Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Create an Increments rule based on limiting the probability of toxicity #860

Closed
Puzzled-Face opened this issue Sep 20, 2024 · 0 comments · Fixed by #861
Closed

Create an Increments rule based on limiting the probability of toxicity #860

Puzzled-Face opened this issue Sep 20, 2024 · 0 comments · Fixed by #861
Assignees
Labels
enhancement New feature or request

Comments

@Puzzled-Face
Copy link
Collaborator

This issue potentially supersedes #855.

Increments rules are used to define the set of doses that are eligible to be used in the next cohort. NextBest rules then select which of these eligible doses should actually be used. Currently, Increments rules exist to limit the set of eligible doses based on (relative) change from the current dose, the number of toxicities observed so far and other criteria. None, however, limit the set of eligible doses based on posterior probabilities of toxicity. (IncrementsHSRBeta uses a beta-binomial model with a fixed prior that is independent of the current fit of the CRM model.)

It would be useful to have such a rule. It should work both for the standard binary CRM as well as for the ordinal CRM. In the latter case, different probability limits for different toxicity grades should be permitted.

For example

[Binary case] The dose for the next cohort should be limited to those doses for which the current posterior mean probability of toxicity is less than 0.33.

Or

[Ordinal case] The dose for the next cohort should be limited to those doses for which the current posterior median probability of grade 1 toxicity is less than 0.4 and of grade 2 toxicity is less than 0.05.

@Puzzled-Face Puzzled-Face added the enhancement New feature or request label Sep 20, 2024
@Puzzled-Face Puzzled-Face self-assigned this Sep 20, 2024
@Puzzled-Face Puzzled-Face linked a pull request Sep 20, 2024 that will close this issue
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
enhancement New feature or request
Projects
None yet
Development

Successfully merging a pull request may close this issue.

1 participant