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3 changes: 1 addition & 2 deletions README.md
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# Ontology for Biomedical Investigations

[![Build Status](https://travis-ci.com/obi-ontology/obi.svg?branch=master)](https://travis-ci.com/obi-ontology/obi)
[![GitHub Actions](https://github.com/obi-ontology/obi/actions/workflows/obi-test.yml/badge.svg)](https://github.com/obi-ontology/obi/actions/workflows/obi-test.yml)
[![Powered by the ROBOT](https://img.shields.io/static/v1?label=Powered%20by&message=ROBOT&color=green&style=flat)](http://robot.obolibrary.org/)
<a href="http://dashboard.obofoundry.org/dashboard/obi/dashboard.html"><img src="https://img.shields.io/endpoint?url=https%3A%2F%2Fraw.githubusercontent.com%2FOBOFoundry%2Fobo-dash.github.io%2Fgh-pages%2Fdashboard%2Fobi%2Fdashboard-score-badge.json" /></a>
<a href="http://dashboard.obofoundry.org/dashboard/obi/dashboard.html"><img src="https://img.shields.io/endpoint?url=https%3A%2F%2Fraw.githubusercontent.com%2FOBOFoundry%2Fobo-dash.github.io%2Fgh-pages%2Fdashboard%2Fobi%2Fdashboard-qc-badge.json" /></a>
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- git [website](https://git-scm.com) with files and documentation
- GitHub [Help](https://help.github.com) and [Flow](https://guides.github.com/introduction/flow/)
- [git command-line overview](http://dont-be-afraid-to-commit.readthedocs.io/en/latest/git/commandlinegit.html)


## Initial Set Up
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16 changes: 16 additions & 0 deletions src/ontology/modules/study-designs.owl
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<!-- http://purl.obolibrary.org/obo/OBI_0003658 -->

<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0003658">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0500000"/>
<obo:IAO_0000111>ring trial design</obo:IAO_0000111>
<obo:IAO_0000112>https://eco-fab.org/about-ecofab-initiative/</obo:IAO_0000112>
<obo:IAO_0000115>A study design with the objective of establishing the reproducibility of an experimental approach by performing experiments in different laboratories under the same conditions and comparing the experimental outcomes.</obo:IAO_0000115>
<obo:IAO_0000117>Bjoern Peters</obo:IAO_0000117>
<obo:IAO_0000117>Sebastian Duesing</obo:IAO_0000117>
<obo:IAO_0000233>https://github.com/obi-ontology/obi/issues/1768</obo:IAO_0000233>
<obo:IAO_0000234>Chris Mungall</obo:IAO_0000234>
<rdfs:label>ring trial design</rdfs:label>
</owl:Class>



<!-- http://purl.obolibrary.org/obo/OBI_0100026 -->

<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0100026"/>
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19 changes: 19 additions & 0 deletions src/ontology/obi-edit.owl
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<!-- http://purl.obolibrary.org/obo/OBI_0003656 -->

<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0003656">
<rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OBI_0302885"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15377"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000111 xml:lang="en">water filtration</obo:IAO_0000111>
<obo:IAO_0000115 xml:lang="en">A filtration process of water intended to remove or reduce the concentration of particulate matter, such as suspended particles, parasites, bacteria, algae, viruses, and fungi, as well as other undesirable chemical and biological contaminants.</obo:IAO_0000115>
<obo:IAO_0000117>Anoosha Sehar https://orcid.org/0000-0001-5275-8866</obo:IAO_0000117>
<obo:IAO_0000234>GENEPIO</obo:IAO_0000234>
<rdfs:label xml:lang="en">water filtration</rdfs:label>
</owl:Class>



<!-- http://purl.obolibrary.org/obo/OBI_0003657 -->

<owl:Class rdf:about="http://purl.obolibrary.org/obo/OBI_0003657">
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1 change: 1 addition & 0 deletions src/ontology/templates/study-designs.tsv
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OBI:0002674 case series design case series study design ready for release A study design that samples only subjects who have experienced a particular event (outcome or exposure). Such a design, in contrast to a cohort study, does not permit calculation of absolute risk as non-case subjects are not included. https://www.ncbi.nlm.nih.gov/pubmed/22213493 PMID: 22213493 http://orcid.org/0000-0002-8844-9165 subclass study design
OBI:0002945 population based design population based design A study design where the selection of the individuals that are included into the study are intended to be representative of all individuals in the a priori defined specific population and is done at the population level or among the population groups, generally to find the cause, incidence or spread of the disease or to see the response to the treatment, nutrition or environment. https://link.springer.com/referenceworkentry/10.1007%2F978-1-4419-1005-9_45, EFO_0001430 population based design Chris Stoeckert https://github.com/obi-ontology/obi/issues/1090 subclass study design
OBI:0003291 in silico design A study design that is executed primarily on a computer. https://en.wikipedia.org/wiki/In_silico Hector Guzman-Orozco CMI-PB https://github.com/obi-ontology/obi/issues/1430 subclass study design
OBI:0003658 ring trial design ring trial design A study design with the objective of establishing the reproducibility of an experimental approach by performing experiments in different laboratories under the same conditions and comparing the experimental outcomes. https://eco-fab.org/about-ecofab-initiative/ Bjoern Peters|Sebastian Duesing Chris Mungall https://github.com/obi-ontology/obi/issues/1768 subclass study design
OBI:0300310 sequential design sequential design pending final vetting Any design in which the decision as to whether to enroll the next patient, pair of patients, or block of patients is determined by whether the cumulative treatment difference for all previous patients is within specified limits. Enrollment is continued if the difference does not exceed the limits. It is terminated if it does MUSC PMID: 17710740.Pharm Stat. 2007 Aug 20.Sequential design approaches for bioequivalence studies with crossover designs. Philippe Rocca-Serra Provenance: OCI subclass intervention design
OBI:0300311 observation design observation design pending final vetting observation design is a study design in which subjects are monitored in the absence of any active intervention by experimentalists. OBI branch derived PMID: 12387964.Lancet. 2002 Oct 12;360(9340):1144-9.Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Philippe Rocca-Serra subclass study design
OBI:0500001 clinical study design clinical study design pending final vetting Plan for the precise procedure to be followed in a clinical trial, including planned and actual timing of events, choice of control group, method of allocating treatments, blinding methods; assigns a subject to pass through one or more epochs in the course of a trial. Specific design elements, e.g., crossover, parallel; dose-escalation [Modified from Pocock, Clinical Trials: A Practical Approach] Clinical Research Glossary Version 4.0 CDICS glossary group PMID: 17655677.J Cardiovasc Electrophysiol. 2007 Aug;18(9):965-71.Biventricular versus right ventricular pacing in patients with AV block (BLOCK HF): clinical study design and rationale. PlanAndPlannedProcess Branch The definition needs to be extended to other things than simply patients subclass study design
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