Control/Observed whole genome.

[rkash]

Hi,

I am wondering if there is a way to create a cooler object cl1/cl2 where clr1 and cl2 are two cooler objects and calculate the EV1 and plot a saddwl plot.
I am actually trying to make a differential saddel plot from two cooler files.
or a difference saddel plot?

Thanks in advance for the help.

[gfudenberg]

Hi @rkash -- there is currently an experimental version of this in the sandbox c/o @sergpolly https://github.com/open2c/cooltools/blob/master/cooltools/sandbox/observed_over_expected_example.ipynb

Let us know if that is helpful!