diff --git a/nxt_editor/__init__.py b/nxt_editor/__init__.py
index cf2523c..0a516d8 100644
--- a/nxt_editor/__init__.py
+++ b/nxt_editor/__init__.py
@@ -36,9 +36,9 @@ class StringSignaler(QtCore.QObject):
 
 
 def make_resources(qrc_path=None, result_path=None):
-    import PySide2
-    pyside_dir = os.path.dirname(PySide2.__file__)
-    full_pyside2rcc_path = os.path.join(pyside_dir, 'pyside2-rcc')
+    import PySide6
+    import subprocess
+    pyside_dir = os.path.dirname(PySide6.__file__)
     full_rcc_path = os.path.join(pyside_dir, 'rcc')
     this_dir = os.path.dirname(os.path.realpath(__file__))
     if not qrc_path:
@@ -47,24 +47,15 @@ def make_resources(qrc_path=None, result_path=None):
         result_path = os.path.join(this_dir, 'qresources.py')
     msg = 'First launch nxt resource generation from {} to {}'
     logger.info(msg.format(qrc_path, result_path))
-    import subprocess
-    ver = ['-py2']
-    if sys.version_info[0] == 3:
-        ver += ['-py3']
-    args = [qrc_path] + ver + ['-o', result_path]
-    try:
-        subprocess.check_call(['pyside2-rcc'] + args)
-    except:
-        pass
-    else:
-        return
 
+    args = [qrc_path, '-o', result_path]
     try:
-        subprocess.check_call([full_pyside2rcc_path] + args)
+        subprocess.check_call(['rcc'] + args)
     except:
         pass
     else:
         return
+
     try:
         subprocess.check_call([full_rcc_path, '-g', 'python', qrc_path,
                                '-o', result_path], cwd=pyside_dir)
@@ -77,7 +68,7 @@ def make_resources(qrc_path=None, result_path=None):
                                '-o', result_path], cwd=pyside_dir)
     except:
         raise Exception("Failed to generate UI resources using pyside2 rcc!"
-                        " Reinstalling pyside2 may fix the problem. If you "
+                        " Reinstalling PySide6 may fix the problem. If you "
                         "know how to use rcc please build from: \"{}\" and "
                         "output to \"{}\"".format(qrc_path, result_path))
     else:
@@ -129,9 +120,12 @@ def launch_editor(paths=None, start_rpc=True):
 
 def show_new_editor(paths=None, start_rpc=True):
     path = None
-    if paths is not None:
+    if paths and isinstance(paths, list):
         path = paths[0]
         paths.pop(0)
+    elif isinstance(paths, str):
+        path = paths
+        paths = []
     else:
         paths = []
     # Deferred import since main window relies on us
diff --git a/nxt_editor/dialogs.py b/nxt_editor/dialogs.py
index c6653bc..998edaa 100644
--- a/nxt_editor/dialogs.py
+++ b/nxt_editor/dialogs.py
@@ -297,7 +297,7 @@ def build_widgets(self):
         self.save_details_button.released.connect(self.on_save_details)
 
         self.detail_buttons_layout = QtWidgets.QHBoxLayout()
-        self.detail_buttons_layout.addStretch(streth=1)
+        self.detail_buttons_layout.addStretch(1)
         self.detail_buttons_layout.addWidget(self.save_details_button)
         self.detail_buttons_layout.addWidget(self.copy_details_button)
 
@@ -314,7 +314,7 @@ def build_widgets(self):
         self.top_right_layout = QtWidgets.QVBoxLayout()
         self.top_right_layout.addWidget(self.text_label)
         self.top_right_layout.addWidget(self.info_label)
-        self.top_right_layout.addStretch(streth=1)
+        self.top_right_layout.addStretch(1)
         self.top_right_layout.addLayout(self.buttons_layout)
         self.top_layout = QtWidgets.QHBoxLayout()
         self.top_layout.addWidget(self.icon)
diff --git a/nxt_editor/dockwidgets/build_view.py b/nxt_editor/dockwidgets/build_view.py
index 3d21643..768e214 100644
--- a/nxt_editor/dockwidgets/build_view.py
+++ b/nxt_editor/dockwidgets/build_view.py
@@ -315,7 +315,7 @@ class BuildTable(QtWidgets.QTableView):
     """
     def __init__(self):
         super(BuildTable, self).__init__()
-        self.setSelectionMode(self.NoSelection)
+        self.setSelectionMode(QtWidgets.QAbstractItemView.NoSelection)
         self.horizontalHeader().hide()
         self.verticalHeader().hide()
         self.break_delegate = LetterCheckboxDelegeate('B')
@@ -342,7 +342,7 @@ def setModel(self, model):
         header = self.horizontalHeader()
         header.setStretchLastSection(False)
         header.setDefaultSectionSize(28)
-        header.setSectionResizeMode(header.Fixed)
+        header.setSectionResizeMode(QtWidgets.QHeaderView.Fixed)
         if header.count():
             column = BuildModel.PATH_COLUMN
             header.setSectionResizeMode(column, QtWidgets.QHeaderView.Stretch)
diff --git a/nxt_editor/dockwidgets/code_editor.py b/nxt_editor/dockwidgets/code_editor.py
index 0005dda..307a18c 100644
--- a/nxt_editor/dockwidgets/code_editor.py
+++ b/nxt_editor/dockwidgets/code_editor.py
@@ -1271,7 +1271,7 @@ def paintEvent(self, event):
 
     def get_width(self):
         count = self.editor.blockCount()
-        width = self.fontMetrics().width(str(count)) + 10
+        width = self.fontMetrics().horizontalAdvance(str(count)) + 10
         return width
 
     def update_width(self):
diff --git a/nxt_editor/dockwidgets/find_rep.py b/nxt_editor/dockwidgets/find_rep.py
index bd94f67..23aaa9c 100644
--- a/nxt_editor/dockwidgets/find_rep.py
+++ b/nxt_editor/dockwidgets/find_rep.py
@@ -196,7 +196,7 @@ def setModel(self, model):
         super(SearchResultsTree, self).setModel(model)
         header = self.header()
         header.setStretchLastSection(False)
-        header.setSectionResizeMode(header.ResizeToContents)
+        header.setSectionResizeMode(QtWidgets.QHeaderView.ResizeToContents)
         if self.model():
             self.model().modelReset.connect(self.expandAll)
 
diff --git a/nxt_editor/dockwidgets/layer_manager.py b/nxt_editor/dockwidgets/layer_manager.py
index c65c9a1..0800400 100644
--- a/nxt_editor/dockwidgets/layer_manager.py
+++ b/nxt_editor/dockwidgets/layer_manager.py
@@ -100,7 +100,7 @@ def setModel(self, model):
         header = self.header()
         header.setStretchLastSection(False)
         header.setDefaultSectionSize(LayerTreeView.SIZE)
-        header.setSectionResizeMode(header.Fixed)
+        header.setSectionResizeMode(QtWidgets.QHeaderView.Fixed)
         if header.count():
             header.setSectionResizeMode(0, QtWidgets.QHeaderView.Stretch)
             self.hideColumn(LayerModel.TARGET_COLUMN)
diff --git a/nxt_editor/dockwidgets/output_log.py b/nxt_editor/dockwidgets/output_log.py
index b5ec502..0ec8508 100644
--- a/nxt_editor/dockwidgets/output_log.py
+++ b/nxt_editor/dockwidgets/output_log.py
@@ -205,7 +205,7 @@ def __init__(self, graph_model=None, parent=None):
 
         self.buttons_layout = QtWidgets.QHBoxLayout()
         self.buttons_layout.addWidget(self.log_filter_button)
-        self.buttons_layout.addStretch(stretch=1)
+        self.buttons_layout.addStretch(1)
         self.buttons_layout.addWidget(self.clear_rich_button)
 
         self.rich_output_layout = QtWidgets.QVBoxLayout()
diff --git a/nxt_editor/dockwidgets/property_editor.py b/nxt_editor/dockwidgets/property_editor.py
index 2f80f38..2c114e0 100644
--- a/nxt_editor/dockwidgets/property_editor.py
+++ b/nxt_editor/dockwidgets/property_editor.py
@@ -12,7 +12,7 @@
     QtCore.QStringListModel
 except AttributeError:
     del QtCore
-    from PySide2 import QtCore
+    from PySide6 import QtCore
 
 # Internal
 from nxt_editor import user_dir
diff --git a/nxt_editor/dockwidgets/syntax.py b/nxt_editor/dockwidgets/syntax.py
index 246c23f..aae7750 100644
--- a/nxt_editor/dockwidgets/syntax.py
+++ b/nxt_editor/dockwidgets/syntax.py
@@ -117,7 +117,7 @@ def highlightBlock(self, text):
         # Do other syntax formatting
         for rule in self.rules:
             expression, nth, formatting = rule
-            index = expression.indexIn(text, 0)
+            index = expression.match(text).capturedStart()
             # This is here because you can't do nested logic in regex
             nested = 0
             if rule in self.special_rules:
@@ -151,17 +151,19 @@ def match_multiline(self, text, delimiter, in_state, style):
             add = 0
         # Otherwise, look for the delimiter on this line
         else:
-            start = delimiter.indexIn(text)
+            match = delimiter.match(text)
+            start = match.capturedStart()
             # Move past this match
-            add = delimiter.matchedLength()
+            add = match.capturedLength()
 
         # As long as there's a delimiter match on this line...
         while start >= 0:
+            match = delimiter.match(text)
             # Look for the ending delimiter
-            end = delimiter.indexIn(text, start + add)
+            end = match.capturedStart() + (start + add)
             # Ending delimiter on this line?
             if end >= add:
-                length = end - start + add + delimiter.matchedLength()
+                length = end - start + add + match.capturedLength()
                 self.setCurrentBlockState(0)
             # No; multi-line string
             else:
@@ -170,7 +172,7 @@ def match_multiline(self, text, delimiter, in_state, style):
             # Apply formatting
             self.setFormat(start, length, style)
             # Look for the next match
-            start = delimiter.indexIn(text, start + length)
+            start = match.capturedStart() + (start + length)
 
         # Return True if still inside a multi-line string, False otherwise
         if self.currentBlockState() == in_state:
diff --git a/nxt_editor/dockwidgets/widget_builder.py b/nxt_editor/dockwidgets/widget_builder.py
index b773b2c..1ecb1a2 100644
--- a/nxt_editor/dockwidgets/widget_builder.py
+++ b/nxt_editor/dockwidgets/widget_builder.py
@@ -15,7 +15,7 @@
     QtCore.QStringListModel
 except AttributeError:
     del QtCore
-    from PySide2 import QtCore
+    from PySide6 import QtCore
 
 # Internal
 import nxt_editor
diff --git a/nxt_editor/node_graphics_item.py b/nxt_editor/node_graphics_item.py
index b8de726..5abc1da 100644
--- a/nxt_editor/node_graphics_item.py
+++ b/nxt_editor/node_graphics_item.py
@@ -9,7 +9,7 @@
 from Qt import QtWidgets
 from Qt import QtGui
 from Qt import QtCore
-from PySide2 import __version_info__ as qt_version
+from PySide6 import __version_info__ as qt_version
 
 # Internal
 import nxt_editor
@@ -262,13 +262,13 @@ def screen_pos(self):
     def itemChange(self, change, value):
         """Override of QtWidgets.QGraphicsItem itemChange."""
         # keep connections drawing to node as it moves
-        if change is self.ItemScenePositionHasChanged:
+        if change is QtWidgets.QGraphicsItem.ItemPositionChange:
             graphics = self.view.get_node_connection_graphics(self.node_path)
             for connection in graphics:
                 connection.rebuild_line()
         # TODO: Take into account the positions of every selected node and snap them all to a grid as soon as
         #  the user preses shift. This will avoid the weird wavy snapping effect we have right now
-        if change == self.ItemPositionChange and self.scene():
+        if change == QtWidgets.QGraphicsItem.ItemPositionChange and self.scene():
             ml = QtWidgets.QApplication.mouseButtons() == QtCore.Qt.LeftButton
             shift = QtWidgets.QApplication.keyboardModifiers() == QtCore.Qt.ShiftModifier
             force_snap = self.view.alignment_actions.snap_action.isChecked()
diff --git a/nxt_editor/stage_view.py b/nxt_editor/stage_view.py
index 11151ec..dc243f1 100644
--- a/nxt_editor/stage_view.py
+++ b/nxt_editor/stage_view.py
@@ -8,6 +8,7 @@
 from Qt import QtWidgets
 from Qt import QtGui
 from Qt import QtCore
+from Qt import QtCompat
 
 # Interal
 import nxt_editor
@@ -79,8 +80,8 @@ def __init__(self, model, parent=None):
         self.setVerticalScrollBarPolicy(QtCore.Qt.ScrollBarAlwaysOff)
         self.horizontalScrollBar().setValue(0)
         self.verticalScrollBar().setValue(0)
-        self.setOptimizationFlag(self.DontSavePainterState, enabled=True)
-        self.setOptimizationFlag(self.DontAdjustForAntialiasing, enabled=True)
+        self.setOptimizationFlag(QtWidgets.QGraphicsView.DontSavePainterState, enabled=True)
+        self.setOptimizationFlag(QtWidgets.QGraphicsView.DontAdjustForAntialiasing, enabled=True)
         # scene
         self._scene = QtWidgets.QGraphicsScene()
         self.setScene(self._scene)
@@ -700,7 +701,7 @@ def mousePressEvent(self, event):
             self.zoom_start_pos = event.pos()
             self._previous_mouse_pos = event.pos()
             event.accept()
-        if event.buttons() == QtCore.Qt.LeftButton | QtCore.Qt.MidButton:
+        if event.buttons() == QtCore.Qt.LeftButton | QtCompat.QtCore.Qt.MidButton:
             self.zooming = True
             self.zoom_start_pos = event.pos()
             self._previous_mouse_pos = event.pos()
@@ -747,7 +748,7 @@ def mousePressEvent(self, event):
                 return  # block immediate node movement
 
         # middle and right button events
-        elif event.button() == QtCore.Qt.MiddleButton:
+        elif event.button() == QtCompat.QtCore.Qt.MidButton:
             # start panning action
             self.panning = True
             self._previous_mouse_pos = None
@@ -825,11 +826,11 @@ def mouseReleaseEvent(self, event):
             event.accept()
 
         if self.zooming:
-            if event.buttons() == QtCore.Qt.LeftButton | QtCore.Qt.MidButton:
+            if event.buttons() == QtCore.Qt.LeftButton | QtCompat.QtCore.Qt.MidButton:
                 self.zooming = False
             elif event.buttons() == QtCore.Qt.LeftButton:
                 self.zooming = False
-            elif event.buttons() == QtCore.Qt.MidButton:
+            elif event.buttons() == QtCompat.QtCore.Qt.MidButton:
                 self.zooming = False
         if (self._rubber_band_origin is not None and
            event.button() is QtCore.Qt.LeftButton):
@@ -967,7 +968,7 @@ def mouseReleaseEvent(self, event):
             self.block_context_menu = False
             self.contextMenuEvent(event)
         # complete panning action
-        if self.panning and event.button() == QtCore.Qt.MiddleButton:
+        if self.panning and event.button() == QtCompat.QtCore.Qt.MidButton:
             self._previous_mouse_pos = None
             self.panning = False
             self._current_pan_distance = 0.0
@@ -993,11 +994,11 @@ def mouseDoubleClickEvent(self, event):
                     item.collapse_node()
 
     def wheelEvent(self, event):
-        self._view_pos = event.pos()
+        self._view_pos = event.position().toPoint()
         self._scene_pos = self.mapToScene(self._view_pos)
 
         try:
-            new_scale = event.delta() * .001 + 1.0
+            new_scale = event.angleDelta().y() * .001 + 1.0
         except AttributeError:
             new_scale = 1.1
 
diff --git a/nxt_editor/user_dir.py b/nxt_editor/user_dir.py
index 6353f68..2b6c4c9 100644
--- a/nxt_editor/user_dir.py
+++ b/nxt_editor/user_dir.py
@@ -10,6 +10,7 @@
 
 import json
 import logging
+import shutil
 import sys
 
 if sys.version_info[0] == 2:
@@ -209,10 +210,10 @@ def read(self):
             return
         try:
             with open(self.path, 'r+b') as fp:
-                if sys.version_info[0] == 2:
-                    contents = pickle.load(fp)
-                else:
-                    contents = pickle.load(fp, encoding='bytes')
+                contents = pickle.load(fp, encoding='bytes')
+        except ModuleNotFoundError as e:
+            if 'PySide2' in e.msg:
+                shutil.move(self.path, self.path + '.backup')
         except pickle.UnpicklingError:
             broken_files.setdefault(self.path, 0)
             times_hit = broken_files[self.path]
diff --git a/setup.py b/setup.py
index 7b98ff4..6161dbe 100644
--- a/setup.py
+++ b/setup.py
@@ -31,7 +31,7 @@
     python_requires='>=3.7, <3.11',
     install_requires=['nxt-core<1.0,>=0.14',
                       'qt.py<3',
-                      'pyside2>=5.11,<=5.16'
+                      'PySide6>=6,<6.8'
                       ],
     package_data={
         # covers text nxt files