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Robust error model and more features

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@mikessh mikessh released this 07 Oct 05:30
· 39 commits to master since this release

New features

  • Minor based error model now adjusts for false discovery rate (sequencing errors that are considered PCR errors, multiple testing correction) and limited recall due to stochastic sampling of PCR minors. Poisson distribution is used to model both sequencing error rate and PCR minor sampling.
  • CQS rescue aka Torrent454 assembler implemented
  • Can run for raw data, skipping consensus assembly step
  • Multiple error models supported in variant caller
  • Splitting long references to speed up and decrease memory footprint
  • Spaced k-mers making initial reference mapping more robust
  • Calling indels (no call quality is provided though)