diff --git a/src/Microsoft.ComponentDetection.Detectors/pip/IPyPiClient.cs b/src/Microsoft.ComponentDetection.Detectors/pip/IPyPiClient.cs
index 49a5cc2db..d1c9abb1f 100644
--- a/src/Microsoft.ComponentDetection.Detectors/pip/IPyPiClient.cs
+++ b/src/Microsoft.ComponentDetection.Detectors/pip/IPyPiClient.cs
@@ -54,6 +54,9 @@ public sealed class PyPiClient : IPyPiClient, IDisposable
     private readonly IEnvironmentVariableService environmentVariableService;
     private readonly ILogger<PyPiClient> logger;
 
+    // Semaphore to limit the number of concurrent calls to pypi.org
+    private readonly SemaphoreSlim semaphore;
+
     private bool checkedMaxEntriesVariable;
 
     // retries used so far for calls to pypi.org
@@ -80,6 +83,7 @@ public PyPiClient(IEnvironmentVariableService environmentVariableService, ILogge
             FinalCacheSize = 0,
         };
         this.logger = logger;
+        this.semaphore = new SemaphoreSlim(10, 10);
     }
 
     public static HttpClient HttpClient { get; internal set; } = new HttpClient(HttpClientHandler);
@@ -246,11 +250,13 @@ private async Task<HttpResponseMessage> GetAndCachePyPiResponseAsync(Uri uri)
             return result;
         }
 
+        await this.semaphore.WaitAsync();
         this.logger.LogInformation("Getting Python data from {Uri}", uri);
         using var request = new HttpRequestMessage(HttpMethod.Get, uri);
         request.Headers.UserAgent.Add(ProductValue);
         request.Headers.UserAgent.Add(CommentValue);
         var response = await HttpClient.SendAsync(request);
+        this.semaphore.Release();
 
         // The `first - wins` response accepted into the cache. This might be different from the input if another caller wins the race.
         return await this.cachedResponses.GetOrCreateAsync(uri, cacheEntry =>
@@ -282,5 +288,6 @@ public void Dispose()
         this.cacheTelemetry.FinalCacheSize = this.cachedResponses.Count;
         this.cacheTelemetry.Dispose();
         this.cachedResponses.Dispose();
+        this.semaphore.Dispose();
     }
 }
diff --git a/src/Microsoft.ComponentDetection.Detectors/pip/SimplePypiClient.cs b/src/Microsoft.ComponentDetection.Detectors/pip/SimplePypiClient.cs
index 72b9bb0e7..8696761a7 100644
--- a/src/Microsoft.ComponentDetection.Detectors/pip/SimplePypiClient.cs
+++ b/src/Microsoft.ComponentDetection.Detectors/pip/SimplePypiClient.cs
@@ -41,6 +41,9 @@ public sealed class SimplePyPiClient : ISimplePyPiClient, IDisposable
     // Keep telemetry on how the cache is being used for future refinements
     private readonly SimplePypiCacheTelemetryRecord cacheTelemetry = new SimplePypiCacheTelemetryRecord();
 
+    // Semaphore to limit the number of concurrent calls to pypi.org
+    private readonly SemaphoreSlim semaphore;
+
     /// <summary>
     /// A thread safe cache implementation which contains a mapping of URI -> SimpleProject for simplepypi api projects
     /// and has a limited number of entries which will expire after the cache fills or a specified interval.
@@ -62,6 +65,7 @@ public SimplePyPiClient(IEnvironmentVariableService environmentVariableService,
     {
         this.environmentVariableService = environmentVariableService;
         this.logger = logger;
+        this.semaphore = new SemaphoreSlim(10, 10);
     }
 
     public static HttpClient HttpClient { get; internal set; } = new HttpClient(HttpClientHandler);
@@ -265,12 +269,14 @@ private async Task<HttpResponseMessage> RetryPypiRequestAsync(Uri uri, PipDepend
     /// <returns> Returns the httpresponsemessage. </returns>
     private async Task<HttpResponseMessage> GetPypiResponseAsync(Uri uri)
     {
+        await this.semaphore.WaitAsync();
         this.logger.LogInformation("Getting Python data from {Uri}", uri);
         using var request = new HttpRequestMessage(HttpMethod.Get, uri);
         request.Headers.UserAgent.Add(ProductValue);
         request.Headers.UserAgent.Add(CommentValue);
         request.Headers.Accept.Add(new MediaTypeWithQualityHeaderValue("application/vnd.pypi.simple.v1+json"));
         var response = await HttpClient.SendAsync(request);
+        this.semaphore.Release();
         return response;
     }
 
@@ -282,5 +288,6 @@ public void Dispose()
         this.cachedProjectWheelFiles.Dispose();
         this.cachedSimplePyPiProjects.Dispose();
         HttpClient.Dispose();
+        this.semaphore.Dispose();
     }
 }