Find the paper here: https://academic.oup.com/bioinformatics/article/40/6/btae337/7689679.
Channel interference in mass cytometry can cause spillover and may result in miscounting of protein markers. We develop a nonparametric finite mixture model, and use the mixture components to estimate the probability of spillover. We implement our method using expectation-maximization to fit the mixture model.
Our R package is available on Bioconductor:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
# The following initializes usage of Bioc devel
BiocManager::install(version='devel')
BiocManager::install("spillR")