diff --git a/newsfragments/4746.feature.rst b/newsfragments/4746.feature.rst
new file mode 100644
index 0000000000..a66da9e943
--- /dev/null
+++ b/newsfragments/4746.feature.rst
@@ -0,0 +1,2 @@
+Removed support for ``SETUPTOOLS_DANGEROUSLY_SKIP_PYPROJECT_VALIDATION``, as it
+is deemed prone to errors.
diff --git a/setuptools/config/pyprojecttoml.py b/setuptools/config/pyprojecttoml.py
index fb277f5b7a..15b0baa18e 100644
--- a/setuptools/config/pyprojecttoml.py
+++ b/setuptools/config/pyprojecttoml.py
@@ -41,19 +41,6 @@ def load_file(filepath: StrPath) -> dict:
 
 
 def validate(config: dict, filepath: StrPath) -> bool:
-    skip = os.getenv("SETUPTOOLS_DANGEROUSLY_SKIP_PYPROJECT_VALIDATION", "false")
-    if skip.lower() == "true":  # https://github.com/pypa/setuptools/issues/4459
-        SetuptoolsWarning.emit(
-            "Skipping the validation of `pyproject.toml`.",
-            """
-            Please note that some setuptools functionalities rely on the validation of
-            `pyproject.toml` against misconfiguration to ensure proper operation.
-            By skipping the automatic checks, you taking responsibility for making sure
-            the file is valid. Otherwise unexpected behaviours may occur.
-            """,
-        )
-        return True
-
     from . import _validate_pyproject as validator
 
     trove_classifier = validator.FORMAT_FUNCTIONS.get("trove-classifier")
diff --git a/setuptools/tests/config/test_pyprojecttoml.py b/setuptools/tests/config/test_pyprojecttoml.py
index df27487d51..db40fcd23d 100644
--- a/setuptools/tests/config/test_pyprojecttoml.py
+++ b/setuptools/tests/config/test_pyprojecttoml.py
@@ -17,7 +17,6 @@
 )
 from setuptools.dist import Distribution
 from setuptools.errors import OptionError
-from setuptools.warnings import SetuptoolsWarning
 
 import distutils.core
 
@@ -395,9 +394,3 @@ def test_warn_tools_typo(tmp_path):
 
     with pytest.warns(_ToolsTypoInMetadata):
         read_configuration(pyproject)
-
-
-def test_warn_skipping_validation(monkeypatch):
-    monkeypatch.setenv("SETUPTOOLS_DANGEROUSLY_SKIP_PYPROJECT_VALIDATION", "true")
-    with pytest.warns(SetuptoolsWarning, match="Skipping the validation"):
-        assert validate({"completely-wrong": "data"}, "pyproject.toml") is True