diff --git a/sdk-extensions/autoconfigure-spi/src/main/java/io/opentelemetry/sdk/autoconfigure/spi/internal/DefaultConfigProperties.java b/sdk-extensions/autoconfigure-spi/src/main/java/io/opentelemetry/sdk/autoconfigure/spi/internal/DefaultConfigProperties.java
index b8673993fe3..af0e4bae2bf 100644
--- a/sdk-extensions/autoconfigure-spi/src/main/java/io/opentelemetry/sdk/autoconfigure/spi/internal/DefaultConfigProperties.java
+++ b/sdk-extensions/autoconfigure-spi/src/main/java/io/opentelemetry/sdk/autoconfigure/spi/internal/DefaultConfigProperties.java
@@ -159,7 +159,7 @@ public Duration getDuration(String name) {
     try {
       long rawNumber = Long.parseLong(numberString.trim());
       TimeUnit unit = getDurationUnit(unitString.trim());
-      return Duration.ofMillis(TimeUnit.MILLISECONDS.convert(rawNumber, unit));
+      return Duration.ofNanos(TimeUnit.NANOSECONDS.convert(rawNumber, unit));
     } catch (NumberFormatException ex) {
       throw new ConfigurationException(
           "Invalid duration property "
@@ -256,6 +256,10 @@ private static List<String> filterBlanksAndNulls(String[] values) {
   /** Returns the TimeUnit associated with a unit string. Defaults to milliseconds. */
   private static TimeUnit getDurationUnit(String unitString) {
     switch (unitString) {
+      case "us":
+        return TimeUnit.MICROSECONDS;
+      case "ns":
+        return TimeUnit.NANOSECONDS;
       case "": // Fallthrough expected
       case "ms":
         return TimeUnit.MILLISECONDS;
diff --git a/sdk-extensions/autoconfigure-spi/src/test/java/io/opentelemetry/sdk/autoconfigure/spi/internal/ConfigPropertiesTest.java b/sdk-extensions/autoconfigure-spi/src/test/java/io/opentelemetry/sdk/autoconfigure/spi/internal/ConfigPropertiesTest.java
index e0fe198dc9e..78cc6806c08 100644
--- a/sdk-extensions/autoconfigure-spi/src/test/java/io/opentelemetry/sdk/autoconfigure/spi/internal/ConfigPropertiesTest.java
+++ b/sdk-extensions/autoconfigure-spi/src/test/java/io/opentelemetry/sdk/autoconfigure/spi/internal/ConfigPropertiesTest.java
@@ -185,8 +185,24 @@ void invalidDuration() {
         .hasMessage("Invalid duration property duration=9mm. Invalid duration string, found: mm");
   }
 
+  @Test
+  void durationNegativeParsing() {
+    assertThat(
+            DefaultConfigProperties.createFromMap(Collections.singletonMap("duration", "-41"))
+                .getDuration("duration"))
+        .isEqualTo(Duration.ofMillis(-41));
+  }
+
   @Test
   void durationUnitParsing() {
+    assertThat(
+            DefaultConfigProperties.createFromMap(Collections.singletonMap("duration", "3ns"))
+                .getDuration("duration"))
+        .isEqualTo(Duration.ofNanos(3));
+    assertThat(
+            DefaultConfigProperties.createFromMap(Collections.singletonMap("duration", "2us"))
+                .getDuration("duration"))
+        .isEqualTo(Duration.ofNanos(2000));
     assertThat(
             DefaultConfigProperties.createFromMap(Collections.singletonMap("duration", "1"))
                 .getDuration("duration"))