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Is it possible to separate Hi-C signal into weights and observed contacts #15

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koustav-pal opened this issue May 2, 2020 · 0 comments

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koustav-pal commented May 2, 2020

Pros:

If we do this, then we can retrieve any single normalization factor on the fly

Cons:

This means we will have yet another variable that must be defined.
We can circumvent this problem by offering a way to modify the json, so that a single normalization factor is retrieved by default, and if a user wants to retrieve another normalization factor, they are free to do so using a variable.

The above procedure seems clunky, and introduces another layer of complexity, so I do not think users will really go for this.

And anyways, how many Hi-C studies are there that do comparisons across normalizations?

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