rRNADif is a method to measure intragenomic 16S rRNA variability within the desired genome sequence against a chosen set of organisms. The app is calculating ML phylogenetic tree and uses mean/median branch length within set of 16S rRNA as a measure of variability between them
By default precomputed database of 21000+ fully sequenced bacterial genomes is available for comparison. However, custom database generation is possible (see documentation)
If you want to contribute, please feel free to do so !(:
Documentation and user guides are available in the website
This is work in progress, so no publication is available at the moment. If you found this approach valuable, you can site this repo:
P. Hrab & B. Ostash 2020: rRNADif, GitHub repository: https://github.com/pavlohrab/rRNADif
The latest doi is
