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update vignettes
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linquynus committed Sep 17, 2019
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4 changes: 2 additions & 2 deletions vignettes/TFregulomeR.Rmd
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Expand Up @@ -43,12 +43,12 @@ source, TF source ID, number of peaks and number of peaks with motif.
In TFregulomeR project, we
used MEME-ChIP to perform motif de novo discovery in each ChIP-seq. Highly and centrally enriched
motifs were selected and compared with the existing TFBS databases, such as HOCOMOCO and JASPAR.
89 highly enriched motifs were not consistent with the TFBS databases. it might
91 highly enriched motifs were not consistent with the TFBS databases. it might
be due to the fact that in those cell types, the given TFs are indirectly recruited to genome,
and/or that highly abundant presence of cohesion and polycomb group proteins masks the motif
enrichment of the ChIP’ed TF.
Besides, 136 motifs were not recorded for their corresponding TFs in the databases.
In order to confirm the reliability of these 225 motifs, we used HOMER to perform a de novo motif
In order to confirm the reliability of these 227 motifs, we used HOMER to perform a de novo motif
discovery again. Motif results by HOMER were compared with those by MEME-ChIP and their similarity
were measured by normalised Pearson correlation coefficient using compare-matrices function in
RSAT with the formula: Ncor = cor * w / w_smaller,
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