diff --git a/Cargo.lock b/Cargo.lock
index e2fac0d..e38e3f9 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -261,7 +261,7 @@ dependencies = [
  "futures",
  "hmac",
  "include_dir",
- "itertools",
+ "itertools 0.12.1",
  "jsonwebtoken",
  "kiddo",
  "lazy_static",
@@ -292,6 +292,18 @@ dependencies = [
  "wasm-bindgen",
 ]
 
+[[package]]
+name = "biomedgps-graph"
+version = "0.1.0"
+dependencies = [
+ "getrandom 0.2.13",
+ "rustworkx-core",
+ "serde",
+ "serde-wasm-bindgen",
+ "wasm-bindgen",
+ "wasm-bindgen-test",
+]
+
 [[package]]
 name = "bitflags"
 version = "1.3.2"
@@ -421,6 +433,16 @@ dependencies = [
  "unicode-width",
 ]
 
+[[package]]
+name = "console_error_panic_hook"
+version = "0.1.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a06aeb73f470f66dcdbf7223caeebb85984942f22f1adb2a088cf9668146bbbc"
+dependencies = [
+ "cfg-if",
+ "wasm-bindgen",
+]
+
 [[package]]
 name = "convert_case"
 version = "0.4.0"
@@ -897,6 +919,12 @@ dependencies = [
  "typenum",
 ]
 
+[[package]]
+name = "fixedbitset"
+version = "0.4.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "0ce7134b9999ecaf8bcd65542e436736ef32ddca1b3e06094cb6ec5755203b80"
+
 [[package]]
 name = "fnv"
 version = "1.0.7"
@@ -1539,6 +1567,7 @@ checksum = "168fb715dda47215e360912c096649d23d58bf392ac62f73919e831745e40f26"
 dependencies = [
  "equivalent",
  "hashbrown 0.14.3",
+ "rayon",
 ]
 
 [[package]]
@@ -1571,6 +1600,15 @@ version = "2.9.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "8f518f335dce6725a761382244631d86cf0ccb2863413590b31338feb467f9c3"
 
+[[package]]
+name = "itertools"
+version = "0.11.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b1c173a5686ce8bfa551b3563d0c2170bf24ca44da99c7ca4bfdab5418c3fe57"
+dependencies = [
+ "either",
+]
+
 [[package]]
 name = "itertools"
 version = "0.12.1"
@@ -1638,7 +1676,7 @@ dependencies = [
  "fixed",
  "generator",
  "init_with",
- "itertools",
+ "itertools 0.12.1",
  "log",
  "num-traits",
  "ordered-float 4.2.0",
@@ -2312,6 +2350,16 @@ version = "2.3.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "e3148f5046208a5d56bcfc03053e3ca6334e51da8dfb19b6cdc8b306fae3283e"
 
+[[package]]
+name = "petgraph"
+version = "0.6.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b4c5cc86750666a3ed20bdaf5ca2a0344f9c67674cae0515bec2da16fbaa47db"
+dependencies = [
+ "fixedbitset",
+ "indexmap 2.2.6",
+]
+
 [[package]]
 name = "phf"
 version = "0.8.0"
@@ -2873,6 +2921,16 @@ version = "0.1.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "925383efa346730478fb4838dbe9137d2a47675ad789c546d150a6e1dd4ab31c"
 
+[[package]]
+name = "priority-queue"
+version = "1.4.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a0bda9164fe05bc9225752d54aae413343c36f684380005398a6a8fde95fe785"
+dependencies = [
+ "autocfg",
+ "indexmap 1.9.3",
+]
+
 [[package]]
 name = "proc-macro-crate"
 version = "1.3.1"
@@ -2972,7 +3030,7 @@ dependencies = [
  "rand_chacha 0.2.2",
  "rand_core 0.5.1",
  "rand_hc",
- "rand_pcg",
+ "rand_pcg 0.2.1",
 ]
 
 [[package]]
@@ -3052,6 +3110,15 @@ dependencies = [
  "rand_core 0.5.1",
 ]
 
+[[package]]
+name = "rand_pcg"
+version = "0.3.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "59cad018caf63deb318e5a4586d99a24424a364f40f1e5778c29aca23f4fc73e"
+dependencies = [
+ "rand_core 0.6.4",
+]
+
 [[package]]
 name = "rayon"
 version = "1.10.0"
@@ -3062,6 +3129,17 @@ dependencies = [
  "rayon-core",
 ]
 
+[[package]]
+name = "rayon-cond"
+version = "0.3.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "059f538b55efd2309c9794130bc149c6a553db90e9d99c2030785c82f0bd7df9"
+dependencies = [
+ "either",
+ "itertools 0.11.0",
+ "rayon",
+]
+
 [[package]]
 name = "rayon-core"
 version = "1.12.1"
@@ -3362,6 +3440,25 @@ version = "1.0.14"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "7ffc183a10b4478d04cbbbfc96d0873219d962dd5accaff2ffbd4ceb7df837f4"
 
+[[package]]
+name = "rustworkx-core"
+version = "0.14.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "529027dfaa8125aa61bb7736ae9484f41e8544f448af96918c8da6b1def7f57b"
+dependencies = [
+ "ahash 0.8.11",
+ "fixedbitset",
+ "hashbrown 0.14.3",
+ "indexmap 2.2.6",
+ "num-traits",
+ "petgraph",
+ "priority-queue",
+ "rand 0.8.5",
+ "rand_pcg 0.3.1",
+ "rayon",
+ "rayon-cond",
+]
+
 [[package]]
 name = "ryu"
 version = "1.0.17"
@@ -3386,6 +3483,12 @@ dependencies = [
  "windows-sys 0.52.0",
 ]
 
+[[package]]
+name = "scoped-tls"
+version = "1.0.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e1cf6437eb19a8f4a6cc0f7dca544973b0b78843adbfeb3683d1a94a0024a294"
+
 [[package]]
 name = "scopeguard"
 version = "1.2.0"
@@ -3470,6 +3573,17 @@ dependencies = [
  "serde",
 ]
 
+[[package]]
+name = "serde-wasm-bindgen"
+version = "0.6.5"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8302e169f0eddcc139c70f139d19d6467353af16f9fce27e8c30158036a1e16b"
+dependencies = [
+ "js-sys",
+ "serde",
+ "wasm-bindgen",
+]
+
 [[package]]
 name = "serde_derive"
 version = "1.0.197"
@@ -3651,7 +3765,7 @@ version = "0.2.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "ce81b7bd7c4493975347ef60d8c7e8b742d4694f4c49f93e0a12ea263938176c"
 dependencies = [
- "itertools",
+ "itertools 0.12.1",
  "nom",
  "unicode_categories",
 ]
@@ -4583,6 +4697,31 @@ version = "0.2.92"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "af190c94f2773fdb3729c55b007a722abb5384da03bc0986df4c289bf5567e96"
 
+[[package]]
+name = "wasm-bindgen-test"
+version = "0.3.42"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d9bf62a58e0780af3e852044583deee40983e5886da43a271dd772379987667b"
+dependencies = [
+ "console_error_panic_hook",
+ "js-sys",
+ "scoped-tls",
+ "wasm-bindgen",
+ "wasm-bindgen-futures",
+ "wasm-bindgen-test-macro",
+]
+
+[[package]]
+name = "wasm-bindgen-test-macro"
+version = "0.3.42"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b7f89739351a2e03cb94beb799d47fb2cac01759b40ec441f7de39b00cbf7ef0"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn 2.0.58",
+]
+
 [[package]]
 name = "wasm-streams"
 version = "0.4.0"
diff --git a/Cargo.toml b/Cargo.toml
index a782c52..c71f2de 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -1,3 +1,8 @@
+[workspace]
+members = [
+    "wasm"
+]
+
 [package]
 authors = ["Jingcheng Yang <yjcyxky@163.com>"]
 documentation = "https://github.com/yjcyxky/biomedgps/blob/master/README.md"
diff --git a/studio/src/pages/KnowledgeTable/index.less b/studio/src/pages/KnowledgeTable/index.less
index 8c7ba7b..ce71e9b 100644
--- a/studio/src/pages/KnowledgeTable/index.less
+++ b/studio/src/pages/KnowledgeTable/index.less
@@ -9,6 +9,7 @@
     .ant-collapse {
         width: 100%;
 
+        .ant-collapse-item:nth-child(1),
         .ant-collapse-item:nth-child(2) {
             .ant-collapse-header {
                 border-bottom: 1px solid #f0f0f0;
@@ -27,7 +28,7 @@
 
         .ant-collapse-header,
         .ant-collapse-content-box {
-            border-radius: 0;
+            border-radius: 0 !important;
             padding: 20px 0;
         }
     }
diff --git a/wasm/Cargo.toml b/wasm/Cargo.toml
new file mode 100644
index 0000000..c935b83
--- /dev/null
+++ b/wasm/Cargo.toml
@@ -0,0 +1,22 @@
+[package]
+name = "biomedgps-graph"
+description = ""
+version = "0.1.0"
+authors = ["Jingcheng Yang <yjcyxky@163.com>"]
+edition = "2021"
+
+[lib]
+crate-type = ["cdylib"]
+
+[dependencies]
+rustworkx-core = "0.14.2"
+serde = { version = "1.0", features = ["derive"] }
+wasm-bindgen = "0.2"
+serde-wasm-bindgen = "0.6.5"
+getrandom = { version = "0.2", features = ["js"] }
+
+[dev-dependencies]
+wasm-bindgen-test = "0.3"
+
+[profile.release]
+opt-level = "s"
diff --git a/wasm/README.md b/wasm/README.md
new file mode 100644
index 0000000..af978c2
--- /dev/null
+++ b/wasm/README.md
@@ -0,0 +1,35 @@
+# BiomedGPS Graph
+
+This project provides a Rust implementation for calculating various centrality measures of a graph, compiled to WebAssembly (Wasm) for use in a web frontend.
+
+## Getting Started
+
+### Prerequisites
+
+Ensure you have the following tools installed:
+
+- [Rust](https://www.rust-lang.org/tools/install)
+- [wasm-pack](https://rustwasm.github.io/wasm-pack/installer/)
+
+### Build Instructions
+
+1. Clone the repository:
+
+   ```sh
+   git clone https://github.com/yjcyxky/biomedgps.git
+   cd biomedgps/wasm
+   ```
+
+2. Build the project:
+
+   ```sh
+   wasm-pack build --target web
+   ```
+
+3. Run example.js:
+
+   ```sh
+   python3 -m http.server 8000
+   ```
+
+   Open `http://localhost:8000` in your browser and see the output.
diff --git a/wasm/index.html b/wasm/index.html
new file mode 100644
index 0000000..d462347
--- /dev/null
+++ b/wasm/index.html
@@ -0,0 +1,105 @@
+<!DOCTYPE html>
+<html lang="en">
+
+<head>
+    <meta charset="UTF-8">
+    <meta name="viewport" content="width=device-width, initial-scale=1.0">
+    <title>DataTables Example</title>
+    <link rel="stylesheet" href="https://cdn.datatables.net/1.10.24/css/jquery.dataTables.min.css">
+    <style>
+        table {
+            width: 100%;
+        }
+    </style>
+</head>
+
+<body>
+    <h1>WebAssembly Centrality Calculation</h1>
+    <table id="example" class="display" style="width:100%">
+        <thead>
+            <tr>
+                <th>Entity ID</th>
+                <th>Entity Type</th>
+                <th>Entity Name</th>
+                <th>Betweenness Score</th>
+                <th>Degree Score</th>
+                <th>Closeness Score</th>
+                <th>Eigenvector Score</th>
+                <th>PageRank Score</th>
+            </tr>
+        </thead>
+        <tbody>
+        </tbody>
+    </table>
+
+    <script src="https://code.jquery.com/jquery-3.6.0.min.js"></script>
+    <script src="https://cdn.datatables.net/1.10.24/js/jquery.dataTables.min.js"></script>
+
+    <script type="module">
+        import init, * as wasm from './pkg/biomedgps_graph.js';
+
+        async function run() {
+            await init();
+            const relations = await fetch('./mecfs_subgraph.json').then(response => response.json());
+            // Filter the data to only include relationships where both nodes are genes
+            const filteredRelations = relations.filter(rel =>
+                rel.source_type === "Gene" || rel.target_type === "Gene"
+            );
+            const result = wasm.calculate_centrality(filteredRelations);
+            const genes = result.filter(entity => entity.entity_type === "Gene");
+
+            // Populate DataTable with data
+            $('#example').DataTable({
+                data: genes,
+                columns: [
+                    { data: 'entity_id' },
+                    { data: 'entity_type' },
+                    { data: 'entity_name' },
+                    { data: 'betweenness_score' },
+                    { data: 'degree_score' },
+                    { data: 'closeness_score' },
+                    { data: 'eigenvector_score' },
+                    { data: 'pagerank_score' }
+                ],
+                total: genes.length
+            });
+        }
+
+        run();
+
+        /**
+            WebAssembly Centrality Calculation
+            [
+                {
+                    "entity_id": "B",
+                    "entity_type": "Person",
+                    "betweenness_score": 2,
+                    "degree_score": 0,
+                    "closeness_score": 1,
+                    "eigenvector_score": 0,
+                    "pagerank_score": 0
+                },
+                {
+                    "entity_id": "A",
+                    "entity_type": "Person",
+                    "betweenness_score": 2,
+                    "degree_score": 0,
+                    "closeness_score": 0,
+                    "eigenvector_score": 0,
+                    "pagerank_score": 0
+                },
+                {
+                    "entity_id": "C",
+                    "entity_type": "unknown",
+                    "betweenness_score": 2,
+                    "degree_score": 0,
+                    "closeness_score": 1,
+                    "eigenvector_score": 0,
+                    "pagerank_score": 0
+                }
+            ] 
+        */
+    </script>
+</body>
+
+</html>
\ No newline at end of file
diff --git a/wasm/mecfs_subgraph.json b/wasm/mecfs_subgraph.json
new file mode 100644
index 0000000..950e72a
--- /dev/null
+++ b/wasm/mecfs_subgraph.json
@@ -0,0 +1,56262 @@
+[
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "Orthostatic Intolerance",
+        "score": 0.9405058622,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "MESH:D054971"
+    },
+    {
+        "reltype": "Hetionet::DpS::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "Orthostatic Intolerance",
+        "score": 0.8495634198,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "MESH:D054971"
+    },
+    {
+        "reltype": "Hetionet::DpS::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "cough",
+        "score": 0.91563344,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "SYMP:0000614"
+    },
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "cough",
+        "score": 0.5360760093,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "SYMP:0000614"
+    },
+    {
+        "reltype": "Hetionet::DpS::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "nausea",
+        "score": 0.911737144,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "SYMP:0000458"
+    },
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "nausea",
+        "score": 0.5261166692,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "SYMP:0000458"
+    },
+    {
+        "reltype": "Hetionet::DpS::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "decreased appetite",
+        "score": 0.9090417027,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "SYMP:0000245"
+    },
+    {
+        "reltype": "Hetionet::DpS::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "breathing problems",
+        "score": 0.9075162411,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "SYMP:0000868"
+    },
+    {
+        "reltype": "Hetionet::DpS::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "chills",
+        "score": 0.9025090933,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "SYMP:0019174"
+    },
+    {
+        "reltype": "Hetionet::DpS::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "palpitation",
+        "score": 0.8891083002,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "SYMP:0000530"
+    },
+    {
+        "reltype": "Hetionet::DpS::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "tinnitus",
+        "score": 0.8834840655,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "SYMP:0000393"
+    },
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "Pain",
+        "score": 0.7702038884,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "MESH:D010146"
+    },
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "Fatigue",
+        "score": 0.768619597,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "MESH:D005221"
+    },
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "Body Weight",
+        "score": 0.7619843483,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "MESH:D001835"
+    },
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "Abdominal Pain",
+        "score": 0.7541909814,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "MESH:D015746"
+    },
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "Hypocapnia",
+        "score": 0.7489036322,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "MESH:D016857"
+    },
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
+        "source_name": "myalgic encephalomeyelitis\/chronic fatigue syndrome",
+        "target_name": "Mental Fatigue",
+        "score": 0.7377772927,
+        "source_type": "Disease",
+        "target_type": "Symptom",
+        "source_id": "MONDO:0005404",
+        "target_id": "MESH:D005222"
+    },
+    {
+        "reltype": "HSDN::has_symptom::Disease:Symptom",
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+        "reltype": "STRING::CATALYSIS::Gene:Gene",
+        "source_name": "PF4",
+        "target_name": "POMC",
+        "score": 0.8427327275,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5196",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "STRING::REACTION::Gene:Gene",
+        "source_name": "PF4",
+        "target_name": "POMC",
+        "score": 0.8380010724,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5196",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "STRING::CATALYSIS::Gene:Gene",
+        "source_name": "POMC",
+        "target_name": "PF4",
+        "score": 0.8458305597,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5443",
+        "target_id": "ENTREZ:5196"
+    },
+    {
+        "reltype": "STRING::REACTION::Gene:Gene",
+        "source_name": "POMC",
+        "target_name": "PF4",
+        "score": 0.8410188556,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5443",
+        "target_id": "ENTREZ:5196"
+    },
+    {
+        "reltype": "Hetionet::DaG::Disease:Gene",
+        "source_name": "rheumatoid arthritis",
+        "target_name": "POMC",
+        "score": 0.8403896689,
+        "source_type": "Disease",
+        "target_type": "Gene",
+        "source_id": "MONDO:0008383",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "Hetionet::DaG::Disease:Gene",
+        "source_name": "hypothyroidism",
+        "target_name": "POMC",
+        "score": 0.9031550288,
+        "source_type": "Disease",
+        "target_type": "Gene",
+        "source_id": "MONDO:0005420",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "NITRIC OXIDE",
+        "target_name": "POMC",
+        "score": 0.7759616971,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00435",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "bioarx::HumGenHumGen::Gene:Gene",
+        "source_name": "PPARA",
+        "target_name": "PPARA",
+        "score": 0.9994243383,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5465",
+        "target_id": "ENTREZ:5465"
+    },
+    {
+        "reltype": "Hetionet::DaG::Disease:Gene",
+        "source_name": "type 2 diabetes mellitus",
+        "target_name": "PPARA",
+        "score": 0.8884749413,
+        "source_type": "Disease",
+        "target_type": "Gene",
+        "source_id": "MONDO:0005148",
+        "target_id": "ENTREZ:5465"
+    },
+    {
+        "reltype": "bioarx::DrugHumGen::Compound:Gene",
+        "source_name": "VALPROIC ACID",
+        "target_name": "PPARD",
+        "score": 0.7222037911,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00313",
+        "target_id": "ENTREZ:5467"
+    },
+    {
+        "reltype": "DRUGBANK::target::Compound:Gene",
+        "source_name": "VALPROIC ACID",
+        "target_name": "PPARD",
+        "score": 0.7457374334,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00313",
+        "target_id": "ENTREZ:5467"
+    },
+    {
+        "reltype": "Hetionet::Gr>G::Gene:Gene",
+        "source_name": "HMGB1",
+        "target_name": "PPARD",
+        "score": 0.8266680837,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:3146",
+        "target_id": "ENTREZ:5467"
+    },
+    {
+        "reltype": "bioarx::HumGenHumGen::Gene:Gene",
+        "source_name": "PPARD",
+        "target_name": "PPARD",
+        "score": 0.9994243383,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5467",
+        "target_id": "ENTREZ:5467"
+    },
+    {
+        "reltype": "bioarx::DrugHumGen::Compound:Gene",
+        "source_name": "VALPROIC ACID",
+        "target_name": "PPARG",
+        "score": 0.7304102182,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00313",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "DRUGBANK::target::Compound:Gene",
+        "source_name": "VALPROIC ACID",
+        "target_name": "PPARG",
+        "score": 0.7549638748,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00313",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "Hetionet::CuG::Compound:Gene",
+        "source_name": "TRIAMCINOLONE",
+        "target_name": "PPARG",
+        "score": 0.7017259002,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00620",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "GNBR::N::Compound:Gene",
+        "source_name": "TESTOSTERONE",
+        "target_name": "PPARG",
+        "score": 0.758338511,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00624",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "GNBR::N::Compound:Gene",
+        "source_name": "HYDROCORTISONE",
+        "target_name": "PPARG",
+        "score": 0.7441446781,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00741",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "Hetionet::CuG::Compound:Gene",
+        "source_name": "TRETINOIN",
+        "target_name": "PPARG",
+        "score": 0.831479907,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00755",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "GNBR::O::Compound:Gene",
+        "source_name": "ESTRADIOL",
+        "target_name": "PPARG",
+        "score": 0.8138648868,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00783",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "Hetionet::CuG::Compound:Gene",
+        "source_name": "Budesonide",
+        "target_name": "PPARG",
+        "score": 0.7473050356,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB01222",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "DEXAMETHASONE",
+        "target_name": "PPARG",
+        "score": 0.7691184878,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB01234",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "Hetionet::DaG::Disease:Gene",
+        "source_name": "type 2 diabetes mellitus",
+        "target_name": "PPARG",
+        "score": 0.9362075925,
+        "source_type": "Disease",
+        "target_type": "Gene",
+        "source_id": "MONDO:0005148",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "INTACT::DIRECT INTERACTION::Gene:Gene",
+        "source_name": "PF4",
+        "target_name": "PF4",
+        "score": 0.9988586903,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5196",
+        "target_id": "ENTREZ:5196"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "NICOTINE",
+        "target_name": "POMC",
+        "score": 0.8030239344,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00184",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "VALPROIC ACID",
+        "target_name": "POMC",
+        "score": 0.8024657369,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00313",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "INDOMETHACIN",
+        "target_name": "POMC",
+        "score": 0.8052337766,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00328",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "METHADONE",
+        "target_name": "POMC",
+        "score": 0.7759832144,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00333",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "METHADONE",
+        "target_name": "POMC",
+        "score": 0.7820868492,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00333",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "NOREPINEPHRINE",
+        "target_name": "POMC",
+        "score": 0.8548738956,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00368",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "NOREPINEPHRINE",
+        "target_name": "POMC",
+        "score": 0.8566397429,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00368",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::N::Compound:Gene",
+        "source_name": "PROGESTERONE",
+        "target_name": "POMC",
+        "score": 0.8169198036,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00396",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "LEVOTHYROXINE",
+        "target_name": "POMC",
+        "score": 0.8236854672,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00451",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "LEVOTHYROXINE",
+        "target_name": "POMC",
+        "score": 0.8074041605,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00451",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "PROPRANOLOL",
+        "target_name": "POMC",
+        "score": 0.8435637355,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00571",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "CLONIDINE",
+        "target_name": "POMC",
+        "score": 0.7899121642,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00575",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "CLONIDINE",
+        "target_name": "POMC",
+        "score": 0.788451314,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00575",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "TESTOSTERONE",
+        "target_name": "POMC",
+        "score": 0.8903133273,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00624",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::O::Compound:Gene",
+        "source_name": "TESTOSTERONE",
+        "target_name": "POMC",
+        "score": 0.7920438647,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00624",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "EPINEPHRINE",
+        "target_name": "POMC",
+        "score": 0.8782302737,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00668",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "EPINEPHRINE",
+        "target_name": "POMC",
+        "score": 0.8730282187,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00668",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "HYDROCORTISONE",
+        "target_name": "POMC",
+        "score": 0.9000060558,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00741",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "HYDROCORTISONE",
+        "target_name": "POMC",
+        "score": 0.9022701979,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00741",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "ESTRADIOL",
+        "target_name": "POMC",
+        "score": 0.8672583103,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00783",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "ESTRADIOL",
+        "target_name": "POMC",
+        "score": 0.8622447848,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00783",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "ALCOHOL",
+        "target_name": "POMC",
+        "score": 0.83385849,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00898",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "ALCOHOL",
+        "target_name": "POMC",
+        "score": 0.8442081809,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB00898",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "MELATONIN",
+        "target_name": "POMC",
+        "score": 0.825417161,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB01065",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::E::Compound:Gene",
+        "source_name": "DEXAMETHASONE",
+        "target_name": "POMC",
+        "score": 0.851149857,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB01234",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "GNBR::K::Compound:Gene",
+        "source_name": "DEXAMETHASONE",
+        "target_name": "POMC",
+        "score": 0.863702774,
+        "source_type": "Compound",
+        "target_type": "Gene",
+        "source_id": "DrugBank:DB01234",
+        "target_id": "ENTREZ:5443"
+    },
+    {
+        "reltype": "Hetionet::Gr>G::Gene:Gene",
+        "source_name": "USP6NL",
+        "target_name": "PPARD",
+        "score": 0.5038150549,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:9712",
+        "target_id": "ENTREZ:5467"
+    },
+    {
+        "reltype": "GNBR::B::Gene:Gene",
+        "source_name": "IL2",
+        "target_name": "PPARG",
+        "score": 0.6548278928,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:3558",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "GNBR::Q::Gene:Gene",
+        "source_name": "PPARD",
+        "target_name": "PPARG",
+        "score": 0.9478077888,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5467",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "bioarx::HumGenHumGen::Gene:Gene",
+        "source_name": "PPARG",
+        "target_name": "PPARG",
+        "score": 0.9994243383,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5468",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "INTACT::ASSOCIATION::Gene:Gene",
+        "source_name": "PPARG",
+        "target_name": "PPARG",
+        "score": 0.9990384579,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5468",
+        "target_id": "ENTREZ:5468"
+    },
+    {
+        "reltype": "INTACT::PHYSICAL ASSOCIATION::Gene:Gene",
+        "source_name": "PPARG",
+        "target_name": "PPARG",
+        "score": 0.9997935891,
+        "source_type": "Gene",
+        "target_type": "Gene",
+        "source_id": "ENTREZ:5468",
+        "target_id": "ENTREZ:5468"
+    }
+]
\ No newline at end of file
diff --git a/wasm/src/lib.rs b/wasm/src/lib.rs
new file mode 100644
index 0000000..01f8de9
--- /dev/null
+++ b/wasm/src/lib.rs
@@ -0,0 +1,191 @@
+use rustworkx_core::centrality::{
+    betweenness_centrality, closeness_centrality, eigenvector_centrality, katz_centrality,
+};
+use rustworkx_core::petgraph::graph::EdgeReference;
+use rustworkx_core::petgraph::graph::NodeIndex;
+use rustworkx_core::petgraph::graph::{DiGraph, UnGraph};
+use serde::{Deserialize, Serialize};
+use serde_wasm_bindgen::{from_value, to_value};
+use std::collections::HashMap;
+use wasm_bindgen::prelude::*;
+
+#[derive(Serialize, Deserialize, Debug, Clone)]
+struct Relation {
+    reltype: String,
+    source_name: String,
+    source_type: String,
+    source_id: String,
+    target_name: String,
+    target_type: String,
+    target_id: String,
+    score: f64,
+}
+
+#[derive(Serialize, Deserialize, Debug, Clone)]
+struct CentralityResult {
+    entity_id: String,
+    entity_type: String,
+    entity_name: String,
+    betweenness_score: f64,
+    degree_score: f64,
+    closeness_score: f64,
+    eigenvector_score: f64,
+    pagerank_score: f64,
+}
+
+fn calculate_centralities(relations: Vec<Relation>) -> Vec<CentralityResult> {
+    // let mut graph = DiGraph::<String, f64>::new();
+    let mut graph = UnGraph::<String, f64>::new_undirected();
+    let mut node_indices: HashMap<String, NodeIndex> = HashMap::new();
+
+    for rel in &relations {
+        let source_id = &rel.source_id;
+        let target_id = &rel.target_id;
+        if !node_indices.contains_key(source_id) {
+            let node_index = graph.add_node(source_id.clone());
+            node_indices.insert(source_id.clone(), node_index);
+        }
+        if !node_indices.contains_key(target_id) {
+            let node_index = graph.add_node(target_id.clone());
+            node_indices.insert(target_id.clone(), node_index);
+        }
+        let source_index = node_indices[source_id];
+        let target_index = node_indices[target_id];
+        graph.add_edge(source_index, target_index, rel.score);
+    }
+
+    let betweenness_scores = betweenness_centrality(&graph, false, true, 100);
+    let closeness_scores = closeness_centrality(&graph, false);
+    // More details on the parameters for eigenvector_centrality can be found at https://docs.rs/rustworkx-core/latest/rustworkx_core/centrality/fn.eigenvector_centrality.html
+    let eigenvector_scores = match eigenvector_centrality(
+        &graph,
+        |edge: EdgeReference<f64>| -> Result<f64, ()> { Ok(*edge.weight()) },
+        None,
+        None,
+    ) {
+        Ok(scores) => scores.unwrap_or(vec![]),
+        Err(_) => vec![],
+    };
+
+    // let degree_scores = degree_centrality(&graph);
+    // let pagerank_scores = pagerank(&graph, 0.85, 0.0001).unwrap();
+
+    let mut results = Vec::new();
+    for (node, index) in node_indices.iter() {
+        let entity_id = node.clone();
+        let entity_info = relations
+            .iter()
+            .find(|r| &r.source_id == node || &r.target_id == node);
+
+        let (entity_type, entity_name) = match entity_info {
+            Some(relation) => {
+                if &relation.source_id == node {
+                    (relation.source_type.clone(), relation.source_name.clone())
+                } else {
+                    (relation.target_type.clone(), relation.target_name.clone())
+                }
+            }
+            None => ("Unknown".to_string(), "Unknown".to_string()),
+        };
+        let betweenness_score = match *betweenness_scores.get(index.index()).unwrap_or(&None) {
+            Some(score) => score,
+            None => 0.0,
+        };
+        let closeness_score = match *closeness_scores.get(index.index()).unwrap_or(&None) {
+            Some(score) => score,
+            None => 0.0,
+        };
+        let eigenvector_score = *eigenvector_scores.get(index.index()).unwrap_or(&0.0);
+
+        let degree_score = 0.0;
+        let pagerank_score = 0.0;
+
+        // let degree_score = *degree_scores.get(index.index()).unwrap_or(&0.0);
+        // let pagerank_score = *pagerank_scores.get(index.index()).unwrap_or(&0.0);
+
+        results.push(CentralityResult {
+            entity_id,
+            entity_type,
+            entity_name,
+            betweenness_score,
+            closeness_score,
+            eigenvector_score,
+            degree_score,
+            pagerank_score,
+        });
+    }
+
+    results
+}
+
+#[wasm_bindgen]
+pub fn calculate_centrality(relations: JsValue) -> JsValue {
+    let relations: Vec<Relation> = from_value(relations).unwrap();
+    let results = calculate_centralities(relations);
+    to_value(&results).unwrap()
+}
+
+#[cfg(test)]
+mod tests {
+    use super::*;
+
+    #[test]
+    fn test_calculate_centralities() {
+        let relations = vec![
+            Relation {
+                reltype: "related".to_string(),
+                source_name: "A".to_string(),
+                source_type: "Person".to_string(),
+                source_id: "A".to_string(),
+                target_name: "B".to_string(),
+                target_type: "Person".to_string(),
+                target_id: "B".to_string(),
+                score: 0.5,
+            },
+            Relation {
+                reltype: "related".to_string(),
+                source_name: "A".to_string(),
+                source_type: "Person".to_string(),
+                source_id: "A".to_string(),
+                target_name: "C".to_string(),
+                target_type: "Person".to_string(),
+                target_id: "C".to_string(),
+                score: 0.5,
+            },
+            Relation {
+                reltype: "related".to_string(),
+                source_name: "B".to_string(),
+                source_type: "Person".to_string(),
+                source_id: "B".to_string(),
+                target_name: "C".to_string(),
+                target_type: "Person".to_string(),
+                target_id: "C".to_string(),
+                score: 0.5,
+            },
+        ];
+
+        let results = calculate_centralities(relations);
+        for result in &results {
+            println!(
+                "entity_id: {}, entity_type: {}, betweenness_score: {}, closeness_score: {}, eigenvector_score: {}, degree_score: {}, pagerank_score: {}",
+                result.entity_id,
+                result.entity_type,
+                result.betweenness_score,
+                result.closeness_score,
+                result.eigenvector_score,
+                result.degree_score,
+                result.pagerank_score,
+            );
+        }
+
+        assert_eq!(results.len(), 3);
+
+        let a_node = results.iter().find(|r| r.entity_id == "A").unwrap();
+        assert_eq!(a_node.entity_type, "Person");
+        assert_eq!(a_node.betweenness_score, 2.0);
+        assert_eq!(a_node.closeness_score, 0.0);
+        assert_eq!(a_node.eigenvector_score, 0.0);
+        assert_eq!(a_node.degree_score, 0.0);
+        assert_eq!(a_node.pagerank_score, 0.0);
+    }
+}