SCCAF-D example.ipynb

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   "source": [
    "# Resptive and complete analysis of SCCAF-D framework"
   ]
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   "cell_type": "markdown",
   "id": "455ba3eb-27e8-4ac4-b313-d6535dc5bb54",
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   "source": [
    "***Cell type deconvolution methods can impute cell proportions from bulk transcriptomics data, revealing changes in disease progression or organ development. But benchmarking studies often use simulated bulk data from the same source as the reference, which limits its application scenarios. This study examines batch effects in deconvolution and introduces SCCAF-D, a computational workflow that ensures a Pearson Correlation Coefficient above 0.75 across simulated and real bulk data for various tissue types. Applied to non-alcoholic fatty liver disease, SCCAF-D unveils meaningful insights into changes in cell proportions during disease progression.***"
   ]
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   "source": [
    "We devide the SCCAF-D into two parts[prepare for Optimised reference and deconvolution] to be more flexible for users. Users can use ad.X, ad.obsm['X_pca'] et al to get the cell score matrix and the use the deconvolution part to get cell proportion."
   ]
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   "outputs": [],
   "source": []
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   "cell_type": "markdown",
   "id": "5742a175-5e3d-4526-b8a6-e87c99a7b75f",
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   "source": [
    "# Use the framework\n",
    "user can also use the SCCAF-D to get the cell type proportion"
   ]
  },
  {
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   "execution_count": null,
   "id": "1c74af80-c14c-4851-9d25-dece99d6d0ae",
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   "outputs": [],
   "source": [
    "#set the path "
   ]
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   "execution_count": 1,
   "id": "64132598-ba42-4e75-8a97-42cfd949ebbd",
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   "source": [
    "setwd('/data/')"
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     "text": [
      "< table of extent 0 >\n",
      "[1] \"number of intersect features: 14346\"\n"
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    },
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      "Repeated column names found in count matrix\n",
      "\n",
      "Using  as id variables\n",
      "\n",
      "No dimnames in `exprsArray`, assuming `fData` and `cData` are sorted according to `exprsArray`\n",
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      "\n",
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      "Done!\n",
      "\n"
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     "text": [
      "Fitted zlm on 3446 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
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     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
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      "\n",
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      "Done!\n",
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      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
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     "text": [
      "Fitted zlm on 3727 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
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     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
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      "\n",
      "\n",
      "Done!\n",
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      "Done!\n",
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     "text": [
      "Fitted zlm on 1579 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
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     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
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      "Using  as id variables\n",
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      "\n",
      "\n",
      "Done!\n",
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     "text": [
      "Fitted zlm on 2105 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
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     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
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      "Using  as id variables\n",
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      "\n",
      "\n",
      "Done!\n",
      "\n"
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     "text": [
      "Fitted zlm on 2877 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
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      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
    },
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     "text": [
      "Fitted zlm on 3962 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
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      "Using  as id variables\n",
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      "\n",
      "Assuming data assay in position 1, with name Et is log-transformed.\n",
      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
    },
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     "text": [
      "Fitted zlm on 3508 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
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     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24454  0.17253  0.32219  0.07073  0.07782  0.02146  0.09072 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24280  0.17208  0.31665  0.07075  0.07863  0.02293  0.09616 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24747  0.17143  0.32129  0.06586  0.08359  0.02164  0.08873 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25148  0.17135  0.31428  0.06816  0.07705  0.02157  0.09610 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23843  0.17077  0.31393  0.07202  0.07869  0.02052  0.10564 \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Warning message in data.table::melt(RESULTS):\n",
      "“data.table 中的 melt 泛型函数被传递了 matrix 即将转向到 reshape2 中的相关方法；请注意 reshape2 已经弃用，这个转向也已经弃用。如果要在 data.table 和 reshape2 同时附着的情况下继续使用 reshape2 中的 melt 方法，（例如 melt.list），你可以把命名空间写在函数名称前面，例如 reshape2::melt(RESULTS)。在下一个版本中，此警告将变成为错误。”\n",
      "Warning message in data.table::melt(P, id.vars = \"CT\"):\n",
      "“data.table 中的 melt 泛型函数被传递了 data.frame 即将转向到 reshape2 中的相关方法；请注意 reshape2 已经弃用，这个转向也已经弃用。如果要在 data.table 和 reshape2 同时附着的情况下继续使用 reshape2 中的 melt 方法，（例如 melt.list），你可以把命名空间写在函数名称前面，例如 reshape2::melt(P)。在下一个版本中，此警告将变成为错误。”\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Aligning reference and mixture... \n",
      "Normalizing reference... \n",
      "Run Gibbs sampling... \n",
      "Start run... \n",
      "1  2  3  4  5  \n"
     ]
    }
   ],
   "source": [
    "source('/SCCAF-D/SCCAF_D.R')\n",
    "results <- SCCAF_D(bulk = 'pseudobulk_Baron_T.rds',reference = 'integrated_baron.rds',return_expr = TRUE,python_home='/home/miniconda3/envs/sccaf/bin/python')\n",
    "saveRDS(results,'./pseudobulk_Baron_integrated_baron_sccaf_test.rds')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "id": "8e89689e-5900-48e0-812e-03d2c0c84fd4",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "List of 2\n",
      " $ cell_pro:'data.frame':\t35 obs. of  4 variables:\n",
      "  ..$ CT             : Factor w/ 7 levels \"acinar\",\"alpha\",..: 1 1 1 1 1 2 2 2 2 2 ...\n",
      "  ..$ tissue         : Factor w/ 5 levels \"mix1\",\"mix2\",..: 1 2 3 4 5 1 2 3 4 5 ...\n",
      "  ..$ observed_values: num [1:35] 0.245 0.243 0.247 0.251 0.238 0.173 0.172 0.171 0.171 0.171 ...\n",
      "  ..$ expected_values: num [1:35] 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 ...\n",
      " $ expr    : num [1:5, 1:14346, 1:7] 0.608 0.712 0.572 0.708 0.716 ...\n",
      "  ..- attr(*, \"dimnames\")=List of 3\n",
      "  .. ..$ : chr [1:5] \"mix1\" \"mix2\" \"mix3\" \"mix4\" ...\n",
      "  .. ..$ : chr [1:14346] \"A1BG\" \"A1CF\" \"A2M\" \"A4GALT\" ...\n",
      "  .. ..$ : chr [1:7] \"acinar\" \"alpha\" \"beta\" \"delta\" ...\n"
     ]
    }
   ],
   "source": [
    "str(results)"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "7c490cce-e94a-439b-950d-624a5faa1ff8",
   "metadata": {},
   "source": [
    "## To produce the cell score matrix\n",
    "The part use the SCCAF to get a cell score matrix to identify the high-quality cells"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "id": "f483b3a4-10e2-4beb-8523-a19984b99b04",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "%pylab is deprecated, use %matplotlib inline and import the required libraries.\n",
      "Populating the interactive namespace from numpy and matplotlib\n"
     ]
    }
   ],
   "source": [
    "%pylab inline\n",
    "import warnings\n",
    "warnings.filterwarnings(\"ignore\")\n",
    "from SCCAF import *\n",
    "import os\n",
    "import urllib.request"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "id": "42e62c03-5016-4c38-9a70-8a1d943bb528",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "'/home/feng_shuo/deconvolution'"
      ]
     },
     "execution_count": 2,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "pwd"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "id": "bed7615b-e2bd-4d05-9fa7-0469664fe6cd",
   "metadata": {},
   "outputs": [],
   "source": [
    "os.chdir('./SCCAF-D-test/')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "id": "04141245-fb9a-4f45-acd6-80077841c4b5",
   "metadata": {},
   "outputs": [],
   "source": [
    "ad=sc.read_h5ad('./integrated_baron.h5')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "id": "2ec229ca-5aed-4f44-a76d-21dbe9c1be4d",
   "metadata": {},
   "outputs": [],
   "source": [
    "ad.layers['counts']=ad.X.copy()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "id": "c938b2fa-166f-4a8b-9406-725dae6d92e4",
   "metadata": {},
   "outputs": [],
   "source": [
    "sc.pp.normalize_total(ad,target_sum=1e4)\n",
    "sc.pp.log1p(ad)\n",
    "ad.raw=ad"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "id": "74657eae-3b47-488a-ade7-21b51c81c8b9",
   "metadata": {},
   "outputs": [],
   "source": [
    "sc.pp.highly_variable_genes(\n",
    "    ad,\n",
    "    flavor=\"seurat_v3\",\n",
    "    n_top_genes=2000,\n",
    "    layer=\"counts\",\n",
    "    batch_key=\"sampleID\",\n",
    "    subset=False\n",
    "\n",
    "    \n",
    "    \n",
    ")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "id": "e11c5fe5-67f0-4ec8-bace-b3ec88eb9c66",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "2000"
      ]
     },
     "execution_count": 8,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "ad.var['highly_variable'].sum()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "id": "6658bb18-3a5c-4227-9c9c-9e5442eee8e5",
   "metadata": {},
   "outputs": [],
   "source": [
    "sc.tl.pca(ad, svd_solver='arpack', use_highly_variable=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "id": "94b80c13-7460-42fa-afe7-b00ac15e96e8",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "2024-09-02 00:09:02,950 - harmonypy - INFO - Computing initial centroids with sklearn.KMeans...\n",
      "2024-09-02 00:09:22,466 - harmonypy - INFO - sklearn.KMeans initialization complete.\n",
      "2024-09-02 00:09:22,580 - harmonypy - INFO - Iteration 1 of 30\n",
      "2024-09-02 00:09:31,217 - harmonypy - INFO - Iteration 2 of 30\n",
      "2024-09-02 00:09:43,328 - harmonypy - INFO - Iteration 3 of 30\n",
      "2024-09-02 00:09:53,121 - harmonypy - INFO - Iteration 4 of 30\n",
      "2024-09-02 00:10:03,632 - harmonypy - INFO - Iteration 5 of 30\n",
      "2024-09-02 00:10:13,416 - harmonypy - INFO - Iteration 6 of 30\n",
      "2024-09-02 00:10:17,306 - harmonypy - INFO - Converged after 6 iterations\n"
     ]
    }
   ],
   "source": [
    "sc.external.pp.harmony_integrate(ad, key='sampleID', basis='X_pca', adjusted_basis='X_pca_harmony',max_iter_harmony=30)"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "82433099-f1a2-4099-8d9d-1b6d78f346de",
   "metadata": {},
   "source": [
    "## Use SCCAF to get a cell score matrix"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "id": "a2ae1dc0-d440-47eb-9efc-2f61ba7adbe0",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Mean CV accuracy: 0.9933\n",
      "Accuracy on the training set: 0.9985\n",
      "Accuracy on the hold-out set: 0.9968\n"
     ]
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 640x480 with 2 Axes>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "y_prob, y_pred, y_test, clf, cvsm, acc = SCCAF_assessment(ad.obsm['X_pca_harmony'], ad.obs['cellType'],n=500)\n",
    "aucs = plot_roc(y_prob, y_test, clf, cvsm=cvsm, acc=acc)\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "1a2c9b49-eb0a-4ca4-923d-09252e8c04d1",
   "metadata": {},
   "source": [
    "### Use other iterm in obsm"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "6870aeb9-9142-496b-87e5-fd1f60b64093",
   "metadata": {},
   "outputs": [],
   "source": [
    "y_prob, y_pred, y_test, clf, cvsm, acc = SCCAF_assessment(ad.obsm['X_'], ad.obs['cellType'],n=500)\n",
    "aucs = plot_roc(y_prob, y_test, clf, cvsm=cvsm, acc=acc)\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "2251816d-9abd-41ac-b1bf-5b19e76bad5c",
   "metadata": {},
   "source": [
    "### Use the ad.X"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "a964cf28-f330-4eb1-833f-c36cbfc60006",
   "metadata": {},
   "outputs": [],
   "source": [
    "y_prob, y_pred, y_test, clf, cvsm, acc = SCCAF_assessment(ad.X, ad.obs['cellType'],n=500)\n",
    "aucs = plot_roc(y_prob, y_test, clf, cvsm=cvsm, acc=acc)\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "850e744a-b674-45a9-9f00-a060d2998e23",
   "metadata": {},
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "id": "b49d45b1-1cda-46e2-a335-7c950ac4d769",
   "metadata": {},
   "outputs": [],
   "source": [
    "prob=pd.DataFrame(y_prob,columns=clf.classes_)\n",
    "pred=pd.DataFrame(y_pred,columns=['predict'])\n",
    "sccaf=pd.concat([pred,prob],axis=1)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "id": "bd22932a-4002-42dc-8ee3-52e26c261089",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>predict</th>\n",
       "      <th>acinar</th>\n",
       "      <th>alpha</th>\n",
       "      <th>beta</th>\n",
       "      <th>delta</th>\n",
       "      <th>duct</th>\n",
       "      <th>gamma</th>\n",
       "      <th>stellate</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>alpha</td>\n",
       "      <td>0.002524</td>\n",
       "      <td>0.993048</td>\n",
       "      <td>0.000956</td>\n",
       "      <td>0.000412</td>\n",
       "      <td>0.001195</td>\n",
       "      <td>0.000562</td>\n",
       "      <td>0.001305</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>duct</td>\n",
       "      <td>0.023060</td>\n",
       "      <td>0.002835</td>\n",
       "      <td>0.000494</td>\n",
       "      <td>0.002461</td>\n",
       "      <td>0.967943</td>\n",
       "      <td>0.000022</td>\n",
       "      <td>0.003184</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>alpha</td>\n",
       "      <td>0.000319</td>\n",
       "      <td>0.990186</td>\n",
       "      <td>0.001648</td>\n",
       "      <td>0.000405</td>\n",
       "      <td>0.000129</td>\n",
       "      <td>0.006003</td>\n",
       "      <td>0.001312</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>alpha</td>\n",
       "      <td>0.000671</td>\n",
       "      <td>0.992968</td>\n",
       "      <td>0.000064</td>\n",
       "      <td>0.000223</td>\n",
       "      <td>0.000473</td>\n",
       "      <td>0.004698</td>\n",
       "      <td>0.000902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>alpha</td>\n",
       "      <td>0.000170</td>\n",
       "      <td>0.983094</td>\n",
       "      <td>0.009720</td>\n",
       "      <td>0.001533</td>\n",
       "      <td>0.003911</td>\n",
       "      <td>0.001073</td>\n",
       "      <td>0.000499</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29087</th>\n",
       "      <td>alpha</td>\n",
       "      <td>0.000163</td>\n",
       "      <td>0.998157</td>\n",
       "      <td>0.000230</td>\n",
       "      <td>0.000238</td>\n",
       "      <td>0.000680</td>\n",
       "      <td>0.000202</td>\n",
       "      <td>0.000330</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29088</th>\n",
       "      <td>gamma</td>\n",
       "      <td>0.000010</td>\n",
       "      <td>0.000004</td>\n",
       "      <td>0.000048</td>\n",
       "      <td>0.000027</td>\n",
       "      <td>0.000384</td>\n",
       "      <td>0.999263</td>\n",
       "      <td>0.000264</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29089</th>\n",
       "      <td>alpha</td>\n",
       "      <td>0.000148</td>\n",
       "      <td>0.998264</td>\n",
       "      <td>0.000213</td>\n",
       "      <td>0.000074</td>\n",
       "      <td>0.000732</td>\n",
       "      <td>0.000416</td>\n",
       "      <td>0.000153</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29090</th>\n",
       "      <td>alpha</td>\n",
       "      <td>0.000347</td>\n",
       "      <td>0.997513</td>\n",
       "      <td>0.000338</td>\n",
       "      <td>0.000476</td>\n",
       "      <td>0.000324</td>\n",
       "      <td>0.000486</td>\n",
       "      <td>0.000515</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29091</th>\n",
       "      <td>alpha</td>\n",
       "      <td>0.000208</td>\n",
       "      <td>0.995778</td>\n",
       "      <td>0.000552</td>\n",
       "      <td>0.000258</td>\n",
       "      <td>0.000624</td>\n",
       "      <td>0.002067</td>\n",
       "      <td>0.000515</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>29092 rows × 8 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "      predict    acinar     alpha      beta     delta      duct     gamma  \\\n",
       "0       alpha  0.002524  0.993048  0.000956  0.000412  0.001195  0.000562   \n",
       "1        duct  0.023060  0.002835  0.000494  0.002461  0.967943  0.000022   \n",
       "2       alpha  0.000319  0.990186  0.001648  0.000405  0.000129  0.006003   \n",
       "3       alpha  0.000671  0.992968  0.000064  0.000223  0.000473  0.004698   \n",
       "4       alpha  0.000170  0.983094  0.009720  0.001533  0.003911  0.001073   \n",
       "...       ...       ...       ...       ...       ...       ...       ...   \n",
       "29087   alpha  0.000163  0.998157  0.000230  0.000238  0.000680  0.000202   \n",
       "29088   gamma  0.000010  0.000004  0.000048  0.000027  0.000384  0.999263   \n",
       "29089   alpha  0.000148  0.998264  0.000213  0.000074  0.000732  0.000416   \n",
       "29090   alpha  0.000347  0.997513  0.000338  0.000476  0.000324  0.000486   \n",
       "29091   alpha  0.000208  0.995778  0.000552  0.000258  0.000624  0.002067   \n",
       "\n",
       "       stellate  \n",
       "0      0.001305  \n",
       "1      0.003184  \n",
       "2      0.001312  \n",
       "3      0.000902  \n",
       "4      0.000499  \n",
       "...         ...  \n",
       "29087  0.000330  \n",
       "29088  0.000264  \n",
       "29089  0.000153  \n",
       "29090  0.000515  \n",
       "29091  0.000515  \n",
       "\n",
       "[29092 rows x 8 columns]"
      ]
     },
     "execution_count": 13,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "sccaf"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "e65c57ed-2ce2-4540-8c15-a0af16b75da9",
   "metadata": {},
   "source": [
    "## Get the optimise cells"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "id": "49805c64-9c3a-4b40-b029-6c0249532400",
   "metadata": {},
   "outputs": [],
   "source": [
    "sccaf.to_csv('./sccaf-result.csv')\n",
    "y_test.to_csv('./y_test-result.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "id": "74adc9d9-6c02-4c47-a606-f80f4f22333c",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "AAACCTGAGAATCTCC-9-6    alpha\n",
       "AAACCTGAGAGGACGG-6-6     duct\n",
       "AAACCTGAGCCATCGC-1-6    alpha\n",
       "AAACCTGAGCTGAAAT-1-6    alpha\n",
       "AAACCTGAGCTGCAAG-9-6    alpha\n",
       "                        ...  \n",
       "HP1526901T2D_I16-2      alpha\n",
       "HP1526901T2D_F7-2       gamma\n",
       "HP1525301T2D_K3-2       alpha\n",
       "HP1526901T2D_N8-2       alpha\n",
       "HP1526901T2D_A8-2       alpha\n",
       "Name: cellType, Length: 29092, dtype: category\n",
       "Categories (7, object): ['acinar', 'alpha', 'beta', 'delta', 'duct', 'gamma', 'stellate']"
      ]
     },
     "execution_count": 15,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "y_test"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "0aae40bd-9e6a-4ed2-bfdf-a951801fe192",
   "metadata": {},
   "source": [
    "## Get the optimised reference in R\n",
    "use the cell score matrix produced by SCCAF to choose the high-quality cells to construct the Optimised reference"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "id": "23478700-77cc-467e-97e7-5242e62e0504",
   "metadata": {},
   "outputs": [],
   "source": [
    "setwd('./SCCAF-D-test/')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "id": "127c070e-6932-4a45-ae20-d0e89475207d",
   "metadata": {},
   "outputs": [],
   "source": [
    "data <- read.csv('./sccaf-result.csv')\n",
    "test <- read.csv('./y_test-result.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "id": "8090bb55-4f40-49fc-ae30-733f42c811b3",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 29092 × 9</caption>\n",
       "<thead>\n",
       "\t<tr><th scope=col>X</th><th scope=col>predict</th><th scope=col>acinar</th><th scope=col>alpha</th><th scope=col>beta</th><th scope=col>delta</th><th scope=col>duct</th><th scope=col>gamma</th><th scope=col>stellate</th></tr>\n",
       "\t<tr><th scope=col>&lt;int&gt;</th><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;dbl&gt;</th><th scope=col>&lt;dbl&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><td> 0</td><td>alpha   </td><td>2.523625e-03</td><td>9.930476e-01</td><td>9.557116e-04</td><td>4.116669e-04</td><td>1.195134e-03</td><td>5.615644e-04</td><td>1.304728e-03</td></tr>\n",
       "\t<tr><td> 1</td><td>duct    </td><td>2.305970e-02</td><td>2.835409e-03</td><td>4.942601e-04</td><td>2.461061e-03</td><td>9.679434e-01</td><td>2.206803e-05</td><td>3.184093e-03</td></tr>\n",
       "\t<tr><td> 2</td><td>alpha   </td><td>3.185584e-04</td><td>9.901859e-01</td><td>1.647774e-03</td><td>4.048915e-04</td><td>1.285959e-04</td><td>6.002691e-03</td><td>1.311558e-03</td></tr>\n",
       "\t<tr><td> 3</td><td>alpha   </td><td>6.708328e-04</td><td>9.929678e-01</td><td>6.445491e-05</td><td>2.229686e-04</td><td>4.734551e-04</td><td>4.698264e-03</td><td>9.022457e-04</td></tr>\n",
       "\t<tr><td> 4</td><td>alpha   </td><td>1.702901e-04</td><td>9.830942e-01</td><td>9.719752e-03</td><td>1.533001e-03</td><td>3.910589e-03</td><td>1.073420e-03</td><td>4.987844e-04</td></tr>\n",
       "\t<tr><td> 5</td><td>beta    </td><td>3.701693e-04</td><td>3.744820e-05</td><td>9.989130e-01</td><td>3.762119e-04</td><td>1.827715e-05</td><td>2.135052e-04</td><td>7.135931e-05</td></tr>\n",
       "\t<tr><td> 6</td><td>alpha   </td><td>2.001694e-04</td><td>9.730731e-01</td><td>3.073920e-03</td><td>8.243625e-04</td><td>1.808154e-02</td><td>1.532124e-03</td><td>3.214812e-03</td></tr>\n",
       "\t<tr><td> 7</td><td>beta    </td><td>7.066203e-04</td><td>9.665642e-04</td><td>9.945378e-01</td><td>2.240554e-03</td><td>3.442729e-04</td><td>4.523838e-04</td><td>7.517654e-04</td></tr>\n",
       "\t<tr><td> 8</td><td>alpha   </td><td>3.978360e-04</td><td>9.807133e-01</td><td>8.931585e-04</td><td>5.225677e-04</td><td>3.691214e-03</td><td>1.070129e-02</td><td>3.080590e-03</td></tr>\n",
       "\t<tr><td> 9</td><td>beta    </td><td>1.015954e-03</td><td>1.917081e-04</td><td>9.686971e-01</td><td>8.222200e-05</td><td>3.905501e-05</td><td>2.962298e-02</td><td>3.510069e-04</td></tr>\n",
       "\t<tr><td>10</td><td>alpha   </td><td>3.390742e-04</td><td>9.935155e-01</td><td>1.303447e-03</td><td>6.745474e-04</td><td>1.166001e-03</td><td>6.099511e-04</td><td>2.391475e-03</td></tr>\n",
       "\t<tr><td>11</td><td>alpha   </td><td>9.436912e-05</td><td>9.520689e-01</td><td>1.495515e-03</td><td>2.525724e-03</td><td>2.502974e-02</td><td>1.441474e-02</td><td>4.370973e-03</td></tr>\n",
       "\t<tr><td>12</td><td>beta    </td><td>3.557968e-04</td><td>3.985752e-05</td><td>9.979962e-01</td><td>5.186043e-05</td><td>5.701570e-05</td><td>1.465985e-03</td><td>3.331756e-05</td></tr>\n",
       "\t<tr><td>13</td><td>duct    </td><td>4.841770e-02</td><td>2.025435e-05</td><td>1.401116e-05</td><td>5.263976e-05</td><td>9.509580e-01</td><td>5.480158e-05</td><td>4.826371e-04</td></tr>\n",
       "\t<tr><td>14</td><td>alpha   </td><td>1.274111e-04</td><td>9.797836e-01</td><td>5.042733e-04</td><td>1.355771e-03</td><td>9.628996e-04</td><td>1.595669e-02</td><td>1.309348e-03</td></tr>\n",
       "\t<tr><td>15</td><td>duct    </td><td>3.565785e-05</td><td>1.283491e-08</td><td>3.337080e-05</td><td>5.764746e-06</td><td>9.999017e-01</td><td>1.505071e-07</td><td>2.333532e-05</td></tr>\n",
       "\t<tr><td>16</td><td>stellate</td><td>6.716983e-05</td><td>2.380079e-03</td><td>1.303874e-04</td><td>7.124046e-04</td><td>7.377167e-04</td><td>1.894802e-05</td><td>9.959533e-01</td></tr>\n",
       "\t<tr><td>17</td><td>beta    </td><td>4.880132e-03</td><td>1.419451e-02</td><td>9.542829e-01</td><td>2.713014e-03</td><td>2.209261e-02</td><td>1.095346e-03</td><td>7.414887e-04</td></tr>\n",
       "\t<tr><td>18</td><td>beta    </td><td>1.109751e-04</td><td>1.857820e-05</td><td>9.956531e-01</td><td>1.176140e-03</td><td>2.412570e-04</td><td>2.711803e-03</td><td>8.818844e-05</td></tr>\n",
       "\t<tr><td>19</td><td>alpha   </td><td>2.567502e-05</td><td>9.810060e-01</td><td>2.920295e-04</td><td>5.291018e-03</td><td>1.254999e-02</td><td>5.349628e-04</td><td>3.003095e-04</td></tr>\n",
       "\t<tr><td>20</td><td>duct    </td><td>1.927141e-03</td><td>4.285223e-05</td><td>1.361103e-04</td><td>3.503108e-04</td><td>9.974311e-01</td><td>9.892366e-07</td><td>1.114494e-04</td></tr>\n",
       "\t<tr><td>21</td><td>alpha   </td><td>2.303729e-03</td><td>9.491266e-01</td><td>3.088019e-02</td><td>1.818334e-03</td><td>2.518410e-03</td><td>4.318724e-03</td><td>9.034021e-03</td></tr>\n",
       "\t<tr><td>22</td><td>beta    </td><td>2.828629e-03</td><td>5.917714e-04</td><td>9.955304e-01</td><td>3.833408e-04</td><td>2.556777e-04</td><td>1.589116e-04</td><td>2.512577e-04</td></tr>\n",
       "\t<tr><td>23</td><td>alpha   </td><td>2.077535e-05</td><td>9.757305e-01</td><td>9.865372e-04</td><td>1.593353e-03</td><td>9.631327e-03</td><td>1.098137e-02</td><td>1.056174e-03</td></tr>\n",
       "\t<tr><td>24</td><td>duct    </td><td>2.086870e-01</td><td>9.264927e-07</td><td>3.311341e-05</td><td>1.167857e-03</td><td>7.897971e-01</td><td>1.014191e-04</td><td>2.125082e-04</td></tr>\n",
       "\t<tr><td>25</td><td>alpha   </td><td>1.379834e-04</td><td>9.876730e-01</td><td>6.998695e-04</td><td>8.307599e-04</td><td>2.551426e-03</td><td>7.527433e-03</td><td>5.795343e-04</td></tr>\n",
       "\t<tr><td>26</td><td>beta    </td><td>1.097899e-04</td><td>4.181784e-04</td><td>9.979378e-01</td><td>1.178247e-03</td><td>1.216797e-05</td><td>3.133939e-04</td><td>3.037484e-05</td></tr>\n",
       "\t<tr><td>27</td><td>stellate</td><td>1.105161e-06</td><td>1.329291e-08</td><td>5.394267e-08</td><td>3.572790e-06</td><td>7.190274e-06</td><td>4.995273e-07</td><td>9.999876e-01</td></tr>\n",
       "\t<tr><td>28</td><td>acinar  </td><td>9.975088e-01</td><td>5.580027e-04</td><td>7.581151e-07</td><td>9.447376e-05</td><td>5.595250e-06</td><td>1.646842e-03</td><td>1.855654e-04</td></tr>\n",
       "\t<tr><td>29</td><td>beta    </td><td>1.378065e-04</td><td>6.868493e-04</td><td>9.925053e-01</td><td>1.100108e-03</td><td>4.182595e-03</td><td>9.854255e-04</td><td>4.019159e-04</td></tr>\n",
       "\t<tr><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td><td>⋮</td></tr>\n",
       "\t<tr><td>29062</td><td>beta  </td><td>4.394788e-05</td><td>1.218523e-04</td><td>9.985503e-01</td><td>1.778451e-04</td><td>3.954396e-04</td><td>6.420616e-04</td><td>6.859171e-05</td></tr>\n",
       "\t<tr><td>29063</td><td>duct  </td><td>6.933344e-04</td><td>5.968059e-06</td><td>1.825604e-07</td><td>1.092788e-05</td><td>9.992870e-01</td><td>1.139492e-06</td><td>1.407417e-06</td></tr>\n",
       "\t<tr><td>29064</td><td>acinar</td><td>9.999800e-01</td><td>1.110949e-05</td><td>3.354584e-09</td><td>4.942753e-06</td><td>8.350731e-09</td><td>3.909656e-06</td><td>7.564617e-08</td></tr>\n",
       "\t<tr><td>29065</td><td>alpha </td><td>1.224204e-04</td><td>9.957421e-01</td><td>3.895632e-04</td><td>3.727669e-04</td><td>1.764282e-04</td><td>2.068665e-03</td><td>1.128099e-03</td></tr>\n",
       "\t<tr><td>29066</td><td>alpha </td><td>9.816760e-05</td><td>9.971248e-01</td><td>9.152074e-04</td><td>2.976353e-04</td><td>4.350716e-04</td><td>6.693589e-04</td><td>4.597280e-04</td></tr>\n",
       "\t<tr><td>29067</td><td>duct  </td><td>1.068653e-03</td><td>1.556742e-05</td><td>1.353988e-05</td><td>5.106282e-05</td><td>9.987518e-01</td><td>6.466272e-07</td><td>9.876085e-05</td></tr>\n",
       "\t<tr><td>29068</td><td>beta  </td><td>2.337721e-04</td><td>1.615675e-03</td><td>9.976876e-01</td><td>4.303768e-05</td><td>5.139336e-05</td><td>2.573669e-04</td><td>1.111106e-04</td></tr>\n",
       "\t<tr><td>29069</td><td>duct  </td><td>3.700421e-04</td><td>1.532492e-08</td><td>4.604144e-07</td><td>2.836458e-05</td><td>9.995979e-01</td><td>2.738002e-07</td><td>2.917929e-06</td></tr>\n",
       "\t<tr><td>29070</td><td>alpha </td><td>2.304981e-04</td><td>9.962260e-01</td><td>1.768206e-03</td><td>5.263080e-04</td><td>6.304350e-04</td><td>1.878947e-04</td><td>4.306651e-04</td></tr>\n",
       "\t<tr><td>29071</td><td>beta  </td><td>1.065727e-04</td><td>8.420286e-05</td><td>9.992751e-01</td><td>1.770896e-05</td><td>1.287907e-04</td><td>3.075168e-04</td><td>8.015755e-05</td></tr>\n",
       "\t<tr><td>29072</td><td>beta  </td><td>8.509444e-05</td><td>4.660879e-05</td><td>9.988639e-01</td><td>7.255598e-05</td><td>9.682647e-05</td><td>8.048358e-04</td><td>3.022037e-05</td></tr>\n",
       "\t<tr><td>29073</td><td>duct  </td><td>1.658694e-04</td><td>7.512600e-07</td><td>2.215835e-06</td><td>1.430035e-05</td><td>9.998100e-01</td><td>3.517045e-08</td><td>6.846096e-06</td></tr>\n",
       "\t<tr><td>29074</td><td>duct  </td><td>1.894446e-04</td><td>5.092363e-05</td><td>2.304384e-06</td><td>7.460762e-05</td><td>9.996808e-01</td><td>2.243326e-08</td><td>1.895678e-06</td></tr>\n",
       "\t<tr><td>29075</td><td>gamma </td><td>1.836700e-05</td><td>2.079393e-06</td><td>1.771047e-05</td><td>2.409275e-05</td><td>1.263926e-05</td><td>9.998753e-01</td><td>4.984474e-05</td></tr>\n",
       "\t<tr><td>29076</td><td>duct  </td><td>1.452335e-03</td><td>2.327077e-08</td><td>1.074055e-05</td><td>2.321697e-05</td><td>9.984229e-01</td><td>9.324434e-07</td><td>8.989403e-05</td></tr>\n",
       "\t<tr><td>29077</td><td>alpha </td><td>4.222165e-05</td><td>9.937201e-01</td><td>6.771315e-04</td><td>4.042096e-04</td><td>2.810935e-03</td><td>1.977582e-03</td><td>3.678035e-04</td></tr>\n",
       "\t<tr><td>29078</td><td>gamma </td><td>5.894657e-06</td><td>1.512721e-07</td><td>6.044936e-05</td><td>2.927199e-06</td><td>9.831511e-05</td><td>9.997872e-01</td><td>4.503490e-05</td></tr>\n",
       "\t<tr><td>29079</td><td>alpha </td><td>1.371566e-03</td><td>9.026048e-01</td><td>5.497506e-02</td><td>2.740008e-03</td><td>2.687787e-02</td><td>9.678122e-04</td><td>1.046291e-02</td></tr>\n",
       "\t<tr><td>29080</td><td>gamma </td><td>1.045735e-05</td><td>3.813786e-08</td><td>7.051981e-05</td><td>2.392847e-05</td><td>2.115447e-03</td><td>9.973289e-01</td><td>4.507014e-04</td></tr>\n",
       "\t<tr><td>29081</td><td>duct  </td><td>4.310035e-04</td><td>2.632368e-07</td><td>1.115145e-06</td><td>2.452124e-05</td><td>9.995421e-01</td><td>9.811183e-08</td><td>9.368929e-07</td></tr>\n",
       "\t<tr><td>29082</td><td>alpha </td><td>1.406901e-04</td><td>9.953293e-01</td><td>1.458256e-03</td><td>3.832590e-04</td><td>5.161730e-04</td><td>1.592005e-03</td><td>5.802942e-04</td></tr>\n",
       "\t<tr><td>29083</td><td>alpha </td><td>3.304715e-04</td><td>9.959426e-01</td><td>6.028092e-04</td><td>2.102243e-04</td><td>1.498775e-03</td><td>5.308502e-04</td><td>8.843012e-04</td></tr>\n",
       "\t<tr><td>29084</td><td>delta </td><td>3.946450e-06</td><td>4.458195e-05</td><td>2.406513e-06</td><td>9.998935e-01</td><td>1.689439e-05</td><td>1.082426e-05</td><td>2.786068e-05</td></tr>\n",
       "\t<tr><td>29085</td><td>acinar</td><td>9.999592e-01</td><td>2.601091e-05</td><td>5.458523e-09</td><td>1.351573e-05</td><td>1.844890e-11</td><td>1.112029e-06</td><td>2.037021e-07</td></tr>\n",
       "\t<tr><td>29086</td><td>acinar</td><td>9.999664e-01</td><td>2.476475e-05</td><td>6.204360e-09</td><td>4.831253e-06</td><td>9.368507e-08</td><td>3.698027e-06</td><td>2.424624e-07</td></tr>\n",
       "\t<tr><td>29087</td><td>alpha </td><td>1.628246e-04</td><td>9.981574e-01</td><td>2.301742e-04</td><td>2.381150e-04</td><td>6.795445e-04</td><td>2.024305e-04</td><td>3.295036e-04</td></tr>\n",
       "\t<tr><td>29088</td><td>gamma </td><td>9.625409e-06</td><td>4.329126e-06</td><td>4.775212e-05</td><td>2.666124e-05</td><td>3.844863e-04</td><td>9.992634e-01</td><td>2.637269e-04</td></tr>\n",
       "\t<tr><td>29089</td><td>alpha </td><td>1.483870e-04</td><td>9.982644e-01</td><td>2.133345e-04</td><td>7.367281e-05</td><td>7.315569e-04</td><td>4.160401e-04</td><td>1.525765e-04</td></tr>\n",
       "\t<tr><td>29090</td><td>alpha </td><td>3.473087e-04</td><td>9.975134e-01</td><td>3.378643e-04</td><td>4.762924e-04</td><td>3.239968e-04</td><td>4.863546e-04</td><td>5.147505e-04</td></tr>\n",
       "\t<tr><td>29091</td><td>alpha </td><td>2.078125e-04</td><td>9.957775e-01</td><td>5.517187e-04</td><td>2.576372e-04</td><td>6.238872e-04</td><td>2.066518e-03</td><td>5.149099e-04</td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 29092 × 9\n",
       "\\begin{tabular}{lllllllll}\n",
       " X & predict & acinar & alpha & beta & delta & duct & gamma & stellate\\\\\n",
       " <int> & <chr> & <dbl> & <dbl> & <dbl> & <dbl> & <dbl> & <dbl> & <dbl>\\\\\n",
       "\\hline\n",
       "\t  0 & alpha    & 2.523625e-03 & 9.930476e-01 & 9.557116e-04 & 4.116669e-04 & 1.195134e-03 & 5.615644e-04 & 1.304728e-03\\\\\n",
       "\t  1 & duct     & 2.305970e-02 & 2.835409e-03 & 4.942601e-04 & 2.461061e-03 & 9.679434e-01 & 2.206803e-05 & 3.184093e-03\\\\\n",
       "\t  2 & alpha    & 3.185584e-04 & 9.901859e-01 & 1.647774e-03 & 4.048915e-04 & 1.285959e-04 & 6.002691e-03 & 1.311558e-03\\\\\n",
       "\t  3 & alpha    & 6.708328e-04 & 9.929678e-01 & 6.445491e-05 & 2.229686e-04 & 4.734551e-04 & 4.698264e-03 & 9.022457e-04\\\\\n",
       "\t  4 & alpha    & 1.702901e-04 & 9.830942e-01 & 9.719752e-03 & 1.533001e-03 & 3.910589e-03 & 1.073420e-03 & 4.987844e-04\\\\\n",
       "\t  5 & beta     & 3.701693e-04 & 3.744820e-05 & 9.989130e-01 & 3.762119e-04 & 1.827715e-05 & 2.135052e-04 & 7.135931e-05\\\\\n",
       "\t  6 & alpha    & 2.001694e-04 & 9.730731e-01 & 3.073920e-03 & 8.243625e-04 & 1.808154e-02 & 1.532124e-03 & 3.214812e-03\\\\\n",
       "\t  7 & beta     & 7.066203e-04 & 9.665642e-04 & 9.945378e-01 & 2.240554e-03 & 3.442729e-04 & 4.523838e-04 & 7.517654e-04\\\\\n",
       "\t  8 & alpha    & 3.978360e-04 & 9.807133e-01 & 8.931585e-04 & 5.225677e-04 & 3.691214e-03 & 1.070129e-02 & 3.080590e-03\\\\\n",
       "\t  9 & beta     & 1.015954e-03 & 1.917081e-04 & 9.686971e-01 & 8.222200e-05 & 3.905501e-05 & 2.962298e-02 & 3.510069e-04\\\\\n",
       "\t 10 & alpha    & 3.390742e-04 & 9.935155e-01 & 1.303447e-03 & 6.745474e-04 & 1.166001e-03 & 6.099511e-04 & 2.391475e-03\\\\\n",
       "\t 11 & alpha    & 9.436912e-05 & 9.520689e-01 & 1.495515e-03 & 2.525724e-03 & 2.502974e-02 & 1.441474e-02 & 4.370973e-03\\\\\n",
       "\t 12 & beta     & 3.557968e-04 & 3.985752e-05 & 9.979962e-01 & 5.186043e-05 & 5.701570e-05 & 1.465985e-03 & 3.331756e-05\\\\\n",
       "\t 13 & duct     & 4.841770e-02 & 2.025435e-05 & 1.401116e-05 & 5.263976e-05 & 9.509580e-01 & 5.480158e-05 & 4.826371e-04\\\\\n",
       "\t 14 & alpha    & 1.274111e-04 & 9.797836e-01 & 5.042733e-04 & 1.355771e-03 & 9.628996e-04 & 1.595669e-02 & 1.309348e-03\\\\\n",
       "\t 15 & duct     & 3.565785e-05 & 1.283491e-08 & 3.337080e-05 & 5.764746e-06 & 9.999017e-01 & 1.505071e-07 & 2.333532e-05\\\\\n",
       "\t 16 & stellate & 6.716983e-05 & 2.380079e-03 & 1.303874e-04 & 7.124046e-04 & 7.377167e-04 & 1.894802e-05 & 9.959533e-01\\\\\n",
       "\t 17 & beta     & 4.880132e-03 & 1.419451e-02 & 9.542829e-01 & 2.713014e-03 & 2.209261e-02 & 1.095346e-03 & 7.414887e-04\\\\\n",
       "\t 18 & beta     & 1.109751e-04 & 1.857820e-05 & 9.956531e-01 & 1.176140e-03 & 2.412570e-04 & 2.711803e-03 & 8.818844e-05\\\\\n",
       "\t 19 & alpha    & 2.567502e-05 & 9.810060e-01 & 2.920295e-04 & 5.291018e-03 & 1.254999e-02 & 5.349628e-04 & 3.003095e-04\\\\\n",
       "\t 20 & duct     & 1.927141e-03 & 4.285223e-05 & 1.361103e-04 & 3.503108e-04 & 9.974311e-01 & 9.892366e-07 & 1.114494e-04\\\\\n",
       "\t 21 & alpha    & 2.303729e-03 & 9.491266e-01 & 3.088019e-02 & 1.818334e-03 & 2.518410e-03 & 4.318724e-03 & 9.034021e-03\\\\\n",
       "\t 22 & beta     & 2.828629e-03 & 5.917714e-04 & 9.955304e-01 & 3.833408e-04 & 2.556777e-04 & 1.589116e-04 & 2.512577e-04\\\\\n",
       "\t 23 & alpha    & 2.077535e-05 & 9.757305e-01 & 9.865372e-04 & 1.593353e-03 & 9.631327e-03 & 1.098137e-02 & 1.056174e-03\\\\\n",
       "\t 24 & duct     & 2.086870e-01 & 9.264927e-07 & 3.311341e-05 & 1.167857e-03 & 7.897971e-01 & 1.014191e-04 & 2.125082e-04\\\\\n",
       "\t 25 & alpha    & 1.379834e-04 & 9.876730e-01 & 6.998695e-04 & 8.307599e-04 & 2.551426e-03 & 7.527433e-03 & 5.795343e-04\\\\\n",
       "\t 26 & beta     & 1.097899e-04 & 4.181784e-04 & 9.979378e-01 & 1.178247e-03 & 1.216797e-05 & 3.133939e-04 & 3.037484e-05\\\\\n",
       "\t 27 & stellate & 1.105161e-06 & 1.329291e-08 & 5.394267e-08 & 3.572790e-06 & 7.190274e-06 & 4.995273e-07 & 9.999876e-01\\\\\n",
       "\t 28 & acinar   & 9.975088e-01 & 5.580027e-04 & 7.581151e-07 & 9.447376e-05 & 5.595250e-06 & 1.646842e-03 & 1.855654e-04\\\\\n",
       "\t 29 & beta     & 1.378065e-04 & 6.868493e-04 & 9.925053e-01 & 1.100108e-03 & 4.182595e-03 & 9.854255e-04 & 4.019159e-04\\\\\n",
       "\t ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮ & ⋮\\\\\n",
       "\t 29062 & beta   & 4.394788e-05 & 1.218523e-04 & 9.985503e-01 & 1.778451e-04 & 3.954396e-04 & 6.420616e-04 & 6.859171e-05\\\\\n",
       "\t 29063 & duct   & 6.933344e-04 & 5.968059e-06 & 1.825604e-07 & 1.092788e-05 & 9.992870e-01 & 1.139492e-06 & 1.407417e-06\\\\\n",
       "\t 29064 & acinar & 9.999800e-01 & 1.110949e-05 & 3.354584e-09 & 4.942753e-06 & 8.350731e-09 & 3.909656e-06 & 7.564617e-08\\\\\n",
       "\t 29065 & alpha  & 1.224204e-04 & 9.957421e-01 & 3.895632e-04 & 3.727669e-04 & 1.764282e-04 & 2.068665e-03 & 1.128099e-03\\\\\n",
       "\t 29066 & alpha  & 9.816760e-05 & 9.971248e-01 & 9.152074e-04 & 2.976353e-04 & 4.350716e-04 & 6.693589e-04 & 4.597280e-04\\\\\n",
       "\t 29067 & duct   & 1.068653e-03 & 1.556742e-05 & 1.353988e-05 & 5.106282e-05 & 9.987518e-01 & 6.466272e-07 & 9.876085e-05\\\\\n",
       "\t 29068 & beta   & 2.337721e-04 & 1.615675e-03 & 9.976876e-01 & 4.303768e-05 & 5.139336e-05 & 2.573669e-04 & 1.111106e-04\\\\\n",
       "\t 29069 & duct   & 3.700421e-04 & 1.532492e-08 & 4.604144e-07 & 2.836458e-05 & 9.995979e-01 & 2.738002e-07 & 2.917929e-06\\\\\n",
       "\t 29070 & alpha  & 2.304981e-04 & 9.962260e-01 & 1.768206e-03 & 5.263080e-04 & 6.304350e-04 & 1.878947e-04 & 4.306651e-04\\\\\n",
       "\t 29071 & beta   & 1.065727e-04 & 8.420286e-05 & 9.992751e-01 & 1.770896e-05 & 1.287907e-04 & 3.075168e-04 & 8.015755e-05\\\\\n",
       "\t 29072 & beta   & 8.509444e-05 & 4.660879e-05 & 9.988639e-01 & 7.255598e-05 & 9.682647e-05 & 8.048358e-04 & 3.022037e-05\\\\\n",
       "\t 29073 & duct   & 1.658694e-04 & 7.512600e-07 & 2.215835e-06 & 1.430035e-05 & 9.998100e-01 & 3.517045e-08 & 6.846096e-06\\\\\n",
       "\t 29074 & duct   & 1.894446e-04 & 5.092363e-05 & 2.304384e-06 & 7.460762e-05 & 9.996808e-01 & 2.243326e-08 & 1.895678e-06\\\\\n",
       "\t 29075 & gamma  & 1.836700e-05 & 2.079393e-06 & 1.771047e-05 & 2.409275e-05 & 1.263926e-05 & 9.998753e-01 & 4.984474e-05\\\\\n",
       "\t 29076 & duct   & 1.452335e-03 & 2.327077e-08 & 1.074055e-05 & 2.321697e-05 & 9.984229e-01 & 9.324434e-07 & 8.989403e-05\\\\\n",
       "\t 29077 & alpha  & 4.222165e-05 & 9.937201e-01 & 6.771315e-04 & 4.042096e-04 & 2.810935e-03 & 1.977582e-03 & 3.678035e-04\\\\\n",
       "\t 29078 & gamma  & 5.894657e-06 & 1.512721e-07 & 6.044936e-05 & 2.927199e-06 & 9.831511e-05 & 9.997872e-01 & 4.503490e-05\\\\\n",
       "\t 29079 & alpha  & 1.371566e-03 & 9.026048e-01 & 5.497506e-02 & 2.740008e-03 & 2.687787e-02 & 9.678122e-04 & 1.046291e-02\\\\\n",
       "\t 29080 & gamma  & 1.045735e-05 & 3.813786e-08 & 7.051981e-05 & 2.392847e-05 & 2.115447e-03 & 9.973289e-01 & 4.507014e-04\\\\\n",
       "\t 29081 & duct   & 4.310035e-04 & 2.632368e-07 & 1.115145e-06 & 2.452124e-05 & 9.995421e-01 & 9.811183e-08 & 9.368929e-07\\\\\n",
       "\t 29082 & alpha  & 1.406901e-04 & 9.953293e-01 & 1.458256e-03 & 3.832590e-04 & 5.161730e-04 & 1.592005e-03 & 5.802942e-04\\\\\n",
       "\t 29083 & alpha  & 3.304715e-04 & 9.959426e-01 & 6.028092e-04 & 2.102243e-04 & 1.498775e-03 & 5.308502e-04 & 8.843012e-04\\\\\n",
       "\t 29084 & delta  & 3.946450e-06 & 4.458195e-05 & 2.406513e-06 & 9.998935e-01 & 1.689439e-05 & 1.082426e-05 & 2.786068e-05\\\\\n",
       "\t 29085 & acinar & 9.999592e-01 & 2.601091e-05 & 5.458523e-09 & 1.351573e-05 & 1.844890e-11 & 1.112029e-06 & 2.037021e-07\\\\\n",
       "\t 29086 & acinar & 9.999664e-01 & 2.476475e-05 & 6.204360e-09 & 4.831253e-06 & 9.368507e-08 & 3.698027e-06 & 2.424624e-07\\\\\n",
       "\t 29087 & alpha  & 1.628246e-04 & 9.981574e-01 & 2.301742e-04 & 2.381150e-04 & 6.795445e-04 & 2.024305e-04 & 3.295036e-04\\\\\n",
       "\t 29088 & gamma  & 9.625409e-06 & 4.329126e-06 & 4.775212e-05 & 2.666124e-05 & 3.844863e-04 & 9.992634e-01 & 2.637269e-04\\\\\n",
       "\t 29089 & alpha  & 1.483870e-04 & 9.982644e-01 & 2.133345e-04 & 7.367281e-05 & 7.315569e-04 & 4.160401e-04 & 1.525765e-04\\\\\n",
       "\t 29090 & alpha  & 3.473087e-04 & 9.975134e-01 & 3.378643e-04 & 4.762924e-04 & 3.239968e-04 & 4.863546e-04 & 5.147505e-04\\\\\n",
       "\t 29091 & alpha  & 2.078125e-04 & 9.957775e-01 & 5.517187e-04 & 2.576372e-04 & 6.238872e-04 & 2.066518e-03 & 5.149099e-04\\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 29092 × 9\n",
       "\n",
       "| X &lt;int&gt; | predict &lt;chr&gt; | acinar &lt;dbl&gt; | alpha &lt;dbl&gt; | beta &lt;dbl&gt; | delta &lt;dbl&gt; | duct &lt;dbl&gt; | gamma &lt;dbl&gt; | stellate &lt;dbl&gt; |\n",
       "|---|---|---|---|---|---|---|---|---|\n",
       "|  0 | alpha    | 2.523625e-03 | 9.930476e-01 | 9.557116e-04 | 4.116669e-04 | 1.195134e-03 | 5.615644e-04 | 1.304728e-03 |\n",
       "|  1 | duct     | 2.305970e-02 | 2.835409e-03 | 4.942601e-04 | 2.461061e-03 | 9.679434e-01 | 2.206803e-05 | 3.184093e-03 |\n",
       "|  2 | alpha    | 3.185584e-04 | 9.901859e-01 | 1.647774e-03 | 4.048915e-04 | 1.285959e-04 | 6.002691e-03 | 1.311558e-03 |\n",
       "|  3 | alpha    | 6.708328e-04 | 9.929678e-01 | 6.445491e-05 | 2.229686e-04 | 4.734551e-04 | 4.698264e-03 | 9.022457e-04 |\n",
       "|  4 | alpha    | 1.702901e-04 | 9.830942e-01 | 9.719752e-03 | 1.533001e-03 | 3.910589e-03 | 1.073420e-03 | 4.987844e-04 |\n",
       "|  5 | beta     | 3.701693e-04 | 3.744820e-05 | 9.989130e-01 | 3.762119e-04 | 1.827715e-05 | 2.135052e-04 | 7.135931e-05 |\n",
       "|  6 | alpha    | 2.001694e-04 | 9.730731e-01 | 3.073920e-03 | 8.243625e-04 | 1.808154e-02 | 1.532124e-03 | 3.214812e-03 |\n",
       "|  7 | beta     | 7.066203e-04 | 9.665642e-04 | 9.945378e-01 | 2.240554e-03 | 3.442729e-04 | 4.523838e-04 | 7.517654e-04 |\n",
       "|  8 | alpha    | 3.978360e-04 | 9.807133e-01 | 8.931585e-04 | 5.225677e-04 | 3.691214e-03 | 1.070129e-02 | 3.080590e-03 |\n",
       "|  9 | beta     | 1.015954e-03 | 1.917081e-04 | 9.686971e-01 | 8.222200e-05 | 3.905501e-05 | 2.962298e-02 | 3.510069e-04 |\n",
       "| 10 | alpha    | 3.390742e-04 | 9.935155e-01 | 1.303447e-03 | 6.745474e-04 | 1.166001e-03 | 6.099511e-04 | 2.391475e-03 |\n",
       "| 11 | alpha    | 9.436912e-05 | 9.520689e-01 | 1.495515e-03 | 2.525724e-03 | 2.502974e-02 | 1.441474e-02 | 4.370973e-03 |\n",
       "| 12 | beta     | 3.557968e-04 | 3.985752e-05 | 9.979962e-01 | 5.186043e-05 | 5.701570e-05 | 1.465985e-03 | 3.331756e-05 |\n",
       "| 13 | duct     | 4.841770e-02 | 2.025435e-05 | 1.401116e-05 | 5.263976e-05 | 9.509580e-01 | 5.480158e-05 | 4.826371e-04 |\n",
       "| 14 | alpha    | 1.274111e-04 | 9.797836e-01 | 5.042733e-04 | 1.355771e-03 | 9.628996e-04 | 1.595669e-02 | 1.309348e-03 |\n",
       "| 15 | duct     | 3.565785e-05 | 1.283491e-08 | 3.337080e-05 | 5.764746e-06 | 9.999017e-01 | 1.505071e-07 | 2.333532e-05 |\n",
       "| 16 | stellate | 6.716983e-05 | 2.380079e-03 | 1.303874e-04 | 7.124046e-04 | 7.377167e-04 | 1.894802e-05 | 9.959533e-01 |\n",
       "| 17 | beta     | 4.880132e-03 | 1.419451e-02 | 9.542829e-01 | 2.713014e-03 | 2.209261e-02 | 1.095346e-03 | 7.414887e-04 |\n",
       "| 18 | beta     | 1.109751e-04 | 1.857820e-05 | 9.956531e-01 | 1.176140e-03 | 2.412570e-04 | 2.711803e-03 | 8.818844e-05 |\n",
       "| 19 | alpha    | 2.567502e-05 | 9.810060e-01 | 2.920295e-04 | 5.291018e-03 | 1.254999e-02 | 5.349628e-04 | 3.003095e-04 |\n",
       "| 20 | duct     | 1.927141e-03 | 4.285223e-05 | 1.361103e-04 | 3.503108e-04 | 9.974311e-01 | 9.892366e-07 | 1.114494e-04 |\n",
       "| 21 | alpha    | 2.303729e-03 | 9.491266e-01 | 3.088019e-02 | 1.818334e-03 | 2.518410e-03 | 4.318724e-03 | 9.034021e-03 |\n",
       "| 22 | beta     | 2.828629e-03 | 5.917714e-04 | 9.955304e-01 | 3.833408e-04 | 2.556777e-04 | 1.589116e-04 | 2.512577e-04 |\n",
       "| 23 | alpha    | 2.077535e-05 | 9.757305e-01 | 9.865372e-04 | 1.593353e-03 | 9.631327e-03 | 1.098137e-02 | 1.056174e-03 |\n",
       "| 24 | duct     | 2.086870e-01 | 9.264927e-07 | 3.311341e-05 | 1.167857e-03 | 7.897971e-01 | 1.014191e-04 | 2.125082e-04 |\n",
       "| 25 | alpha    | 1.379834e-04 | 9.876730e-01 | 6.998695e-04 | 8.307599e-04 | 2.551426e-03 | 7.527433e-03 | 5.795343e-04 |\n",
       "| 26 | beta     | 1.097899e-04 | 4.181784e-04 | 9.979378e-01 | 1.178247e-03 | 1.216797e-05 | 3.133939e-04 | 3.037484e-05 |\n",
       "| 27 | stellate | 1.105161e-06 | 1.329291e-08 | 5.394267e-08 | 3.572790e-06 | 7.190274e-06 | 4.995273e-07 | 9.999876e-01 |\n",
       "| 28 | acinar   | 9.975088e-01 | 5.580027e-04 | 7.581151e-07 | 9.447376e-05 | 5.595250e-06 | 1.646842e-03 | 1.855654e-04 |\n",
       "| 29 | beta     | 1.378065e-04 | 6.868493e-04 | 9.925053e-01 | 1.100108e-03 | 4.182595e-03 | 9.854255e-04 | 4.019159e-04 |\n",
       "| ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ | ⋮ |\n",
       "| 29062 | beta   | 4.394788e-05 | 1.218523e-04 | 9.985503e-01 | 1.778451e-04 | 3.954396e-04 | 6.420616e-04 | 6.859171e-05 |\n",
       "| 29063 | duct   | 6.933344e-04 | 5.968059e-06 | 1.825604e-07 | 1.092788e-05 | 9.992870e-01 | 1.139492e-06 | 1.407417e-06 |\n",
       "| 29064 | acinar | 9.999800e-01 | 1.110949e-05 | 3.354584e-09 | 4.942753e-06 | 8.350731e-09 | 3.909656e-06 | 7.564617e-08 |\n",
       "| 29065 | alpha  | 1.224204e-04 | 9.957421e-01 | 3.895632e-04 | 3.727669e-04 | 1.764282e-04 | 2.068665e-03 | 1.128099e-03 |\n",
       "| 29066 | alpha  | 9.816760e-05 | 9.971248e-01 | 9.152074e-04 | 2.976353e-04 | 4.350716e-04 | 6.693589e-04 | 4.597280e-04 |\n",
       "| 29067 | duct   | 1.068653e-03 | 1.556742e-05 | 1.353988e-05 | 5.106282e-05 | 9.987518e-01 | 6.466272e-07 | 9.876085e-05 |\n",
       "| 29068 | beta   | 2.337721e-04 | 1.615675e-03 | 9.976876e-01 | 4.303768e-05 | 5.139336e-05 | 2.573669e-04 | 1.111106e-04 |\n",
       "| 29069 | duct   | 3.700421e-04 | 1.532492e-08 | 4.604144e-07 | 2.836458e-05 | 9.995979e-01 | 2.738002e-07 | 2.917929e-06 |\n",
       "| 29070 | alpha  | 2.304981e-04 | 9.962260e-01 | 1.768206e-03 | 5.263080e-04 | 6.304350e-04 | 1.878947e-04 | 4.306651e-04 |\n",
       "| 29071 | beta   | 1.065727e-04 | 8.420286e-05 | 9.992751e-01 | 1.770896e-05 | 1.287907e-04 | 3.075168e-04 | 8.015755e-05 |\n",
       "| 29072 | beta   | 8.509444e-05 | 4.660879e-05 | 9.988639e-01 | 7.255598e-05 | 9.682647e-05 | 8.048358e-04 | 3.022037e-05 |\n",
       "| 29073 | duct   | 1.658694e-04 | 7.512600e-07 | 2.215835e-06 | 1.430035e-05 | 9.998100e-01 | 3.517045e-08 | 6.846096e-06 |\n",
       "| 29074 | duct   | 1.894446e-04 | 5.092363e-05 | 2.304384e-06 | 7.460762e-05 | 9.996808e-01 | 2.243326e-08 | 1.895678e-06 |\n",
       "| 29075 | gamma  | 1.836700e-05 | 2.079393e-06 | 1.771047e-05 | 2.409275e-05 | 1.263926e-05 | 9.998753e-01 | 4.984474e-05 |\n",
       "| 29076 | duct   | 1.452335e-03 | 2.327077e-08 | 1.074055e-05 | 2.321697e-05 | 9.984229e-01 | 9.324434e-07 | 8.989403e-05 |\n",
       "| 29077 | alpha  | 4.222165e-05 | 9.937201e-01 | 6.771315e-04 | 4.042096e-04 | 2.810935e-03 | 1.977582e-03 | 3.678035e-04 |\n",
       "| 29078 | gamma  | 5.894657e-06 | 1.512721e-07 | 6.044936e-05 | 2.927199e-06 | 9.831511e-05 | 9.997872e-01 | 4.503490e-05 |\n",
       "| 29079 | alpha  | 1.371566e-03 | 9.026048e-01 | 5.497506e-02 | 2.740008e-03 | 2.687787e-02 | 9.678122e-04 | 1.046291e-02 |\n",
       "| 29080 | gamma  | 1.045735e-05 | 3.813786e-08 | 7.051981e-05 | 2.392847e-05 | 2.115447e-03 | 9.973289e-01 | 4.507014e-04 |\n",
       "| 29081 | duct   | 4.310035e-04 | 2.632368e-07 | 1.115145e-06 | 2.452124e-05 | 9.995421e-01 | 9.811183e-08 | 9.368929e-07 |\n",
       "| 29082 | alpha  | 1.406901e-04 | 9.953293e-01 | 1.458256e-03 | 3.832590e-04 | 5.161730e-04 | 1.592005e-03 | 5.802942e-04 |\n",
       "| 29083 | alpha  | 3.304715e-04 | 9.959426e-01 | 6.028092e-04 | 2.102243e-04 | 1.498775e-03 | 5.308502e-04 | 8.843012e-04 |\n",
       "| 29084 | delta  | 3.946450e-06 | 4.458195e-05 | 2.406513e-06 | 9.998935e-01 | 1.689439e-05 | 1.082426e-05 | 2.786068e-05 |\n",
       "| 29085 | acinar | 9.999592e-01 | 2.601091e-05 | 5.458523e-09 | 1.351573e-05 | 1.844890e-11 | 1.112029e-06 | 2.037021e-07 |\n",
       "| 29086 | acinar | 9.999664e-01 | 2.476475e-05 | 6.204360e-09 | 4.831253e-06 | 9.368507e-08 | 3.698027e-06 | 2.424624e-07 |\n",
       "| 29087 | alpha  | 1.628246e-04 | 9.981574e-01 | 2.301742e-04 | 2.381150e-04 | 6.795445e-04 | 2.024305e-04 | 3.295036e-04 |\n",
       "| 29088 | gamma  | 9.625409e-06 | 4.329126e-06 | 4.775212e-05 | 2.666124e-05 | 3.844863e-04 | 9.992634e-01 | 2.637269e-04 |\n",
       "| 29089 | alpha  | 1.483870e-04 | 9.982644e-01 | 2.133345e-04 | 7.367281e-05 | 7.315569e-04 | 4.160401e-04 | 1.525765e-04 |\n",
       "| 29090 | alpha  | 3.473087e-04 | 9.975134e-01 | 3.378643e-04 | 4.762924e-04 | 3.239968e-04 | 4.863546e-04 | 5.147505e-04 |\n",
       "| 29091 | alpha  | 2.078125e-04 | 9.957775e-01 | 5.517187e-04 | 2.576372e-04 | 6.238872e-04 | 2.066518e-03 | 5.149099e-04 |\n",
       "\n"
      ],
      "text/plain": [
       "      X     predict  acinar       alpha        beta         delta       \n",
       "1      0    alpha    2.523625e-03 9.930476e-01 9.557116e-04 4.116669e-04\n",
       "2      1    duct     2.305970e-02 2.835409e-03 4.942601e-04 2.461061e-03\n",
       "3      2    alpha    3.185584e-04 9.901859e-01 1.647774e-03 4.048915e-04\n",
       "4      3    alpha    6.708328e-04 9.929678e-01 6.445491e-05 2.229686e-04\n",
       "5      4    alpha    1.702901e-04 9.830942e-01 9.719752e-03 1.533001e-03\n",
       "6      5    beta     3.701693e-04 3.744820e-05 9.989130e-01 3.762119e-04\n",
       "7      6    alpha    2.001694e-04 9.730731e-01 3.073920e-03 8.243625e-04\n",
       "8      7    beta     7.066203e-04 9.665642e-04 9.945378e-01 2.240554e-03\n",
       "9      8    alpha    3.978360e-04 9.807133e-01 8.931585e-04 5.225677e-04\n",
       "10     9    beta     1.015954e-03 1.917081e-04 9.686971e-01 8.222200e-05\n",
       "11    10    alpha    3.390742e-04 9.935155e-01 1.303447e-03 6.745474e-04\n",
       "12    11    alpha    9.436912e-05 9.520689e-01 1.495515e-03 2.525724e-03\n",
       "13    12    beta     3.557968e-04 3.985752e-05 9.979962e-01 5.186043e-05\n",
       "14    13    duct     4.841770e-02 2.025435e-05 1.401116e-05 5.263976e-05\n",
       "15    14    alpha    1.274111e-04 9.797836e-01 5.042733e-04 1.355771e-03\n",
       "16    15    duct     3.565785e-05 1.283491e-08 3.337080e-05 5.764746e-06\n",
       "17    16    stellate 6.716983e-05 2.380079e-03 1.303874e-04 7.124046e-04\n",
       "18    17    beta     4.880132e-03 1.419451e-02 9.542829e-01 2.713014e-03\n",
       "19    18    beta     1.109751e-04 1.857820e-05 9.956531e-01 1.176140e-03\n",
       "20    19    alpha    2.567502e-05 9.810060e-01 2.920295e-04 5.291018e-03\n",
       "21    20    duct     1.927141e-03 4.285223e-05 1.361103e-04 3.503108e-04\n",
       "22    21    alpha    2.303729e-03 9.491266e-01 3.088019e-02 1.818334e-03\n",
       "23    22    beta     2.828629e-03 5.917714e-04 9.955304e-01 3.833408e-04\n",
       "24    23    alpha    2.077535e-05 9.757305e-01 9.865372e-04 1.593353e-03\n",
       "25    24    duct     2.086870e-01 9.264927e-07 3.311341e-05 1.167857e-03\n",
       "26    25    alpha    1.379834e-04 9.876730e-01 6.998695e-04 8.307599e-04\n",
       "27    26    beta     1.097899e-04 4.181784e-04 9.979378e-01 1.178247e-03\n",
       "28    27    stellate 1.105161e-06 1.329291e-08 5.394267e-08 3.572790e-06\n",
       "29    28    acinar   9.975088e-01 5.580027e-04 7.581151e-07 9.447376e-05\n",
       "30    29    beta     1.378065e-04 6.868493e-04 9.925053e-01 1.100108e-03\n",
       "⋮     ⋮     ⋮        ⋮            ⋮            ⋮            ⋮           \n",
       "29063 29062 beta     4.394788e-05 1.218523e-04 9.985503e-01 1.778451e-04\n",
       "29064 29063 duct     6.933344e-04 5.968059e-06 1.825604e-07 1.092788e-05\n",
       "29065 29064 acinar   9.999800e-01 1.110949e-05 3.354584e-09 4.942753e-06\n",
       "29066 29065 alpha    1.224204e-04 9.957421e-01 3.895632e-04 3.727669e-04\n",
       "29067 29066 alpha    9.816760e-05 9.971248e-01 9.152074e-04 2.976353e-04\n",
       "29068 29067 duct     1.068653e-03 1.556742e-05 1.353988e-05 5.106282e-05\n",
       "29069 29068 beta     2.337721e-04 1.615675e-03 9.976876e-01 4.303768e-05\n",
       "29070 29069 duct     3.700421e-04 1.532492e-08 4.604144e-07 2.836458e-05\n",
       "29071 29070 alpha    2.304981e-04 9.962260e-01 1.768206e-03 5.263080e-04\n",
       "29072 29071 beta     1.065727e-04 8.420286e-05 9.992751e-01 1.770896e-05\n",
       "29073 29072 beta     8.509444e-05 4.660879e-05 9.988639e-01 7.255598e-05\n",
       "29074 29073 duct     1.658694e-04 7.512600e-07 2.215835e-06 1.430035e-05\n",
       "29075 29074 duct     1.894446e-04 5.092363e-05 2.304384e-06 7.460762e-05\n",
       "29076 29075 gamma    1.836700e-05 2.079393e-06 1.771047e-05 2.409275e-05\n",
       "29077 29076 duct     1.452335e-03 2.327077e-08 1.074055e-05 2.321697e-05\n",
       "29078 29077 alpha    4.222165e-05 9.937201e-01 6.771315e-04 4.042096e-04\n",
       "29079 29078 gamma    5.894657e-06 1.512721e-07 6.044936e-05 2.927199e-06\n",
       "29080 29079 alpha    1.371566e-03 9.026048e-01 5.497506e-02 2.740008e-03\n",
       "29081 29080 gamma    1.045735e-05 3.813786e-08 7.051981e-05 2.392847e-05\n",
       "29082 29081 duct     4.310035e-04 2.632368e-07 1.115145e-06 2.452124e-05\n",
       "29083 29082 alpha    1.406901e-04 9.953293e-01 1.458256e-03 3.832590e-04\n",
       "29084 29083 alpha    3.304715e-04 9.959426e-01 6.028092e-04 2.102243e-04\n",
       "29085 29084 delta    3.946450e-06 4.458195e-05 2.406513e-06 9.998935e-01\n",
       "29086 29085 acinar   9.999592e-01 2.601091e-05 5.458523e-09 1.351573e-05\n",
       "29087 29086 acinar   9.999664e-01 2.476475e-05 6.204360e-09 4.831253e-06\n",
       "29088 29087 alpha    1.628246e-04 9.981574e-01 2.301742e-04 2.381150e-04\n",
       "29089 29088 gamma    9.625409e-06 4.329126e-06 4.775212e-05 2.666124e-05\n",
       "29090 29089 alpha    1.483870e-04 9.982644e-01 2.133345e-04 7.367281e-05\n",
       "29091 29090 alpha    3.473087e-04 9.975134e-01 3.378643e-04 4.762924e-04\n",
       "29092 29091 alpha    2.078125e-04 9.957775e-01 5.517187e-04 2.576372e-04\n",
       "      duct         gamma        stellate    \n",
       "1     1.195134e-03 5.615644e-04 1.304728e-03\n",
       "2     9.679434e-01 2.206803e-05 3.184093e-03\n",
       "3     1.285959e-04 6.002691e-03 1.311558e-03\n",
       "4     4.734551e-04 4.698264e-03 9.022457e-04\n",
       "5     3.910589e-03 1.073420e-03 4.987844e-04\n",
       "6     1.827715e-05 2.135052e-04 7.135931e-05\n",
       "7     1.808154e-02 1.532124e-03 3.214812e-03\n",
       "8     3.442729e-04 4.523838e-04 7.517654e-04\n",
       "9     3.691214e-03 1.070129e-02 3.080590e-03\n",
       "10    3.905501e-05 2.962298e-02 3.510069e-04\n",
       "11    1.166001e-03 6.099511e-04 2.391475e-03\n",
       "12    2.502974e-02 1.441474e-02 4.370973e-03\n",
       "13    5.701570e-05 1.465985e-03 3.331756e-05\n",
       "14    9.509580e-01 5.480158e-05 4.826371e-04\n",
       "15    9.628996e-04 1.595669e-02 1.309348e-03\n",
       "16    9.999017e-01 1.505071e-07 2.333532e-05\n",
       "17    7.377167e-04 1.894802e-05 9.959533e-01\n",
       "18    2.209261e-02 1.095346e-03 7.414887e-04\n",
       "19    2.412570e-04 2.711803e-03 8.818844e-05\n",
       "20    1.254999e-02 5.349628e-04 3.003095e-04\n",
       "21    9.974311e-01 9.892366e-07 1.114494e-04\n",
       "22    2.518410e-03 4.318724e-03 9.034021e-03\n",
       "23    2.556777e-04 1.589116e-04 2.512577e-04\n",
       "24    9.631327e-03 1.098137e-02 1.056174e-03\n",
       "25    7.897971e-01 1.014191e-04 2.125082e-04\n",
       "26    2.551426e-03 7.527433e-03 5.795343e-04\n",
       "27    1.216797e-05 3.133939e-04 3.037484e-05\n",
       "28    7.190274e-06 4.995273e-07 9.999876e-01\n",
       "29    5.595250e-06 1.646842e-03 1.855654e-04\n",
       "30    4.182595e-03 9.854255e-04 4.019159e-04\n",
       "⋮     ⋮            ⋮            ⋮           \n",
       "29063 3.954396e-04 6.420616e-04 6.859171e-05\n",
       "29064 9.992870e-01 1.139492e-06 1.407417e-06\n",
       "29065 8.350731e-09 3.909656e-06 7.564617e-08\n",
       "29066 1.764282e-04 2.068665e-03 1.128099e-03\n",
       "29067 4.350716e-04 6.693589e-04 4.597280e-04\n",
       "29068 9.987518e-01 6.466272e-07 9.876085e-05\n",
       "29069 5.139336e-05 2.573669e-04 1.111106e-04\n",
       "29070 9.995979e-01 2.738002e-07 2.917929e-06\n",
       "29071 6.304350e-04 1.878947e-04 4.306651e-04\n",
       "29072 1.287907e-04 3.075168e-04 8.015755e-05\n",
       "29073 9.682647e-05 8.048358e-04 3.022037e-05\n",
       "29074 9.998100e-01 3.517045e-08 6.846096e-06\n",
       "29075 9.996808e-01 2.243326e-08 1.895678e-06\n",
       "29076 1.263926e-05 9.998753e-01 4.984474e-05\n",
       "29077 9.984229e-01 9.324434e-07 8.989403e-05\n",
       "29078 2.810935e-03 1.977582e-03 3.678035e-04\n",
       "29079 9.831511e-05 9.997872e-01 4.503490e-05\n",
       "29080 2.687787e-02 9.678122e-04 1.046291e-02\n",
       "29081 2.115447e-03 9.973289e-01 4.507014e-04\n",
       "29082 9.995421e-01 9.811183e-08 9.368929e-07\n",
       "29083 5.161730e-04 1.592005e-03 5.802942e-04\n",
       "29084 1.498775e-03 5.308502e-04 8.843012e-04\n",
       "29085 1.689439e-05 1.082426e-05 2.786068e-05\n",
       "29086 1.844890e-11 1.112029e-06 2.037021e-07\n",
       "29087 9.368507e-08 3.698027e-06 2.424624e-07\n",
       "29088 6.795445e-04 2.024305e-04 3.295036e-04\n",
       "29089 3.844863e-04 9.992634e-01 2.637269e-04\n",
       "29090 7.315569e-04 4.160401e-04 1.525765e-04\n",
       "29091 3.239968e-04 4.863546e-04 5.147505e-04\n",
       "29092 6.238872e-04 2.066518e-03 5.149099e-04"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "data"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "id": "a25a0a0e-0d8a-42a3-87be-e42ed3cdeb4d",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table class=\"dataframe\">\n",
       "<caption>A data.frame: 29092 × 2</caption>\n",
       "<thead>\n",
       "\t<tr><th scope=col>X</th><th scope=col>cellType</th></tr>\n",
       "\t<tr><th scope=col>&lt;chr&gt;</th><th scope=col>&lt;chr&gt;</th></tr>\n",
       "</thead>\n",
       "<tbody>\n",
       "\t<tr><td>AAACCTGAGAATCTCC-9-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGAGAGGACGG-6-6</td><td>duct    </td></tr>\n",
       "\t<tr><td>AAACCTGAGCCATCGC-1-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGAGCTGAAAT-1-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGAGCTGCAAG-9-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGAGGGAACGG-3-6</td><td>beta    </td></tr>\n",
       "\t<tr><td>AAACCTGAGGTACTCT-7-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGAGGTGACCA-2-6</td><td>beta    </td></tr>\n",
       "\t<tr><td>AAACCTGAGTCACGCC-9-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGAGTCCTCCT-9-6</td><td>beta    </td></tr>\n",
       "\t<tr><td>AAACCTGAGTGCGATG-3-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGAGTGGCACA-9-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGCAATACGCT-3-6</td><td>beta    </td></tr>\n",
       "\t<tr><td>AAACCTGCAATCTACG-4-6</td><td>duct    </td></tr>\n",
       "\t<tr><td>AAACCTGCACACCGCA-3-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGCACACTGCG-4-6</td><td>duct    </td></tr>\n",
       "\t<tr><td>AAACCTGCACCATGTA-7-6</td><td>stellate</td></tr>\n",
       "\t<tr><td>AAACCTGCACGGCTAC-7-6</td><td>beta    </td></tr>\n",
       "\t<tr><td>AAACCTGCACTATCTT-8-6</td><td>beta    </td></tr>\n",
       "\t<tr><td>AAACCTGCAGGAATGC-9-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGCAGTCCTTC-3-6</td><td>duct    </td></tr>\n",
       "\t<tr><td>AAACCTGCATCCTAGA-8-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGCATCTATGG-7-6</td><td>beta    </td></tr>\n",
       "\t<tr><td>AAACCTGCATCTGGTA-8-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGCATGACATC-7-6</td><td>duct    </td></tr>\n",
       "\t<tr><td>AAACCTGCATGACGGA-9-6</td><td>alpha   </td></tr>\n",
       "\t<tr><td>AAACCTGCATGCCACG-3-6</td><td>beta    </td></tr>\n",
       "\t<tr><td>AAACCTGCATTGGTAC-7-6</td><td>stellate</td></tr>\n",
       "\t<tr><td>AAACCTGGTACCGGCT-4-6</td><td>acinar  </td></tr>\n",
       "\t<tr><td>AAACCTGGTAGCGTCC-9-6</td><td>beta    </td></tr>\n",
       "\t<tr><td>⋮</td><td>⋮</td></tr>\n",
       "\t<tr><td>HP1526901T2D_D17-2</td><td>beta  </td></tr>\n",
       "\t<tr><td>HP1525301T2D_C22-2</td><td>duct  </td></tr>\n",
       "\t<tr><td>HP1525301T2D_B12-2</td><td>acinar</td></tr>\n",
       "\t<tr><td>HP1526901T2D_K15-2</td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1525301T2D_J1-2 </td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1525301T2D_N6-2 </td><td>duct  </td></tr>\n",
       "\t<tr><td>HP1526901T2D_A14-2</td><td>beta  </td></tr>\n",
       "\t<tr><td>HP1526901T2D_N11-2</td><td>duct  </td></tr>\n",
       "\t<tr><td>HP1526901T2D_I15-2</td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1526901T2D_B10-2</td><td>beta  </td></tr>\n",
       "\t<tr><td>HP1526901T2D_K7-2 </td><td>beta  </td></tr>\n",
       "\t<tr><td>HP1526901T2D_H8-2 </td><td>duct  </td></tr>\n",
       "\t<tr><td>HP1525301T2D_I16-2</td><td>duct  </td></tr>\n",
       "\t<tr><td>HP1526901T2D_N19-2</td><td>gamma </td></tr>\n",
       "\t<tr><td>HP1526901T2D_B3-2 </td><td>duct  </td></tr>\n",
       "\t<tr><td>HP1526901T2D_G8-2 </td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1525301T2D_O11-2</td><td>gamma </td></tr>\n",
       "\t<tr><td>HP1525301T2D_E8-2 </td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1526901T2D_M3-2 </td><td>gamma </td></tr>\n",
       "\t<tr><td>HP1525301T2D_P23-2</td><td>duct  </td></tr>\n",
       "\t<tr><td>HP1525301T2D_N24-2</td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1526901T2D_M7-2 </td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1526901T2D_N16-2</td><td>delta </td></tr>\n",
       "\t<tr><td>HP1526901T2D_C8-2 </td><td>acinar</td></tr>\n",
       "\t<tr><td>HP1526901T2D_H2-2 </td><td>acinar</td></tr>\n",
       "\t<tr><td>HP1526901T2D_I16-2</td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1526901T2D_F7-2 </td><td>gamma </td></tr>\n",
       "\t<tr><td>HP1525301T2D_K3-2 </td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1526901T2D_N8-2 </td><td>alpha </td></tr>\n",
       "\t<tr><td>HP1526901T2D_A8-2 </td><td>alpha </td></tr>\n",
       "</tbody>\n",
       "</table>\n"
      ],
      "text/latex": [
       "A data.frame: 29092 × 2\n",
       "\\begin{tabular}{ll}\n",
       " X & cellType\\\\\n",
       " <chr> & <chr>\\\\\n",
       "\\hline\n",
       "\t AAACCTGAGAATCTCC-9-6 & alpha   \\\\\n",
       "\t AAACCTGAGAGGACGG-6-6 & duct    \\\\\n",
       "\t AAACCTGAGCCATCGC-1-6 & alpha   \\\\\n",
       "\t AAACCTGAGCTGAAAT-1-6 & alpha   \\\\\n",
       "\t AAACCTGAGCTGCAAG-9-6 & alpha   \\\\\n",
       "\t AAACCTGAGGGAACGG-3-6 & beta    \\\\\n",
       "\t AAACCTGAGGTACTCT-7-6 & alpha   \\\\\n",
       "\t AAACCTGAGGTGACCA-2-6 & beta    \\\\\n",
       "\t AAACCTGAGTCACGCC-9-6 & alpha   \\\\\n",
       "\t AAACCTGAGTCCTCCT-9-6 & beta    \\\\\n",
       "\t AAACCTGAGTGCGATG-3-6 & alpha   \\\\\n",
       "\t AAACCTGAGTGGCACA-9-6 & alpha   \\\\\n",
       "\t AAACCTGCAATACGCT-3-6 & beta    \\\\\n",
       "\t AAACCTGCAATCTACG-4-6 & duct    \\\\\n",
       "\t AAACCTGCACACCGCA-3-6 & alpha   \\\\\n",
       "\t AAACCTGCACACTGCG-4-6 & duct    \\\\\n",
       "\t AAACCTGCACCATGTA-7-6 & stellate\\\\\n",
       "\t AAACCTGCACGGCTAC-7-6 & beta    \\\\\n",
       "\t AAACCTGCACTATCTT-8-6 & beta    \\\\\n",
       "\t AAACCTGCAGGAATGC-9-6 & alpha   \\\\\n",
       "\t AAACCTGCAGTCCTTC-3-6 & duct    \\\\\n",
       "\t AAACCTGCATCCTAGA-8-6 & alpha   \\\\\n",
       "\t AAACCTGCATCTATGG-7-6 & beta    \\\\\n",
       "\t AAACCTGCATCTGGTA-8-6 & alpha   \\\\\n",
       "\t AAACCTGCATGACATC-7-6 & duct    \\\\\n",
       "\t AAACCTGCATGACGGA-9-6 & alpha   \\\\\n",
       "\t AAACCTGCATGCCACG-3-6 & beta    \\\\\n",
       "\t AAACCTGCATTGGTAC-7-6 & stellate\\\\\n",
       "\t AAACCTGGTACCGGCT-4-6 & acinar  \\\\\n",
       "\t AAACCTGGTAGCGTCC-9-6 & beta    \\\\\n",
       "\t ⋮ & ⋮\\\\\n",
       "\t HP1526901T2D\\_D17-2 & beta  \\\\\n",
       "\t HP1525301T2D\\_C22-2 & duct  \\\\\n",
       "\t HP1525301T2D\\_B12-2 & acinar\\\\\n",
       "\t HP1526901T2D\\_K15-2 & alpha \\\\\n",
       "\t HP1525301T2D\\_J1-2  & alpha \\\\\n",
       "\t HP1525301T2D\\_N6-2  & duct  \\\\\n",
       "\t HP1526901T2D\\_A14-2 & beta  \\\\\n",
       "\t HP1526901T2D\\_N11-2 & duct  \\\\\n",
       "\t HP1526901T2D\\_I15-2 & alpha \\\\\n",
       "\t HP1526901T2D\\_B10-2 & beta  \\\\\n",
       "\t HP1526901T2D\\_K7-2  & beta  \\\\\n",
       "\t HP1526901T2D\\_H8-2  & duct  \\\\\n",
       "\t HP1525301T2D\\_I16-2 & duct  \\\\\n",
       "\t HP1526901T2D\\_N19-2 & gamma \\\\\n",
       "\t HP1526901T2D\\_B3-2  & duct  \\\\\n",
       "\t HP1526901T2D\\_G8-2  & alpha \\\\\n",
       "\t HP1525301T2D\\_O11-2 & gamma \\\\\n",
       "\t HP1525301T2D\\_E8-2  & alpha \\\\\n",
       "\t HP1526901T2D\\_M3-2  & gamma \\\\\n",
       "\t HP1525301T2D\\_P23-2 & duct  \\\\\n",
       "\t HP1525301T2D\\_N24-2 & alpha \\\\\n",
       "\t HP1526901T2D\\_M7-2  & alpha \\\\\n",
       "\t HP1526901T2D\\_N16-2 & delta \\\\\n",
       "\t HP1526901T2D\\_C8-2  & acinar\\\\\n",
       "\t HP1526901T2D\\_H2-2  & acinar\\\\\n",
       "\t HP1526901T2D\\_I16-2 & alpha \\\\\n",
       "\t HP1526901T2D\\_F7-2  & gamma \\\\\n",
       "\t HP1525301T2D\\_K3-2  & alpha \\\\\n",
       "\t HP1526901T2D\\_N8-2  & alpha \\\\\n",
       "\t HP1526901T2D\\_A8-2  & alpha \\\\\n",
       "\\end{tabular}\n"
      ],
      "text/markdown": [
       "\n",
       "A data.frame: 29092 × 2\n",
       "\n",
       "| X &lt;chr&gt; | cellType &lt;chr&gt; |\n",
       "|---|---|\n",
       "| AAACCTGAGAATCTCC-9-6 | alpha    |\n",
       "| AAACCTGAGAGGACGG-6-6 | duct     |\n",
       "| AAACCTGAGCCATCGC-1-6 | alpha    |\n",
       "| AAACCTGAGCTGAAAT-1-6 | alpha    |\n",
       "| AAACCTGAGCTGCAAG-9-6 | alpha    |\n",
       "| AAACCTGAGGGAACGG-3-6 | beta     |\n",
       "| AAACCTGAGGTACTCT-7-6 | alpha    |\n",
       "| AAACCTGAGGTGACCA-2-6 | beta     |\n",
       "| AAACCTGAGTCACGCC-9-6 | alpha    |\n",
       "| AAACCTGAGTCCTCCT-9-6 | beta     |\n",
       "| AAACCTGAGTGCGATG-3-6 | alpha    |\n",
       "| AAACCTGAGTGGCACA-9-6 | alpha    |\n",
       "| AAACCTGCAATACGCT-3-6 | beta     |\n",
       "| AAACCTGCAATCTACG-4-6 | duct     |\n",
       "| AAACCTGCACACCGCA-3-6 | alpha    |\n",
       "| AAACCTGCACACTGCG-4-6 | duct     |\n",
       "| AAACCTGCACCATGTA-7-6 | stellate |\n",
       "| AAACCTGCACGGCTAC-7-6 | beta     |\n",
       "| AAACCTGCACTATCTT-8-6 | beta     |\n",
       "| AAACCTGCAGGAATGC-9-6 | alpha    |\n",
       "| AAACCTGCAGTCCTTC-3-6 | duct     |\n",
       "| AAACCTGCATCCTAGA-8-6 | alpha    |\n",
       "| AAACCTGCATCTATGG-7-6 | beta     |\n",
       "| AAACCTGCATCTGGTA-8-6 | alpha    |\n",
       "| AAACCTGCATGACATC-7-6 | duct     |\n",
       "| AAACCTGCATGACGGA-9-6 | alpha    |\n",
       "| AAACCTGCATGCCACG-3-6 | beta     |\n",
       "| AAACCTGCATTGGTAC-7-6 | stellate |\n",
       "| AAACCTGGTACCGGCT-4-6 | acinar   |\n",
       "| AAACCTGGTAGCGTCC-9-6 | beta     |\n",
       "| ⋮ | ⋮ |\n",
       "| HP1526901T2D_D17-2 | beta   |\n",
       "| HP1525301T2D_C22-2 | duct   |\n",
       "| HP1525301T2D_B12-2 | acinar |\n",
       "| HP1526901T2D_K15-2 | alpha  |\n",
       "| HP1525301T2D_J1-2  | alpha  |\n",
       "| HP1525301T2D_N6-2  | duct   |\n",
       "| HP1526901T2D_A14-2 | beta   |\n",
       "| HP1526901T2D_N11-2 | duct   |\n",
       "| HP1526901T2D_I15-2 | alpha  |\n",
       "| HP1526901T2D_B10-2 | beta   |\n",
       "| HP1526901T2D_K7-2  | beta   |\n",
       "| HP1526901T2D_H8-2  | duct   |\n",
       "| HP1525301T2D_I16-2 | duct   |\n",
       "| HP1526901T2D_N19-2 | gamma  |\n",
       "| HP1526901T2D_B3-2  | duct   |\n",
       "| HP1526901T2D_G8-2  | alpha  |\n",
       "| HP1525301T2D_O11-2 | gamma  |\n",
       "| HP1525301T2D_E8-2  | alpha  |\n",
       "| HP1526901T2D_M3-2  | gamma  |\n",
       "| HP1525301T2D_P23-2 | duct   |\n",
       "| HP1525301T2D_N24-2 | alpha  |\n",
       "| HP1526901T2D_M7-2  | alpha  |\n",
       "| HP1526901T2D_N16-2 | delta  |\n",
       "| HP1526901T2D_C8-2  | acinar |\n",
       "| HP1526901T2D_H2-2  | acinar |\n",
       "| HP1526901T2D_I16-2 | alpha  |\n",
       "| HP1526901T2D_F7-2  | gamma  |\n",
       "| HP1525301T2D_K3-2  | alpha  |\n",
       "| HP1526901T2D_N8-2  | alpha  |\n",
       "| HP1526901T2D_A8-2  | alpha  |\n",
       "\n"
      ],
      "text/plain": [
       "      X                    cellType\n",
       "1     AAACCTGAGAATCTCC-9-6 alpha   \n",
       "2     AAACCTGAGAGGACGG-6-6 duct    \n",
       "3     AAACCTGAGCCATCGC-1-6 alpha   \n",
       "4     AAACCTGAGCTGAAAT-1-6 alpha   \n",
       "5     AAACCTGAGCTGCAAG-9-6 alpha   \n",
       "6     AAACCTGAGGGAACGG-3-6 beta    \n",
       "7     AAACCTGAGGTACTCT-7-6 alpha   \n",
       "8     AAACCTGAGGTGACCA-2-6 beta    \n",
       "9     AAACCTGAGTCACGCC-9-6 alpha   \n",
       "10    AAACCTGAGTCCTCCT-9-6 beta    \n",
       "11    AAACCTGAGTGCGATG-3-6 alpha   \n",
       "12    AAACCTGAGTGGCACA-9-6 alpha   \n",
       "13    AAACCTGCAATACGCT-3-6 beta    \n",
       "14    AAACCTGCAATCTACG-4-6 duct    \n",
       "15    AAACCTGCACACCGCA-3-6 alpha   \n",
       "16    AAACCTGCACACTGCG-4-6 duct    \n",
       "17    AAACCTGCACCATGTA-7-6 stellate\n",
       "18    AAACCTGCACGGCTAC-7-6 beta    \n",
       "19    AAACCTGCACTATCTT-8-6 beta    \n",
       "20    AAACCTGCAGGAATGC-9-6 alpha   \n",
       "21    AAACCTGCAGTCCTTC-3-6 duct    \n",
       "22    AAACCTGCATCCTAGA-8-6 alpha   \n",
       "23    AAACCTGCATCTATGG-7-6 beta    \n",
       "24    AAACCTGCATCTGGTA-8-6 alpha   \n",
       "25    AAACCTGCATGACATC-7-6 duct    \n",
       "26    AAACCTGCATGACGGA-9-6 alpha   \n",
       "27    AAACCTGCATGCCACG-3-6 beta    \n",
       "28    AAACCTGCATTGGTAC-7-6 stellate\n",
       "29    AAACCTGGTACCGGCT-4-6 acinar  \n",
       "30    AAACCTGGTAGCGTCC-9-6 beta    \n",
       "⋮     ⋮                    ⋮       \n",
       "29063 HP1526901T2D_D17-2   beta    \n",
       "29064 HP1525301T2D_C22-2   duct    \n",
       "29065 HP1525301T2D_B12-2   acinar  \n",
       "29066 HP1526901T2D_K15-2   alpha   \n",
       "29067 HP1525301T2D_J1-2    alpha   \n",
       "29068 HP1525301T2D_N6-2    duct    \n",
       "29069 HP1526901T2D_A14-2   beta    \n",
       "29070 HP1526901T2D_N11-2   duct    \n",
       "29071 HP1526901T2D_I15-2   alpha   \n",
       "29072 HP1526901T2D_B10-2   beta    \n",
       "29073 HP1526901T2D_K7-2    beta    \n",
       "29074 HP1526901T2D_H8-2    duct    \n",
       "29075 HP1525301T2D_I16-2   duct    \n",
       "29076 HP1526901T2D_N19-2   gamma   \n",
       "29077 HP1526901T2D_B3-2    duct    \n",
       "29078 HP1526901T2D_G8-2    alpha   \n",
       "29079 HP1525301T2D_O11-2   gamma   \n",
       "29080 HP1525301T2D_E8-2    alpha   \n",
       "29081 HP1526901T2D_M3-2    gamma   \n",
       "29082 HP1525301T2D_P23-2   duct    \n",
       "29083 HP1525301T2D_N24-2   alpha   \n",
       "29084 HP1526901T2D_M7-2    alpha   \n",
       "29085 HP1526901T2D_N16-2   delta   \n",
       "29086 HP1526901T2D_C8-2    acinar  \n",
       "29087 HP1526901T2D_H2-2    acinar  \n",
       "29088 HP1526901T2D_I16-2   alpha   \n",
       "29089 HP1526901T2D_F7-2    gamma   \n",
       "29090 HP1525301T2D_K3-2    alpha   \n",
       "29091 HP1526901T2D_N8-2    alpha   \n",
       "29092 HP1526901T2D_A8-2    alpha   "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "test"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "id": "dc9dd7f6-a3ff-4c2f-bd72-0fae56c44a04",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "X -> counts\n",
      "\n"
     ]
    }
   ],
   "source": [
    "data <- read.csv('./sccaf-result.csv')\n",
    "test <- read.csv('./y_test-result.csv')\n",
    "data <- data[,-1]\n",
    "sccaf <- cbind(test,data)\n",
    "rownames(sccaf) <- sccaf[,1]\n",
    "sccaf <- sccaf[,-1]\n",
    "index <- sccaf$cellType==sccaf$predict\n",
    "sccaf_index <- sccaf[index,]\n",
    "library(dplyr)\n",
    "mydata <- data.frame(matrix(ncol=2,nrow=0))\n",
    "for(i in 3:ncol(sccaf_index)){\n",
    "    name <- arrange(sccaf_index,desc(sccaf_index[,i]))\n",
    "    name <- name[c(1:100),]\n",
    "    name <- name[,c(1,i)]\n",
    "    colnames(name) <- c('celltype','score')\n",
    "    mydata <- rbind(mydata,name)\n",
    "}  \n",
    "X2=sceasy::convertFormat('./integrated_baron.h5',from='anndata',to='seurat')\n",
    "X2=X2[,rownames(mydata)]\n",
    "saveRDS(X2,'./integrated_baron_opt.rds')"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "386b33f0-52eb-424f-91fc-9b86a263df97",
   "metadata": {},
   "source": [
    "## Deoconvolution in R\n",
    "use the optimised reference to conduct the cell type deconvolution, we choose the six algorithms performed well in cross-reference. We suggest use the DWLS to conduct the deconvolution"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "id": "0b256eb7-c8ff-476a-84b8-bd7a14c17aeb",
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      " [1] \"pseudobulk_Baron_T.rds\"   \"integrated_baron_opt.rds\"\n",
      " [3] \"none\"                     \"sc\"                      \n",
      " [5] \"TMM\"                      \"TMM\"                     \n",
      " [7] \"DWLS\"                     \"10000\"                   \n",
      " [9] \"none\"                     \"1\"                       \n",
      "[11] \"T\"                       \n",
      "[1] \"number of intersect features: 14346\"\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Repeated column names found in count matrix\n",
      "\n",
      "Using  as id variables\n",
      "\n",
      "No dimnames in `exprsArray`, assuming `fData` and `cData` are sorted according to `exprsArray`\n",
      "\n",
      "Assuming data assay in position 1, with name Et is log-transformed.\n",
      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Fitted zlm on 3446 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Using  as id variables\n",
      "\n",
      "No dimnames in `exprsArray`, assuming `fData` and `cData` are sorted according to `exprsArray`\n",
      "\n",
      "Assuming data assay in position 1, with name Et is log-transformed.\n",
      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Fitted zlm on 3727 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Using  as id variables\n",
      "\n",
      "No dimnames in `exprsArray`, assuming `fData` and `cData` are sorted according to `exprsArray`\n",
      "\n",
      "Assuming data assay in position 1, with name Et is log-transformed.\n",
      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Fitted zlm on 1579 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Using  as id variables\n",
      "\n",
      "No dimnames in `exprsArray`, assuming `fData` and `cData` are sorted according to `exprsArray`\n",
      "\n",
      "Assuming data assay in position 1, with name Et is log-transformed.\n",
      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Fitted zlm on 2105 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Using  as id variables\n",
      "\n",
      "No dimnames in `exprsArray`, assuming `fData` and `cData` are sorted according to `exprsArray`\n",
      "\n",
      "Assuming data assay in position 1, with name Et is log-transformed.\n",
      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Fitted zlm on 2877 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Using  as id variables\n",
      "\n",
      "No dimnames in `exprsArray`, assuming `fData` and `cData` are sorted according to `exprsArray`\n",
      "\n",
      "Assuming data assay in position 1, with name Et is log-transformed.\n",
      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Fitted zlm on 3962 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Using  as id variables\n",
      "\n",
      "No dimnames in `exprsArray`, assuming `fData` and `cData` are sorted according to `exprsArray`\n",
      "\n",
      "Assuming data assay in position 1, with name Et is log-transformed.\n",
      "\n",
      "\n",
      "Done!\n",
      "\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Fitted zlm on 3508 genes and 700 cells.\n",
      " Using BayesGLMlike ~ Population \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Combining coefficients and standard errors\n",
      "\n",
      "Calculating log-fold changes\n",
      "\n",
      "Refitting on reduced model...\n",
      "\n",
      "\n",
      "Done!\n",
      "\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n",
      "Warning message in type.convert.default(X[[i]], ...):\n",
      "“'as.is' should be specified by the caller; using TRUE”\n"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24454  0.17253  0.32219  0.07073  0.07782  0.02146  0.09072 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24280  0.17208  0.31665  0.07075  0.07863  0.02293  0.09616 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24747  0.17143  0.32129  0.06586  0.08359  0.02164  0.08873 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25148  0.17135  0.31428  0.06816  0.07705  0.02157  0.09610 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23843  0.17077  0.31393  0.07202  0.07869  0.02052  0.10564 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23815  0.17549  0.31902  0.07261  0.08224  0.02246  0.09002 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28523  0.18599  0.30964  0.09675  0.04043  0.02121  0.06075 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24112  0.17268  0.32538  0.07387  0.07789  0.01992  0.08914 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25749  0.16764  0.30486  0.06861  0.08050  0.02417  0.09673 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24506  0.16895  0.31052  0.06894  0.07510  0.02585  0.10558 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25170  0.17577  0.30842  0.06586  0.08279  0.02156  0.09389 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24873  0.17743  0.31502  0.06494  0.07643  0.02288  0.09457 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24355  0.17519  0.30499  0.07232  0.07351  0.02262  0.10782 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23729  0.17472  0.32129  0.06768  0.07765  0.01963  0.10174 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24364  0.17393  0.31636  0.07284  0.07894  0.02276  0.09153 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24228  0.17649  0.30930  0.06908  0.08991  0.02260  0.09033 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24026  0.16927  0.30133  0.06704  0.07946  0.02563  0.11701 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24959  0.17155  0.31577  0.07324  0.07790  0.02254  0.08941 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25354  0.17479  0.31112  0.06779  0.07785  0.02381  0.09110 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25949  0.17459  0.30593  0.07075  0.07749  0.02246  0.08928 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24209  0.17028  0.31293  0.07709  0.07874  0.02053  0.09834 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24642  0.17769  0.30920  0.06944  0.08679  0.02265  0.08781 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26003  0.16812  0.30994  0.07010  0.07863  0.02372  0.08945 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29123  0.18039  0.30903  0.09140  0.04306  0.01994  0.06495 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24450  0.17308  0.31820  0.07522  0.08089  0.02159  0.08651 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24814  0.17347  0.31718  0.06735  0.08415  0.02109  0.08862 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23939  0.17972  0.32365  0.07032  0.07858  0.02350  0.08484 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25319  0.17071  0.31029  0.06983  0.08080  0.02278  0.09240 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25105  0.18175  0.30760  0.06752  0.08179  0.02131  0.08897 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24799  0.18194  0.31254  0.07157  0.07847  0.02303  0.08446 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24661  0.17269  0.30452  0.07117  0.08339  0.02569  0.09594 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24665  0.17148  0.31197  0.07265  0.08381  0.02141  0.09203 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24353  0.17176  0.31335  0.06821  0.07516  0.02150  0.10648 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25488  0.16929  0.30042  0.06783  0.08343  0.02238  0.10177 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29202  0.17863  0.30998  0.09342  0.04042  0.02076  0.06477 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28356  0.18743  0.30720  0.09422  0.04501  0.01880  0.06378 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23725  0.17259  0.31339  0.07010  0.07326  0.02303  0.11038 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25341  0.17723  0.31992  0.06853  0.07438  0.02356  0.08297 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24068  0.17230  0.31959  0.06830  0.08125  0.02175  0.09613 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24456  0.17200  0.31404  0.06751  0.07675  0.02376  0.10138 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24893  0.17443  0.32201  0.06765  0.08083  0.02340  0.08274 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24380  0.17257  0.31217  0.07597  0.08019  0.02224  0.09305 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24501  0.17259  0.31905  0.07218  0.07749  0.02170  0.09198 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24855  0.17826  0.31976  0.06527  0.07261  0.02456  0.09100 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24437  0.16971  0.31684  0.06885  0.08138  0.02319  0.09566 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24708  0.17009  0.30302  0.07059  0.07865  0.02287  0.10770 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24263  0.17375  0.30592  0.06720  0.07889  0.02169  0.10992 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24183  0.17827  0.32308  0.07396  0.07751  0.02267  0.08268 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25642  0.16534  0.31582  0.06901  0.07933  0.01873  0.09535 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23307  0.17384  0.32448  0.07334  0.07280  0.02483  0.09763 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24851  0.16871  0.31018  0.06832  0.07471  0.02196  0.10761 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24950  0.17392  0.31605  0.07358  0.08041  0.02301  0.08353 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24627  0.17466  0.31381  0.07199  0.08229  0.01915  0.09183 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28872  0.18617  0.30676  0.09382  0.04704  0.01978  0.05772 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24836  0.17889  0.31657  0.06917  0.07457  0.01962  0.09281 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24458  0.17649  0.30791  0.06604  0.08151  0.02315  0.10032 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25752  0.17271  0.30714  0.06764  0.08049  0.02266  0.09184 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24694  0.17613  0.30452  0.06929  0.08047  0.02244  0.10021 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24734  0.17200  0.31355  0.07110  0.07903  0.01919  0.09779 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24931  0.17145  0.31794  0.06823  0.07980  0.02125  0.09202 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24422  0.17371  0.31229  0.07197  0.08126  0.02181  0.09474 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24200  0.17348  0.31616  0.07466  0.07931  0.02209  0.09229 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24402  0.17745  0.30912  0.06841  0.07415  0.01949  0.10736 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24563  0.17118  0.30567  0.06788  0.07896  0.02428  0.10639 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24754  0.17203  0.31430  0.06848  0.08026  0.02495  0.09244 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25514  0.17608  0.30540  0.07261  0.07567  0.02190  0.09320 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24732  0.16810  0.32108  0.07496  0.07581  0.02124  0.09149 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24677  0.17843  0.31907  0.07020  0.08309  0.01950  0.08294 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24006  0.16907  0.31243  0.07611  0.08216  0.02493  0.09524 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24651  0.16935  0.31699  0.06618  0.07864  0.02076  0.10157 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26068  0.17594  0.30826  0.06730  0.08161  0.02481  0.08140 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24357  0.17083  0.30959  0.07257  0.07742  0.02256  0.10347 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24260  0.17830  0.31362  0.07072  0.07634  0.02170  0.09671 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24804  0.18015  0.30574  0.06722  0.07741  0.02089  0.10054 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25140  0.16736  0.30804  0.07076  0.07696  0.02284  0.10264 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23592  0.17137  0.31249  0.06845  0.07997  0.02225  0.10955 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24342  0.18132  0.32586  0.06715  0.07295  0.02118  0.08812 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24154  0.17202  0.31841  0.06958  0.08421  0.02429  0.08996 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24448  0.17792  0.31197  0.07567  0.07835  0.02202  0.08959 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25302  0.17004  0.29936  0.07170  0.07792  0.02455  0.10340 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25907  0.17073  0.31166  0.07371  0.08123  0.02313  0.08047 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24008  0.16706  0.31227  0.06888  0.08289  0.02376  0.10506 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28643  0.17832  0.31321  0.09624  0.04087  0.02167  0.06325 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24942  0.17082  0.30942  0.06867  0.08032  0.02177  0.09958 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23560  0.18612  0.31729  0.07071  0.08935  0.02161  0.07932 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25411  0.17415  0.30550  0.07465  0.07654  0.02541  0.08964 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29195  0.18389  0.29708  0.09270  0.04103  0.01827  0.07508 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23394  0.17366  0.31623  0.07262  0.07744  0.02262  0.10348 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24712  0.17332  0.30916  0.06944  0.08058  0.02476  0.09563 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24864  0.17082  0.30543  0.06734  0.08382  0.02306  0.10090 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24785  0.17656  0.32087  0.07032  0.07772  0.02121  0.08548 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23772  0.17275  0.30946  0.07418  0.08502  0.02321  0.09765 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23952  0.17366  0.31722  0.07815  0.08560  0.02162  0.08423 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24156  0.17896  0.31139  0.07453  0.08026  0.02338  0.08993 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24962  0.16894  0.31675  0.07072  0.07502  0.02344  0.09551 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23983  0.17676  0.30317  0.06848  0.08926  0.02370  0.09878 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25067  0.17625  0.32064  0.07506  0.07616  0.02230  0.07891 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25076  0.17587  0.30552  0.07156  0.08107  0.02171  0.09350 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25466  0.17468  0.31581  0.06776  0.07867  0.02021  0.08821 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24355  0.17258  0.30513  0.06678  0.07876  0.02371  0.10950 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24883  0.17761  0.32166  0.06769  0.07714  0.02382  0.08325 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25399  0.17425  0.31026  0.06058  0.08315  0.02350  0.09428 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24122  0.18051  0.32374  0.07203  0.07742  0.02119  0.08389 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24242  0.17793  0.31825  0.07079  0.08210  0.02506  0.08345 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24201  0.17917  0.32420  0.07396  0.07737  0.02296  0.08032 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24922  0.17973  0.30732  0.07129  0.08020  0.02356  0.08868 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29536  0.17954  0.31105  0.09630  0.03654  0.02045  0.06076 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24398  0.17533  0.31287  0.06986  0.07908  0.02357  0.09530 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23005  0.16482  0.33108  0.07183  0.07561  0.02585  0.10076 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24349  0.17599  0.31313  0.07185  0.07693  0.02076  0.09785 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25707  0.17418  0.30614  0.06652  0.07945  0.01878  0.09786 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25285  0.17478  0.31466  0.06452  0.07475  0.02017  0.09827 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25506  0.17147  0.32228  0.07110  0.07576  0.02299  0.08135 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25142  0.17787  0.30852  0.07323  0.07631  0.02192  0.09074 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24247  0.17774  0.31866  0.06969  0.07886  0.02237  0.09020 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23682  0.17460  0.31949  0.06930  0.07670  0.02430  0.09879 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24657  0.17365  0.30811  0.07195  0.08455  0.01944  0.09572 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24625  0.17863  0.32245  0.06993  0.07578  0.02343  0.08353 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25126  0.16456  0.31274  0.06912  0.08559  0.02468  0.09205 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24464  0.17465  0.32076  0.06994  0.07514  0.02407  0.09079 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24374  0.17969  0.32361  0.07019  0.07877  0.02447  0.07952 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24533  0.16869  0.31397  0.06928  0.08345  0.02372  0.09556 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23481  0.17553  0.32322  0.07264  0.07743  0.02133  0.09504 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23852  0.17014  0.30419  0.07098  0.08282  0.02577  0.10757 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24422  0.17793  0.32312  0.06752  0.07341  0.02143  0.09236 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24917  0.17553  0.31795  0.07400  0.07569  0.02314  0.08451 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24845  0.17106  0.30352  0.06995  0.07694  0.02141  0.10867 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24462  0.17101  0.31295  0.06911  0.07955  0.02441  0.09835 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24932  0.16890  0.31707  0.07151  0.08282  0.02415  0.08623 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24951  0.17986  0.32562  0.06614  0.07835  0.02127  0.07926 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25145  0.17197  0.30706  0.07258  0.07785  0.02207  0.09702 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25417  0.17326  0.31491  0.07026  0.07839  0.02184  0.08716 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24086  0.17792  0.32431  0.07033  0.08015  0.02310  0.08332 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25049  0.17448  0.31686  0.07047  0.08116  0.01930  0.08723 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24846  0.17899  0.31622  0.06959  0.07448  0.02110  0.09117 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29302  0.18424  0.30865  0.09142  0.04337  0.01910  0.06021 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24506  0.17484  0.31464  0.07202  0.08069  0.02202  0.09074 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28924  0.18035  0.31051  0.09498  0.04277  0.01996  0.06220 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23493  0.18020  0.32196  0.07235  0.08237  0.01996  0.08823 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24566  0.17297  0.30668  0.06751  0.08354  0.02224  0.10139 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23392  0.17782  0.31834  0.06986  0.08244  0.01851  0.09911 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23409  0.17870  0.32991  0.07079  0.07861  0.01944  0.08846 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24896  0.17751  0.29734  0.06463  0.08468  0.02121  0.10567 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24919  0.16738  0.31110  0.07509  0.08163  0.02432  0.09129 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24456  0.17430  0.31115  0.07590  0.07807  0.02293  0.09308 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23999  0.17209  0.30408  0.07149  0.07897  0.02339  0.10997 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23682  0.17889  0.31766  0.06989  0.08049  0.02330  0.09295 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23836  0.16893  0.31205  0.07195  0.07961  0.02080  0.10831 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23399  0.17799  0.32314  0.07182  0.08117  0.02292  0.08897 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24870  0.17755  0.32368  0.07085  0.07704  0.02139  0.08079 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24985  0.16678  0.31443  0.07417  0.08388  0.02559  0.08529 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.27923  0.18882  0.30527  0.09688  0.03932  0.01903  0.07144 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24914  0.17378  0.31030  0.07275  0.08086  0.02058  0.09259 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24625  0.17877  0.31889  0.07259  0.07413  0.02100  0.08837 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24075  0.17082  0.31799  0.07236  0.07775  0.01918  0.10115 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25751  0.16978  0.30612  0.07109  0.07889  0.02265  0.09395 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25002  0.16861  0.30522  0.07273  0.08351  0.01910  0.10080 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24902  0.16997  0.31512  0.06955  0.07595  0.02104  0.09934 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25061  0.16487  0.31676  0.06791  0.08503  0.02088  0.09394 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29368  0.18489  0.30805  0.09201  0.04184  0.01946  0.06007 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24625  0.17217  0.31165  0.07295  0.07731  0.02281  0.09685 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24171  0.17102  0.30364  0.07041  0.08699  0.02531  0.10093 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25176  0.17218  0.31265  0.07487  0.08107  0.02361  0.08386 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24971  0.17102  0.30078  0.06803  0.07923  0.02224  0.10900 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24352  0.17793  0.32375  0.06665  0.07783  0.02453  0.08579 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25328  0.17240  0.31005  0.07194  0.08326  0.02546  0.08360 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24608  0.17939  0.30745  0.06842  0.07950  0.02514  0.09402 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24528  0.17722  0.32535  0.06632  0.07907  0.02298  0.08378 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25738  0.17102  0.31735  0.07129  0.07320  0.02275  0.08701 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23851  0.18290  0.31567  0.07245  0.08263  0.02083  0.08702 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24189  0.17137  0.32161  0.07273  0.08080  0.01966  0.09195 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25038  0.17206  0.32689  0.07144  0.07340  0.02227  0.08356 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25205  0.17028  0.31734  0.07210  0.07836  0.02377  0.08611 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25088  0.16946  0.31685  0.07303  0.08410  0.02236  0.08332 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25286  0.17237  0.31647  0.07015  0.07482  0.02078  0.09257 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25142  0.17437  0.31058  0.07276  0.07677  0.02090  0.09321 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25329  0.17145  0.30821  0.07005  0.07776  0.02505  0.09418 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23435  0.18025  0.31998  0.06898  0.07776  0.02218  0.09650 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25501  0.17660  0.30397  0.07030  0.07852  0.02274  0.09286 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24494  0.16447  0.32418  0.07785  0.07865  0.02282  0.08708 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25236  0.17425  0.31795  0.06655  0.07762  0.01960  0.09166 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24399  0.17446  0.31312  0.06760  0.07999  0.02431  0.09653 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24749  0.16621  0.31302  0.06849  0.08416  0.02368  0.09694 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25604  0.17064  0.30625  0.06741  0.07189  0.02120  0.10657 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23981  0.17352  0.31009  0.06900  0.08196  0.02385  0.10178 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24643  0.17588  0.31144  0.06992  0.08765  0.02501  0.08366 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24507  0.17674  0.31702  0.07238  0.07811  0.02146  0.08922 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23994  0.17360  0.30864  0.06655  0.08413  0.02443  0.10272 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25087  0.17572  0.31256  0.06819  0.07916  0.02341  0.09009 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.27722  0.19005  0.31292  0.09455  0.04422  0.01901  0.06203 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24124  0.18171  0.30798  0.07192  0.08531  0.02063  0.09122 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25585  0.17435  0.31577  0.07322  0.08114  0.02234  0.07734 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24739  0.16786  0.30524  0.07354  0.08641  0.02266  0.09689 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24639  0.16942  0.31442  0.07118  0.08115  0.02087  0.09657 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29076  0.17909  0.30576  0.09363  0.03911  0.01795  0.07371 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24730  0.17337  0.31426  0.06948  0.08291  0.02140  0.09128 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25228  0.17492  0.30984  0.07078  0.08049  0.02156  0.09013 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25228  0.16641  0.31731  0.07387  0.07118  0.02241  0.09654 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25508  0.17438  0.30965  0.07058  0.08079  0.02224  0.08727 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29547  0.17833  0.31056  0.09463  0.04004  0.02074  0.06023 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25301  0.18036  0.31509  0.06986  0.07885  0.02013  0.08270 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28592  0.17466  0.30112  0.09836  0.04519  0.01965  0.07511 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24550  0.17459  0.30209  0.07348  0.07622  0.02264  0.10549 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24453  0.18000  0.30783  0.07643  0.08260  0.02182  0.08678 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24798  0.17010  0.31343  0.07071  0.07478  0.02425  0.09876 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24553  0.18444  0.32045  0.06945  0.07498  0.02063  0.08452 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29385  0.18378  0.30500  0.09782  0.03916  0.01875  0.06164 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.27434  0.19550  0.31420  0.09677  0.04141  0.02024  0.05754 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24401  0.17637  0.30207  0.06547  0.08455  0.02349  0.10404 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24200  0.17259  0.33036  0.07332  0.07714  0.02006  0.08453 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24688  0.17409  0.31591  0.06833  0.07631  0.02013  0.09835 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23777  0.16895  0.32504  0.07295  0.07752  0.02100  0.09676 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24962  0.17104  0.31809  0.07257  0.08138  0.02287  0.08443 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24410  0.18205  0.30967  0.06453  0.07785  0.02151  0.10029 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25347  0.17171  0.31450  0.06638  0.07862  0.02450  0.09081 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25301  0.16862  0.31337  0.07126  0.07886  0.02296  0.09192 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23849  0.16973  0.31192  0.06923  0.08589  0.01977  0.10498 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23871  0.17971  0.30970  0.06382  0.07965  0.02133  0.10710 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24492  0.17601  0.31448  0.06638  0.08218  0.02095  0.09509 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23351  0.17498  0.32162  0.07042  0.08251  0.02097  0.09599 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25294  0.16741  0.29695  0.07041  0.08172  0.02367  0.10690 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24404  0.17565  0.31750  0.07000  0.08559  0.02047  0.08675 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24077  0.17481  0.31617  0.06742  0.08357  0.02170  0.09556 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25208  0.17539  0.30457  0.06981  0.07684  0.02154  0.09976 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24974  0.17806  0.31352  0.07599  0.07868  0.02222  0.08179 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24669  0.16743  0.30248  0.07235  0.07681  0.02352  0.11072 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24528  0.17253  0.31470  0.07071  0.08128  0.02182  0.09368 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23048  0.17988  0.32019  0.06613  0.08402  0.02339  0.09591 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24612  0.17751  0.30993  0.07032  0.07628  0.02214  0.09770 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23280  0.17842  0.30869  0.06942  0.08265  0.02194  0.10609 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23638  0.17989  0.30610  0.06834  0.07788  0.02213  0.10928 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23851  0.17666  0.32562  0.07172  0.07570  0.02257  0.08921 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23966  0.16622  0.31907  0.07004  0.07799  0.02434  0.10269 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23855  0.17455  0.31397  0.06767  0.07737  0.02040  0.10748 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25313  0.17105  0.30995  0.07610  0.08364  0.02226  0.08387 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25682  0.16720  0.30541  0.06287  0.08096  0.02065  0.10609 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26388  0.16926  0.30465  0.06816  0.07341  0.02547  0.09516 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24563  0.17281  0.30624  0.06880  0.08201  0.01921  0.10531 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24464  0.17295  0.32014  0.07181  0.07817  0.02141  0.09087 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25372  0.17086  0.30803  0.06817  0.07769  0.02306  0.09847 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23856  0.17832  0.30579  0.07130  0.07808  0.02291  0.10503 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24482  0.17043  0.31768  0.06703  0.08322  0.02487  0.09195 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23846  0.17490  0.31078  0.06763  0.07915  0.02147  0.10762 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24672  0.18370  0.31202  0.06661  0.07438  0.02263  0.09393 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24696  0.17552  0.31599  0.06992  0.08033  0.02133  0.08995 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.27786  0.18222  0.31003  0.09084  0.04486  0.02117  0.07304 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25427  0.17209  0.31361  0.07056  0.07846  0.02177  0.08925 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24989  0.17438  0.31142  0.07097  0.07973  0.02327  0.09034 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24956  0.17252  0.30034  0.06645  0.07819  0.02465  0.10829 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25284  0.17454  0.30850  0.06863  0.07739  0.02186  0.09623 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24993  0.17548  0.29678  0.07190  0.07878  0.02416  0.10298 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25297  0.17587  0.31234  0.07575  0.07587  0.02276  0.08445 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24259  0.17339  0.31880  0.07210  0.07431  0.02144  0.09737 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28573  0.18742  0.30262  0.09189  0.04178  0.02309  0.06747 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24318  0.17322  0.30668  0.07282  0.07557  0.02145  0.10708 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25036  0.17328  0.31476  0.07122  0.08379  0.01810  0.08848 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24299  0.17010  0.31272  0.07128  0.07408  0.02370  0.10513 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24344  0.17305  0.31586  0.07340  0.08188  0.02200  0.09037 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23959  0.17792  0.30621  0.06866  0.07784  0.02115  0.10863 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24407  0.17657  0.32201  0.07226  0.07452  0.02333  0.08724 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29326  0.18077  0.30809  0.09294  0.04301  0.02143  0.06051 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24894  0.17606  0.30442  0.07488  0.07904  0.02239  0.09427 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25908  0.17166  0.32258  0.07030  0.07697  0.02172  0.07769 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23740  0.17610  0.32176  0.07179  0.07705  0.02133  0.09457 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23910  0.17169  0.31402  0.07240  0.08484  0.02159  0.09636 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25905  0.17858  0.29863  0.06902  0.07312  0.02253  0.09908 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24299  0.16882  0.32253  0.06616  0.07796  0.02314  0.09839 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24507  0.17082  0.32032  0.07188  0.08060  0.02045  0.09087 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25692  0.16912  0.31334  0.06819  0.07671  0.02276  0.09295 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25387  0.17145  0.30609  0.06698  0.07977  0.02365  0.09820 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24948  0.18044  0.30457  0.06759  0.07940  0.02253  0.09599 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29001  0.18632  0.30474  0.09320  0.03749  0.02247  0.06577 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24958  0.18138  0.31238  0.07091  0.07276  0.02084  0.09214 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25761  0.16771  0.29802  0.06852  0.08313  0.02223  0.10277 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25027  0.17265  0.31884  0.06979  0.07573  0.02035  0.09237 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29627  0.18058  0.30676  0.09253  0.04055  0.01916  0.06416 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24382  0.17064  0.32597  0.07091  0.07837  0.02183  0.08846 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24999  0.16839  0.32288  0.07159  0.07455  0.02167  0.09093 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24561  0.17916  0.31256  0.06835  0.07843  0.02549  0.09039 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24602  0.16897  0.32352  0.07132  0.07778  0.02379  0.08860 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26057  0.16690  0.31423  0.06383  0.07802  0.02280  0.09364 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23787  0.18055  0.31523  0.07038  0.08633  0.02096  0.08868 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25815  0.17576  0.31738  0.06647  0.07264  0.02191  0.08769 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25326  0.17428  0.31548  0.07055  0.08110  0.02161  0.08373 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24237  0.17003  0.32424  0.07066  0.08230  0.02136  0.08904 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24380  0.17755  0.32656  0.06998  0.07701  0.02085  0.08426 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25069  0.18085  0.31899  0.06904  0.07697  0.02169  0.08176 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23558  0.16921  0.32949  0.07203  0.07925  0.02131  0.09313 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24922  0.17156  0.31647  0.07097  0.08285  0.02170  0.08723 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24667  0.17835  0.30812  0.06702  0.08378  0.02144  0.09462 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23299  0.17684  0.30927  0.07098  0.08335  0.02138  0.10520 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24704  0.17230  0.30475  0.06826  0.07877  0.02199  0.10690 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24942  0.16894  0.32063  0.07070  0.07846  0.02175  0.09010 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24747  0.16633  0.30383  0.07210  0.07754  0.02230  0.11044 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23657  0.17645  0.31474  0.07404  0.07926  0.02111  0.09784 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23908  0.17923  0.31475  0.06916  0.07954  0.02382  0.09442 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25055  0.16947  0.31585  0.06913  0.07766  0.02470  0.09263 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28627  0.18377  0.30429  0.09237  0.04370  0.02091  0.06868 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24416  0.18249  0.31036  0.06671  0.08315  0.02197  0.09116 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28058  0.18184  0.31158  0.09515  0.04592  0.02131  0.06361 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23545  0.17877  0.30379  0.07083  0.08391  0.02375  0.10350 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26107  0.16900  0.30954  0.06519  0.07742  0.02395  0.09385 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25372  0.17101  0.30936  0.07016  0.08673  0.02396  0.08506 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.30085  0.18149  0.29893  0.08887  0.03929  0.02094  0.06961 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25163  0.17090  0.31599  0.07583  0.06837  0.02310  0.09420 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24039  0.17104  0.31271  0.06931  0.08447  0.01903  0.10306 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24084  0.17760  0.31900  0.07286  0.07660  0.02021  0.09289 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24387  0.16995  0.32060  0.06864  0.08000  0.02203  0.09490 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24919  0.17718  0.30726  0.06812  0.08239  0.02432  0.09155 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24780  0.17451  0.31119  0.07220  0.08629  0.02020  0.08782 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29672  0.18472  0.31478  0.09031  0.03941  0.01868  0.05537 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24479  0.17462  0.31926  0.07045  0.08055  0.02398  0.08634 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25671  0.17388  0.31190  0.07109  0.08050  0.02194  0.08398 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23984  0.17585  0.31603  0.06884  0.07927  0.02447  0.09570 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24710  0.17626  0.31696  0.07004  0.07546  0.01899  0.09519 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24201  0.17459  0.31290  0.07056  0.07260  0.02430  0.10305 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24045  0.16870  0.31007  0.06876  0.07548  0.02304  0.11350 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25191  0.17132  0.31061  0.06665  0.08057  0.02280  0.09614 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24372  0.17733  0.30950  0.06985  0.08499  0.02392  0.09070 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24223  0.17285  0.31971  0.07182  0.07714  0.02088  0.09536 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25811  0.16900  0.30847  0.07029  0.07991  0.02136  0.09287 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26164  0.17267  0.30524  0.06508  0.08572  0.02146  0.08817 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29096  0.18621  0.31038  0.09544  0.03897  0.02162  0.05643 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24430  0.17754  0.30525  0.06941  0.08002  0.02075  0.10274 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24320  0.17847  0.31495  0.07091  0.08114  0.02036  0.09097 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24679  0.17728  0.31064  0.07141  0.07815  0.02199  0.09374 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25101  0.17178  0.31337  0.07114  0.08261  0.02423  0.08586 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25024  0.17198  0.31309  0.06564  0.07885  0.02507  0.09513 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24404  0.17217  0.30507  0.06780  0.07744  0.02226  0.11120 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29683  0.17752  0.30411  0.09320  0.04242  0.01977  0.06615 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24415  0.17747  0.30955  0.06905  0.07241  0.02728  0.10010 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25578  0.16969  0.30161  0.06806  0.07842  0.02453  0.10191 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24591  0.17210  0.32060  0.07193  0.07552  0.02377  0.09018 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28451  0.18895  0.30731  0.09420  0.04074  0.02174  0.06255 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24347  0.16908  0.31036  0.07087  0.08213  0.02213  0.10195 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24869  0.16960  0.31996  0.07436  0.07675  0.02185  0.08879 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23573  0.17622  0.31504  0.06585  0.07894  0.02345  0.10476 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24157  0.17384  0.30932  0.07271  0.08404  0.02386  0.09466 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24786  0.17964  0.30995  0.07303  0.07422  0.02322  0.09208 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24616  0.18031  0.29529  0.07053  0.09034  0.02123  0.09614 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25932  0.17326  0.31508  0.07114  0.07807  0.02095  0.08218 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24540  0.17438  0.31730  0.07058  0.07943  0.02375  0.08917 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24037  0.17455  0.31943  0.07438  0.07394  0.02621  0.09111 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24694  0.18108  0.31445  0.07103  0.07505  0.02388  0.08756 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23988  0.17724  0.31400  0.07022  0.08295  0.01978  0.09592 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24602  0.17791  0.31872  0.07033  0.07332  0.02128  0.09242 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25023  0.17249  0.31032  0.07411  0.07451  0.02376  0.09457 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24421  0.17554  0.31262  0.06905  0.08370  0.02242  0.09245 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24029  0.17071  0.31217  0.07354  0.08717  0.02328  0.09283 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23659  0.17073  0.31485  0.07322  0.07866  0.02154  0.10442 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24249  0.16758  0.31714  0.06634  0.08261  0.02115  0.10269 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24914  0.17418  0.31315  0.06729  0.08284  0.02287  0.09052 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24036  0.17720  0.31930  0.07416  0.08230  0.01881  0.08787 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28954  0.18038  0.30584  0.09695  0.04394  0.02047  0.06288 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24668  0.16763  0.31280  0.07290  0.08026  0.02246  0.09727 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24833  0.17203  0.32147  0.07244  0.07790  0.02259  0.08524 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25696  0.17594  0.30815  0.07425  0.07476  0.02004  0.08990 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24152  0.17526  0.31861  0.07338  0.07743  0.02212  0.09168 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24182  0.17404  0.32493  0.06684  0.08709  0.02302  0.08226 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23453  0.16702  0.31704  0.07272  0.07959  0.02114  0.10795 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29055  0.18716  0.30363  0.09416  0.03948  0.02225  0.06277 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29183  0.17835  0.30272  0.09356  0.04267  0.01958  0.07129 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23777  0.18065  0.31662  0.07013  0.08175  0.02018  0.09290 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29486  0.17935  0.30852  0.09712  0.04503  0.01862  0.05651 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24679  0.17499  0.31852  0.07066  0.07368  0.01944  0.09592 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24526  0.17924  0.31549  0.07274  0.07708  0.02022  0.08996 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25816  0.16526  0.30881  0.06509  0.07958  0.02194  0.10116 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25653  0.17261  0.30872  0.06490  0.08194  0.02359  0.09171 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25321  0.17103  0.31180  0.06611  0.08393  0.02112  0.09280 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23866  0.17851  0.30988  0.06751  0.08184  0.02230  0.10130 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24438  0.17448  0.31996  0.07220  0.07668  0.02112  0.09120 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24364  0.17507  0.32429  0.07100  0.07625  0.02132  0.08843 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25540  0.17315  0.31024  0.07145  0.07353  0.02513  0.09110 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24870  0.17292  0.31688  0.06842  0.08440  0.02285  0.08583 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25913  0.16918  0.31907  0.07323  0.07257  0.02524  0.08158 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23601  0.17606  0.31867  0.07071  0.07749  0.02044  0.10061 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24519  0.17761  0.30864  0.06742  0.08795  0.02063  0.09254 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25898  0.16609  0.31443  0.07049  0.07537  0.02140  0.09324 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24167  0.17557  0.30851  0.06943  0.07252  0.02028  0.11202 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24492  0.17476  0.32066  0.06668  0.07925  0.02406  0.08967 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24525  0.17140  0.31577  0.07056  0.08215  0.02310  0.09177 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23778  0.17050  0.30446  0.07146  0.08230  0.02352  0.10998 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23673  0.16915  0.31518  0.06985  0.07569  0.02327  0.11013 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25872  0.16169  0.30285  0.06842  0.07723  0.02205  0.10905 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25430  0.16657  0.30944  0.07037  0.07832  0.01913  0.10187 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24883  0.17764  0.31250  0.06749  0.07998  0.02294  0.09063 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23796  0.17548  0.32352  0.07024  0.07153  0.02245  0.09883 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24834  0.18573  0.31771  0.06914  0.08060  0.01938  0.07909 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24405  0.17242  0.31038  0.07364  0.07788  0.02323  0.09839 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25342  0.17861  0.30825  0.06559  0.07731  0.02137  0.09546 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25487  0.17398  0.30976  0.07085  0.07198  0.02124  0.09731 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24770  0.17405  0.30503  0.06709  0.07985  0.02200  0.10429 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25038  0.17884  0.31413  0.07202  0.07350  0.02097  0.09017 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24057  0.17261  0.30852  0.07168  0.07788  0.02148  0.10727 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25071  0.16922  0.31748  0.07029  0.07531  0.01988  0.09710 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28737  0.18402  0.30639  0.08937  0.04406  0.02329  0.06551 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24274  0.17055  0.31857  0.07429  0.07780  0.02224  0.09381 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24796  0.17147  0.32215  0.06909  0.07851  0.02330  0.08753 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24346  0.16994  0.32114  0.07360  0.07530  0.01920  0.09737 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24425  0.17493  0.31542  0.06648  0.08132  0.02337  0.09423 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24226  0.17836  0.31804  0.07017  0.08382  0.02381  0.08354 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23809  0.17765  0.31682  0.07339  0.08380  0.02119  0.08906 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24269  0.16901  0.31028  0.07147  0.08743  0.02528  0.09386 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25788  0.17454  0.30306  0.06847  0.08280  0.02178  0.09148 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24855  0.17533  0.31375  0.06982  0.08033  0.02358  0.08863 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25579  0.17023  0.31376  0.06989  0.07618  0.02315  0.09101 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24702  0.17270  0.31764  0.07068  0.08004  0.02215  0.08977 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24575  0.17511  0.31190  0.06884  0.07539  0.02262  0.10039 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29341  0.18337  0.30499  0.09145  0.04489  0.02019  0.06170 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25013  0.16684  0.31575  0.07569  0.07528  0.01976  0.09655 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24315  0.17810  0.30764  0.07187  0.08167  0.02367  0.09391 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24520  0.17040  0.31746  0.07125  0.08006  0.02174  0.09389 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24369  0.16797  0.30683  0.06901  0.08522  0.02283  0.10446 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28997  0.18162  0.30547  0.09644  0.04173  0.01943  0.06535 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24969  0.17752  0.32132  0.06963  0.07761  0.02049  0.08374 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24486  0.18180  0.31344  0.07557  0.07810  0.02336  0.08286 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25808  0.17385  0.30829  0.07396  0.07885  0.01995  0.08702 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24038  0.17446  0.31876  0.07124  0.07972  0.02431  0.09112 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24698  0.17167  0.30988  0.06764  0.08566  0.02086  0.09731 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24625  0.17906  0.31385  0.07168  0.07840  0.02166  0.08910 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24772  0.17232  0.31317  0.06604  0.08138  0.02331  0.09606 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23997  0.17683  0.31357  0.06885  0.09283  0.01927  0.08868 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24801  0.16961  0.31391  0.07263  0.08563  0.02054  0.08967 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25546  0.17484  0.30755  0.06926  0.08082  0.02216  0.08990 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23819  0.17506  0.31518  0.07079  0.08515  0.01959  0.09605 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24192  0.18128  0.31199  0.06907  0.08208  0.02042  0.09323 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23656  0.17702  0.32604  0.06833  0.07368  0.02198  0.09639 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24233  0.17167  0.30629  0.07070  0.07832  0.02331  0.10738 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28633  0.18350  0.31057  0.09388  0.03717  0.02006  0.06849 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24806  0.17761  0.31651  0.06958  0.08200  0.02264  0.08360 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24493  0.17071  0.32031  0.06884  0.07913  0.02047  0.09559 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24544  0.17438  0.31932  0.06784  0.07626  0.02291  0.09386 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24561  0.17176  0.31891  0.07018  0.07517  0.02368  0.09470 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23711  0.17187  0.31374  0.07432  0.07960  0.02222  0.10114 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24667  0.17707  0.31638  0.07220  0.07876  0.02161  0.08730 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24806  0.17151  0.30944  0.06418  0.08205  0.01981  0.10495 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24648  0.17822  0.31369  0.06745  0.08367  0.02461  0.08587 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24581  0.17270  0.31023  0.06580  0.07883  0.02152  0.10511 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24426  0.16741  0.30564  0.06875  0.07890  0.02011  0.11493 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24541  0.17253  0.31745  0.07010  0.08179  0.02286  0.08986 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.30941  0.18018  0.29408  0.09439  0.04613  0.02035  0.05545 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24133  0.17274  0.31194  0.07623  0.07779  0.02418  0.09580 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23888  0.16990  0.31240  0.07518  0.07737  0.02395  0.10232 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25592  0.17416  0.32524  0.06818  0.07775  0.01914  0.07960 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25031  0.17547  0.31679  0.07055  0.08556  0.02264  0.07867 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24637  0.17334  0.30941  0.07284  0.08084  0.02528  0.09192 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25327  0.17280  0.30757  0.07189  0.07634  0.02331  0.09481 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24230  0.17554  0.32359  0.07685  0.07832  0.02348  0.07993 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24231  0.18265  0.31818  0.06698  0.07529  0.02174  0.09284 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24765  0.17250  0.30681  0.06670  0.08123  0.02273  0.10239 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24840  0.17395  0.30547  0.07751  0.08448  0.02283  0.08735 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24877  0.17193  0.32021  0.07003  0.07872  0.02014  0.09021 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25044  0.17014  0.31884  0.07363  0.07571  0.02175  0.08950 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25063  0.17414  0.31861  0.07090  0.07098  0.02354  0.09120 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24551  0.17212  0.29906  0.07122  0.07530  0.02057  0.11623 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28327  0.18875  0.31259  0.08982  0.03597  0.01927  0.07034 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25125  0.17086  0.31801  0.06567  0.07711  0.02628  0.09082 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24368  0.17217  0.33158  0.07022  0.07529  0.02196  0.08510 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25797  0.17365  0.31067  0.06966  0.07851  0.02280  0.08673 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24921  0.17270  0.31614  0.07224  0.08277  0.01876  0.08818 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29624  0.17927  0.30662  0.09384  0.04181  0.01817  0.06406 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25718  0.16986  0.30553  0.06835  0.08692  0.01916  0.09299 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24777  0.17839  0.32690  0.07153  0.07164  0.02036  0.08341 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24007  0.16704  0.30335  0.06749  0.08741  0.02332  0.11132 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24308  0.17515  0.31472  0.07427  0.07998  0.02230  0.09050 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29222  0.18164  0.30961  0.09863  0.03692  0.02099  0.05998 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24020  0.17166  0.31458  0.06743  0.08164  0.02262  0.10187 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24163  0.17209  0.31779  0.07039  0.07837  0.02317  0.09655 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23858  0.16584  0.32281  0.07230  0.08073  0.02345  0.09629 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24201  0.17433  0.32081  0.07107  0.08096  0.02178  0.08904 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23646  0.17792  0.31410  0.07629  0.08007  0.02194  0.09322 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24269  0.17032  0.30545  0.07333  0.07565  0.02342  0.10915 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24760  0.17070  0.30503  0.07522  0.07921  0.02364  0.09861 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25266  0.17233  0.31505  0.06815  0.07645  0.01992  0.09545 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29657  0.17938  0.30413  0.09202  0.04287  0.02076  0.06428 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24697  0.17361  0.32230  0.07007  0.08095  0.02131  0.08479 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24022  0.17395  0.32188  0.06420  0.08068  0.02245  0.09661 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24356  0.17890  0.31512  0.07416  0.07944  0.02330  0.08552 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24664  0.17913  0.32208  0.06896  0.08081  0.02483  0.07755 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24632  0.17581  0.31512  0.07467  0.07596  0.02466  0.08747 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.30062  0.17677  0.30503  0.09107  0.04170  0.01873  0.06608 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23646  0.17434  0.32188  0.07274  0.07536  0.02504  0.09419 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24848  0.17481  0.31996  0.07152  0.06996  0.02397  0.09131 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24342  0.16852  0.30819  0.06915  0.07965  0.01950  0.11156 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25057  0.16711  0.29972  0.06494  0.08164  0.02083  0.11519 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24700  0.17457  0.31247  0.07164  0.07993  0.02283  0.09155 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23327  0.17711  0.31849  0.07187  0.07951  0.02369  0.09607 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24772  0.16864  0.31054  0.06721  0.07417  0.02575  0.10597 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28465  0.18436  0.30719  0.09998  0.04260  0.01851  0.06271 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25117  0.17968  0.30843  0.07218  0.08618  0.01991  0.08245 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24617  0.16856  0.31179  0.06777  0.08907  0.02264  0.09400 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29076  0.18106  0.30994  0.09449  0.04031  0.01898  0.06446 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23382  0.17642  0.30973  0.07588  0.07791  0.02425  0.10198 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25358  0.16730  0.30748  0.06956  0.07436  0.02172  0.10599 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24920  0.17358  0.32170  0.07210  0.07267  0.02495  0.08580 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.27927  0.18353  0.30811  0.09292  0.04641  0.02299  0.06678 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24723  0.17002  0.31934  0.06800  0.07272  0.02342  0.09928 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25940  0.17150  0.30907  0.07126  0.07921  0.02559  0.08396 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25517  0.16939  0.31048  0.06862  0.08132  0.02218  0.09284 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24973  0.16901  0.30915  0.06696  0.07860  0.02147  0.10507 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23532  0.17142  0.31962  0.07610  0.07955  0.02398  0.09401 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24177  0.16902  0.31110  0.06772  0.08249  0.02261  0.10531 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29042  0.18100  0.30443  0.09756  0.04170  0.01918  0.06571 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25151  0.16959  0.31355  0.07212  0.07330  0.02344  0.09650 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24922  0.18009  0.31461  0.07140  0.07456  0.02570  0.08441 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25780  0.17189  0.30323  0.06629  0.08182  0.02111  0.09785 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24258  0.17519  0.31064  0.07029  0.07470  0.02443  0.10217 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24255  0.18096  0.31769  0.06991  0.08258  0.02381  0.08250 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25035  0.17679  0.31801  0.07294  0.07359  0.02247  0.08585 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23521  0.17398  0.31237  0.06904  0.08202  0.02262  0.10476 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24351  0.17074  0.30666  0.06946  0.07997  0.02029  0.10938 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24690  0.17658  0.30722  0.07179  0.08399  0.01970  0.09383 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24789  0.17971  0.31776  0.06383  0.07960  0.02020  0.09103 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25351  0.17084  0.31072  0.06948  0.07893  0.02400  0.09252 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24347  0.16893  0.32245  0.07343  0.07746  0.02063  0.09364 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24934  0.17200  0.32561  0.06809  0.08019  0.02086  0.08390 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29112  0.18529  0.30005  0.09691  0.03921  0.01842  0.06899 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24281  0.17919  0.31335  0.07243  0.07877  0.02240  0.09104 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24565  0.17459  0.30025  0.06643  0.08023  0.02492  0.10793 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29716  0.18506  0.29919  0.09586  0.03953  0.02036  0.06284 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24209  0.17318  0.32131  0.07132  0.07965  0.02286  0.08960 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25294  0.17019  0.31031  0.06679  0.08528  0.02342  0.09107 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25806  0.17174  0.30312  0.06917  0.07655  0.01851  0.10284 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24645  0.16819  0.30746  0.07068  0.08104  0.02395  0.10224 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23822  0.17243  0.30586  0.06511  0.08302  0.02009  0.11527 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23767  0.18840  0.31206  0.06692  0.08134  0.02147  0.09214 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25186  0.16333  0.31012  0.07221  0.07995  0.01951  0.10302 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28820  0.18695  0.30713  0.08897  0.03931  0.02271  0.06673 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23641  0.17470  0.31679  0.07394  0.08229  0.01907  0.09679 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25921  0.16866  0.30539  0.06862  0.08076  0.01965  0.09772 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24331  0.17698  0.30648  0.07210  0.08242  0.02424  0.09446 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25442  0.16882  0.29736  0.06583  0.08234  0.02133  0.10990 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24338  0.17363  0.29759  0.06635  0.08649  0.01897  0.11359 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24690  0.17474  0.29953  0.06960  0.08324  0.02391  0.10208 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24406  0.17537  0.32082  0.06852  0.08021  0.02245  0.08858 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25180  0.16304  0.31470  0.07053  0.08327  0.02283  0.09383 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29601  0.18511  0.30912  0.09214  0.03849  0.02165  0.05749 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26058  0.16598  0.29542  0.07057  0.07849  0.02558  0.10338 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24365  0.17862  0.31366  0.06932  0.07664  0.02091  0.09720 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25772  0.16959  0.30354  0.07078  0.08327  0.02137  0.09373 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24201  0.17677  0.32053  0.06633  0.08000  0.02356  0.09080 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25203  0.17031  0.31479  0.07210  0.07792  0.02199  0.09087 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24678  0.17410  0.32522  0.06817  0.07446  0.02333  0.08794 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24835  0.17149  0.30595  0.06493  0.07702  0.02467  0.10758 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24540  0.16916  0.30617  0.07084  0.08742  0.01974  0.10126 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24992  0.17880  0.31182  0.06991  0.08299  0.02386  0.08269 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25783  0.17348  0.30195  0.07300  0.08245  0.01966  0.09163 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24266  0.17849  0.31154  0.07340  0.08362  0.02226  0.08804 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25039  0.17083  0.31712  0.06865  0.07280  0.02506  0.09515 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24302  0.17530  0.32676  0.06911  0.07908  0.02118  0.08555 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24262  0.17907  0.31403  0.07023  0.08092  0.02167  0.09146 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24653  0.17290  0.31539  0.06954  0.07900  0.02037  0.09627 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23898  0.17882  0.30365  0.07474  0.08198  0.02103  0.10082 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28963  0.17988  0.30766  0.09237  0.04271  0.02005  0.06770 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24440  0.17920  0.32370  0.07325  0.07755  0.02318  0.07871 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24965  0.17328  0.31614  0.06695  0.07677  0.02063  0.09657 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24632  0.17189  0.30664  0.07058  0.07965  0.02321  0.10172 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29637  0.18397  0.31047  0.08849  0.04194  0.02230  0.05645 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28888  0.19094  0.30022  0.09164  0.04416  0.02081  0.06333 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24677  0.16625  0.32321  0.06867  0.07818  0.02396  0.09295 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25058  0.16988  0.31298  0.07623  0.07700  0.01869  0.09464 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23540  0.17328  0.33438  0.07366  0.07954  0.02312  0.08063 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23967  0.17701  0.32339  0.07005  0.07977  0.01964  0.09047 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24228  0.16812  0.31291  0.06787  0.08182  0.01899  0.10801 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24953  0.17073  0.30947  0.06625  0.07750  0.02259  0.10392 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25049  0.17482  0.30970  0.07020  0.08340  0.02157  0.08983 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25233  0.17160  0.30217  0.07282  0.07987  0.02085  0.10036 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23488  0.17715  0.31248  0.07197  0.08386  0.02407  0.09559 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25560  0.17067  0.29742  0.06623  0.08519  0.02041  0.10446 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24472  0.17445  0.30999  0.07004  0.08298  0.02487  0.09296 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24012  0.17474  0.30747  0.06646  0.08056  0.02306  0.10758 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24942  0.16782  0.29879  0.07210  0.08202  0.02176  0.10809 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26015  0.17704  0.31456  0.06529  0.07888  0.02283  0.08124 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24015  0.17401  0.32414  0.06565  0.08263  0.02048  0.09294 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24609  0.16565  0.31076  0.06993  0.07982  0.02222  0.10555 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23866  0.17135  0.32883  0.07175  0.08313  0.02076  0.08552 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24856  0.17409  0.30743  0.06793  0.08015  0.02049  0.10136 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28350  0.18527  0.31046  0.09100  0.04085  0.02135  0.06757 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24980  0.17957  0.31316  0.07141  0.07975  0.02202  0.08429 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23624  0.17408  0.30790  0.07104  0.07967  0.02265  0.10843 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24438  0.17520  0.31191  0.06631  0.07862  0.01961  0.10397 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24936  0.16562  0.31114  0.07384  0.07931  0.02216  0.09857 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25460  0.17779  0.30943  0.06407  0.08201  0.02152  0.09058 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24762  0.17361  0.31562  0.07235  0.07894  0.02232  0.08954 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24079  0.17670  0.31089  0.06991  0.07845  0.02382  0.09945 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.22356  0.18087  0.32170  0.07449  0.08196  0.02218  0.09523 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23717  0.17569  0.30225  0.06935  0.07973  0.02342  0.11239 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28694  0.18825  0.30929  0.08981  0.04224  0.02093  0.06255 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26087  0.17461  0.32075  0.06967  0.07666  0.02339  0.07404 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23433  0.17180  0.32217  0.06908  0.08178  0.02478  0.09605 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25822  0.16800  0.30732  0.06628  0.07697  0.02396  0.09925 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23279  0.16658  0.31683  0.07228  0.07739  0.02224  0.11189 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23343  0.17649  0.30703  0.07023  0.08406  0.02335  0.10541 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23646  0.17798  0.31399  0.07233  0.08068  0.02299  0.09557 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23883  0.18020  0.31127  0.07191  0.07917  0.02606  0.09257 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28405  0.18173  0.31676  0.09668  0.04108  0.01833  0.06137 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25092  0.17261  0.31791  0.07064  0.07816  0.02250  0.08726 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25454  0.17234  0.30142  0.06974  0.07759  0.02288  0.10150 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25762  0.17285  0.30944  0.06874  0.07920  0.02345  0.08870 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23882  0.18089  0.31503  0.07004  0.07597  0.02232  0.09692 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.22918  0.16865  0.30809  0.07012  0.08902  0.02192  0.11302 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24991  0.17745  0.31689  0.06608  0.07998  0.02308  0.08661 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24960  0.17695  0.30200  0.06645  0.08255  0.02245  0.10001 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24386  0.17320  0.31343  0.06937  0.08479  0.02087  0.09449 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24089  0.17632  0.31840  0.07343  0.07897  0.02287  0.08911 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24545  0.16978  0.30908  0.06815  0.08034  0.02473  0.10247 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24398  0.18012  0.31292  0.07223  0.08022  0.02164  0.08889 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24590  0.17103  0.30797  0.07049  0.07802  0.02011  0.10648 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29428  0.18287  0.30197  0.09413  0.03931  0.01986  0.06759 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24521  0.17098  0.30900  0.07453  0.08004  0.02230  0.09794 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25428  0.17738  0.30914  0.07204  0.07566  0.02617  0.08533 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24010  0.18118  0.32676  0.06690  0.07352  0.02494  0.08660 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24043  0.17634  0.31985  0.06955  0.07670  0.02113  0.09600 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24004  0.17402  0.31844  0.07365  0.08181  0.02065  0.09139 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24746  0.17461  0.32456  0.06663  0.06799  0.02419  0.09456 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23361  0.17235  0.31728  0.07356  0.07847  0.02250  0.10223 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25037  0.17901  0.31514  0.06746  0.08192  0.01969  0.08642 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23589  0.17576  0.31197  0.07363  0.08257  0.02344  0.09674 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24193  0.17501  0.32728  0.07061  0.07249  0.02279  0.08989 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24436  0.17693  0.30929  0.06671  0.08012  0.02147  0.10112 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29861  0.18174  0.30135  0.09712  0.04008  0.02102  0.06009 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24815  0.17233  0.30306  0.06697  0.07822  0.02478  0.10648 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24039  0.16879  0.31633  0.07184  0.08487  0.02457  0.09321 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24767  0.17197  0.31514  0.06862  0.08048  0.02058  0.09554 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24458  0.17397  0.31151  0.07009  0.07952  0.02444  0.09589 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25118  0.17480  0.30548  0.06796  0.07973  0.02090  0.09995 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24795  0.17412  0.31149  0.06667  0.08236  0.02094  0.09647 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24529  0.17137  0.32867  0.07455  0.07595  0.02300  0.08118 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24792  0.17672  0.30902  0.07430  0.07540  0.01877  0.09786 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24648  0.16914  0.31319  0.06884  0.08425  0.02118  0.09692 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24760  0.17490  0.31277  0.06971  0.07664  0.02166  0.09673 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24635  0.17080  0.31252  0.06701  0.07087  0.02231  0.11015 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28578  0.18586  0.31498  0.09273  0.04370  0.02108  0.05588 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28620  0.18271  0.30247  0.09622  0.04661  0.02155  0.06425 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24664  0.17874  0.31050  0.07469  0.07916  0.02057  0.08969 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23991  0.17580  0.32471  0.06971  0.07815  0.02284  0.08888 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24989  0.17455  0.31304  0.06898  0.07917  0.02101  0.09336 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25073  0.17502  0.31356  0.07491  0.08071  0.02262  0.08244 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24672  0.17344  0.30076  0.06706  0.08313  0.02195  0.10693 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23838  0.18025  0.31009  0.07588  0.07571  0.02047  0.09922 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24438  0.17313  0.31292  0.06971  0.08143  0.02230  0.09613 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25241  0.17794  0.30888  0.06655  0.07938  0.02298  0.09186 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24865  0.17353  0.32348  0.06497  0.08267  0.02291  0.08379 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24933  0.17063  0.30609  0.07191  0.08046  0.02200  0.09957 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24368  0.17126  0.30971  0.07577  0.08178  0.02410  0.09369 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28973  0.18422  0.30342  0.09771  0.04351  0.01671  0.06470 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29648  0.17936  0.30715  0.09196  0.04278  0.02037  0.06191 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25109  0.16655  0.30816  0.06540  0.07974  0.02341  0.10565 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24364  0.17840  0.30396  0.07175  0.08326  0.02196  0.09703 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24551  0.17043  0.32045  0.06783  0.07732  0.02269  0.09576 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25879  0.17907  0.30912  0.07464  0.07729  0.02474  0.07634 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24362  0.17970  0.31917  0.07227  0.07627  0.01959  0.08939 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24572  0.17226  0.30872  0.07361  0.08717  0.02326  0.08926 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24642  0.17201  0.31350  0.07130  0.07673  0.02280  0.09723 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23702  0.17925  0.31757  0.06662  0.08103  0.02544  0.09306 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24890  0.17402  0.30770  0.07070  0.08043  0.02263  0.09561 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25098  0.17462  0.31231  0.06847  0.08460  0.01980  0.08922 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24961  0.17844  0.31494  0.07228  0.07663  0.02500  0.08309 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23841  0.18081  0.31922  0.06819  0.07701  0.02360  0.09276 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24355  0.17336  0.32192  0.06778  0.08517  0.02028  0.08794 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25142  0.17475  0.30328  0.07285  0.07459  0.02356  0.09955 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24525  0.17362  0.31430  0.07572  0.07477  0.02190  0.09444 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25676  0.17859  0.31350  0.06351  0.08026  0.02529  0.08208 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23539  0.18370  0.30412  0.07305  0.08631  0.02004  0.09738 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24073  0.18027  0.32596  0.07370  0.07708  0.02384  0.07842 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24572  0.16709  0.31777  0.07143  0.08119  0.02676  0.09004 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28554  0.18719  0.30531  0.09359  0.04546  0.02309  0.05982 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24986  0.17015  0.31653  0.07468  0.08059  0.02338  0.08483 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25232  0.16631  0.30503  0.06872  0.08260  0.02083  0.10418 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24729  0.17771  0.31756  0.07053  0.07469  0.02571  0.08651 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25221  0.16472  0.29574  0.07397  0.08297  0.02260  0.10778 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24441  0.17676  0.30561  0.07436  0.07453  0.02237  0.10196 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24320  0.17269  0.31905  0.07271  0.07569  0.02226  0.09440 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24437  0.17701  0.31389  0.07200  0.07792  0.02376  0.09105 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24910  0.17691  0.30945  0.06664  0.08175  0.02278  0.09337 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24737  0.17252  0.30960  0.06926  0.08783  0.02205  0.09136 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24868  0.17164  0.31805  0.06983  0.07394  0.02279  0.09507 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24601  0.18385  0.30915  0.07143  0.07800  0.02428  0.08727 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24469  0.17943  0.31818  0.06952  0.08093  0.02523  0.08203 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25224  0.17084  0.31095  0.06738  0.08262  0.02360  0.09237 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24588  0.17252  0.31702  0.07252  0.08223  0.02518  0.08465 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25457  0.17400  0.31676  0.07093  0.07897  0.01794  0.08683 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25044  0.18186  0.32133  0.06980  0.07737  0.02211  0.07709 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23771  0.17531  0.31522  0.07291  0.07929  0.02362  0.09595 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25451  0.17183  0.29363  0.07098  0.08139  0.02468  0.10299 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25203  0.17047  0.31555  0.07311  0.07797  0.02128  0.08959 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23584  0.17380  0.30713  0.07588  0.07403  0.02135  0.11197 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24416  0.17315  0.30664  0.06372  0.08015  0.02080  0.11138 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24856  0.16855  0.30858  0.06651  0.08791  0.02427  0.09562 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24083  0.17265  0.31911  0.06732  0.08060  0.02582  0.09366 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23614  0.17176  0.31763  0.07398  0.08297  0.02390  0.09363 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28687  0.18245  0.30904  0.09778  0.03944  0.02125  0.06317 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24668  0.17493  0.30935  0.06860  0.08167  0.02216  0.09661 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24467  0.17722  0.31470  0.06997  0.08100  0.02112  0.09131 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24181  0.16850  0.32527  0.06841  0.07699  0.02011  0.09891 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24264  0.17779  0.32736  0.06920  0.08253  0.02035  0.08012 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25608  0.17442  0.31256  0.07250  0.07482  0.02518  0.08444 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24258  0.17088  0.31159  0.07418  0.08425  0.02384  0.09268 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25117  0.16958  0.31504  0.07259  0.07807  0.01919  0.09436 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24251  0.16770  0.32382  0.07376  0.08325  0.02019  0.08877 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24463  0.17454  0.32061  0.07285  0.07828  0.02528  0.08381 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24865  0.17532  0.31284  0.07215  0.08375  0.02591  0.08138 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25178  0.17519  0.30638  0.06646  0.07394  0.02513  0.10112 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24851  0.17994  0.31041  0.07086  0.07803  0.02081  0.09143 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24872  0.17379  0.30961  0.06882  0.08540  0.02307  0.09058 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25042  0.18255  0.31096  0.06655  0.07458  0.02066  0.09428 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24739  0.16766  0.31658  0.06928  0.08384  0.02502  0.09024 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24749  0.17169  0.32133  0.06779  0.08055  0.02368  0.08747 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24590  0.17409  0.31204  0.06804  0.08079  0.02103  0.09811 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24756  0.17204  0.32189  0.06997  0.08050  0.02237  0.08567 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23858  0.17706  0.30238  0.06877  0.08672  0.02161  0.10489 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25332  0.17332  0.30459  0.06627  0.08037  0.02279  0.09934 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25221  0.16797  0.30542  0.06761  0.09325  0.01892  0.09462 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24439  0.17550  0.31130  0.06636  0.08199  0.02301  0.09745 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24240  0.17662  0.31862  0.07434  0.07698  0.01883  0.09221 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25197  0.16974  0.31847  0.06952  0.07946  0.01989  0.09096 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25169  0.17107  0.30626  0.07270  0.07950  0.01956  0.09923 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24898  0.17117  0.30947  0.06872  0.08028  0.02118  0.10020 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24298  0.17196  0.32287  0.06389  0.07776  0.02142  0.09911 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24557  0.17440  0.31202  0.07117  0.07976  0.02392  0.09318 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25612  0.17509  0.30899  0.07022  0.07576  0.02349  0.09033 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24607  0.17664  0.32193  0.07266  0.07607  0.02329  0.08333 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24547  0.16702  0.32124  0.06730  0.07426  0.02283  0.10188 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24732  0.17487  0.31950  0.07415  0.07109  0.02108  0.09199 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24332  0.17787  0.31096  0.07656  0.07956  0.02086  0.09088 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24690  0.17219  0.31784  0.06399  0.08663  0.02456  0.08789 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24678  0.16343  0.30269  0.07230  0.08808  0.01948  0.10725 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24253  0.16646  0.31183  0.07142  0.08242  0.02498  0.10037 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24846  0.17117  0.32544  0.07233  0.08002  0.02219  0.08039 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29920  0.17299  0.30833  0.08985  0.04136  0.02220  0.06607 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24707  0.17202  0.30674  0.06818  0.08448  0.02165  0.09987 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24742  0.17217  0.31301  0.06416  0.08119  0.02042  0.10164 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24864  0.17598  0.30785  0.06859  0.07845  0.02143  0.09906 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.30161  0.17750  0.30303  0.09402  0.04104  0.02008  0.06272 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25294  0.16897  0.31273  0.06209  0.07950  0.02269  0.10108 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26121  0.16753  0.31379  0.06565  0.08060  0.02000  0.09122 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25403  0.17224  0.30669  0.06892  0.07854  0.02682  0.09276 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24268  0.17336  0.30544  0.06491  0.08136  0.02439  0.10785 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24570  0.16904  0.31292  0.07850  0.08915  0.02005  0.08464 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25606  0.16344  0.31258  0.06990  0.07909  0.02545  0.09348 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24102  0.17717  0.32445  0.06982  0.07159  0.02170  0.09425 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24233  0.18014  0.31415  0.06971  0.07783  0.02505  0.09079 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24862  0.17803  0.32046  0.06740  0.08173  0.02248  0.08127 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29435  0.18805  0.30485  0.09406  0.03839  0.02179  0.05850 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24393  0.17829  0.32578  0.06879  0.08107  0.02219  0.07995 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23807  0.17685  0.31094  0.07149  0.08197  0.01965  0.10103 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25519  0.17488  0.31438  0.06521  0.08133  0.02202  0.08698 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28676  0.18264  0.30203  0.09237  0.04706  0.02438  0.06476 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25790  0.16698  0.30576  0.06416  0.07791  0.02325  0.10403 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23611  0.17752  0.32633  0.07205  0.07830  0.02279  0.08691 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24410  0.17677  0.31240  0.06772  0.08400  0.02351  0.09149 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24542  0.17715  0.30324  0.06615  0.07524  0.02476  0.10803 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24403  0.16755  0.30774  0.06961  0.08289  0.02245  0.10572 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24591  0.17192  0.31666  0.07707  0.08231  0.02222  0.08390 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23602  0.17968  0.31696  0.07195  0.08594  0.02406  0.08538 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24914  0.16422  0.30893  0.07025  0.07812  0.02466  0.10467 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28937  0.17723  0.31056  0.09759  0.03800  0.01864  0.06859 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25209  0.17494  0.31137  0.06847  0.08212  0.02052  0.09050 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24220  0.17237  0.31052  0.06956  0.08533  0.02256  0.09746 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24802  0.17749  0.30969  0.06793  0.07746  0.02206  0.09735 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23041  0.17380  0.31593  0.06731  0.08494  0.02389  0.10371 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24898  0.17065  0.31160  0.07320  0.08479  0.02380  0.08697 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25439  0.17252  0.31559  0.06578  0.07933  0.02353  0.08886 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24737  0.17625  0.30361  0.07298  0.07606  0.02351  0.10021 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24783  0.17351  0.32084  0.07295  0.07708  0.02530  0.08249 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24986  0.17617  0.30549  0.06381  0.07974  0.02167  0.10326 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26253  0.17546  0.31494  0.06343  0.07534  0.02123  0.08705 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24702  0.17519  0.31447  0.06819  0.08313  0.02221  0.08978 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24998  0.16729  0.31337  0.07354  0.08784  0.02619  0.08179 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24444  0.17565  0.32239  0.06929  0.07847  0.02127  0.08850 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24801  0.17012  0.31021  0.07006  0.07613  0.02112  0.10434 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24468  0.18502  0.31298  0.07101  0.08192  0.02092  0.08345 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24142  0.17029  0.31808  0.07585  0.07872  0.02181  0.09382 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25472  0.16760  0.31135  0.06897  0.07863  0.02296  0.09577 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24467  0.17660  0.30277  0.06761  0.08024  0.02310  0.10501 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24355  0.17171  0.30567  0.06916  0.08227  0.02358  0.10406 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24492  0.16698  0.31362  0.06997  0.07927  0.02016  0.10509 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24624  0.17001  0.32485  0.07222  0.07959  0.02444  0.08264 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24119  0.18071  0.31070  0.06684  0.08394  0.02021  0.09642 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25198  0.17583  0.32173  0.07195  0.07399  0.02114  0.08338 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24030  0.17608  0.31759  0.07079  0.07754  0.02350  0.09421 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25327  0.17348  0.30330  0.06711  0.07920  0.02198  0.10166 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24151  0.17054  0.29663  0.07061  0.08334  0.02253  0.11482 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25407  0.17174  0.29749  0.06996  0.07813  0.02502  0.10359 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24765  0.16798  0.30375  0.06858  0.07914  0.02168  0.11121 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24029  0.17373  0.31722  0.06938  0.07768  0.02080  0.10091 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24586  0.17119  0.32373  0.07080  0.07187  0.02419  0.09236 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25673  0.17240  0.29622  0.07183  0.07977  0.02202  0.10102 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24245  0.17654  0.31758  0.06720  0.07613  0.02182  0.09828 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25580  0.16953  0.30996  0.06825  0.08460  0.02260  0.08926 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24695  0.17559  0.31451  0.07364  0.08092  0.02345  0.08494 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25248  0.17479  0.30819  0.06853  0.07581  0.02222  0.09798 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23931  0.16470  0.31481  0.06906  0.08624  0.02074  0.10514 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25094  0.17475  0.30523  0.06983  0.07678  0.02271  0.09977 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24221  0.17021  0.31227  0.06832  0.08026  0.02476  0.10198 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23937  0.17572  0.31252  0.06752  0.08805  0.02243  0.09440 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25251  0.16988  0.31109  0.07109  0.07621  0.02048  0.09873 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24031  0.17017  0.32210  0.07235  0.08056  0.02077  0.09374 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24192  0.17573  0.32258  0.07188  0.08160  0.02302  0.08327 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24720  0.18096  0.32827  0.06966  0.07484  0.02039  0.07868 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24097  0.17465  0.32305  0.07446  0.07297  0.02717  0.08673 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23589  0.17876  0.31005  0.07083  0.08319  0.02343  0.09786 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25239  0.17130  0.30863  0.06891  0.07973  0.02232  0.09672 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23674  0.17295  0.32622  0.06986  0.08558  0.02362  0.08504 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24793  0.17632  0.30991  0.07621  0.07386  0.02178  0.09399 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25205  0.17044  0.30542  0.06925  0.07935  0.02525  0.09825 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24306  0.16808  0.31285  0.06970  0.07798  0.02315  0.10517 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25667  0.17431  0.31167  0.06452  0.07521  0.02251  0.09510 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28036  0.19494  0.30831  0.09032  0.04074  0.02106  0.06426 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24277  0.17021  0.31792  0.07008  0.08262  0.02074  0.09566 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25495  0.17684  0.30803  0.06831  0.08264  0.02346  0.08577 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24420  0.16973  0.30343  0.07091  0.08048  0.02293  0.10832 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24804  0.17449  0.31801  0.06794  0.07477  0.02307  0.09367 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24511  0.17875  0.31709  0.07187  0.07659  0.02046  0.09014 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23997  0.17128  0.31753  0.06965  0.07751  0.02125  0.10281 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24734  0.16807  0.31354  0.07043  0.08203  0.01994  0.09865 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25489  0.17186  0.30148  0.06763  0.07594  0.02090  0.10730 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24832  0.16877  0.32261  0.06973  0.07963  0.02297  0.08797 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24863  0.17545  0.31227  0.06817  0.07696  0.02364  0.09487 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24768  0.16575  0.30991  0.06781  0.07747  0.02098  0.11041 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25531  0.17438  0.29687  0.06862  0.09063  0.02127  0.09292 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29010  0.18852  0.30329  0.09645  0.03864  0.01860  0.06442 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24688  0.17406  0.31624  0.06645  0.07857  0.02288  0.09493 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24786  0.16744  0.31503  0.07155  0.07631  0.02505  0.09676 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24192  0.17258  0.30806  0.07536  0.07996  0.02501  0.09711 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25411  0.17827  0.31177  0.07424  0.07689  0.02066  0.08405 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24460  0.16867  0.30515  0.07189  0.08130  0.02358  0.10481 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24140  0.18248  0.31042  0.07216  0.07605  0.02463  0.09286 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25356  0.17741  0.30243  0.06826  0.08668  0.02182  0.08983 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.26563  0.17089  0.30594  0.06764  0.07783  0.02204  0.09003 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23587  0.17718  0.32241  0.06539  0.08701  0.02200  0.09013 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25192  0.17186  0.30531  0.06955  0.07607  0.01865  0.10664 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25524  0.17968  0.30478  0.06480  0.08138  0.02046  0.09366 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24299  0.16951  0.31959  0.06859  0.07306  0.02242  0.10385 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24079  0.17645  0.32424  0.06997  0.07655  0.02188  0.09012 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25286  0.17240  0.31955  0.07129  0.07636  0.02080  0.08673 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24584  0.17004  0.30449  0.07024  0.07792  0.02465  0.10681 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25450  0.17188  0.30773  0.06865  0.08167  0.02096  0.09461 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28612  0.18245  0.30466  0.09722  0.03947  0.02204  0.06804 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24003  0.17682  0.31175  0.07433  0.08151  0.02127  0.09428 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24480  0.17214  0.31784  0.06984  0.08134  0.02012  0.09391 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25186  0.16797  0.30780  0.06766  0.07593  0.02341  0.10537 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24762  0.17643  0.31486  0.07360  0.08426  0.02049  0.08274 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24498  0.17676  0.31696  0.06804  0.07709  0.02125  0.09492 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24972  0.17831  0.31403  0.06743  0.08141  0.02145  0.08766 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24975  0.17493  0.29736  0.06840  0.08244  0.01934  0.10778 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24033  0.17279  0.32236  0.06419  0.07734  0.02080  0.10219 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24768  0.17297  0.30988  0.06986  0.07959  0.02222  0.09781 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24104  0.17197  0.32330  0.06952  0.07952  0.02343  0.09123 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25011  0.17316  0.32124  0.07152  0.07892  0.02044  0.08462 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25830  0.16700  0.31179  0.07205  0.08272  0.02358  0.08456 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23456  0.17916  0.32092  0.07637  0.07213  0.02111  0.09575 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24771  0.17424  0.31025  0.07042  0.07897  0.02401  0.09439 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24380  0.17570  0.30342  0.06898  0.08316  0.02131  0.10363 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28602  0.18802  0.30924  0.09724  0.03893  0.02169  0.05886 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25190  0.17804  0.30968  0.06740  0.08521  0.02413  0.08364 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24314  0.17632  0.31862  0.07068  0.07311  0.02260  0.09553 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29730  0.17698  0.30590  0.09748  0.04185  0.01971  0.06079 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24938  0.17457  0.31155  0.06919  0.07983  0.02199  0.09350 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25104  0.17383  0.30461  0.06570  0.07676  0.02393  0.10412 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25001  0.17227  0.31480  0.07653  0.07710  0.02401  0.08528 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25276  0.17386  0.31579  0.07060  0.07876  0.02290  0.08533 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24209  0.17140  0.31764  0.07048  0.08427  0.02353  0.09059 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24309  0.17586  0.32056  0.07123  0.07933  0.02251  0.08741 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24747  0.16966  0.31783  0.06871  0.07774  0.02456  0.09403 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28817  0.18587  0.30448  0.09946  0.03585  0.01996  0.06621 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24302  0.17245  0.32031  0.07164  0.08046  0.01871  0.09341 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23889  0.17970  0.30531  0.06718  0.08006  0.02292  0.10595 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24470  0.17267  0.31580  0.06467  0.08330  0.02347  0.09539 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24296  0.17551  0.30793  0.07076  0.08236  0.02215  0.09834 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25325  0.17264  0.30342  0.07320  0.08549  0.02292  0.08908 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23785  0.16886  0.31662  0.07064  0.08560  0.02124  0.09919 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25099  0.17725  0.31167  0.06965  0.07755  0.02274  0.09014 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29025  0.18289  0.31290  0.09501  0.04327  0.02063  0.05505 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25511  0.17317  0.30465  0.06921  0.07556  0.01787  0.10443 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24801  0.17376  0.31163  0.07216  0.08255  0.02110  0.09080 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.30124  0.18301  0.30137  0.09460  0.04080  0.01698  0.06200 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24468  0.17210  0.32927  0.07252  0.08018  0.02294  0.07832 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23529  0.17252  0.31281  0.06909  0.07823  0.02231  0.10975 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25653  0.16845  0.30604  0.06979  0.07949  0.02120  0.09849 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24203  0.17460  0.31448  0.07193  0.08203  0.02282  0.09212 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25049  0.17687  0.30945  0.07042  0.07614  0.02377  0.09285 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24769  0.16385  0.30900  0.06486  0.07908  0.02316  0.11236 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23769  0.17195  0.30510  0.06878  0.08644  0.02011  0.10994 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24757  0.16683  0.31817  0.06408  0.07596  0.02329  0.10412 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23965  0.17238  0.31500  0.06956  0.07876  0.02438  0.10027 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25837  0.17291  0.30740  0.07125  0.07925  0.02332  0.08750 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24574  0.16503  0.31823  0.07500  0.07705  0.02166  0.09729 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25653  0.16924  0.29974  0.06412  0.07558  0.02415  0.11065 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24088  0.17029  0.29943  0.07647  0.08847  0.02271  0.10175 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24663  0.17080  0.31674  0.07071  0.08259  0.02461  0.08792 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25659  0.18109  0.30867  0.06952  0.07530  0.01932  0.08953 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25357  0.18131  0.31747  0.07411  0.07491  0.01982  0.07881 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24383  0.17129  0.32039  0.07272  0.07925  0.02528  0.08725 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25276  0.17025  0.32025  0.06926  0.07458  0.02335  0.08955 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24957  0.17112  0.31745  0.06565  0.07852  0.02497  0.09271 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25363  0.18142  0.31201  0.07130  0.07472  0.01918  0.08774 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25657  0.17300  0.30505  0.07053  0.08099  0.02255  0.09131 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24723  0.17099  0.31895  0.06937  0.08450  0.02369  0.08528 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24392  0.16949  0.32123  0.06989  0.07664  0.02429  0.09454 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25885  0.16488  0.31347  0.07216  0.07536  0.02161  0.09367 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24112  0.17063  0.30980  0.06654  0.07826  0.02495  0.10870 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24719  0.16889  0.30202  0.07019  0.07816  0.02401  0.10953 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24640  0.17499  0.31582  0.07493  0.08325  0.02292  0.08170 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25625  0.16953  0.31306  0.07228  0.08294  0.02243  0.08351 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24230  0.17560  0.31392  0.07025  0.08726  0.01936  0.09130 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25759  0.16901  0.31449  0.06437  0.07590  0.02086  0.09777 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24854  0.16800  0.31892  0.07412  0.07140  0.02049  0.09852 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24479  0.17553  0.31241  0.07136  0.08200  0.02013  0.09378 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24326  0.17601  0.31440  0.06758  0.08086  0.02283  0.09506 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24405  0.16524  0.30973  0.06690  0.08217  0.02302  0.10888 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24652  0.17598  0.31817  0.07249  0.07891  0.02443  0.08351 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23630  0.18303  0.32871  0.07414  0.07595  0.02380  0.07808 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24731  0.17361  0.31202  0.07065  0.07866  0.02260  0.09515 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24090  0.17844  0.30247  0.07326  0.08573  0.02003  0.09917 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24916  0.17476  0.32611  0.07133  0.07278  0.02045  0.08542 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25733  0.17986  0.31050  0.07139  0.07798  0.02358  0.07935 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29158  0.18193  0.30944  0.09137  0.04132  0.01985  0.06450 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24305  0.17828  0.31065  0.07085  0.08177  0.02234  0.09307 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24931  0.16864  0.31140  0.07171  0.07643  0.02375  0.09876 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25511  0.17640  0.30860  0.06857  0.07103  0.02655  0.09375 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24029  0.18733  0.30049  0.06339  0.08283  0.02043  0.10523 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25165  0.17465  0.31568  0.07429  0.08154  0.02246  0.07973 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25444  0.17392  0.31645  0.06655  0.08118  0.02108  0.08638 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23984  0.17229  0.31228  0.06937  0.08059  0.02351  0.10212 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24361  0.17033  0.31148  0.07117  0.07590  0.02021  0.10729 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24841  0.16832  0.31124  0.06377  0.08467  0.02074  0.10285 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.30170  0.18545  0.30644  0.09363  0.03855  0.02018  0.05404 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23736  0.17450  0.31741  0.06964  0.08175  0.02491  0.09443 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24729  0.16801  0.30367  0.06577  0.08459  0.01938  0.11129 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24294  0.16593  0.30625  0.06813  0.08214  0.02264  0.11197 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24521  0.16636  0.31194  0.07029  0.07626  0.02403  0.10591 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24746  0.17729  0.30208  0.06912  0.07720  0.02290  0.10395 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23425  0.17440  0.30278  0.07119  0.07752  0.02360  0.11627 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24049  0.17368  0.32708  0.06883  0.07858  0.02292  0.08842 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23535  0.17545  0.32477  0.07129  0.08258  0.01960  0.09096 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24630  0.17171  0.30982  0.07412  0.08230  0.02233  0.09342 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24543  0.17268  0.32585  0.07071  0.07509  0.02452  0.08571 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25037  0.17402  0.30845  0.07079  0.07195  0.02127  0.10315 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24816  0.17538  0.32001  0.06996  0.07914  0.02219  0.08516 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24558  0.17737  0.31098  0.07138  0.08092  0.02039  0.09338 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25324  0.17114  0.30944  0.07463  0.07795  0.02488  0.08871 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24854  0.17236  0.32410  0.06842  0.07425  0.02305  0.08929 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24028  0.18238  0.32124  0.06964  0.07714  0.01789  0.09143 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24776  0.17494  0.32383  0.06909  0.07599  0.02205  0.08634 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24830  0.16709  0.31601  0.06487  0.07235  0.02306  0.10834 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25644  0.17253  0.30820  0.07348  0.07893  0.02466  0.08575 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23780  0.17953  0.30948  0.06970  0.07861  0.02048  0.10439 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29114  0.18745  0.30542  0.08625  0.04261  0.02190  0.06524 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24448  0.17719  0.30661  0.06935  0.07859  0.01967  0.10410 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24679  0.17012  0.30717  0.07661  0.06950  0.02161  0.10819 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24360  0.17238  0.31031  0.06865  0.08356  0.02103  0.10047 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24461  0.17492  0.29965  0.06999  0.08199  0.02160  0.10723 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25323  0.16835  0.30998  0.06889  0.08974  0.02131  0.08851 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24406  0.17752  0.32091  0.06783  0.07638  0.02060  0.09271 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25332  0.17012  0.30632  0.07024  0.08013  0.02172  0.09815 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24778  0.17278  0.30110  0.07132  0.08310  0.02135  0.10257 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25225  0.17205  0.31209  0.06746  0.08143  0.02518  0.08953 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25196  0.17443  0.30715  0.07376  0.07901  0.02488  0.08882 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24641  0.17312  0.32295  0.06709  0.08026  0.02028  0.08990 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25674  0.16850  0.30968  0.06875  0.08305  0.02203  0.09126 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24787  0.16884  0.31348  0.06751  0.08752  0.02457  0.09022 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23538  0.18098  0.33057  0.07146  0.08111  0.02558  0.07492 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24588  0.17360  0.32029  0.07232  0.07552  0.02268  0.08972 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24474  0.17103  0.32254  0.07006  0.07527  0.02140  0.09496 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24999  0.16223  0.31172  0.06736  0.08374  0.02084  0.10413 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25582  0.17124  0.29925  0.07157  0.08089  0.02303  0.09821 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25191  0.17386  0.31413  0.07073  0.07736  0.02169  0.09033 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24231  0.17643  0.32041  0.06830  0.07938  0.02411  0.08907 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24833  0.17660  0.32022  0.07012  0.07454  0.02357  0.08662 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25749  0.18037  0.30924  0.06940  0.08261  0.02271  0.07818 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25010  0.18211  0.31711  0.07540  0.07135  0.02385  0.08008 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25183  0.16811  0.30710  0.06512  0.08236  0.01902  0.10646 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.29620  0.18572  0.29551  0.10013  0.04311  0.02071  0.05863 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25855  0.16820  0.31680  0.06840  0.07701  0.02217  0.08887 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23856  0.17291  0.31249  0.07221  0.07562  0.02254  0.10568 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24367  0.17687  0.30496  0.06834  0.08295  0.02083  0.10239 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24629  0.17075  0.31178  0.06873  0.08038  0.02256  0.09951 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24213  0.17110  0.30744  0.07341  0.08229  0.02416  0.09947 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24324  0.17009  0.30925  0.06832  0.07822  0.02127  0.10961 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25504  0.17089  0.29961  0.07010  0.07459  0.02186  0.10791 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24363  0.17914  0.32051  0.07282  0.07681  0.01971  0.08738 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24285  0.17379  0.31977  0.07485  0.07952  0.01770  0.09153 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24872  0.17646  0.30789  0.06978  0.08245  0.02148  0.09322 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24964  0.16482  0.31039  0.07285  0.07684  0.01916  0.10631 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25676  0.17461  0.31524  0.07147  0.07601  0.02188  0.08402 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25052  0.16658  0.31943  0.07033  0.08182  0.02269  0.08862 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24698  0.16993  0.30396  0.06679  0.08243  0.02530  0.10461 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23686  0.16914  0.31733  0.07173  0.08336  0.02533  0.09625 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24893  0.17059  0.31667  0.07336  0.07951  0.02403  0.08691 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.24518  0.17715  0.31286  0.07053  0.07439  0.02295  0.09695 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.22982  0.17866  0.31887  0.07356  0.08169  0.01928  0.09813 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23724  0.17979  0.32448  0.07336  0.08100  0.02141  0.08271 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23711  0.17066  0.31935  0.06763  0.07784  0.02536  0.10205 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25342  0.17220  0.31766  0.07086  0.07781  0.01943  0.08862 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28669  0.18332  0.31290  0.08967  0.04545  0.02008  0.06188 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.28769  0.18022  0.30918  0.09497  0.04048  0.01980  0.06766 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23828  0.18297  0.31295  0.07469  0.08490  0.01959  0.08661 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.25162  0.17698  0.31774  0.07030  0.07826  0.02371  0.08140 \n",
      "  acinar    alpha     beta    delta     duct    gamma stellate \n",
      " 0.23318  0.17771  0.31867  0.07444  0.07895  0.02418  0.09287 \n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Warning message in data.table::melt(RESULTS):\n",
      "“data.table 中的 melt 泛型函数被传递了 matrix 即将转向到 reshape2 中的相关方法；请注意 reshape2 已经弃用，这个转向也已经弃用。如果要在 data.table 和 reshape2 同时附着的情况下继续使用 reshape2 中的 melt 方法，（例如 melt.list），你可以把命名空间写在函数名称前面，例如 reshape2::melt(RESULTS)。在下一个版本中，此警告将变成为错误。”\n",
      "Warning message in data.table::melt(P, id.vars = \"CT\"):\n",
      "“data.table 中的 melt 泛型函数被传递了 data.frame 即将转向到 reshape2 中的相关方法；请注意 reshape2 已经弃用，这个转向也已经弃用。如果要在 data.table 和 reshape2 同时附着的情况下继续使用 reshape2 中的 melt 方法，（例如 melt.list），你可以把命名空间写在函数名称前面，例如 reshape2::melt(P)。在下一个版本中，此警告将变成为错误。”\n"
     ]
    }
   ],
   "source": [
    "source(\"../SCCAF-D/benchmark1.R\")\n",
    "source(\"../SCCAF-D/deconvolution1.R\")\n",
    "source(\"../../Rscript/framework1.R\")\n",
    "source(\"../SCCAF-D/DWLS.R\")\n",
    "setwd(\"/home/feng_shuo/deconvolution/SCCAF-D-test/\")\n",
    "df <- c('integrated_baron_opt.rds')\n",
    "bulk_methods =c('nnls','FARDEEP','EpiDISH','RLR')\n",
    "sc_methods = c(\"DWLS\")\n",
    "deconvolution = c(sc_methods)\n",
    "transformation <- 'none'\n",
    "norm <- 'TMM'\n",
    "NormTrans <- 'T'\n",
    "files=c()\n",
    "for (i in 1:length(df)){\n",
    "  files[i] <- strsplit(df[i],split = \"\\\\.\")[[1]][1]\n",
    "}\n",
    " for (method in deconvolution) {\n",
    "        if (method %in% sc_methods) {\n",
    "            deconv_type <- 'sc'\n",
    "            norm2 <- norm\n",
    "        } else {\n",
    "            deconv_type <- 'bulk'\n",
    "            norm2 <- 'all'\n",
    "        }\n",
    "        for (i in 1:length(df)) {\n",
    "            path <- paste(getwd(), \"/DWLS_\", files[i], sep = \"\")\n",
    "            setwd(\"/home/feng_shuo/deconvolution/SCCAF-D-test/\")\n",
    "            param_bulkreal <- c(\"pseudobulk_Baron_T.rds\",df[i], transformation, deconv_type, norm, norm2, method, 10000,\"none\", 1, NormTrans)\n",
    "            print(param_bulkreal)\n",
    "            #\n",
    "            tryCatch({\n",
    "                results <- bulk_reference(param_bulkreal)\n",
    "                setwd(\"/home/feng_shuo/deconvolution/SCCAF-D-test/\")\n",
    "                saveRDS(results, paste0(files[i], \"_\", method, \"_2024-8-8\", \"_pancreas_cross\", \".rds\"))\n",
    "            }, error = function(e) {\n",
    "                cat(\"Error with df[\", i, \"] and method \", method, \": \", conditionMessage(e), \"\\n\")\n",
    "            })\n",
    "    }\n",
    "}"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "45cd7314-d4ca-484a-b709-ada298d49041",
   "metadata": {},
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "id": "3a0d78a8-e39d-4623-a95f-524b7ed9800b",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "R version 4.3.1 (2023-06-16)\n",
       "Platform: x86_64-conda-linux-gnu (64-bit)\n",
       "Running under: CentOS Linux 7 (Core)\n",
       "\n",
       "Matrix products: default\n",
       "BLAS/LAPACK: /home/feng_shuo/miniconda3/envs/deconvolution/lib/libopenblasp-r0.3.24.so;  LAPACK version 3.11.0\n",
       "\n",
       "locale:\n",
       " [1] LC_CTYPE=zh_CN.UTF-8       LC_NUMERIC=C              \n",
       " [3] LC_TIME=zh_CN.UTF-8        LC_COLLATE=zh_CN.UTF-8    \n",
       " [5] LC_MONETARY=zh_CN.UTF-8    LC_MESSAGES=zh_CN.UTF-8   \n",
       " [7] LC_PAPER=zh_CN.UTF-8       LC_NAME=C                 \n",
       " [9] LC_ADDRESS=C               LC_TELEPHONE=C            \n",
       "[11] LC_MEASUREMENT=zh_CN.UTF-8 LC_IDENTIFICATION=C       \n",
       "\n",
       "time zone: Asia/Shanghai\n",
       "tzcode source: system (glibc)\n",
       "\n",
       "attached base packages:\n",
       "[1] stats4    stats     graphics  grDevices utils     datasets  methods  \n",
       "[8] base     \n",
       "\n",
       "other attached packages:\n",
       " [1] MAST_1.26.0                 SingleCellExperiment_1.22.0\n",
       " [3] SummarizedExperiment_1.30.2 GenomicRanges_1.52.0       \n",
       " [5] GenomeInfoDb_1.36.1         IRanges_2.34.1             \n",
       " [7] S4Vectors_0.38.1            varhandle_2.0.6            \n",
       " [9] ROCR_1.0-11                 SeuratObject_4.1.4         \n",
       "[11] Seurat_4.4.0                e1071_1.7-13               \n",
       "[13] reshape_0.8.9               quadprog_1.5-8             \n",
       "[15] Biobase_2.60.0              BiocGenerics_0.46.0        \n",
       "[17] reshape2_1.4.4              sparseMatrixStats_1.12.2   \n",
       "[19] MatrixGenerics_1.12.2       matrixStats_1.0.0          \n",
       "[21] Matrix_1.6-1                pheatmap_1.0.12            \n",
       "[23] dplyr_1.1.3                 limma_3.56.2               \n",
       "\n",
       "loaded via a namespace (and not attached):\n",
       "  [1] RColorBrewer_1.1-3      jsonlite_1.8.7          magrittr_2.0.3         \n",
       "  [4] spatstat.utils_3.0-5    zlibbioc_1.46.0         vctrs_0.6.3            \n",
       "  [7] spatstat.explore_3.2-3  RCurl_1.98-1.12         base64enc_0.1-3        \n",
       " [10] progress_1.2.2          S4Arrays_1.2.0          htmltools_0.5.6.1      \n",
       " [13] sctransform_0.4.0       parallelly_1.36.0       KernSmooth_2.23-22     \n",
       " [16] htmlwidgets_1.6.2       ica_1.0-3               plyr_1.8.9             \n",
       " [19] plotly_4.10.2           zoo_1.8-12              uuid_1.1-1             \n",
       " [22] igraph_1.5.1            mime_0.12               lifecycle_1.0.3        \n",
       " [25] pkgconfig_2.0.3         R6_2.5.1                fastmap_1.1.1          \n",
       " [28] GenomeInfoDbData_1.2.10 fitdistrplus_1.1-11     future_1.33.0          \n",
       " [31] shiny_1.7.5             digest_0.6.33           colorspace_2.1-0       \n",
       " [34] patchwork_1.1.3         tensor_1.5              irlba_2.3.5.1          \n",
       " [37] progressr_0.14.0        fansi_1.0.5             spatstat.sparse_3.0-2  \n",
       " [40] httr_1.4.7              polyclip_1.10-6         abind_1.4-5            \n",
       " [43] compiler_4.3.1          proxy_0.4-27            withr_2.5.1            \n",
       " [46] MASS_7.3-60             DelayedArray_0.26.6     gtools_3.9.4           \n",
       " [49] tools_4.3.1             lmtest_0.9-40           httpuv_1.6.11          \n",
       " [52] future.apply_1.11.0     goftest_1.2-3           glue_1.6.2             \n",
       " [55] nlme_3.1-163            promises_1.2.1          grid_4.3.1             \n",
       " [58] pbdZMQ_0.3-10           Rtsne_0.16              cluster_2.1.4          \n",
       " [61] generics_0.1.3          gtable_0.3.4            spatstat.data_3.0-1    \n",
       " [64] class_7.3-22            tidyr_1.3.0             hms_1.1.3              \n",
       " [67] data.table_1.14.8       XVector_0.40.0          sp_2.1-0               \n",
       " [70] utf8_1.2.3              spatstat.geom_3.2-5     RcppAnnoy_0.0.21       \n",
       " [73] ggrepel_0.9.3           RANN_2.6.1              pillar_1.9.0           \n",
       " [76] stringr_1.5.0           IRdisplay_1.1           later_1.3.1            \n",
       " [79] splines_4.3.1           lattice_0.21-9          survival_3.5-7         \n",
       " [82] deldir_1.0-9            tidyselect_1.2.0        locfit_1.5-9.8         \n",
       " [85] miniUI_0.1.1.1          pbapply_1.7-2           gridExtra_2.3          \n",
       " [88] edgeR_4.0.6             scattermore_1.2         stringi_1.7.12         \n",
       " [91] lazyeval_0.2.2          evaluate_0.22           codetools_0.2-19       \n",
       " [94] tibble_3.2.1            cli_3.6.1               uwot_0.1.16            \n",
       " [97] IRkernel_1.3.2          xtable_1.8-4            reticulate_1.32.0      \n",
       "[100] repr_1.1.6              munsell_0.5.0           Rcpp_1.0.12            \n",
       "[103] globals_0.16.2          spatstat.random_3.1-6   png_0.1-8              \n",
       "[106] parallel_4.3.1          ellipsis_0.3.2          ggplot2_3.4.3          \n",
       "[109] prettyunits_1.2.0       sceasy_0.0.7            bitops_1.0-7           \n",
       "[112] listenv_0.9.0           viridisLite_0.4.2       scales_1.2.1           \n",
       "[115] ggridges_0.5.4          leiden_0.4.3            purrr_1.0.2            \n",
       "[118] crayon_1.5.2            rlang_1.1.1             cowplot_1.1.1          "
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "sessionInfo()"
   ]
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  {
   "cell_type": "code",
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  {
   "cell_type": "code",
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   "id": "2d486424-6f85-4d2c-b50b-9d55f894de14",
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  {
   "cell_type": "code",
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   "id": "5c60e3d9-f59d-4a5a-8897-9f9780c597c7",
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   "cell_type": "code",
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  {
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