params.conditional[alteration]) { - if (alteration === 'disp_mrna') { - this.userAlterationColors[alteration][type] = rule - .rule_params.conditional[alteration][type].shapes[0] - .stroke as RGBAColor; - } else { - this.userAlterationColors[alteration][type] = rule - .rule_params.conditional[alteration][type].shapes[0] - .fill as RGBAColor; - } + public setDefaultAlterationColors(rule: IGeneticAlterationRuleSetParams) { + let alterationColors: { + [alterationType: string]: { + [type: string]: RGBAColor; + }; + } = {}; + _.forIn( + Object.keys(rule.rule_params.conditional), + (alterationType: string) => { + alterationColors[alterationType] = {}; + _.forIn( + Object.keys(rule.rule_params.conditional[alterationType]), + (type: string) => { + if (alterationType === 'disp_mrna') { + alterationColors[alterationType][type] = rule + .rule_params.conditional[alterationType][type] + .shapes[0].stroke as RGBAColor; + } else { + alterationColors[alterationType][type] = rule + .rule_params.conditional[alterationType][type] + .shapes[0].fill as RGBAColor; + } + } + ); } - } + ); + this._defaultAlterationColors = alterationColors; + this.userSelectedAlterationColors = {}; } // @action public showAlterationWarningSign( diff --git a/src/shared/components/oncoprint/DeltaUtils.ts b/src/shared/components/oncoprint/DeltaUtils.ts index 0f53eb589e4..ba6d611ec54 100644 --- a/src/shared/components/oncoprint/DeltaUtils.ts +++ b/src/shared/components/oncoprint/DeltaUtils.ts @@ -591,7 +591,7 @@ function hasGeneticTrackRuleSetChanged( nextProps.distinguishDrivers !== prevProps.distinguishDrivers || nextProps.distinguishGermlineMutations !== prevProps.distinguishGermlineMutations || - nextProps.test !== prevProps.test + nextProps.changeRule !== prevProps.changeRule ); } @@ -1117,11 +1117,6 @@ function transitionGeneticTrack( nextProps.distinguishDrivers, nextProps.distinguishGermlineMutations ); - console.log(rule); - // if (rule.rule_params.conditional.disp_mut.inframe) { - // console.log('hi') - // rule.rule_params.conditional.disp_mut.inframe.shapes[0].fill = [153, 52, 4, 1] - // } // Add track const createCustomOncoprintTooltip = getCustomJsFunctions() .createCustomOncoprintTooltip; diff --git a/src/shared/components/oncoprint/Oncoprint.tsx b/src/shared/components/oncoprint/Oncoprint.tsx index 95e82776165..98377441a1c 100644 --- a/src/shared/components/oncoprint/Oncoprint.tsx +++ b/src/shared/components/oncoprint/Oncoprint.tsx @@ -276,7 +276,7 @@ export interface IOncoprintProps { alterationTypesInQuery?: string[]; distinguishMutationType?: boolean; - test?: boolean; + changeRule?: boolean; rule?: IGeneticAlterationRuleSetParams; distinguishDrivers?: boolean; distinguishGermlineMutations?: boolean; diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index ee0661bf7f3..3824a01bdf4 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -139,6 +139,37 @@ export type AdditionalTrackGroupRecord = { molecularProfile: MolecularProfile; }; +export function editRule( + color: RGBAColor | undefined, + alteration: string, + type: string, + store: ResultsViewPageStore, + currentRule: IGeneticAlterationRuleSetParams +) { + let rule: IGeneticAlterationRuleSetParams = currentRule; + if (color == undefined) { + if (alteration === 'disp_mrna') { + rule.rule_params.conditional[alteration][type].shapes[0].stroke = + store.defaultAlterationColors[alteration][type]; + } else { + rule.rule_params.conditional[alteration][type].shapes[0].fill = + store.defaultAlterationColors[alteration][type]; + } + } else { + if (alteration === 'disp_mrna') { + rule.rule_params.conditional[alteration][ + type + ].shapes[0].stroke = color; + } else { + rule.rule_params.conditional[alteration][ + type + ].shapes[0].fill = color; + } + } + store.onAlterationColorChange(alteration, type, color); + return rule; +} + /* fields and methods in the class below are ordered based on roughly /* chronological setup concerns, rather than on encapsulation and public API */ /* tslint:disable: member-ordering */ @@ -268,7 +299,7 @@ export default class ResultsViewOncoprint extends React.Component< this.distinguishGermlineMutations ); - @observable test: boolean = false; + @observable changeRule: boolean = false; private heatmapGeneInputValueUpdater: IReactionDisposer; @@ -423,7 +454,7 @@ export default class ResultsViewOncoprint extends React.Component< super(props); makeObservable(this); - this.props.store.setDefaultUserAlterationColors(this.rule); + this.props.store.setDefaultAlterationColors(this.rule); this.showOqlInLabels = props.store.queryContainsOql; (window as any).resultsViewOncoprint = this; @@ -509,8 +540,8 @@ export default class ResultsViewOncoprint extends React.Component< get distinguishMutationType() { return self.distinguishMutationType; }, - get test() { - return self.test; + get changeRule() { + return self.changeRule; }, get distinguishDrivers() { return self.distinguishDrivers; @@ -729,11 +760,8 @@ export default class ResultsViewOncoprint extends React.Component< onSelectDistinguishMutationType: (s: boolean) => { this.distinguishMutationType = s; }, - onSelectTest: (s: boolean) => { - this.test = s; - }, - onSetRule: (rule: IGeneticAlterationRuleSetParams) => { - this.rule = rule; + onChangeRule: (s: boolean) => { + this.changeRule = s; }, onSelectDistinguishDrivers: action((s: boolean) => { if (!s) { @@ -1720,7 +1748,7 @@ export default class ResultsViewOncoprint extends React.Component< this .selectedGenericAssayEntitiesGroupedByGenericAssayTypeFromUrl } - setRules={this.setRules} + setRule={this.setRule} /> ); @@ -1825,65 +1853,18 @@ export default class ResultsViewOncoprint extends React.Component< } @action.bound - public setRules( + public setRule( alteration: string, type: string, color: RGBAColor | undefined ) { - if (color == undefined) { - this.rule = getGeneticTrackRuleSetParams( - this.distinguishMutationType, - this.distinguishDrivers, - this.distinguishGermlineMutations - ); - for (let a in this.props.store.userAlterationColors) { - for (let t in this.props.store.userAlterationColors[a]) { - if (a === 'disp_mrna') { - if (a !== alteration && t !== type) { - this.rule.rule_params.conditional[a][ - t - ].shapes[0].stroke = this.props.store.userAlterationColors[ - a - ][t]; - } else { - this.props.store.onAlterationColorChange( - alteration, - type, - this.rule.rule_params.conditional[a][t] - .shapes[0].stroke as RGBAColor - ); - } - } else { - if (a !== alteration || t !== type) { - this.rule.rule_params.conditional[a][ - t - ].shapes[0].fill = this.props.store.userAlterationColors[ - a - ][t]; - } else { - this.props.store.onAlterationColorChange( - alteration, - type, - this.rule.rule_params.conditional[a][t] - .shapes[0].fill as RGBAColor - ); - } - } - } - } - } else { - if (alteration === 'disp_mrna') { - this.rule.rule_params.conditional[alteration][ - type - ].shapes[0].stroke = color; - } else { - this.rule.rule_params.conditional[alteration][ - type - ].shapes[0].fill = color; - } - this.props.store.onAlterationColorChange(alteration, type, color); - } - // console.log(this.rule); + this.rule = editRule( + color, + alteration, + type, + this.props.store, + this.rule + ); } public render() { @@ -1987,7 +1968,7 @@ export default class ResultsViewOncoprint extends React.Component< distinguishMutationType={ this.distinguishMutationType } - test={this.test} + changeRule={this.changeRule} distinguishDrivers={this.distinguishDrivers} distinguishGermlineMutations={ this.distinguishGermlineMutations diff --git a/src/shared/components/oncoprint/controls/OncoprintColors.tsx b/src/shared/components/oncoprint/controls/OncoprintColors.tsx index 0d0a5bd1ec6..373b788c0f7 100644 --- a/src/shared/components/oncoprint/controls/OncoprintColors.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintColors.tsx @@ -28,7 +28,7 @@ export interface IGroupCheckboxProps { store?: ResultsViewPageStore; handlers: IOncoprintControlsHandlers; state: IOncoprintControlsState; - setRules?: ( + setRule?: ( alteration: string, type: string, color: RGBAColor | undefined @@ -99,23 +99,23 @@ export default class OncoprintColors extends React.Component< handleChangeComplete = (color: any, event: any) => { // if same color is select, unselect it (go back to no color) if (color.hex === rgbaToHex(this.props.color)) { - this.props.setRules && - this.props.setRules( + this.props.setRule && + this.props.setRule( this.props.alteration, this.props.type, undefined ); } else { - this.props.setRules && - this.props.setRules(this.props.alteration, this.props.type, [ + this.props.setRule && + this.props.setRule(this.props.alteration, this.props.type, [ color.rgb.r, color.rgb.g, color.rgb.b, color.rgb.a, ]); } - this.props.handlers.onSelectTest && - this.props.handlers.onSelectTest(!this.props.state.test!); + this.props.handlers.onChangeRule && + this.props.handlers.onChangeRule(!this.props.state.changeRule!); }; @computed get colorList() { diff --git a/src/shared/components/oncoprint/controls/OncoprintControls.tsx b/src/shared/components/oncoprint/controls/OncoprintControls.tsx index 8703a996a4e..0a6ebfeec5a 100644 --- a/src/shared/components/oncoprint/controls/OncoprintControls.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintControls.tsx @@ -46,7 +46,7 @@ import { ClinicalTrackConfigMap, } from 'shared/components/oncoprint/Oncoprint'; import { getServerConfig } from 'config/config'; -import { IGeneticAlterationRuleSetParams, RGBAColor } from 'oncoprintjs'; +import { RGBAColor } from 'oncoprintjs'; import OncoprintColors, { alterationToTypeToLabel } from './OncoprintColors'; export interface IOncoprintControlsHandlers @@ -62,8 +62,7 @@ export interface IOncoprintControlsHandlers onSelectShowMinimap: (showMinimap: boolean) => void; onSelectDistinguishMutationType: (distinguish: boolean) => void; onSelectDistinguishGermlineMutations: (distinguish: boolean) => void; - onSelectTest?: (distinguish: boolean) => void; - onSetRule?: (rule: IGeneticAlterationRuleSetParams) => void; + onChangeRule?: (changed: boolean) => void; onSelectHideVUS: (hide: boolean) => void; onSelectHideGermlineMutations: (hide: boolean) => void; @@ -107,8 +106,7 @@ export interface IOncoprintControlsState sortByCaseListDisabled: boolean; hidePutativePassengers: boolean; hideGermlineMutations: boolean; - test?: boolean; - rule?: IGeneticAlterationRuleSetParams; + changeRule?: boolean; sortMode?: SortMode; clinicalAttributesPromise?: MobxPromise; @@ -144,7 +142,7 @@ export interface IOncoprintControlsProps { selectedGenericAssayEntitiesGroupedByGenericAssayTypeFromUrl?: { [genericAssayType: string]: string[]; }; - setRules?: ( + setRule?: ( alteration: string, type: string, color: RGBAColor | undefined @@ -191,10 +189,21 @@ const EVENT_KEY = { downloadOncoprinter: '29.1', horzZoomSlider: '30', viewNGCHM: '31', - test: '32', - rule: '33', }; +export function getOncoprintColor( + alteration: string, + type: string, + store?: ResultsViewPageStore +): RGBAColor { + return store + ? !store.userSelectedAlterationColors[alteration] || + !store.userSelectedAlterationColors[alteration][type] + ? store.defaultAlterationColors[alteration][type] + : store.userSelectedAlterationColors[alteration][type] + : ([255, 255, 255, 1] as RGBAColor); +} + @observer export default class OncoprintControls extends React.Component< IOncoprintControlsProps, @@ -866,13 +875,13 @@ export default class OncoprintControls extends React.Component< type={type} handlers={this.props.handlers} state={this.props.state} - setRules={this.props.setRules} + setRule={this.props.setRule} store={this.props.store} - color={ - this.props.store?.userAlterationColors[ - alteration - ][type]! - } + color={getOncoprintColor( + alteration, + type, + this.props.store + )} markedWithWarningSign={this.props.store!.isAlterationMarkedWithWarningSign( alteration )} From e175bd79a13e3fca78eeba1728efeae0b3d427b6 Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Fri, 29 Sep 2023 13:11:59 -0400 Subject: [PATCH 04/15] added color config for clinical tracks --- src/pages/resultsView/ResultsViewPageStore.ts | 111 ++++++++------ src/shared/components/oncoprint/DeltaUtils.ts | 77 +++++----- src/shared/components/oncoprint/Oncoprint.tsx | 8 +- .../components/oncoprint/OncoprintUtils.ts | 14 +- .../oncoprint/ResultsViewOncoprint.tsx | 142 +++++++++++------- .../oncoprint/controls/OncoprintColors.tsx | 105 ++++--------- .../oncoprint/controls/OncoprintControls.tsx | 94 +++++++----- 7 files changed, 289 insertions(+), 262 deletions(-) diff --git a/src/pages/resultsView/ResultsViewPageStore.ts b/src/pages/resultsView/ResultsViewPageStore.ts index 1e3e173689d..7d4b4a0793d 100644 --- a/src/pages/resultsView/ResultsViewPageStore.ts +++ b/src/pages/resultsView/ResultsViewPageStore.ts @@ -305,6 +305,7 @@ import { USE_DEFAULT_PUBLIC_INSTANCE_FOR_ONCOKB, } from 'react-mutation-mapper'; import { IGeneticAlterationRuleSetParams, RGBAColor } from 'oncoprintjs'; +import { hexToRGBA } from 'shared/lib/Colors'; type Optional = | { isApplicable: true; value: T } @@ -574,22 +575,22 @@ export class ResultsViewPageStore extends AnalysisStore @observable queryFormVisible: boolean = false; - @observable userSelectedAlterationColors: { - [alterationType: string]: { - [type: string]: RGBAColor; + @observable _userSelectedClinicalAttributeColors: { + [label: string]: { + [value: string]: RGBAColor; }; } = {}; - @observable _defaultAlterationColors: { - [alterationType: string]: { - [type: string]: RGBAColor; + @observable _defaultClinicalAttributeColors: { + [label: string]: { + [value: string]: RGBAColor; }; } = {}; - private _selectedComparisonGroupsWarningSigns = observable.map< - string, - boolean - >({}, { deep: false }); + // private _selectedComparisonGroupsWarningSigns = observable.map< + // string, + // boolean + // >({}, { deep: false }); @computed get doNonSelectedDownloadableMolecularProfilesExist() { return ( @@ -605,58 +606,68 @@ export class ResultsViewPageStore extends AnalysisStore | undefined = undefined; @action.bound - public onAlterationColorChange( - alterationType: string, - type: string, + public onClinicalAttributeColorChange( + label: string, + value: string, color: RGBAColor | undefined ) { + // if color is undefined, delete color from userSelectedClinicalAttributeColors if exists if ( !color && - this.userSelectedAlterationColors[alterationType] && - this.userSelectedAlterationColors[alterationType][type] + this._userSelectedClinicalAttributeColors[label] && + this._userSelectedClinicalAttributeColors[label][value] ) { - delete this.userSelectedAlterationColors[alterationType][type]; + delete this._userSelectedClinicalAttributeColors[label][value]; + // else, set the color in userSelectedClinicalAttributeColors } else if (color) { - if (!this.userSelectedAlterationColors[alterationType]) { - this.userSelectedAlterationColors[alterationType] = {}; + if (!this._userSelectedClinicalAttributeColors[label]) { + this._userSelectedClinicalAttributeColors[label] = {}; } - this.userSelectedAlterationColors[alterationType][type] = color; + this._userSelectedClinicalAttributeColors[label][value] = color; } } - @computed get defaultAlterationColors() { - return this._defaultAlterationColors; + @computed get defaultClinicalAttributeColors() { + return this._defaultClinicalAttributeColors; + } + + @computed get userSelectedClinicalAttributeColors() { + return this._userSelectedClinicalAttributeColors; } @action.bound - public setDefaultAlterationColors(rule: IGeneticAlterationRuleSetParams) { - let alterationColors: { - [alterationType: string]: { - [type: string]: RGBAColor; - }; - } = {}; - _.forIn( - Object.keys(rule.rule_params.conditional), - (alterationType: string) => { - alterationColors[alterationType] = {}; - _.forIn( - Object.keys(rule.rule_params.conditional[alterationType]), - (type: string) => { - if (alterationType === 'disp_mrna') { - alterationColors[alterationType][type] = rule - .rule_params.conditional[alterationType][type] - .shapes[0].stroke as RGBAColor; - } else { - alterationColors[alterationType][type] = rule - .rule_params.conditional[alterationType][type] - .shapes[0].fill as RGBAColor; - } - } + public setDefaultClinicalAttributeColor( + label: string, + categoryToColor?: { [value: string]: string }, + countsCategoryLabels?: string[], + countsCategoryFills?: RGBAColor[] + ) { + // if default for attribute doesn't already exist + if (!this._defaultClinicalAttributeColors[label]) { + // if categoryToColor given, use this mapping for colors + if (categoryToColor) { + this._defaultClinicalAttributeColors[label] = _.mapValues( + categoryToColor, + hexToRGBA ); + // sample type attributes have unique "Mixed" label with set color + if (label === 'Sample Type' || label === 'Sample type id') { + this._defaultClinicalAttributeColors[label]['Mixed'] = [ + 48, + 97, + 194, + 1, + ]; + } + // if labels and fills given, set each label with its corresponding color + } else if (countsCategoryLabels && countsCategoryFills) { + this._defaultClinicalAttributeColors[label] = {}; + _.forEach(countsCategoryLabels, (value, i) => { + this._defaultClinicalAttributeColors[label][value] = + countsCategoryFills[i]; + }); } - ); - this._defaultAlterationColors = alterationColors; - this.userSelectedAlterationColors = {}; + } } // @action public showAlterationWarningSign( @@ -691,9 +702,9 @@ export class ResultsViewPageStore extends AnalysisStore // ); // } - public isAlterationMarkedWithWarningSign(alteration: string): boolean { - return !!this._selectedComparisonGroupsWarningSigns.get(alteration); - } + // public isAlterationMarkedWithWarningSign(alteration: string): boolean { + // return !!this._selectedComparisonGroupsWarningSigns.get(alteration); + // } @action.bound public setOncoprintAnalysisCaseType(e: OncoprintAnalysisCaseType) { diff --git a/src/shared/components/oncoprint/DeltaUtils.ts b/src/shared/components/oncoprint/DeltaUtils.ts index ba6d611ec54..b9ee4ca3772 100644 --- a/src/shared/components/oncoprint/DeltaUtils.ts +++ b/src/shared/components/oncoprint/DeltaUtils.ts @@ -61,8 +61,7 @@ export function transition( getTrackSpecKeyToTrackId: () => { [key: string]: TrackId }, getMolecularProfileMap: () => | { [molecularProfileId: string]: MolecularProfile } - | undefined, - customRule?: IGeneticAlterationRuleSetParams + | undefined ) { const notKeepingSorted = shouldNotKeepSortedForTransition( nextProps, @@ -92,8 +91,7 @@ export function transition( prevProps, oncoprint, getTrackSpecKeyToTrackId, - getMolecularProfileMap, - customRule + getMolecularProfileMap ); transitionSortConfig(nextProps, prevProps, oncoprint); transitionTrackGroupSortPriority(nextProps, prevProps, oncoprint); @@ -590,8 +588,7 @@ function hasGeneticTrackRuleSetChanged( prevProps.distinguishMutationType || nextProps.distinguishDrivers !== prevProps.distinguishDrivers || nextProps.distinguishGermlineMutations !== - prevProps.distinguishGermlineMutations || - nextProps.changeRule !== prevProps.changeRule + prevProps.distinguishGermlineMutations ); } @@ -602,8 +599,7 @@ function transitionTracks( getTrackSpecKeyToTrackId: () => { [key: string]: TrackId }, getMolecularProfileMap: () => | { [molecularProfileId: string]: MolecularProfile } - | undefined, - customRule?: IGeneticAlterationRuleSetParams + | undefined ) { // Initialize tracks for rule set sharing const trackIdForRuleSetSharing = { @@ -745,9 +741,7 @@ function transitionTracks( oncoprint, nextProps, prevProps, - trackIdForRuleSetSharing, - undefined, - customRule + trackIdForRuleSetSharing ); delete prevGeneticTracks[track.key]; } @@ -763,9 +757,7 @@ function transitionTracks( oncoprint, nextProps, prevProps, - trackIdForRuleSetSharing, - undefined, - customRule + trackIdForRuleSetSharing ); } } @@ -788,7 +780,8 @@ function transitionTracks( prevClinicalTracks[track.key], getTrackSpecKeyToTrackId, oncoprint, - nextProps + nextProps, + prevProps ); delete prevClinicalTracks[track.key]; } @@ -800,7 +793,8 @@ function transitionTracks( prevClinicalTracks[track.key], getTrackSpecKeyToTrackId, oncoprint, - nextProps + nextProps, + prevProps ); } } @@ -1102,21 +1096,13 @@ function transitionGeneticTrack( nextProps: IOncoprintProps, prevProps: Partial, trackIdForRuleSetSharing: { genetic?: TrackId }, - expansionParentKey?: string, - customRule?: IGeneticAlterationRuleSetParams + expansionParentKey?: string ) { const trackSpecKeyToTrackId = getTrackSpecKeyToTrackId(); if (tryRemoveTrack(nextSpec, prevSpec, trackSpecKeyToTrackId, oncoprint)) { // Remove track return; } else if (nextSpec && !prevSpec) { - let rule = customRule - ? customRule - : getGeneticTrackRuleSetParams( - nextProps.distinguishMutationType, - nextProps.distinguishDrivers, - nextProps.distinguishGermlineMutations - ); // Add track const createCustomOncoprintTooltip = getCustomJsFunctions() .createCustomOncoprintTooltip; @@ -1132,7 +1118,11 @@ function transitionGeneticTrack( ); } const geneticTrackParams: UserTrackSpec = { - rule_set_params: rule, + rule_set_params: getGeneticTrackRuleSetParams( + nextProps.distinguishMutationType, + nextProps.distinguishDrivers, + nextProps.distinguishGermlineMutations + ), label: nextSpec.label, sublabel: nextSpec.sublabel, track_label_color: nextSpec.labelColor || undefined, @@ -1224,16 +1214,15 @@ function transitionGeneticTrack( trackId ); } else { - let rule = customRule - ? customRule - : getGeneticTrackRuleSetParams( - nextProps.distinguishMutationType, - nextProps.distinguishDrivers, - nextProps.distinguishGermlineMutations - ); - console.log(rule); // otherwise, update ruleset - oncoprint.setRuleSet(trackId, rule); + oncoprint.setRuleSet( + trackId, + getGeneticTrackRuleSetParams( + nextProps.distinguishMutationType, + nextProps.distinguishDrivers, + nextProps.distinguishGermlineMutations + ) + ); } } // either way, use this one now @@ -1268,7 +1257,8 @@ function transitionClinicalTrack( prevSpec: ClinicalTrackSpec | undefined, getTrackSpecKeyToTrackId: () => { [key: string]: TrackId }, oncoprint: OncoprintJS, - nextProps: IOncoprintProps + nextProps: IOncoprintProps, + prevProps: Partial ) { const trackSpecKeyToTrackId = getTrackSpecKeyToTrackId(); if (tryRemoveTrack(nextSpec, prevSpec, trackSpecKeyToTrackId, oncoprint)) { @@ -1337,6 +1327,21 @@ function transitionClinicalTrack( if (prevSpec.custom_options !== nextSpec.custom_options) { oncoprint.setTrackCustomOptions(trackId, nextSpec.custom_options); } + + // update ruleset for changed track key + if ( + nextProps.changedTrackKey && + getTrackSpecKeyToTrackId()[nextProps.changedTrackKey] === trackId + ) { + let rule_set_params = getClinicalTrackRuleSetParams(nextSpec); + rule_set_params.legend_label = nextSpec.label; + rule_set_params.exclude_from_legend = !nextProps.showClinicalTrackLegends; + rule_set_params.na_legend_label = nextSpec.na_legend_label; + oncoprint.setRuleSet(trackId, rule_set_params); + // set changed track key back to none + nextProps.onSetChangedTrackKey && + nextProps.onSetChangedTrackKey(''); + } } } function transitionGenesetHeatmapTrack( diff --git a/src/shared/components/oncoprint/Oncoprint.tsx b/src/shared/components/oncoprint/Oncoprint.tsx index 98377441a1c..f149fcdd5b1 100644 --- a/src/shared/components/oncoprint/Oncoprint.tsx +++ b/src/shared/components/oncoprint/Oncoprint.tsx @@ -276,8 +276,6 @@ export interface IOncoprintProps { alterationTypesInQuery?: string[]; distinguishMutationType?: boolean; - changeRule?: boolean; - rule?: IGeneticAlterationRuleSetParams; distinguishDrivers?: boolean; distinguishGermlineMutations?: boolean; @@ -301,6 +299,9 @@ export interface IOncoprintProps { onTrackSortDirectionChange?: (trackId: TrackId, dir: number) => void; onTrackGapChange?: (trackId: TrackId, gap: boolean) => void; + changedTrackKey?: string; + onSetChangedTrackKey?: (key: string) => void; + suppressRendering?: boolean; onSuppressRendering?: () => void; onReleaseRendering?: () => void; @@ -389,8 +390,7 @@ export default class Oncoprint extends React.Component { () => this.trackSpecKeyToTrackId, () => { return this.props.molecularProfileIdToMolecularProfile; - }, - this.props.rule + } ); this.lastTransitionProps = _.clone(props); } diff --git a/src/shared/components/oncoprint/OncoprintUtils.ts b/src/shared/components/oncoprint/OncoprintUtils.ts index acc75f0ca17..e7cf5aec771 100644 --- a/src/shared/components/oncoprint/OncoprintUtils.ts +++ b/src/shared/components/oncoprint/OncoprintUtils.ts @@ -491,8 +491,8 @@ export function getClinicalTrackRuleSetParams(track: ClinicalTrackSpec) { category_key: 'attr_val', category_to_color: Object.assign( {}, - track.category_to_color, - _.mapValues(RESERVED_CLINICAL_VALUE_COLORS, hexToRGBA) + _.mapValues(RESERVED_CLINICAL_VALUE_COLORS, hexToRGBA), + track.category_to_color ), universal_rule_categories: track.universal_rule_categories, }; @@ -1071,6 +1071,10 @@ export function makeClinicalTracksMobxPromise( dataAndColors.categoryToColor, hexToRGBA ); + oncoprint.props.store.setDefaultClinicalAttributeColor( + attribute.displayName, + dataAndColors.categoryToColor + ); } else if ( attribute.clinicalAttributeId === SpecialAttribute.MutationSpectrum @@ -1078,6 +1082,12 @@ export function makeClinicalTracksMobxPromise( ret.datatype = 'counts'; (ret as any).countsCategoryLabels = MUTATION_SPECTRUM_CATEGORIES; (ret as any).countsCategoryFills = MUTATION_SPECTRUM_FILLS; + oncoprint.props.store.setDefaultClinicalAttributeColor( + attribute.displayName, + undefined, + MUTATION_SPECTRUM_CATEGORIES, + MUTATION_SPECTRUM_FILLS + ); } const trackConfig = diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index 3824a01bdf4..f8a7db68d58 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -42,7 +42,6 @@ import { AlterationTypeConstants } from 'shared/constants'; import { ResultsViewPageStore } from '../../../pages/resultsView/ResultsViewPageStore'; import { getAlteredUids, - getGeneticTrackRuleSetParams, getUnalteredUids, makeClinicalTracksMobxPromise, makeGenericAssayProfileCategoricalTracksMobxPromise, @@ -56,13 +55,7 @@ import _ from 'lodash'; import { onMobxPromise, toPromise } from 'cbioportal-frontend-commons'; import { getServerConfig } from 'config/config'; import LoadingIndicator from 'shared/components/loadingIndicator/LoadingIndicator'; -import { - IGeneticAlterationRuleSetParams, - OncoprintJS, - RGBAColor, - TrackGroupIndex, - TrackId, -} from 'oncoprintjs'; +import { OncoprintJS, RGBAColor, TrackGroupIndex, TrackId } from 'oncoprintjs'; import fileDownload from 'react-file-download'; import tabularDownload from './tabularDownload'; import classNames from 'classnames'; @@ -139,35 +132,64 @@ export type AdditionalTrackGroupRecord = { molecularProfile: MolecularProfile; }; -export function editRule( +export function getClinicalAttributeValues( + attributeLabel: string, + clinicalTracks: ClinicalTrackSpec[] +): any[] { + // find track that matches given label + let index = _.findIndex(clinicalTracks, i => i.label === attributeLabel); + // if the datatype is "counts", the attribute values are under countsCategoryLabels + if (clinicalTracks[index] && clinicalTracks[index].datatype === 'counts') { + return (clinicalTracks[index] as any).countsCategoryLabels; + // if the datatype is "string", get attribute values from the track data + } else if ( + clinicalTracks[index] && + clinicalTracks[index].datatype === 'string' + ) { + return _(clinicalTracks[index].data) + .map(d => d.attr_val) + .uniq() + .without(undefined) + .value(); + } + return []; +} + +export function setClinicalAttributeValueColorsInTrack( + attributeLabel: string, + attributeValue: string, color: RGBAColor | undefined, - alteration: string, - type: string, - store: ResultsViewPageStore, - currentRule: IGeneticAlterationRuleSetParams + track: ClinicalTrackSpec, + store: ResultsViewPageStore ) { - let rule: IGeneticAlterationRuleSetParams = currentRule; - if (color == undefined) { - if (alteration === 'disp_mrna') { - rule.rule_params.conditional[alteration][type].shapes[0].stroke = - store.defaultAlterationColors[alteration][type]; + if (track.datatype === 'string') { + // set new color of attribute value in track's category_to_color + if (color) { + (track as any).category_to_color[attributeValue] = color; + // if undefined color, set attribute value's color in track's category_to_color back to its default } else { - rule.rule_params.conditional[alteration][type].shapes[0].fill = - store.defaultAlterationColors[alteration][type]; + (track as any).category_to_color[attributeValue] = + store.defaultClinicalAttributeColors[attributeLabel][ + attributeValue + ]; } - } else { - if (alteration === 'disp_mrna') { - rule.rule_params.conditional[alteration][ - type - ].shapes[0].stroke = color; + } else if (track.datatype === 'counts') { + // get index of attribute value that corresponds with its color + let valueIndex = _.indexOf( + (track as any).countsCategoryLabels, + attributeValue + ); + // set new color of attribute value in track's countsCategoryFills using valueIndex + if (color) { + (track as any).countsCategoryFills[valueIndex] = color; + // if undefined color, set attribute value's color in track's countsCategoryFills back to its default } else { - rule.rule_params.conditional[alteration][ - type - ].shapes[0].fill = color; + (track as any).countsCategoryFills[valueIndex] = + store.defaultClinicalAttributeColors[attributeLabel][ + attributeValue + ]; } } - store.onAlterationColorChange(alteration, type, color); - return rule; } /* fields and methods in the class below are ordered based on roughly @@ -292,14 +314,7 @@ export default class ResultsViewOncoprint extends React.Component< @observable renderingComplete = false; - @observable - rule: IGeneticAlterationRuleSetParams = getGeneticTrackRuleSetParams( - this.distinguishMutationType, - this.distinguishDrivers, - this.distinguishGermlineMutations - ); - - @observable changeRule: boolean = false; + @observable changedTrackKey: string = ''; private heatmapGeneInputValueUpdater: IReactionDisposer; @@ -454,7 +469,6 @@ export default class ResultsViewOncoprint extends React.Component< super(props); makeObservable(this); - this.props.store.setDefaultAlterationColors(this.rule); this.showOqlInLabels = props.store.queryContainsOql; (window as any).resultsViewOncoprint = this; @@ -534,14 +548,11 @@ export default class ResultsViewOncoprint extends React.Component< get sortByCaseListDisabled() { return !self.caseListSortPossible; }, - get rule() { - return self.rule; - }, get distinguishMutationType() { return self.distinguishMutationType; }, - get changeRule() { - return self.changeRule; + get changedTrackKey() { + return self.changedTrackKey; }, get distinguishDrivers() { return self.distinguishDrivers; @@ -760,8 +771,8 @@ export default class ResultsViewOncoprint extends React.Component< onSelectDistinguishMutationType: (s: boolean) => { this.distinguishMutationType = s; }, - onChangeRule: (s: boolean) => { - this.changeRule = s; + onSetChangedTrackKey: (s: string) => { + this.changedTrackKey = s; }, onSelectDistinguishDrivers: action((s: boolean) => { if (!s) { @@ -1748,7 +1759,10 @@ export default class ResultsViewOncoprint extends React.Component< this .selectedGenericAssayEntitiesGroupedByGenericAssayTypeFromUrl } - setRule={this.setRule} + handleClinicalAttributeColorChange={ + this.handleClinicalAttributeColorChange + } + clinicalTracks={this.clinicalTracks.result} /> ); @@ -1853,17 +1867,29 @@ export default class ResultsViewOncoprint extends React.Component< } @action.bound - public setRule( - alteration: string, - type: string, + public handleClinicalAttributeColorChange( + attributeLabel: string, + attributeValue: string, color: RGBAColor | undefined ) { - this.rule = editRule( + // find track that matches given label + let index = _.findIndex( + this.clinicalTracks.result, + i => i.label === attributeLabel + ); + const track = this.clinicalTracks.result[index]; + + setClinicalAttributeValueColorsInTrack( + attributeLabel, + attributeValue, color, - alteration, - type, - this.props.store, - this.rule + track, + this.props.store + ); + this.props.store.onClinicalAttributeColorChange( + attributeLabel, + attributeValue, + color ); } @@ -1968,7 +1994,7 @@ export default class ResultsViewOncoprint extends React.Component< distinguishMutationType={ this.distinguishMutationType } - changeRule={this.changeRule} + changedTrackKey={this.changedTrackKey} distinguishDrivers={this.distinguishDrivers} distinguishGermlineMutations={ this.distinguishGermlineMutations @@ -1992,7 +2018,9 @@ export default class ResultsViewOncoprint extends React.Component< initParams={{ max_height: Number.POSITIVE_INFINITY, }} - rule={this.rule} + onSetChangedTrackKey={ + this.controlsHandlers.onSetChangedTrackKey + } /> diff --git a/src/shared/components/oncoprint/controls/OncoprintColors.tsx b/src/shared/components/oncoprint/controls/OncoprintColors.tsx index 373b788c0f7..7c563d03e2f 100644 --- a/src/shared/components/oncoprint/controls/OncoprintColors.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintColors.tsx @@ -21,70 +21,27 @@ import { IOncoprintControlsState, } from './OncoprintControls'; import { RGBAColor } from 'oncoprintjs'; +import { ClinicalTrackSpec } from '../Oncoprint'; +import _ from 'lodash'; export interface IGroupCheckboxProps { - alteration: string; - type: string; store?: ResultsViewPageStore; handlers: IOncoprintControlsHandlers; state: IOncoprintControlsState; - setRule?: ( - alteration: string, - type: string, + handleClinicalAttributeColorChange?: ( + label: string, + value: string, color: RGBAColor | undefined ) => void; + clinicalAttributeLabel: string; + clinicalAttributeValue: any; color: RGBAColor; - markedWithWarningSign: boolean; + clinicalTrack: ClinicalTrackSpec; + // markedWithWarningSign: boolean; } const COLOR_UNDEFINED = '#FFFFFF'; -export const alterationToTypeToLabel: { - [alteration: string]: { [type: string]: string }; -} = { - // disp_cna - disp_cna: { - 'amp_rec,amp': 'Amplification', - 'gain_rec,gain': 'Gain', - 'hetloss_rec,hetloss': 'Shallow Deletion', - 'homdel_rec,homdel': 'Deep Deletion', - }, - // disp_germ - disp_germ: { - true: 'Germline Mutation', - }, - // disp_mrna - disp_mrna: { - high: 'mRNA High', - low: 'mRNA Low', - }, - // disp_mut - disp_mut: { - missense: 'Missense Mutation (unknown significance)', - missense_rec: 'Missense Mutation (putative driver)', - trunc: 'Truncating Mutation (unknown significance)', - trunc_rec: 'Truncating Mutation (putative driver)', - inframe: 'Inframe Mutation (unknown significance)', - inframe_rec: 'Inframe Mutation (putative driver)', - splice: 'Splice Mutation (unknown significance)', - splice_rec: 'Splice Mutation (putative driver)', - promoter: 'Promoter Mutation (unknown significance)', - promoter_rec: 'Promoter Mutation (putative driver)', - other: 'Other Mutation (unknown significance)', - other_rec: 'Other Mutation (putative driver)', - }, - // disp_prot - disp_prot: { - high: 'Protein High', - low: 'Protein Low', - }, - // disp_structuralVariant - disp_structuralVariant: { - sv: 'Structural Variant (unknown significance)', - sv_rec: 'Structural Variant (putative driver)', - }, -}; - @observer export default class OncoprintColors extends React.Component< IGroupCheckboxProps, @@ -99,23 +56,25 @@ export default class OncoprintColors extends React.Component< handleChangeComplete = (color: any, event: any) => { // if same color is select, unselect it (go back to no color) if (color.hex === rgbaToHex(this.props.color)) { - this.props.setRule && - this.props.setRule( - this.props.alteration, - this.props.type, + this.props.handleClinicalAttributeColorChange && + this.props.handleClinicalAttributeColorChange( + this.props.clinicalAttributeLabel, + this.props.clinicalAttributeValue, undefined ); } else { - this.props.setRule && - this.props.setRule(this.props.alteration, this.props.type, [ - color.rgb.r, - color.rgb.g, - color.rgb.b, - color.rgb.a, - ]); + this.props.handleClinicalAttributeColorChange && + this.props.handleClinicalAttributeColorChange( + this.props.clinicalAttributeLabel, + this.props.clinicalAttributeValue, + [color.rgb.r, color.rgb.g, color.rgb.b, color.rgb.a] + ); } - this.props.handlers.onChangeRule && - this.props.handlers.onChangeRule(!this.props.state.changeRule!); + // set changed track key + this.props.handlers.onSetChangedTrackKey && + this.props.handlers.onSetChangedTrackKey( + this.props.clinicalTrack.key + ); }; @computed get colorList() { @@ -152,17 +111,13 @@ export default class OncoprintColors extends React.Component< render() { return (
- { - alterationToTypeToLabel[this.props.alteration][ - this.props.type - ] - } - - + > */} + {/* {this.props.markedWithWarningSign && ( )} - - + */} + {/* */} void; onSelectDistinguishMutationType: (distinguish: boolean) => void; onSelectDistinguishGermlineMutations: (distinguish: boolean) => void; - onChangeRule?: (changed: boolean) => void; + onSetChangedTrackKey?: (key: string) => void; onSelectHideVUS: (hide: boolean) => void; onSelectHideGermlineMutations: (hide: boolean) => void; @@ -106,7 +107,7 @@ export interface IOncoprintControlsState sortByCaseListDisabled: boolean; hidePutativePassengers: boolean; hideGermlineMutations: boolean; - changeRule?: boolean; + changedTrackKey?: string; sortMode?: SortMode; clinicalAttributesPromise?: MobxPromise; @@ -142,11 +143,12 @@ export interface IOncoprintControlsProps { selectedGenericAssayEntitiesGroupedByGenericAssayTypeFromUrl?: { [genericAssayType: string]: string[]; }; - setRule?: ( - alteration: string, - type: string, + handleClinicalAttributeColorChange?: ( + label: string, + value: string, color: RGBAColor | undefined ) => void; + clinicalTracks?: ClinicalTrackSpec[]; } export interface ISelectOption { @@ -192,16 +194,22 @@ const EVENT_KEY = { }; export function getOncoprintColor( - alteration: string, - type: string, + label: string, + value: string, store?: ResultsViewPageStore ): RGBAColor { - return store - ? !store.userSelectedAlterationColors[alteration] || - !store.userSelectedAlterationColors[alteration][type] - ? store.defaultAlterationColors[alteration][type] - : store.userSelectedAlterationColors[alteration][type] - : ([255, 255, 255, 1] as RGBAColor); + if (store) { + if ( + !store.userSelectedClinicalAttributeColors[label] || + !store.userSelectedClinicalAttributeColors[label][value] + ) { + return store.defaultClinicalAttributeColors[label][value]; + } else { + return store.userSelectedClinicalAttributeColors[label][value]; + } + } else { + return [255, 255, 255, 1] as RGBAColor; + } } @observer @@ -866,28 +874,38 @@ export default class OncoprintControls extends React.Component< className="oncoprint__controls__color_menu" data-test="oncoprintColorDropdownMenu" > - {Object.keys(alterationToTypeToLabel).map(alteration => - Object.keys( - alterationToTypeToLabel[alteration] - ).map(type => ( - - )) - )} + {this.props.clinicalTracks!.map(track => { + return ( +
+ {track.label} + {getClinicalAttributeValues( + track.label, + this.props.clinicalTracks! + ).map(value => ( + + ))} +
+ ); + })}
); From 3606f25858aa5bb92d7a0a15add11a907508cde7 Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Thu, 5 Oct 2023 17:52:37 -0400 Subject: [PATCH 05/15] add toggle to select between white/grey glyph backgrounds and refactoring --- src/pages/resultsView/ResultsViewPageStore.ts | 58 ++++++------ src/shared/components/oncoprint/DeltaUtils.ts | 10 ++- src/shared/components/oncoprint/Oncoprint.tsx | 1 + .../components/oncoprint/OncoprintUtils.ts | 60 ++++++++++--- .../oncoprint/ResultsViewOncoprint.tsx | 42 +++++---- .../oncoprint/controls/OncoprintColors.tsx | 5 +- .../oncoprint/controls/OncoprintControls.tsx | 88 +++++++++++++------ 7 files changed, 172 insertions(+), 92 deletions(-) diff --git a/src/pages/resultsView/ResultsViewPageStore.ts b/src/pages/resultsView/ResultsViewPageStore.ts index 7d4b4a0793d..a3f57341294 100644 --- a/src/pages/resultsView/ResultsViewPageStore.ts +++ b/src/pages/resultsView/ResultsViewPageStore.ts @@ -276,7 +276,10 @@ import { ICBioData } from 'pathway-mapper'; import { getAlterationData } from 'shared/components/oncoprint/OncoprintUtils'; import { PageUserSession } from 'shared/userSession/PageUserSession'; import { PageType } from 'shared/userSession/PageType'; -import { ClinicalTrackConfig } from 'shared/components/oncoprint/Oncoprint'; +import { + ClinicalTrackConfig, + ClinicalTrackSpec, +} from 'shared/components/oncoprint/Oncoprint'; import eventBus from 'shared/events/eventBus'; import { ErrorMessages } from 'shared/errorMessages'; import AnalysisStore from 'shared/lib/comparison/AnalysisStore'; @@ -304,8 +307,7 @@ import { ONCOKB_DEFAULT_INFO, USE_DEFAULT_PUBLIC_INSTANCE_FOR_ONCOKB, } from 'react-mutation-mapper'; -import { IGeneticAlterationRuleSetParams, RGBAColor } from 'oncoprintjs'; -import { hexToRGBA } from 'shared/lib/Colors'; +import { RGBAColor } from 'oncoprintjs'; type Optional = | { isApplicable: true; value: T } @@ -638,35 +640,33 @@ export class ResultsViewPageStore extends AnalysisStore @action.bound public setDefaultClinicalAttributeColor( label: string, - categoryToColor?: { [value: string]: string }, - countsCategoryLabels?: string[], + values: any[], + categoryToColor?: { + [category: string]: [number, number, number, number]; + }, countsCategoryFills?: RGBAColor[] ) { - // if default for attribute doesn't already exist - if (!this._defaultClinicalAttributeColors[label]) { - // if categoryToColor given, use this mapping for colors - if (categoryToColor) { - this._defaultClinicalAttributeColors[label] = _.mapValues( - categoryToColor, - hexToRGBA - ); - // sample type attributes have unique "Mixed" label with set color - if (label === 'Sample Type' || label === 'Sample type id') { - this._defaultClinicalAttributeColors[label]['Mixed'] = [ - 48, - 97, - 194, - 1, - ]; - } - // if labels and fills given, set each label with its corresponding color - } else if (countsCategoryLabels && countsCategoryFills) { - this._defaultClinicalAttributeColors[label] = {}; - _.forEach(countsCategoryLabels, (value, i) => { - this._defaultClinicalAttributeColors[label][value] = - countsCategoryFills[i]; - }); + if (categoryToColor) { + this._defaultClinicalAttributeColors[label] = {}; + _.forEach(values, value => { + this._defaultClinicalAttributeColors[label][value] = + categoryToColor[value]; + }); + // sample type attributes have unique "Mixed" label with set color + if (label === 'Sample Type' || label === 'Sample type id') { + this._defaultClinicalAttributeColors[label]['Mixed'] = [ + 48, + 97, + 194, + 1, + ]; } + } else if (countsCategoryFills) { + this._defaultClinicalAttributeColors[label] = {}; + _.forEach(values, (value, i) => { + this._defaultClinicalAttributeColors[label][value] = + countsCategoryFills[i]; + }); } } diff --git a/src/shared/components/oncoprint/DeltaUtils.ts b/src/shared/components/oncoprint/DeltaUtils.ts index b9ee4ca3772..5dc5a3b5611 100644 --- a/src/shared/components/oncoprint/DeltaUtils.ts +++ b/src/shared/components/oncoprint/DeltaUtils.ts @@ -588,7 +588,9 @@ function hasGeneticTrackRuleSetChanged( prevProps.distinguishMutationType || nextProps.distinguishDrivers !== prevProps.distinguishDrivers || nextProps.distinguishGermlineMutations !== - prevProps.distinguishGermlineMutations + prevProps.distinguishGermlineMutations || + nextProps.enableWhiteBackgroundForGlyphs !== + prevProps.enableWhiteBackgroundForGlyphs ); } @@ -1121,7 +1123,8 @@ function transitionGeneticTrack( rule_set_params: getGeneticTrackRuleSetParams( nextProps.distinguishMutationType, nextProps.distinguishDrivers, - nextProps.distinguishGermlineMutations + nextProps.distinguishGermlineMutations, + nextProps.enableWhiteBackgroundForGlyphs ), label: nextSpec.label, sublabel: nextSpec.sublabel, @@ -1220,7 +1223,8 @@ function transitionGeneticTrack( getGeneticTrackRuleSetParams( nextProps.distinguishMutationType, nextProps.distinguishDrivers, - nextProps.distinguishGermlineMutations + nextProps.distinguishGermlineMutations, + nextProps.enableWhiteBackgroundForGlyphs ) ); } diff --git a/src/shared/components/oncoprint/Oncoprint.tsx b/src/shared/components/oncoprint/Oncoprint.tsx index f149fcdd5b1..c3f6aecb6cb 100644 --- a/src/shared/components/oncoprint/Oncoprint.tsx +++ b/src/shared/components/oncoprint/Oncoprint.tsx @@ -292,6 +292,7 @@ export interface IOncoprintProps { }; showClinicalTrackLegends?: boolean; showWhitespaceBetweenColumns?: boolean; + enableWhiteBackgroundForGlyphs?: boolean; showMinimap?: boolean; onMinimapClose?: () => void; diff --git a/src/shared/components/oncoprint/OncoprintUtils.ts b/src/shared/components/oncoprint/OncoprintUtils.ts index e7cf5aec771..e1c9831ab8d 100644 --- a/src/shared/components/oncoprint/OncoprintUtils.ts +++ b/src/shared/components/oncoprint/OncoprintUtils.ts @@ -32,8 +32,10 @@ import { makeGeneticTrackData, makeHeatmapTrackData, } from './DataUtils'; -import ResultsViewOncoprint from './ResultsViewOncoprint'; import _, { isNumber } from 'lodash'; +import ResultsViewOncoprint, { + getClinicalAttributeValues, +} from './ResultsViewOncoprint'; import { action, IObservableArray, ObservableMap, runInAction } from 'mobx'; import { MobxPromise } from 'mobxpromise'; import GenesetCorrelatedGeneCache from 'shared/cache/GenesetCorrelatedGeneCache'; @@ -54,7 +56,11 @@ import { MUTATION_SPECTRUM_FILLS, SpecialAttribute, } from '../../cache/ClinicalDataCache'; -import { hexToRGBA, RESERVED_CLINICAL_VALUE_COLORS } from 'shared/lib/Colors'; +import { + ASCN_WHITE, + hexToRGBA, + RESERVED_CLINICAL_VALUE_COLORS, +} from 'shared/lib/Colors'; import { ISelectOption } from './controls/OncoprintControls'; import ifNotDefined from '../../lib/ifNotDefined'; import { @@ -446,7 +452,8 @@ export function getGenesetHeatmapTrackRuleSetParams() { export function getGeneticTrackRuleSetParams( distinguishMutationType?: boolean, distinguishDrivers?: boolean, - distinguishGermlineMutations?: boolean + distinguishGermlineMutations?: boolean, + enableWhiteBackgroundForGlyphs?: boolean ): IGeneticAlterationRuleSetParams { let rule_set; if (!distinguishMutationType && !distinguishDrivers) { @@ -462,6 +469,18 @@ export function getGeneticTrackRuleSetParams( if (distinguishGermlineMutations) { Object.assign(rule_set.rule_params.conditional, germline_rule_params); } + if (enableWhiteBackgroundForGlyphs) { + rule_set.legend_base_color = hexToRGBA(ASCN_WHITE); + if (rule_set.rule_params.always) { + rule_set.rule_params.always.shapes = [ + { + type: 'rectangle', + fill: hexToRGBA(ASCN_WHITE), + z: 1, + }, + ]; + } + } return rule_set; } @@ -1071,10 +1090,18 @@ export function makeClinicalTracksMobxPromise( dataAndColors.categoryToColor, hexToRGBA ); - oncoprint.props.store.setDefaultClinicalAttributeColor( - attribute.displayName, - dataAndColors.categoryToColor - ); + // if default for attribute doesn't already exist + if ( + !oncoprint.props.store.defaultClinicalAttributeColors[ + attribute.displayName + ] + ) { + oncoprint.props.store.setDefaultClinicalAttributeColor( + attribute.displayName, + getClinicalAttributeValues(ret), + (ret as any).category_to_color + ); + } } else if ( attribute.clinicalAttributeId === SpecialAttribute.MutationSpectrum @@ -1082,12 +1109,19 @@ export function makeClinicalTracksMobxPromise( ret.datatype = 'counts'; (ret as any).countsCategoryLabels = MUTATION_SPECTRUM_CATEGORIES; (ret as any).countsCategoryFills = MUTATION_SPECTRUM_FILLS; - oncoprint.props.store.setDefaultClinicalAttributeColor( - attribute.displayName, - undefined, - MUTATION_SPECTRUM_CATEGORIES, - MUTATION_SPECTRUM_FILLS - ); + // if default for attribute doesn't already exist + if ( + !oncoprint.props.store.defaultClinicalAttributeColors[ + attribute.displayName + ] + ) { + oncoprint.props.store.setDefaultClinicalAttributeColor( + attribute.displayName, + MUTATION_SPECTRUM_CATEGORIES, + undefined, + MUTATION_SPECTRUM_FILLS + ); + } } const trackConfig = diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index f8a7db68d58..e5b60bb1db6 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -133,20 +133,14 @@ export type AdditionalTrackGroupRecord = { }; export function getClinicalAttributeValues( - attributeLabel: string, - clinicalTracks: ClinicalTrackSpec[] + track: Partial ): any[] { - // find track that matches given label - let index = _.findIndex(clinicalTracks, i => i.label === attributeLabel); // if the datatype is "counts", the attribute values are under countsCategoryLabels - if (clinicalTracks[index] && clinicalTracks[index].datatype === 'counts') { - return (clinicalTracks[index] as any).countsCategoryLabels; - // if the datatype is "string", get attribute values from the track data - } else if ( - clinicalTracks[index] && - clinicalTracks[index].datatype === 'string' - ) { - return _(clinicalTracks[index].data) + // else if the datatype is "string", get attribute values from the track data + if (track.datatype === 'counts') { + return (track as any).countsCategoryLabels; + } else if (track.datatype === 'string') { + return _(track.data) .map(d => d.attr_val) .uniq() .without(undefined) @@ -293,6 +287,7 @@ export default class ResultsViewOncoprint extends React.Component< @observable showClinicalTrackLegends: boolean = true; @observable _onlyShowClinicalLegendForAlteredCases = false; @observable showOqlInLabels = false; + @observable enableWhiteBackgroundForGlyphs: boolean = false; @computed get onlyShowClinicalLegendForAlteredCases() { return ( @@ -536,6 +531,9 @@ export default class ResultsViewOncoprint extends React.Component< get showOqlInLabels() { return self.showOqlInLabels; }, + get enableWhiteBackgroundForGlyphs() { + return self.enableWhiteBackgroundForGlyphs; + }, get showMinimap() { return self.showMinimap; }, @@ -551,15 +549,15 @@ export default class ResultsViewOncoprint extends React.Component< get distinguishMutationType() { return self.distinguishMutationType; }, - get changedTrackKey() { - return self.changedTrackKey; - }, get distinguishDrivers() { return self.distinguishDrivers; }, get distinguishGermlineMutations() { return self.distinguishGermlineMutations; }, + get changedTrackKey() { + return self.changedTrackKey; + }, get annotateDriversOncoKb() { return self.props.store.driverAnnotationSettings.oncoKb; }, @@ -765,15 +763,15 @@ export default class ResultsViewOncoprint extends React.Component< onSelectShowOqlInLabels: (show: boolean) => { this.showOqlInLabels = show; }, + onSelectEnableWhiteBackgroundForGlyphs: (s: boolean) => { + this.enableWhiteBackgroundForGlyphs = s; + }, onSelectShowMinimap: (show: boolean) => { this.showMinimap = show; }, onSelectDistinguishMutationType: (s: boolean) => { this.distinguishMutationType = s; }, - onSetChangedTrackKey: (s: string) => { - this.changedTrackKey = s; - }, onSelectDistinguishDrivers: action((s: boolean) => { if (!s) { this.props.store.driverAnnotationSettings.oncoKb = false; @@ -815,6 +813,9 @@ export default class ResultsViewOncoprint extends React.Component< onSelectDistinguishGermlineMutations: (s: boolean) => { this.distinguishGermlineMutations = s; }, + onSetChangedTrackKey: (s: string) => { + this.changedTrackKey = s; + }, onSelectAnnotateOncoKb: action((s: boolean) => { this.props.store.driverAnnotationSettings.oncoKb = s; }), @@ -1994,11 +1995,11 @@ export default class ResultsViewOncoprint extends React.Component< distinguishMutationType={ this.distinguishMutationType } - changedTrackKey={this.changedTrackKey} distinguishDrivers={this.distinguishDrivers} distinguishGermlineMutations={ this.distinguishGermlineMutations } + changedTrackKey={this.changedTrackKey} sortConfig={this.oncoprintLibrarySortConfig} showClinicalTrackLegends={ this.showClinicalTrackLegends @@ -2006,6 +2007,9 @@ export default class ResultsViewOncoprint extends React.Component< showWhitespaceBetweenColumns={ this.showWhitespaceBetweenColumns } + enableWhiteBackgroundForGlyphs={ + this.enableWhiteBackgroundForGlyphs + } showMinimap={this.showMinimap} onMinimapClose={this.onMinimapClose} onDeleteClinicalTrack={ diff --git a/src/shared/components/oncoprint/controls/OncoprintColors.tsx b/src/shared/components/oncoprint/controls/OncoprintColors.tsx index 7c563d03e2f..60780660ec7 100644 --- a/src/shared/components/oncoprint/controls/OncoprintColors.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintColors.tsx @@ -21,7 +21,6 @@ import { IOncoprintControlsState, } from './OncoprintControls'; import { RGBAColor } from 'oncoprintjs'; -import { ClinicalTrackSpec } from '../Oncoprint'; import _ from 'lodash'; export interface IGroupCheckboxProps { @@ -36,7 +35,7 @@ export interface IGroupCheckboxProps { clinicalAttributeLabel: string; clinicalAttributeValue: any; color: RGBAColor; - clinicalTrack: ClinicalTrackSpec; + clinicalTrackKey: string; // markedWithWarningSign: boolean; } @@ -73,7 +72,7 @@ export default class OncoprintColors extends React.Component< // set changed track key this.props.handlers.onSetChangedTrackKey && this.props.handlers.onSetChangedTrackKey( - this.props.clinicalTrack.key + this.props.clinicalTrackKey ); }; diff --git a/src/shared/components/oncoprint/controls/OncoprintControls.tsx b/src/shared/components/oncoprint/controls/OncoprintControls.tsx index 58bed1e2223..3ce881fc169 100644 --- a/src/shared/components/oncoprint/controls/OncoprintControls.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintControls.tsx @@ -63,6 +63,7 @@ export interface IOncoprintControlsHandlers onSelectShowMinimap: (showMinimap: boolean) => void; onSelectDistinguishMutationType: (distinguish: boolean) => void; onSelectDistinguishGermlineMutations: (distinguish: boolean) => void; + onSelectEnableWhiteBackgroundForGlyphs?: (use: boolean) => void; onSetChangedTrackKey?: (key: string) => void; onSelectHideVUS: (hide: boolean) => void; @@ -96,6 +97,7 @@ export interface IOncoprintControlsState showClinicalTrackLegends?: boolean; onlyShowClinicalLegendForAlteredCases?: boolean; showOqlInLabels?: boolean; + enableWhiteBackgroundForGlyphs?: boolean; showMinimap: boolean; isClinicalTrackConfigDirty: boolean; isLoggedIn: boolean; @@ -164,6 +166,7 @@ const EVENT_KEY = { showClinicalTrackLegends: '4', onlyShowClinicalLegendForAlteredCases: '4.1', showOqlInLabels: '4.2', + enableWhiteBackgroundForGlyphs: '4.3', distinguishMutationType: '5', distinguishGermlineMutations: '5.1', sortByMutationType: '6', @@ -308,6 +311,12 @@ export default class OncoprintControls extends React.Component< !this.props.state.showOqlInLabels ); break; + case EVENT_KEY.enableWhiteBackgroundForGlyphs: + this.props.handlers.onSelectEnableWhiteBackgroundForGlyphs && + this.props.handlers.onSelectEnableWhiteBackgroundForGlyphs( + !this.props.state.enableWhiteBackgroundForGlyphs + ); + break; case EVENT_KEY.columnTypeSample: this.props.handlers.onSelectColumnType && this.props.handlers.onSelectColumnType('sample'); @@ -878,31 +887,30 @@ export default class OncoprintControls extends React.Component< return (
{track.label} - {getClinicalAttributeValues( - track.label, - this.props.clinicalTracks! - ).map(value => ( - - ))} + {getClinicalAttributeValues(track).map( + value => ( + + ) + )}
); })} @@ -1009,6 +1017,21 @@ export default class OncoprintControls extends React.Component< Show legends for clinical tracks +
+ +
); }); @@ -1127,6 +1150,21 @@ export default class OncoprintControls extends React.Component< Show OQL filters +
+ +
); }); From 89a2ce4d6eb54b040ad41185d7d4c38c7e05d5bd Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Fri, 6 Oct 2023 17:10:36 -0400 Subject: [PATCH 06/15] add white background for glyphs query to url --- src/pages/resultsView/ResultsViewURLWrapper.ts | 3 +++ .../components/oncoprint/ResultsViewOncoprint.tsx | 11 +++++++++-- 2 files changed, 12 insertions(+), 2 deletions(-) diff --git a/src/pages/resultsView/ResultsViewURLWrapper.ts b/src/pages/resultsView/ResultsViewURLWrapper.ts index c0a2b75d813..71fb650fa9e 100644 --- a/src/pages/resultsView/ResultsViewURLWrapper.ts +++ b/src/pages/resultsView/ResultsViewURLWrapper.ts @@ -77,6 +77,7 @@ export enum ResultsViewURLQueryEnum { geneset_list = 'geneset_list', generic_assay_groups = 'generic_assay_groups', show_samples = 'show_samples', + enable_white_background_for_glyphs = 'enable_white_background_for_glyphs', heatmap_track_groups = 'heatmap_track_groups', oncoprint_sortby = 'oncoprint_sortby', oncoprint_cluster_profile = 'oncoprint_cluster_profile', @@ -127,6 +128,7 @@ export type ResultsViewURLQuery = { const shouldForceRemount: { [prop in keyof ResultsViewURLQuery]: boolean } = { clinicallist: false, show_samples: false, + enable_white_background_for_glyphs: false, heatmap_track_groups: false, oncoprint_sortby: false, oncoprint_cluster_profile: false, @@ -181,6 +183,7 @@ const propertiesMap = _.mapValues( // oncoprint props clinicallist: { isSessionProp: false }, show_samples: { isSessionProp: false }, + enable_white_background_for_glyphs: { isSessionProp: false }, heatmap_track_groups: { isSessionProp: false }, oncoprint_sortby: { isSessionProp: false }, oncoprint_cluster_profile: { isSessionProp: false }, diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index e5b60bb1db6..f40380a5ed4 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -238,6 +238,12 @@ export default class ResultsViewOncoprint extends React.Component< ); } + @computed get enableWhiteBackgroundForGlyphs() { + return ( + this.urlWrapper.query.enable_white_background_for_glyphs === 'true' + ); + } + @computed get genericAssayPromises() { if (this.props.store.studyIds.result.length === 1) { // we only support generic assay in oncoprint for single study, @@ -287,7 +293,6 @@ export default class ResultsViewOncoprint extends React.Component< @observable showClinicalTrackLegends: boolean = true; @observable _onlyShowClinicalLegendForAlteredCases = false; @observable showOqlInLabels = false; - @observable enableWhiteBackgroundForGlyphs: boolean = false; @computed get onlyShowClinicalLegendForAlteredCases() { return ( @@ -764,7 +769,9 @@ export default class ResultsViewOncoprint extends React.Component< this.showOqlInLabels = show; }, onSelectEnableWhiteBackgroundForGlyphs: (s: boolean) => { - this.enableWhiteBackgroundForGlyphs = s; + this.urlWrapper.updateURL({ + enable_white_background_for_glyphs: s.toString(), + }); }, onSelectShowMinimap: (show: boolean) => { this.showMinimap = show; From 0a0665dfd7e90de4305ba5d9a337f9a41c46bd81 Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Tue, 10 Oct 2023 16:12:14 -0400 Subject: [PATCH 07/15] add button to reset colors and fix crash when going into oncoprinter --- src/pages/resultsView/ResultsViewPageStore.ts | 41 ------ .../oncoprint/controls/OncoprintColors.tsx | 21 --- .../oncoprint/controls/OncoprintControls.tsx | 137 ++++++++++++------ 3 files changed, 94 insertions(+), 105 deletions(-) diff --git a/src/pages/resultsView/ResultsViewPageStore.ts b/src/pages/resultsView/ResultsViewPageStore.ts index a3f57341294..0db3db8295a 100644 --- a/src/pages/resultsView/ResultsViewPageStore.ts +++ b/src/pages/resultsView/ResultsViewPageStore.ts @@ -589,11 +589,6 @@ export class ResultsViewPageStore extends AnalysisStore }; } = {}; - // private _selectedComparisonGroupsWarningSigns = observable.map< - // string, - // boolean - // >({}, { deep: false }); - @computed get doNonSelectedDownloadableMolecularProfilesExist() { return ( this.nonSelectedDownloadableMolecularProfilesGroupByName.result && @@ -670,42 +665,6 @@ export class ResultsViewPageStore extends AnalysisStore } } - // @action public showAlterationWarningSign( - // alteration: string, - // markedValue: boolean - // ) { - // this._selectedComparisonGroupsWarningSigns.set(alteration, markedValue); - // } - - // public flagDuplicateColorsForAlterations( - // alteration: string, - // color: string | undefined - // ) { - // let colors: { [color: string]: number } = {}; - - // Object.keys(this.userAlterationColors).forEach( - // (a: string, i: number) => { - // let alterationColor = - // a === alteration ? color : this.userAlterationColors[a]; - // if ( - // alterationColor == undefined || - // colors[alterationColor] == undefined - // ) { - // if (alterationColor != undefined) - // colors[alterationColor] = 1; - // this.showAlterationWarningSign(alteration, false); - // } else { - // colors[alterationColor] = colors[alterationColor] + 1; - // this.showAlterationWarningSign(alteration, true); - // } - // } - // ); - // } - - // public isAlterationMarkedWithWarningSign(alteration: string): boolean { - // return !!this._selectedComparisonGroupsWarningSigns.get(alteration); - // } - @action.bound public setOncoprintAnalysisCaseType(e: OncoprintAnalysisCaseType) { this.urlWrapper.updateURL({ diff --git a/src/shared/components/oncoprint/controls/OncoprintColors.tsx b/src/shared/components/oncoprint/controls/OncoprintColors.tsx index 60780660ec7..d0212699808 100644 --- a/src/shared/components/oncoprint/controls/OncoprintColors.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintColors.tsx @@ -36,7 +36,6 @@ export interface IGroupCheckboxProps { clinicalAttributeValue: any; color: RGBAColor; clinicalTrackKey: string; - // markedWithWarningSign: boolean; } const COLOR_UNDEFINED = '#FFFFFF'; @@ -111,26 +110,6 @@ export default class OncoprintColors extends React.Component< return (
{this.props.clinicalAttributeValue} - {/* */} - {/* - {this.props.markedWithWarningSign && ( - - )} - */} - {/* */} { - return ( - -
- {this.props.clinicalTracks!.map(track => { - return ( -
- {track.label} - {getClinicalAttributeValues(track).map( - value => ( - + {this.props.clinicalTracks!.map(track => { + if (track.datatype !== 'number') { + return ( +
+ {track.label} + {getClinicalAttributeValues(track).map( + value => ( + + ) + )} +
- ); - })} -
- - ); + onClick={() => { + getClinicalAttributeValues( + track + ).forEach(v => { + this.props + .handleClinicalAttributeColorChange && + this.props.handleClinicalAttributeColorChange( + track.label, + v, + undefined + ); + this.props.handlers + .onSetChangedTrackKey && + this.props.handlers.onSetChangedTrackKey( + track.key + ); + }); + }} + > + Reset Colors + +
+ ); + } + })} +
+ + ); + } else { + return null; + } }); private MutationColorMenu = observer(() => { From ecaf631d7c71d5db94e2d520a1f31010283a836e Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Thu, 12 Oct 2023 18:11:00 -0400 Subject: [PATCH 08/15] move color menu to modal under individual track menu --- src/pages/resultsView/ResultsViewPageStore.ts | 40 ++-- ...olors.tsx => ClinicalTrackColorPicker.tsx} | 43 ++-- src/shared/components/oncoprint/DeltaUtils.ts | 22 +- src/shared/components/oncoprint/Oncoprint.tsx | 5 +- .../components/oncoprint/OncoprintUtils.ts | 28 ++- .../oncoprint/ResultsViewOncoprint.tsx | 195 +++++++++++++----- .../oncoprint/controls/OncoprintControls.tsx | 151 +------------- 7 files changed, 219 insertions(+), 265 deletions(-) rename src/shared/components/oncoprint/{controls/OncoprintColors.tsx => ClinicalTrackColorPicker.tsx} (71%) diff --git a/src/pages/resultsView/ResultsViewPageStore.ts b/src/pages/resultsView/ResultsViewPageStore.ts index 0db3db8295a..be918e03dcf 100644 --- a/src/pages/resultsView/ResultsViewPageStore.ts +++ b/src/pages/resultsView/ResultsViewPageStore.ts @@ -577,13 +577,13 @@ export class ResultsViewPageStore extends AnalysisStore @observable queryFormVisible: boolean = false; - @observable _userSelectedClinicalAttributeColors: { + @observable _userSelectedClinicalTracksColors: { [label: string]: { [value: string]: RGBAColor; }; } = {}; - @observable _defaultClinicalAttributeColors: { + @observable _defaultClinicalTracksColors: { [label: string]: { [value: string]: RGBAColor; }; @@ -603,37 +603,37 @@ export class ResultsViewPageStore extends AnalysisStore | undefined = undefined; @action.bound - public onClinicalAttributeColorChange( + public setUserSelectedClinicalTrackColor( label: string, value: string, color: RGBAColor | undefined ) { // if color is undefined, delete color from userSelectedClinicalAttributeColors if exists + // else, set the color in userSelectedClinicalAttributeColors if ( !color && - this._userSelectedClinicalAttributeColors[label] && - this._userSelectedClinicalAttributeColors[label][value] + this._userSelectedClinicalTracksColors[label] && + this._userSelectedClinicalTracksColors[label][value] ) { - delete this._userSelectedClinicalAttributeColors[label][value]; - // else, set the color in userSelectedClinicalAttributeColors + delete this._userSelectedClinicalTracksColors[label][value]; } else if (color) { - if (!this._userSelectedClinicalAttributeColors[label]) { - this._userSelectedClinicalAttributeColors[label] = {}; + if (!this._userSelectedClinicalTracksColors[label]) { + this._userSelectedClinicalTracksColors[label] = {}; } - this._userSelectedClinicalAttributeColors[label][value] = color; + this._userSelectedClinicalTracksColors[label][value] = color; } } - @computed get defaultClinicalAttributeColors() { - return this._defaultClinicalAttributeColors; + @computed get defaultClinicalTracksColors() { + return this._defaultClinicalTracksColors; } - @computed get userSelectedClinicalAttributeColors() { - return this._userSelectedClinicalAttributeColors; + @computed get userSelectedClinicalTracksColors() { + return this._userSelectedClinicalTracksColors; } @action.bound - public setDefaultClinicalAttributeColor( + public setDefaultClinicalTrackColors( label: string, values: any[], categoryToColor?: { @@ -642,14 +642,14 @@ export class ResultsViewPageStore extends AnalysisStore countsCategoryFills?: RGBAColor[] ) { if (categoryToColor) { - this._defaultClinicalAttributeColors[label] = {}; + this._defaultClinicalTracksColors[label] = {}; _.forEach(values, value => { - this._defaultClinicalAttributeColors[label][value] = + this._defaultClinicalTracksColors[label][value] = categoryToColor[value]; }); // sample type attributes have unique "Mixed" label with set color if (label === 'Sample Type' || label === 'Sample type id') { - this._defaultClinicalAttributeColors[label]['Mixed'] = [ + this._defaultClinicalTracksColors[label]['Mixed'] = [ 48, 97, 194, @@ -657,9 +657,9 @@ export class ResultsViewPageStore extends AnalysisStore ]; } } else if (countsCategoryFills) { - this._defaultClinicalAttributeColors[label] = {}; + this._defaultClinicalTracksColors[label] = {}; _.forEach(values, (value, i) => { - this._defaultClinicalAttributeColors[label][value] = + this._defaultClinicalTracksColors[label][value] = countsCategoryFills[i]; }); } diff --git a/src/shared/components/oncoprint/controls/OncoprintColors.tsx b/src/shared/components/oncoprint/ClinicalTrackColorPicker.tsx similarity index 71% rename from src/shared/components/oncoprint/controls/OncoprintColors.tsx rename to src/shared/components/oncoprint/ClinicalTrackColorPicker.tsx index d0212699808..429bf0b2a78 100644 --- a/src/shared/components/oncoprint/controls/OncoprintColors.tsx +++ b/src/shared/components/oncoprint/ClinicalTrackColorPicker.tsx @@ -16,32 +16,24 @@ import { } from 'shared/lib/Colors'; import { COLORS } from 'pages/studyView/StudyViewUtils'; import { ResultsViewPageStore } from 'pages/resultsView/ResultsViewPageStore'; -import { - IOncoprintControlsHandlers, - IOncoprintControlsState, -} from './OncoprintControls'; import { RGBAColor } from 'oncoprintjs'; import _ from 'lodash'; export interface IGroupCheckboxProps { - store?: ResultsViewPageStore; - handlers: IOncoprintControlsHandlers; - state: IOncoprintControlsState; - handleClinicalAttributeColorChange?: ( - label: string, + store: ResultsViewPageStore; + handleClinicalTrackColorChange?: ( value: string, color: RGBAColor | undefined ) => void; - clinicalAttributeLabel: string; - clinicalAttributeValue: any; + clinicalTrackValue: any; color: RGBAColor; - clinicalTrackKey: string; + setClinicalTrackColorChanged: (changed: boolean) => void; } const COLOR_UNDEFINED = '#FFFFFF'; @observer -export default class OncoprintColors extends React.Component< +export default class ClinicalTrackColorPicker extends React.Component< IGroupCheckboxProps, {} > { @@ -52,27 +44,22 @@ export default class OncoprintColors extends React.Component< @action.bound handleChangeComplete = (color: any, event: any) => { - // if same color is select, unselect it (go back to no color) + // if same color is selected, unselect it (go back to default color) if (color.hex === rgbaToHex(this.props.color)) { - this.props.handleClinicalAttributeColorChange && - this.props.handleClinicalAttributeColorChange( - this.props.clinicalAttributeLabel, - this.props.clinicalAttributeValue, + this.props.handleClinicalTrackColorChange && + this.props.handleClinicalTrackColorChange( + this.props.clinicalTrackValue, undefined ); } else { - this.props.handleClinicalAttributeColorChange && - this.props.handleClinicalAttributeColorChange( - this.props.clinicalAttributeLabel, - this.props.clinicalAttributeValue, + this.props.handleClinicalTrackColorChange && + this.props.handleClinicalTrackColorChange( + this.props.clinicalTrackValue, [color.rgb.r, color.rgb.g, color.rgb.b, color.rgb.a] ); } // set changed track key - this.props.handlers.onSetChangedTrackKey && - this.props.handlers.onSetChangedTrackKey( - this.props.clinicalTrackKey - ); + this.props.setClinicalTrackColorChanged(true); }; @computed get colorList() { @@ -109,7 +96,7 @@ export default class OncoprintColors extends React.Component< render() { return (
- {this.props.clinicalAttributeValue} + {this.props.clinicalTrackValue} { [key: string]: TrackId }, oncoprint: OncoprintJS, - nextProps: IOncoprintProps, - prevProps: Partial + nextProps: IOncoprintProps ) { const trackSpecKeyToTrackId = getTrackSpecKeyToTrackId(); if (tryRemoveTrack(nextSpec, prevSpec, trackSpecKeyToTrackId, oncoprint)) { @@ -1332,19 +1329,20 @@ function transitionClinicalTrack( oncoprint.setTrackCustomOptions(trackId, nextSpec.custom_options); } - // update ruleset for changed track key + // update ruleset if color has changed for selected track if ( - nextProps.changedTrackKey && - getTrackSpecKeyToTrackId()[nextProps.changedTrackKey] === trackId + nextProps.clinicalTrackColorChanged && + nextProps.selectedClinicalTrackKey && + getTrackSpecKeyToTrackId()[nextProps.selectedClinicalTrackKey] === + trackId ) { let rule_set_params = getClinicalTrackRuleSetParams(nextSpec); rule_set_params.legend_label = nextSpec.label; rule_set_params.exclude_from_legend = !nextProps.showClinicalTrackLegends; rule_set_params.na_legend_label = nextSpec.na_legend_label; oncoprint.setRuleSet(trackId, rule_set_params); - // set changed track key back to none - nextProps.onSetChangedTrackKey && - nextProps.onSetChangedTrackKey(''); + nextProps.setClinicalTrackColorChanged && + nextProps.setClinicalTrackColorChanged(false); } } } diff --git a/src/shared/components/oncoprint/Oncoprint.tsx b/src/shared/components/oncoprint/Oncoprint.tsx index c3f6aecb6cb..eb9e5c77ef5 100644 --- a/src/shared/components/oncoprint/Oncoprint.tsx +++ b/src/shared/components/oncoprint/Oncoprint.tsx @@ -300,8 +300,9 @@ export interface IOncoprintProps { onTrackSortDirectionChange?: (trackId: TrackId, dir: number) => void; onTrackGapChange?: (trackId: TrackId, gap: boolean) => void; - changedTrackKey?: string; - onSetChangedTrackKey?: (key: string) => void; + selectedClinicalTrackKey?: string | null; + clinicalTrackColorChanged?: boolean; + setClinicalTrackColorChanged?: (changed: boolean) => void; suppressRendering?: boolean; onSuppressRendering?: () => void; diff --git a/src/shared/components/oncoprint/OncoprintUtils.ts b/src/shared/components/oncoprint/OncoprintUtils.ts index e1c9831ab8d..6dc5969dcff 100644 --- a/src/shared/components/oncoprint/OncoprintUtils.ts +++ b/src/shared/components/oncoprint/OncoprintUtils.ts @@ -34,7 +34,7 @@ import { } from './DataUtils'; import _, { isNumber } from 'lodash'; import ResultsViewOncoprint, { - getClinicalAttributeValues, + getClinicalTrackValues, } from './ResultsViewOncoprint'; import { action, IObservableArray, ObservableMap, runInAction } from 'mobx'; import { MobxPromise } from 'mobxpromise'; @@ -1092,16 +1092,24 @@ export function makeClinicalTracksMobxPromise( ); // if default for attribute doesn't already exist if ( - !oncoprint.props.store.defaultClinicalAttributeColors[ + !oncoprint.props.store.defaultClinicalTracksColors[ attribute.displayName ] ) { - oncoprint.props.store.setDefaultClinicalAttributeColor( + oncoprint.props.store.setDefaultClinicalTrackColors( attribute.displayName, - getClinicalAttributeValues(ret), + getClinicalTrackValues(ret), (ret as any).category_to_color ); } + // add option to open up color config modal + ret.custom_options = [ + { + label: 'Color', + onClick: () => + oncoprint.setSelectedClinicalTrackKey(ret.key!), + }, + ]; } else if ( attribute.clinicalAttributeId === SpecialAttribute.MutationSpectrum @@ -1111,17 +1119,25 @@ export function makeClinicalTracksMobxPromise( (ret as any).countsCategoryFills = MUTATION_SPECTRUM_FILLS; // if default for attribute doesn't already exist if ( - !oncoprint.props.store.defaultClinicalAttributeColors[ + !oncoprint.props.store.defaultClinicalTracksColors[ attribute.displayName ] ) { - oncoprint.props.store.setDefaultClinicalAttributeColor( + oncoprint.props.store.setDefaultClinicalTrackColors( attribute.displayName, MUTATION_SPECTRUM_CATEGORIES, undefined, MUTATION_SPECTRUM_FILLS ); } + // add options to open up color config modal + ret.custom_options = [ + { + label: 'Color', + onClick: () => + oncoprint.setSelectedClinicalTrackKey(ret.key!), + }, + ]; } const trackConfig = diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index f40380a5ed4..c8dea71a035 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -90,6 +90,8 @@ import '../../../globalStyles/oncoprintStyles.scss'; import { GenericAssayTrackInfo } from 'pages/studyView/addChartButton/genericAssaySelection/GenericAssaySelection'; import { toDirectionString } from './SortUtils'; import { RestoreClinicalTracksMenu } from 'pages/resultsView/oncoprint/RestoreClinicalTracksMenu'; +import { Modal } from 'react-bootstrap'; +import ClinicalTrackColorPicker from './ClinicalTrackColorPicker'; interface IResultsViewOncoprintProps { divId: string; @@ -132,11 +134,11 @@ export type AdditionalTrackGroupRecord = { molecularProfile: MolecularProfile; }; -export function getClinicalAttributeValues( +export function getClinicalTrackValues( track: Partial ): any[] { - // if the datatype is "counts", the attribute values are under countsCategoryLabels - // else if the datatype is "string", get attribute values from the track data + // if the datatype is "counts", the values are under countsCategoryLabels + // else if the datatype is "string", get values from the track data if (track.datatype === 'counts') { return (track as any).countsCategoryLabels; } else if (track.datatype === 'string') { @@ -149,40 +151,51 @@ export function getClinicalAttributeValues( return []; } -export function setClinicalAttributeValueColorsInTrack( - attributeLabel: string, - attributeValue: string, - color: RGBAColor | undefined, +export function setClinicalTrackColor( track: ClinicalTrackSpec, + value: string, + color: RGBAColor | undefined, store: ResultsViewPageStore ) { if (track.datatype === 'string') { - // set new color of attribute value in track's category_to_color + // set new color of value in track's category_to_color + // if undefined color, set value's color in track's category_to_color back to its default if (color) { - (track as any).category_to_color[attributeValue] = color; - // if undefined color, set attribute value's color in track's category_to_color back to its default + (track as any).category_to_color[value] = color; } else { - (track as any).category_to_color[attributeValue] = - store.defaultClinicalAttributeColors[attributeLabel][ - attributeValue - ]; + (track as any).category_to_color[value] = + store.defaultClinicalTracksColors[track.label][value]; } } else if (track.datatype === 'counts') { - // get index of attribute value that corresponds with its color - let valueIndex = _.indexOf( - (track as any).countsCategoryLabels, - attributeValue - ); - // set new color of attribute value in track's countsCategoryFills using valueIndex + // get index of value that corresponds with its color + let valueIndex = _.indexOf((track as any).countsCategoryLabels, value); + // set new color of value in track's countsCategoryFills using valueIndex + // if undefined color, set value's color in track's countsCategoryFills back to its default if (color) { (track as any).countsCategoryFills[valueIndex] = color; - // if undefined color, set attribute value's color in track's countsCategoryFills back to its default } else { (track as any).countsCategoryFills[valueIndex] = - store.defaultClinicalAttributeColors[attributeLabel][ - attributeValue - ]; + store.defaultClinicalTracksColors[track.label][value]; + } + } +} + +export function getClinicalTrackColor( + label: string, + value: string, + store?: ResultsViewPageStore +): RGBAColor { + if (store) { + if ( + !store.userSelectedClinicalTracksColors[label] || + !store.userSelectedClinicalTracksColors[label][value] + ) { + return store.defaultClinicalTracksColors[label][value]; + } else { + return store.userSelectedClinicalTracksColors[label][value]; } + } else { + return [255, 255, 255, 1] as RGBAColor; } } @@ -1767,10 +1780,6 @@ export default class ResultsViewOncoprint extends React.Component< this .selectedGenericAssayEntitiesGroupedByGenericAssayTypeFromUrl } - handleClinicalAttributeColorChange={ - this.handleClinicalAttributeColorChange - } - clinicalTracks={this.clinicalTracks.result} /> ); @@ -1875,32 +1884,49 @@ export default class ResultsViewOncoprint extends React.Component< } @action.bound - public handleClinicalAttributeColorChange( - attributeLabel: string, - attributeValue: string, + public handleClinicalTrackColorChange( + value: string, color: RGBAColor | undefined ) { - // find track that matches given label - let index = _.findIndex( - this.clinicalTracks.result, - i => i.label === attributeLabel - ); - const track = this.clinicalTracks.result[index]; - - setClinicalAttributeValueColorsInTrack( - attributeLabel, - attributeValue, + setClinicalTrackColor( + this.selectedClinicalTrack, + value, color, - track, this.props.store ); - this.props.store.onClinicalAttributeColorChange( - attributeLabel, - attributeValue, + this.props.store.setUserSelectedClinicalTrackColor( + this.selectedClinicalTrack.label, + value, color ); } + @observable selectedClinicalTrackKey: string | null = null; + + @action.bound + setSelectedClinicalTrackKey(key: string | null) { + this.selectedClinicalTrackKey = key; + } + + @computed get selectedClinicalTrack() { + let index = _.findIndex( + this.clinicalTracks.result, + t => t.key === this.selectedClinicalTrackKey + ); + return this.clinicalTracks.result[index]; + } + + @computed get selectedClinicalTrackValues() { + return getClinicalTrackValues(this.selectedClinicalTrack); + } + + @observable clinicalTrackColorChanged: boolean = false; + + @action.bound + setClinicalTrackColorChanged(changed: boolean) { + this.clinicalTrackColorChanged = changed; + } + public render() { getBrowserWindow().donk = this; return ( @@ -1938,6 +1964,74 @@ export default class ResultsViewOncoprint extends React.Component< />
+ {this.selectedClinicalTrack && ( + this.setSelectedClinicalTrackKey(null)} + > + + + {this.selectedClinicalTrack.label} + + + +
+ {this.selectedClinicalTrackValues.map(value => ( + + ))} + +
+ + + )} +
diff --git a/src/shared/components/oncoprint/controls/OncoprintControls.tsx b/src/shared/components/oncoprint/controls/OncoprintControls.tsx index 540d15d2320..3b87dbec08f 100644 --- a/src/shared/components/oncoprint/controls/OncoprintControls.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintControls.tsx @@ -7,7 +7,7 @@ import ReactSelect from 'react-select1'; import { MobxPromise } from 'mobxpromise'; import { action, computed, observable, reaction, makeObservable } from 'mobx'; import _ from 'lodash'; -import { getClinicalAttributeValues, SortMode } from '../ResultsViewOncoprint'; +import { SortMode } from '../ResultsViewOncoprint'; import { Gene, MolecularProfile, @@ -32,9 +32,7 @@ import { import OQLTextArea, { GeneBoxType } from '../../GeneSelectionBox/OQLTextArea'; import autobind from 'autobind-decorator'; import { SingleGeneQuery } from '../../../lib/oql/oql-parser'; -import TracksMenu, { - MIN_DROPDOWN_WIDTH, -} from 'pages/resultsView/oncoprint/TracksMenu'; +import TracksMenu from 'pages/resultsView/oncoprint/TracksMenu'; import { GenericAssayTrackInfo } from 'pages/studyView/addChartButton/genericAssaySelection/GenericAssaySelection'; import { IDriverAnnotationControlsHandlers, @@ -44,11 +42,8 @@ import DriverAnnotationControls from 'shared/components/driverAnnotations/Driver import { ClinicalTrackConfig, ClinicalTrackConfigMap, - ClinicalTrackSpec, } from 'shared/components/oncoprint/Oncoprint'; import { getServerConfig } from 'config/config'; -import { RGBAColor } from 'oncoprintjs'; -import OncoprintColors from './OncoprintColors'; export interface IOncoprintControlsHandlers extends IDriverAnnotationControlsHandlers { @@ -64,7 +59,6 @@ export interface IOncoprintControlsHandlers onSelectDistinguishMutationType: (distinguish: boolean) => void; onSelectDistinguishGermlineMutations: (distinguish: boolean) => void; onSelectEnableWhiteBackgroundForGlyphs?: (use: boolean) => void; - onSetChangedTrackKey?: (key: string) => void; onSelectHideVUS: (hide: boolean) => void; onSelectHideGermlineMutations: (hide: boolean) => void; @@ -109,7 +103,6 @@ export interface IOncoprintControlsState sortByCaseListDisabled: boolean; hidePutativePassengers: boolean; hideGermlineMutations: boolean; - changedTrackKey?: string; sortMode?: SortMode; clinicalAttributesPromise?: MobxPromise; @@ -145,12 +138,6 @@ export interface IOncoprintControlsProps { selectedGenericAssayEntitiesGroupedByGenericAssayTypeFromUrl?: { [genericAssayType: string]: string[]; }; - handleClinicalAttributeColorChange?: ( - label: string, - value: string, - color: RGBAColor | undefined - ) => void; - clinicalTracks?: ClinicalTrackSpec[]; } export interface ISelectOption { @@ -196,25 +183,6 @@ const EVENT_KEY = { viewNGCHM: '31', }; -export function getOncoprintColor( - label: string, - value: string, - store?: ResultsViewPageStore -): RGBAColor { - if (store) { - if ( - !store.userSelectedClinicalAttributeColors[label] || - !store.userSelectedClinicalAttributeColors[label][value] - ) { - return store.defaultClinicalAttributeColors[label][value]; - } else { - return store.userSelectedClinicalAttributeColors[label][value]; - } - } else { - return [255, 255, 255, 1] as RGBAColor; - } -} - @observer export default class OncoprintControls extends React.Component< IOncoprintControlsProps, @@ -871,105 +839,6 @@ export default class OncoprintControls extends React.Component< } } - private ColorsMenuOncoprint = observer(() => { - if (this.props.store) { - return ( - -
- {this.props.clinicalTracks!.map(track => { - if (track.datatype !== 'number') { - return ( -
- {track.label} - {getClinicalAttributeValues(track).map( - value => ( - - ) - )} - -
- ); - } - })} -
- - ); - } else { - return null; - } - }); - private MutationColorMenu = observer(() => { return ( -
- -
); }); @@ -1384,7 +1238,6 @@ export default class OncoprintControls extends React.Component< - From ce96829925e7f770fd572a0c9f560cd24634af9b Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Mon, 30 Oct 2023 17:38:50 -0400 Subject: [PATCH 09/15] address review comments --- src/pages/resultsView/ResultsViewPageStore.ts | 48 +---- .../oncoprint/ClinicalTrackColorPicker.tsx | 59 +++--- src/shared/components/oncoprint/DeltaUtils.ts | 30 ++- src/shared/components/oncoprint/Oncoprint.tsx | 6 +- .../components/oncoprint/OncoprintUtils.ts | 71 +++---- .../oncoprint/ResultsViewOncoprint.tsx | 185 +++++++++--------- .../oncoprint/controls/OncoprintControls.tsx | 19 +- 7 files changed, 181 insertions(+), 237 deletions(-) diff --git a/src/pages/resultsView/ResultsViewPageStore.ts b/src/pages/resultsView/ResultsViewPageStore.ts index be918e03dcf..9f52d43f2af 100644 --- a/src/pages/resultsView/ResultsViewPageStore.ts +++ b/src/pages/resultsView/ResultsViewPageStore.ts @@ -276,10 +276,7 @@ import { ICBioData } from 'pathway-mapper'; import { getAlterationData } from 'shared/components/oncoprint/OncoprintUtils'; import { PageUserSession } from 'shared/userSession/PageUserSession'; import { PageType } from 'shared/userSession/PageType'; -import { - ClinicalTrackConfig, - ClinicalTrackSpec, -} from 'shared/components/oncoprint/Oncoprint'; +import { ClinicalTrackConfig } from 'shared/components/oncoprint/Oncoprint'; import eventBus from 'shared/events/eventBus'; import { ErrorMessages } from 'shared/errorMessages'; import AnalysisStore from 'shared/lib/comparison/AnalysisStore'; @@ -583,12 +580,6 @@ export class ResultsViewPageStore extends AnalysisStore }; } = {}; - @observable _defaultClinicalTracksColors: { - [label: string]: { - [value: string]: RGBAColor; - }; - } = {}; - @computed get doNonSelectedDownloadableMolecularProfilesExist() { return ( this.nonSelectedDownloadableMolecularProfilesGroupByName.result && @@ -624,47 +615,10 @@ export class ResultsViewPageStore extends AnalysisStore } } - @computed get defaultClinicalTracksColors() { - return this._defaultClinicalTracksColors; - } - @computed get userSelectedClinicalTracksColors() { return this._userSelectedClinicalTracksColors; } - @action.bound - public setDefaultClinicalTrackColors( - label: string, - values: any[], - categoryToColor?: { - [category: string]: [number, number, number, number]; - }, - countsCategoryFills?: RGBAColor[] - ) { - if (categoryToColor) { - this._defaultClinicalTracksColors[label] = {}; - _.forEach(values, value => { - this._defaultClinicalTracksColors[label][value] = - categoryToColor[value]; - }); - // sample type attributes have unique "Mixed" label with set color - if (label === 'Sample Type' || label === 'Sample type id') { - this._defaultClinicalTracksColors[label]['Mixed'] = [ - 48, - 97, - 194, - 1, - ]; - } - } else if (countsCategoryFills) { - this._defaultClinicalTracksColors[label] = {}; - _.forEach(values, (value, i) => { - this._defaultClinicalTracksColors[label][value] = - countsCategoryFills[i]; - }); - } - } - @action.bound public setOncoprintAnalysisCaseType(e: OncoprintAnalysisCaseType) { this.urlWrapper.updateURL({ diff --git a/src/shared/components/oncoprint/ClinicalTrackColorPicker.tsx b/src/shared/components/oncoprint/ClinicalTrackColorPicker.tsx index 429bf0b2a78..0d09d2ef37e 100644 --- a/src/shared/components/oncoprint/ClinicalTrackColorPicker.tsx +++ b/src/shared/components/oncoprint/ClinicalTrackColorPicker.tsx @@ -71,37 +71,44 @@ export default class ClinicalTrackColorPicker extends React.Component< return colors; } - buildColorChooserWidget = () => ( - -
{ - e.nativeEvent.stopImmediatePropagation(); - }} - onClick={e => { - e.nativeEvent.stopImmediatePropagation(); - }} - > - -
- - ); + @computed get colorChooserElement() { + return ( + +
{ + e.nativeEvent.stopImmediatePropagation(); + }} + onClick={e => { + e.nativeEvent.stopImmediatePropagation(); + }} + > + +
+ + ); + } render() { return ( -
+
{this.props.clinicalTrackValue} - + + nextProps.setTrackKeySelectedForEdit!( + nextSpec.key + ), + }, + ...(nextSpec.custom_options || []), + ] + : nextSpec.custom_options, track_can_show_gaps: nextSpec.datatype === 'string', show_gaps_on_init: nextSpec.gapOn, }; @@ -1332,8 +1346,8 @@ function transitionClinicalTrack( // update ruleset if color has changed for selected track if ( nextProps.clinicalTrackColorChanged && - nextProps.selectedClinicalTrackKey && - getTrackSpecKeyToTrackId()[nextProps.selectedClinicalTrackKey] === + nextProps.trackKeySelectedForEdit && + getTrackSpecKeyToTrackId()[nextProps.trackKeySelectedForEdit] === trackId ) { let rule_set_params = getClinicalTrackRuleSetParams(nextSpec); diff --git a/src/shared/components/oncoprint/Oncoprint.tsx b/src/shared/components/oncoprint/Oncoprint.tsx index eb9e5c77ef5..52dbebbfe13 100644 --- a/src/shared/components/oncoprint/Oncoprint.tsx +++ b/src/shared/components/oncoprint/Oncoprint.tsx @@ -7,7 +7,6 @@ import { TrackSortDirection, InitParams, ColumnLabel, - IGeneticAlterationRuleSetParams, } from 'oncoprintjs'; import { GenePanelData, MolecularProfile } from 'cbioportal-ts-api-client'; import { observer } from 'mobx-react'; @@ -292,7 +291,7 @@ export interface IOncoprintProps { }; showClinicalTrackLegends?: boolean; showWhitespaceBetweenColumns?: boolean; - enableWhiteBackgroundForGlyphs?: boolean; + isWhiteBackgroundForGlyphsEnabled?: boolean; showMinimap?: boolean; onMinimapClose?: () => void; @@ -300,7 +299,8 @@ export interface IOncoprintProps { onTrackSortDirectionChange?: (trackId: TrackId, dir: number) => void; onTrackGapChange?: (trackId: TrackId, gap: boolean) => void; - selectedClinicalTrackKey?: string | null; + trackKeySelectedForEdit?: string | null; + setTrackKeySelectedForEdit?: (key: string | null) => void; clinicalTrackColorChanged?: boolean; setClinicalTrackColorChanged?: (changed: boolean) => void; diff --git a/src/shared/components/oncoprint/OncoprintUtils.ts b/src/shared/components/oncoprint/OncoprintUtils.ts index 6dc5969dcff..492df088405 100644 --- a/src/shared/components/oncoprint/OncoprintUtils.ts +++ b/src/shared/components/oncoprint/OncoprintUtils.ts @@ -453,7 +453,7 @@ export function getGeneticTrackRuleSetParams( distinguishMutationType?: boolean, distinguishDrivers?: boolean, distinguishGermlineMutations?: boolean, - enableWhiteBackgroundForGlyphs?: boolean + isWhiteBackgroundForGlyphsEnabled?: boolean ): IGeneticAlterationRuleSetParams { let rule_set; if (!distinguishMutationType && !distinguishDrivers) { @@ -469,7 +469,7 @@ export function getGeneticTrackRuleSetParams( if (distinguishGermlineMutations) { Object.assign(rule_set.rule_params.conditional, germline_rule_params); } - if (enableWhiteBackgroundForGlyphs) { + if (isWhiteBackgroundForGlyphsEnabled) { rule_set.legend_base_color = hexToRGBA(ASCN_WHITE); if (rule_set.rule_params.always) { rule_set.rule_params.always.shapes = [ @@ -1086,58 +1086,37 @@ export function makeClinicalTracksMobxPromise( } } else if (attribute.datatype === 'STRING') { ret.datatype = 'string'; - (ret as any).category_to_color = _.mapValues( - dataAndColors.categoryToColor, - hexToRGBA - ); - // if default for attribute doesn't already exist - if ( - !oncoprint.props.store.defaultClinicalTracksColors[ + (ret as any).category_to_color = Object.assign( + {}, + _.mapValues(dataAndColors.categoryToColor, hexToRGBA), + oncoprint.props.store.userSelectedClinicalTracksColors[ attribute.displayName ] - ) { - oncoprint.props.store.setDefaultClinicalTrackColors( - attribute.displayName, - getClinicalTrackValues(ret), - (ret as any).category_to_color - ); - } - // add option to open up color config modal - ret.custom_options = [ - { - label: 'Color', - onClick: () => - oncoprint.setSelectedClinicalTrackKey(ret.key!), - }, - ]; + ); } else if ( attribute.clinicalAttributeId === SpecialAttribute.MutationSpectrum ) { ret.datatype = 'counts'; (ret as any).countsCategoryLabels = MUTATION_SPECTRUM_CATEGORIES; - (ret as any).countsCategoryFills = MUTATION_SPECTRUM_FILLS; - // if default for attribute doesn't already exist - if ( - !oncoprint.props.store.defaultClinicalTracksColors[ - attribute.displayName - ] - ) { - oncoprint.props.store.setDefaultClinicalTrackColors( - attribute.displayName, - MUTATION_SPECTRUM_CATEGORIES, - undefined, - MUTATION_SPECTRUM_FILLS - ); - } - // add options to open up color config modal - ret.custom_options = [ - { - label: 'Color', - onClick: () => - oncoprint.setSelectedClinicalTrackKey(ret.key!), - }, - ]; + (ret as any).countsCategoryFills = MUTATION_SPECTRUM_FILLS.slice(); + _.forEach((ret as any).countsCategoryLabels, (label, i) => { + if ( + oncoprint.props.store + .userSelectedClinicalTracksColors[ + attribute.displayName + ] && + oncoprint.props.store + .userSelectedClinicalTracksColors[ + attribute.displayName + ][label] + ) { + (ret as any).countsCategoryFills[i] = + oncoprint.props.store.userSelectedClinicalTracksColors[ + attribute.displayName + ][label]; + } + }); } const trackConfig = diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index c8dea71a035..12462b295da 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -61,6 +61,8 @@ import tabularDownload from './tabularDownload'; import classNames from 'classnames'; import { clinicalAttributeIsLocallyComputed, + MUTATION_SPECTRUM_CATEGORIES, + MUTATION_SPECTRUM_FILLS, SpecialAttribute, } from '../../cache/ClinicalDataCache'; import OqlStatusBanner from '../banners/OqlStatusBanner'; @@ -92,6 +94,7 @@ import { toDirectionString } from './SortUtils'; import { RestoreClinicalTracksMenu } from 'pages/resultsView/oncoprint/RestoreClinicalTracksMenu'; import { Modal } from 'react-bootstrap'; import ClinicalTrackColorPicker from './ClinicalTrackColorPicker'; +import { hexToRGBA } from 'shared/lib/Colors'; interface IResultsViewOncoprintProps { divId: string; @@ -134,66 +137,41 @@ export type AdditionalTrackGroupRecord = { molecularProfile: MolecularProfile; }; -export function getClinicalTrackValues( - track: Partial -): any[] { +export function getClinicalTrackValues(track: ClinicalTrackSpec): any[] { // if the datatype is "counts", the values are under countsCategoryLabels // else if the datatype is "string", get values from the track data if (track.datatype === 'counts') { - return (track as any).countsCategoryLabels; + return track.countsCategoryLabels; } else if (track.datatype === 'string') { - return _(track.data) + const values = _(track.data) .map(d => d.attr_val) .uniq() .without(undefined) .value(); + return values.sort((a: string, b: string) => + a < b ? -1 : a > b ? 1 : 0 + ); } return []; } -export function setClinicalTrackColor( - track: ClinicalTrackSpec, - value: string, - color: RGBAColor | undefined, - store: ResultsViewPageStore -) { - if (track.datatype === 'string') { - // set new color of value in track's category_to_color - // if undefined color, set value's color in track's category_to_color back to its default - if (color) { - (track as any).category_to_color[value] = color; - } else { - (track as any).category_to_color[value] = - store.defaultClinicalTracksColors[track.label][value]; - } - } else if (track.datatype === 'counts') { - // get index of value that corresponds with its color - let valueIndex = _.indexOf((track as any).countsCategoryLabels, value); - // set new color of value in track's countsCategoryFills using valueIndex - // if undefined color, set value's color in track's countsCategoryFills back to its default - if (color) { - (track as any).countsCategoryFills[valueIndex] = color; - } else { - (track as any).countsCategoryFills[valueIndex] = - store.defaultClinicalTracksColors[track.label][value]; - } - } -} - export function getClinicalTrackColor( - label: string, - value: string, - store?: ResultsViewPageStore + track: ClinicalTrackSpec, + value: string ): RGBAColor { - if (store) { + if (track.datatype === 'counts') { + // get index of value that corresponds with its color + let valueIndex = _.indexOf(track.countsCategoryLabels, value); + return track.countsCategoryFills[valueIndex]; + } else if (track.datatype === 'string' && track.category_to_color) { if ( - !store.userSelectedClinicalTracksColors[label] || - !store.userSelectedClinicalTracksColors[label][value] + (track.label === 'Sample Type' || + track.label === 'Sample type id') && + value === 'Mixed' ) { - return store.defaultClinicalTracksColors[label][value]; - } else { - return store.userSelectedClinicalTracksColors[label][value]; + return track.category_to_color[value] || [48, 97, 194, 1]; } + return track.category_to_color[value]; } else { return [255, 255, 255, 1] as RGBAColor; } @@ -251,7 +229,7 @@ export default class ResultsViewOncoprint extends React.Component< ); } - @computed get enableWhiteBackgroundForGlyphs() { + @computed get isWhiteBackgroundForGlyphsEnabled() { return ( this.urlWrapper.query.enable_white_background_for_glyphs === 'true' ); @@ -327,8 +305,6 @@ export default class ResultsViewOncoprint extends React.Component< @observable renderingComplete = false; - @observable changedTrackKey: string = ''; - private heatmapGeneInputValueUpdater: IReactionDisposer; private molecularProfileIdToTrackGroupIndex: { @@ -549,8 +525,8 @@ export default class ResultsViewOncoprint extends React.Component< get showOqlInLabels() { return self.showOqlInLabels; }, - get enableWhiteBackgroundForGlyphs() { - return self.enableWhiteBackgroundForGlyphs; + get isWhiteBackgroundForGlyphsEnabled() { + return self.isWhiteBackgroundForGlyphsEnabled; }, get showMinimap() { return self.showMinimap; @@ -573,9 +549,6 @@ export default class ResultsViewOncoprint extends React.Component< get distinguishGermlineMutations() { return self.distinguishGermlineMutations; }, - get changedTrackKey() { - return self.changedTrackKey; - }, get annotateDriversOncoKb() { return self.props.store.driverAnnotationSettings.oncoKb; }, @@ -781,7 +754,7 @@ export default class ResultsViewOncoprint extends React.Component< onSelectShowOqlInLabels: (show: boolean) => { this.showOqlInLabels = show; }, - onSelectEnableWhiteBackgroundForGlyphs: (s: boolean) => { + onSelectIsWhiteBackgroundForGlyphsEnabled: (s: boolean) => { this.urlWrapper.updateURL({ enable_white_background_for_glyphs: s.toString(), }); @@ -833,9 +806,6 @@ export default class ResultsViewOncoprint extends React.Component< onSelectDistinguishGermlineMutations: (s: boolean) => { this.distinguishGermlineMutations = s; }, - onSetChangedTrackKey: (s: string) => { - this.changedTrackKey = s; - }, onSelectAnnotateOncoKb: action((s: boolean) => { this.props.store.driverAnnotationSettings.oncoKb = s; }), @@ -1884,40 +1854,66 @@ export default class ResultsViewOncoprint extends React.Component< } @action.bound - public handleClinicalTrackColorChange( + public handleSelectedClinicalTrackColorChange( value: string, color: RGBAColor | undefined ) { - setClinicalTrackColor( - this.selectedClinicalTrack, - value, - color, - this.props.store - ); - this.props.store.setUserSelectedClinicalTrackColor( - this.selectedClinicalTrack.label, - value, - color - ); + if (this.selectedClinicalTrack) { + this.props.store.setUserSelectedClinicalTrackColor( + this.selectedClinicalTrack.label, + value, + color + ); + } } - @observable selectedClinicalTrackKey: string | null = null; + @observable trackKeySelectedForEdit: string | null = null; @action.bound - setSelectedClinicalTrackKey(key: string | null) { - this.selectedClinicalTrackKey = key; + setTrackKeySelectedForEdit(key: string | null) { + this.trackKeySelectedForEdit = key; } @computed get selectedClinicalTrack() { - let index = _.findIndex( + return _.find( this.clinicalTracks.result, - t => t.key === this.selectedClinicalTrackKey + t => t.key === this.trackKeySelectedForEdit ); - return this.clinicalTracks.result[index]; + } + + @autobind + private getDefaultSelectedClinicalTrackColor(value: string) { + if (!this.selectedClinicalTrack) { + return [255, 255, 255, 1]; + } + if (this.selectedClinicalTrack.datatype === 'counts') { + return MUTATION_SPECTRUM_FILLS[ + _.indexOf(MUTATION_SPECTRUM_CATEGORIES, value) + ]; + } else if (this.selectedClinicalTrack.datatype === 'string') { + if ( + (this.selectedClinicalTrack.label === 'Sample Type' || + this.selectedClinicalTrack.label === 'Sample type id') && + value === 'Mixed' + ) { + return [48, 97, 194, 1]; + } else { + return hexToRGBA( + this.props.store.clinicalDataCache.get( + this.props.store.clinicalAttributeIdToClinicalAttribute + .result![this.selectedClinicalTrack!.attributeId] + ).result!.categoryToColor![value] + ); + } + } + return [255, 255, 255, 1]; } @computed get selectedClinicalTrackValues() { - return getClinicalTrackValues(this.selectedClinicalTrack); + if (this.selectedClinicalTrack) { + return getClinicalTrackValues(this.selectedClinicalTrack); + } + return []; } @observable clinicalTrackColorChanged: boolean = false; @@ -1967,10 +1963,11 @@ export default class ResultsViewOncoprint extends React.Component< {this.selectedClinicalTrack && ( this.setSelectedClinicalTrackKey(null)} + onHide={() => this.setTrackKeySelectedForEdit(null)} > + Color Configuration:{' '} {this.selectedClinicalTrack.label} @@ -1980,13 +1977,13 @@ export default class ResultsViewOncoprint extends React.Component< getClinicalTrackColor( - this.selectedClinicalTrack - .label, - v as string, - this.props.store + this.selectedClinicalTrack!, + v as string ) === - this.props.store - .defaultClinicalTracksColors[ - this.selectedClinicalTrack.label - ][v] + this.getDefaultSelectedClinicalTrackColor( + v + ) )} onClick={() => { this.selectedClinicalTrackValues.forEach( v => { - this.handleClinicalTrackColorChange( + this.handleSelectedClinicalTrackColorChange( v, undefined ); @@ -2107,8 +2097,8 @@ export default class ResultsViewOncoprint extends React.Component< showWhitespaceBetweenColumns={ this.showWhitespaceBetweenColumns } - enableWhiteBackgroundForGlyphs={ - this.enableWhiteBackgroundForGlyphs + isWhiteBackgroundForGlyphsEnabled={ + this.isWhiteBackgroundForGlyphsEnabled } showMinimap={this.showMinimap} onMinimapClose={this.onMinimapClose} @@ -2122,8 +2112,11 @@ export default class ResultsViewOncoprint extends React.Component< initParams={{ max_height: Number.POSITIVE_INFINITY, }} - selectedClinicalTrackKey={ - this.selectedClinicalTrackKey + trackKeySelectedForEdit={ + this.trackKeySelectedForEdit + } + setTrackKeySelectedForEdit={ + this.setTrackKeySelectedForEdit } clinicalTrackColorChanged={ this.clinicalTrackColorChanged diff --git a/src/shared/components/oncoprint/controls/OncoprintControls.tsx b/src/shared/components/oncoprint/controls/OncoprintControls.tsx index 3b87dbec08f..3b7a0740ceb 100644 --- a/src/shared/components/oncoprint/controls/OncoprintControls.tsx +++ b/src/shared/components/oncoprint/controls/OncoprintControls.tsx @@ -58,7 +58,7 @@ export interface IOncoprintControlsHandlers onSelectShowMinimap: (showMinimap: boolean) => void; onSelectDistinguishMutationType: (distinguish: boolean) => void; onSelectDistinguishGermlineMutations: (distinguish: boolean) => void; - onSelectEnableWhiteBackgroundForGlyphs?: (use: boolean) => void; + onSelectIsWhiteBackgroundForGlyphsEnabled?: (use: boolean) => void; onSelectHideVUS: (hide: boolean) => void; onSelectHideGermlineMutations: (hide: boolean) => void; @@ -91,7 +91,7 @@ export interface IOncoprintControlsState showClinicalTrackLegends?: boolean; onlyShowClinicalLegendForAlteredCases?: boolean; showOqlInLabels?: boolean; - enableWhiteBackgroundForGlyphs?: boolean; + isWhiteBackgroundForGlyphsEnabled?: boolean; showMinimap: boolean; isClinicalTrackConfigDirty: boolean; isLoggedIn: boolean; @@ -153,7 +153,7 @@ const EVENT_KEY = { showClinicalTrackLegends: '4', onlyShowClinicalLegendForAlteredCases: '4.1', showOqlInLabels: '4.2', - enableWhiteBackgroundForGlyphs: '4.3', + isWhiteBackgroundForGlyphsEnabled: '4.3', distinguishMutationType: '5', distinguishGermlineMutations: '5.1', sortByMutationType: '6', @@ -279,10 +279,10 @@ export default class OncoprintControls extends React.Component< !this.props.state.showOqlInLabels ); break; - case EVENT_KEY.enableWhiteBackgroundForGlyphs: - this.props.handlers.onSelectEnableWhiteBackgroundForGlyphs && - this.props.handlers.onSelectEnableWhiteBackgroundForGlyphs( - !this.props.state.enableWhiteBackgroundForGlyphs + case EVENT_KEY.isWhiteBackgroundForGlyphsEnabled: + this.props.handlers.onSelectIsWhiteBackgroundForGlyphsEnabled && + this.props.handlers.onSelectIsWhiteBackgroundForGlyphsEnabled( + !this.props.state.isWhiteBackgroundForGlyphsEnabled ); break; case EVENT_KEY.columnTypeSample: @@ -1059,9 +1059,10 @@ export default class OncoprintControls extends React.Component< + ); } } diff --git a/src/shared/components/oncoprint/DeltaUtils.ts b/src/shared/components/oncoprint/DeltaUtils.ts index 9a1e3439a3e..f8bbffb20f8 100644 --- a/src/shared/components/oncoprint/DeltaUtils.ts +++ b/src/shared/components/oncoprint/DeltaUtils.ts @@ -1307,7 +1307,7 @@ function transitionClinicalTrack( ? // add edit color option that opens color config modal to custom options [ { - label: 'Edit Color', + label: 'Edit Colors', onClick: () => nextProps.setTrackKeySelectedForEdit!( nextSpec.key diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index 287fb9c1f2c..ecb4b8e0305 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -1972,56 +1972,69 @@ export default class ResultsViewOncoprint extends React.Component< -
+ {this.selectedClinicalTrackValues.map(value => ( - - ))} - + + + + ))} +
{value} + +
+ -
+ ) === + rgbaToHex( + this.getDefaultSelectedClinicalTrackColor( + v + ) as RGBAColor + ) + )} + onClick={() => { + this.selectedClinicalTrackValues.forEach( + v => { + this.handleSelectedClinicalTrackColorChange( + v, + undefined + ); + } + ); + this.setClinicalTrackColorChanged(true); + }} + > + Reset Colors + )} From 5459293f509ac3b2dc929f9875ec3efd98ed02d9 Mon Sep 17 00:00:00 2001 From: Bryan Lai Date: Wed, 8 Nov 2023 16:39:58 -0500 Subject: [PATCH 12/15] add e2e tests and screenshots --- ...efault_colors_element_chrome_1600x1000.png | Bin 0 -> 134246 bytes ...lected_colors_element_chrome_1600x1000.png | Bin 0 -> 134794 bytes ...n_not_toggled_element_chrome_1600x1000.png | Bin 0 -> 101238 bytes ...ption_toggled_element_chrome_1600x1000.png | Bin 0 -> 94042 bytes .../core/resultsOncoprintColorConfig.spec.js | 184 ++++++++++++++++++ .../oncoprint/ResultsViewOncoprint.tsx | 1 + .../oncoprint/controls/OncoprintControls.tsx | 1 + 7 files changed, 186 insertions(+) create mode 100644 end-to-end-test/remote/screenshots/reference/oncoprint_reflects_default_colors_element_chrome_1600x1000.png create mode 100644 end-to-end-test/remote/screenshots/reference/oncoprint_reflects_user_selected_colors_element_chrome_1600x1000.png create mode 100644 end-to-end-test/remote/screenshots/reference/oncoprint_uses_default_background_for_glyphs_when_option_not_toggled_element_chrome_1600x1000.png create mode 100644 end-to-end-test/remote/screenshots/reference/oncoprint_uses_white_background_for_glyphs_when_option_toggled_element_chrome_1600x1000.png create mode 100644 end-to-end-test/remote/specs/core/resultsOncoprintColorConfig.spec.js diff --git a/end-to-end-test/remote/screenshots/reference/oncoprint_reflects_default_colors_element_chrome_1600x1000.png b/end-to-end-test/remote/screenshots/reference/oncoprint_reflects_default_colors_element_chrome_1600x1000.png new file mode 100644 index 0000000000000000000000000000000000000000..d078d8cc02950c473f62bb3c12f856d19d03d283 GIT binary 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z`b08b?xm;a+6@ABOk#wiU_(l>8avn0`1oQPk4{f_K@_;6bW^-^NW zWIEM2R@YOCqV(Mgaf9|zrrW)T4{aM)w&t;C%5bw4N<$fQG_JICf`db6I>Mps3H!73fyCqF{ijqOy$SWymPrLMb~yGuy=aHsd{Vd zyK;1V8O-K6i$U_!Va?@%o1;9`sCiGnH+FyKs1P!g-4}bwDTSNv0`p&R@|sljoQhY& zRj}@$+8)`TJ6(;B&vgppqx10T$){?5f<0(?R=JH@cJ#e2rVTgInq0^@A22p7kXZCcU*nn@N9S>$_#_EYs)F*e6 zi-Wmyf!kdPr{q328x*{LQse)xD}n#CAUU5?;>a&8+a21z@q#{S@6QHw5AEvk&Hn?e ChtnMZ literal 0 HcmV?d00001 diff --git a/end-to-end-test/remote/specs/core/resultsOncoprintColorConfig.spec.js b/end-to-end-test/remote/specs/core/resultsOncoprintColorConfig.spec.js new file mode 100644 index 00000000000..1382782526d --- /dev/null +++ b/end-to-end-test/remote/specs/core/resultsOncoprintColorConfig.spec.js @@ -0,0 +1,184 @@ +var assertScreenShotMatch = require('../../../shared/lib/testUtils') + .assertScreenShotMatch; +var assert = require('assert'); +var waitForOncoprint = require('../../../shared/specUtils').waitForOncoprint; +var goToUrlAndSetLocalStorage = require('../../../shared/specUtils') + .goToUrlAndSetLocalStorage; +var getNthOncoprintTrackOptionsElements = require('../../../shared/specUtils') + .getNthOncoprintTrackOptionsElements; +var { + checkOncoprintElement, + getElementByTestHandle, +} = require('../../../shared/specUtils.js'); + +const ONCOPRINT_TIMEOUT = 60000; +const CBIOPORTAL_URL = process.env.CBIOPORTAL_URL.replace(/\/$/, ''); + +describe('oncoprint colors', () => { + describe('clinical tracks color configuration', () => { + before(function() { + goToUrlAndSetLocalStorage( + `${CBIOPORTAL_URL}/results/oncoprint?Action=Submit&RPPA_SCORE_THRESHOLD=2.0&Z_SCORE_THRESHOLD=2.0&cancer_study_list=gbm_tcga&case_set_id=gbm_tcga_all&data_priority=0&gene_list=EGFR%250APTEN%250AIDH1%250ATP53&geneset_list=%20&genetic_profile_ids_PROFILE_COPY_NUMBER_ALTERATION=gbm_tcga_gistic&genetic_profile_ids_PROFILE_MRNA_EXPRESSION=gbm_tcga_mrna_median_all_sample_Zscores&genetic_profile_ids_PROFILE_MUTATION_EXTENDED=gbm_tcga_mutations&hide_unprofiled_samples=false&profileFilter=0&tab_index=tab_visualize&show_samples=false` + ); + waitForOncoprint(ONCOPRINT_TIMEOUT); + }); + + it('color configuration modal reflects user selected colors', () => { + // add "Mutation spectrum" track + const $tracksDropdown = $('#addTracksDropdown'); + $tracksDropdown.click(); + getElementByTestHandle('add-chart-option-mutation-spectrum') + .$('label') + .click(); + waitForOncoprint(ONCOPRINT_TIMEOUT); + $tracksDropdown.click(); + + var trackOptionsElts = getNthOncoprintTrackOptionsElements(5); + // open menu + $(trackOptionsElts.button_selector).click(); + $(trackOptionsElts.dropdown_selector).waitForDisplayed({ + timeout: 1000, + }); + // click "Edit Colors" + $(trackOptionsElts.dropdown_selector + ' li:nth-child(8)').click(); + $('[data-test="color-picker-icon"]').waitForDisplayed(); + + // select new colors for track values + $('[data-test="color-picker-icon"]').click(); + $('.circle-picker [title="#990099"]').click(); + waitForOncoprint(ONCOPRINT_TIMEOUT); + $('[data-test="color-picker-icon"]').click(); + $('.circle-picker').waitForDisplayed({ reverse: true }); + + $$('[data-test="color-picker-icon"]')[1].click(); + $('.circle-picker [title="#109618"]').click(); + waitForOncoprint(ONCOPRINT_TIMEOUT); + $$('[data-test="color-picker-icon"]')[1].click(); + $('.circle-picker').waitForDisplayed({ reverse: true }); + + $$('[data-test="color-picker-icon"]')[2].click(); + $('.circle-picker [title="#8b0707"]').click(); + waitForOncoprint(ONCOPRINT_TIMEOUT); + $$('[data-test="color-picker-icon"]')[2].click(); + $('.circle-picker').waitForDisplayed({ reverse: true }); + + assert.strictEqual( + $('[data-test="color-picker-icon"] rect').getAttribute('fill'), + '#990099' + ); + assert.strictEqual( + $$('[data-test="color-picker-icon"] rect')[1].getAttribute( + 'fill' + ), + '#109618' + ); + assert.strictEqual( + $$('[data-test="color-picker-icon"] rect')[2].getAttribute( + 'fill' + ), + '#8b0707' + ); + }); + + it('oncoprint reflects user selected colors', () => { + // close modal + $('.modal-header [class="close"]').click(); + var res = checkOncoprintElement(); + assertScreenShotMatch(res); + }); + + it('reset colors button is enabled when default colors not used', () => { + // check "Reset Colors" button in modal + var trackOptionsElts = getNthOncoprintTrackOptionsElements(5); + $(trackOptionsElts.button_selector).click(); + $(trackOptionsElts.dropdown_selector).waitForDisplayed({ + timeout: 1000, + }); + $(trackOptionsElts.dropdown_selector + ' li:nth-child(8)').click(); + getElementByTestHandle('resetColors').waitForExist(); + + assert.strictEqual( + getElementByTestHandle('resetColors').isEnabled(), + true + ); + }); + + it('color configuration modal reflects default colors', () => { + // click "Reset Colors" track + getElementByTestHandle('resetColors').click(); + waitForOncoprint(ONCOPRINT_TIMEOUT); + + assert.strictEqual( + $('[data-test="color-picker-icon"] rect').getAttribute('fill'), + '#3d6eb1' + ); + assert.strictEqual( + $$('[data-test="color-picker-icon"] rect')[1].getAttribute( + 'fill' + ), + '#8ebfdc' + ); + assert.strictEqual( + $$('[data-test="color-picker-icon"] rect')[2].getAttribute( + 'fill' + ), + '#dff1f8' + ); + }); + + it('oncoprint reflects default colors', () => { + // close modal + $('.modal-header [class="close"]').click(); + var res = checkOncoprintElement(); + assertScreenShotMatch(res); + }); + + it('reset colors button is disabled when default colors are used', () => { + // check "Reset Colors" button in modal + var trackOptionsElts = getNthOncoprintTrackOptionsElements(5); + $(trackOptionsElts.button_selector).click(); + $(trackOptionsElts.dropdown_selector).waitForDisplayed({ + timeout: 1000, + }); + $(trackOptionsElts.dropdown_selector + ' li:nth-child(8)').click(); + getElementByTestHandle('resetColors').waitForExist(); + + assert.strictEqual( + getElementByTestHandle('resetColors').isEnabled(), + false + ); + }); + }); + + describe('enable white background for glyphs', () => { + before(function() { + goToUrlAndSetLocalStorage( + `${CBIOPORTAL_URL}/results/oncoprint?Action=Submit&RPPA_SCORE_THRESHOLD=2.0&Z_SCORE_THRESHOLD=2.0&cancer_study_list=gbm_tcga&case_set_id=gbm_tcga_all&data_priority=0&gene_list=EGFR%250APTEN%250AIDH1%250ATP53&geneset_list=%20&genetic_profile_ids_PROFILE_COPY_NUMBER_ALTERATION=gbm_tcga_gistic&genetic_profile_ids_PROFILE_MRNA_EXPRESSION=gbm_tcga_mrna_median_all_sample_Zscores&genetic_profile_ids_PROFILE_MUTATION_EXTENDED=gbm_tcga_mutations&hide_unprofiled_samples=false&profileFilter=0&tab_index=tab_visualize&show_samples=false` + ); + waitForOncoprint(ONCOPRINT_TIMEOUT); + }); + it('oncoprint uses white background for glyphs when option toggled', () => { + // toggle on white backgrounds for glyphs + const $viewDropdown = $('#viewDropdownButton'); + $viewDropdown.click(); + waitForOncoprint(2000); + getElementByTestHandle('toggleWhiteBackgroundForGlyphs').click(); + $viewDropdown.click(); + + var res = checkOncoprintElement(); + assertScreenShotMatch(res); + }); + + it('oncoprint uses default background for glyphs when option not toggled', () => { + // toggle off white backgrounds for glyphs + const $viewDropdown = $('#viewDropdownButton'); + $viewDropdown.click(); + waitForOncoprint(2000); + getElementByTestHandle('toggleWhiteBackgroundForGlyphs').click(); + $viewDropdown.click(); + + var res = checkOncoprintElement(); + assertScreenShotMatch(res); + }); + }); +}); diff --git a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx index ecb4b8e0305..44384a5f962 100644 --- a/src/shared/components/oncoprint/ResultsViewOncoprint.tsx +++ b/src/shared/components/oncoprint/ResultsViewOncoprint.tsx @@ -2005,6 +2005,7 @@ export default class ResultsViewOncoprint extends React.Component<