Haga2023

Highlights

• Multi-omics analysis identified TGF-β1–SMAD4 as key regulators in human skin aging
• THBS1 promoted and FMOD suppressed factors in skin aging
• THBS1 controlled high- and low-TGF-β1 state of the binary switch
• SMAD4 is a potential target for inhibiting THBS1 expression and cell senescence

Installation

$ git clone https://github.com/okadalabipr/Haga2023.git

Contents

• bifurcation_analysis/: bifurcation analysis of TGF-β1, THBS1, and FMOD network
• bioinformatics/: sequencing data analysis
• figure/: graphical abstract
• modeling/: mathematical modeling of TGF-β and VEGF signaling pathway dynamics on skin aging

License

MIT