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PAGE-2018

nlmixr short course @ PAGE 2018

The nlmixr team just completed its first full-day hands-on workshop at PAGE 2018 on simulation (RxODE) and parameter estimation using the free and open-source R-based nonlinear mixed effects modelling platform nlmixr. The course consisted of a mixture of lectures and hands-on exercises. Please find the agenda and a link to the course material below. Thank you to all participants from around the world who joined us for this exciting event!

Agenda

Time Presenter Topics
9:00 Matt Fidler Vision of nlmixr
RxODE and nlmixr introduction
RxODE lecture
- RxODE syntax
- RxODE solving and simulations
- Exploring data with RxODE and Shiny
9:30 Coffee Break
10:00 Matt Fidler nlmixr algorithms & functionality
Comparison to NONMEM
Basic population PKPD modeling with nlmixr
- Model syntax
- Running nlmixr models
- Simulating from nlmixr models
11:00 Richard Hooijmaijers Population model building made easy using an interactive shiny app
- nlmixr workflow
- shinyMixR
- xpose for nlmixr
12:00 Lunch Break
13:00 Mirjam Trame, Yuan Xiong, Justin Wilkins Introduction into Hands-On Case Studies
13:30 Hands-On: mAB model
14:00 Hands-On: PBPK model
14:30 Hands-On: Neutropenia model
15:00 Hands-On: PopPK model including covariates
15:30 Discussion of case studies and Q&A
16:30 Wenping Wang Outlook of additional nlmixr capabilities
17:00 END

Course Material

  1. Download and install nlmixr from here and use one of the different nlmixr installers depending on your operating system.

  2. Download the course material from the following links:


Best regards,

The nlmixr team

(Matthew Fidler, Teun M. Post, Richard Hooijmaijers, Rik Schoemaker, Mirjam N. Trame, Justin Wilkins, Yuan Xiong and Wenping Wang)

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PAGE 2018 nlmixr Workshop Materials

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