From f84e162b6c401d27740bbe9e96fd79f358b967ae Mon Sep 17 00:00:00 2001 From: vicpaton Date: Thu, 4 Jul 2024 02:16:50 +0200 Subject: [PATCH] updated vignettes --- docs/src/vignettes/1_simple_example.ipynb | 11039 ++++++++------------ docs/src/vignettes/2_moon.ipynb | 368 +- 2 files changed, 4429 insertions(+), 6978 deletions(-) diff --git a/docs/src/vignettes/1_simple_example.ipynb b/docs/src/vignettes/1_simple_example.ipynb index f9dbad2..f21670f 100644 --- a/docs/src/vignettes/1_simple_example.ipynb +++ b/docs/src/vignettes/1_simple_example.ipynb @@ -24,7 +24,7 @@ "\n", "2. Perform DGE analysis with DESeq2 and TF activity estimation with the CollecTRI GRN and decoupler-py (univariate linear model) to obtain the sign of the perturbation's effects.\n", "\n", - "3. Contextualise the network signalling network, using EGFR as perturbation (inhibited by Afatinib) and TFs as measurements, using several baseline methodologies.\n", + "3. Contextualise the network signalling network, using EGFR as perturbation (inhibited by Afatinib) and TFs as measurements, using several causal and topological methodologies.\n", "\n", "4. Visualise the networks." ] @@ -424,22 +424,22 @@ " They will be converted to hyphens ('-').\n", " self.obsm[\"design_matrix\"] = build_design_matrix(\n", "Fitting size factors...\n", - "... done in 0.03 seconds.\n", + "... done in 0.05 seconds.\n", "\n", "Fitting dispersions...\n", - "... done in 8.22 seconds.\n", + "... done in 7.90 seconds.\n", "\n", "Fitting dispersion trend curve...\n", - "... done in 0.64 seconds.\n", + "... done in 0.71 seconds.\n", "\n", "Fitting MAP dispersions...\n", - "... done in 8.62 seconds.\n", + "... done in 8.24 seconds.\n", "\n", "Fitting LFCs...\n", - "... done in 4.67 seconds.\n", + "... done in 4.74 seconds.\n", "\n", "Calculating cook's distance...\n", - "... done in 0.09 seconds.\n", + "... done in 0.08 seconds.\n", "\n", "Replacing 32 outlier genes.\n", "\n", @@ -481,7 +481,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "... done in 2.15 seconds.\n", + "... done in 2.10 seconds.\n", "\n" ] } @@ -490,6 +490,26 @@ "results = nc.data.omics.deseq2(singlec_countdata, singlec_metadata, test_group=\"ASPC_AFATINIB\", ref_group=\"ASPC_DMSO\")" ] }, + { + "cell_type": "code", + "execution_count": 7, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "nc.visual.build_volcano_plot(results)" + ] + }, { "cell_type": "markdown", "metadata": {}, @@ -500,7 +520,7 @@ }, { "cell_type": "code", - "execution_count": 7, + "execution_count": 8, "metadata": {}, "outputs": [], "source": [ @@ -518,11 +538,11 @@ }, { "cell_type": "code", - "execution_count": 8, + "execution_count": 9, "metadata": {}, "outputs": [], "source": [ - "measurements = nc._utils.targetlayer_formatter(dc_estimates.T)" + "measurements = nc.utils.targetlayer_formatter(dc_estimates.T)" ] }, { @@ -539,186 +559,186 @@ "We have now our set of TF measurements, which we will use as footprints of the perturbation induced by Afatinib. We will use these to contextualised a general PPI network retrieved from OmniPath." ] }, - { - "cell_type": "code", - "execution_count": 9, - "metadata": {}, - "outputs": [], - "source": [ - "network = nc.data.network.omnipath.get_omnipath()" - ] - }, { "cell_type": "code", "execution_count": 10, "metadata": {}, "outputs": [], "source": [ - "graph = nc._utils.network_from_df(network)" - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "Afatinib targets EGFR by inhibition, so we will create a source dictionary containing the origin of perturbation, EGFR, and the sign of the perturbation (negative, therefore -1)." + "network = nc.data.network.get_omnipath()" ] }, { "cell_type": "code", "execution_count": 11, "metadata": {}, - "outputs": [], - "source": [ - "source_df = pd.DataFrame({'source': ['EGFR'], \n", - " 'sign': [-1]}, columns=['source', 'sign'])\n", - "source_df.set_index('source', inplace=True)\n", - "sources = source_df['sign'].to_dict()" - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "### 2.1 CORNETO" - ] - }, - { - "cell_type": "code", - "execution_count": 12, - "metadata": {}, "outputs": [ { "data": { + "text/html": [ + "
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('MAPK14', 'EIF4EBP1', {'sign': -1}), ('MAPK14', 'SIAH2', {'sign': -1}), ('MAPK14', 'PIAS2', {'sign': -1}), ('MAPK14', 'ZNHIT1', {'sign': -1}), ('MAPK14', 'TWIST1', {'sign': -1}), ('MAPK14', 'GATA2', {'sign': -1}), ('MAPK14', 'CASP3', {'sign': -1}), ('MAPK14', 'CDC25C', {'sign': -1}), ('MAPK14', 'SLC9A1', {'sign': -1}), ('MAPK14', 'RB1', {'sign': -1}), ('MAPK14', 'CDX2', {'sign': -1}), ('MAPK14', 'RBSN', {'sign': -1}), ('MAPK14', 'GSK3B', {'sign': -1}), ('MAPK14', 'EEF2K', {'sign': -1}), ('MAPK14', 'MEF2A', {'sign': -1}), ('MAPK14', 'PAK6', {'sign': -1}), ('MAPK14', 'NCOA3', {'sign': -1}), ('MAPK14', 'H3-3A', {'sign': -1}), ('MAPK14', 'PIP4K2B', {'sign': -1}), ('MAPK14', 'ADAM17', {'sign': -1}), ('MAPK14', 'ESR1', {'sign': -1}), ('MAPK14', 'H3C12', {'sign': -1}), ('MAPK14', 'FGFR1', {'sign': -1}), ('MAPK14', 'EZH2', {'sign': -1}), ('MAPK14', 'BAZ1B', {'sign': -1}), ('MAPK14', 'KRT8', {'sign': -1}), ('MAPK14', 'CASP8', {'sign': -1}), ('MAPK14', 'CDKN1C', {'sign': -1}), ('MAPK14', 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{'sign': -1}), ('TIAL1', 'GADD45A', {'sign': -1}), ('NOTCH1', 'PAX8', {'sign': -1}), ('NOTCH1', 'FOXI2', {'sign': -1}), ('NOTCH1', 'WNT1', {'sign': -1}), ('NOTCH1', 'ATOH1', {'sign': -1}), ('NOTCH1', 'HES5', {'sign': -1}), ('NOTCH1', 'SOX2', {'sign': -1}), ('NOTCH1', 'BMP4', {'sign': -1}), ('NOTCH1', 'HES1', {'sign': -1}), ('NOTCH1', 'RBPJ', {'sign': -1}), ('NOTCH1', 'LEF1', {'sign': -1}), ('NOTCH1', 'SNW1', {'sign': -1}), ('NOTCH1', 'CHUK', {'sign': -1}), ('NOTCH1', 'MEF2C', {'sign': -1}), ('NOTCH1', 'HIF1A', {'sign': -1}), ('NOTCH1', 'SMAD1', {'sign': -1}), ('NOTCH1', 'RRAS', {'sign': -1}), ('NOTCH1', 'ZMIZ1', {'sign': -1}), ('ZIC1', 'ATOH1', {'sign': -1}), ('ZIC1', 'GLI1', {'sign': -1}), ('ZIC1', 'GLI3', {'sign': -1}), ('ATOH1', 'HES5', {'sign': -1}), ('ATOH1', 'POU4F3', {'sign': -1}), ('ATOH1', 'BARHL1', {'sign': -1}), ('ZFP36', 'TNF', {'sign': -1}), ('HES5', 'ATOH1', {'sign': -1}), ('TNF', 'PSIP1', {'sign': -1}), ('TNF', 'TNFRSF1B', {'sign': -1}), ('TNF', 'TNFRSF1A', {'sign': 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{'sign': -1}), ('IL2', 'IL2RB', {'sign': -1}), ('IL2', 'IL2RA', {'sign': -1}), ('IL2', 'IL2RA_IL2RB_IL2RG', {'sign': -1}), ('JAG2', 'NOTCH1', {'sign': -1}), ('JAG2', 'NOTCH2', {'sign': -1}), ('JAG2', 'NOTCH3', {'sign': -1}), ('JAG2', 'NOTCH4', {'sign': -1}), ('DLL1', 'NOTCH1', {'sign': -1}), ('DLL1', 'NOTCH2', {'sign': -1}), ('DLL1', 'NOTCH3', {'sign': -1}), ('DLL1', 'NOTCH4', {'sign': -1}), ('SIX1', 'LFNG', {'sign': -1}), ('SIX1', 'OTX2', {'sign': -1}), ('SIX1', 'HMX3', {'sign': -1}), ('SIX1', 'DLX5', {'sign': -1}), ('SIX1', 'OTX1', {'sign': -1}), ('SIX1', 'DACH1', {'sign': -1}), ('SIX1', 'DACH2', {'sign': -1}), ('SIX1', 'PAX2', {'sign': -1}), ('SIX1', 'EYA1', {'sign': -1}), ('SIX1', 'BMP4', {'sign': -1}), ('SIX1', 'FGF10', {'sign': -1}), ('SIX1', 'FGF3', {'sign': -1}), ('SIX1', 'GATA3', {'sign': -1}), ('LFNG', 'NOTCH2', {'sign': -1}), ('LFNG', 'NOTCH1', {'sign': -1}), ('IL10', 'IL10RA', {'sign': -1}), ('IL10', 'RELA', {'sign': -1}), ('IL10', 'NFKB1', {'sign': -1}), ('IL10', 'IL10RB', {'sign': -1}), ('IL6', 'IL6ST', {'sign': -1}), ('IL6', 'IL6R', {'sign': -1}), ('IL6', 'IL6R_IL6ST', {'sign': -1}), ('DLX5', 'MSX2', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'CRTC2', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'TSC2', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'RPTOR', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'HMGCR', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'ACACA', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'TP53', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'CDKN1B', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'ULK1', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'EEF2', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'MLXIPL', {'sign': -1}), ('PRKAA1_PRKAA2_PRKAB1_PRKAB2_PRKAG1_PRKAG2_PRKAG3', 'BAIAP2', {'sign': -1}), 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{'sign': -1}), ('MAPK3', 'XPO5', {'sign': -1}), ('MAPK3', 'RUNX2', {'sign': -1}), ('MAPK3', 'GRK2', {'sign': -1}), ('MAPK3', 'LIFR', {'sign': -1}), ('MAPK3', 'SMAD4', {'sign': -1}), ('MAPK3', 'PDE4D', {'sign': -1}), ('MAPK3', 'HNRNPK', {'sign': -1}), ('MAPK3', 'TH', {'sign': -1}), ('MAPK3', 'PPARG', {'sign': -1}), ('MAPK3', 'PAK1', {'sign': -1}), ('MAPK3', 'EPS8', {'sign': -1}), ('MAPK3', 'GJA1', {'sign': -1}), ('MAPK3', 'SPHK2', {'sign': -1}), ('MAPK3', 'SPHK1', {'sign': -1}), ('MAPK3', 'MRTFA', {'sign': -1}), ('MAPK3', 'RRN3', {'sign': -1}), ('MAPK3', 'NCKIPSD', {'sign': -1}), ('MAPK3', 'HDAC6', {'sign': -1}), ('MAPK3', 'TWIST1', {'sign': -1}), ('MAPK3', 'PGR', {'sign': -1}), ('MAPK3', 'STMN1', {'sign': -1}), ('MAPK3', 'H3-3A', {'sign': -1}), ('MAPK3', 'SCNN1B', {'sign': -1}), ('MAPK3', 'RCAN1', {'sign': -1}), ('MAPK3', 'TP53', {'sign': -1}), ('MAPK3', 'MYB', {'sign': -1}), ('MAPK3', 'LAT', {'sign': -1}), ('MAPK3', 'SYN3', {'sign': -1}), ('MAPK3', 'PPP2R5C', {'sign': -1}), ('MAPK3', 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{'sign': -1}), ('PRKCZ', 'AKT2', {'sign': -1}), ('PRKCZ', 'PEBP1', {'sign': -1}), ('PRKCZ', 'AKT1', {'sign': -1}), ('PRKCZ', 'MET', {'sign': -1}), ('PRKCZ', 'MAPK7', {'sign': -1}), ('PRKCZ', 'NFATC2', {'sign': -1}), ('FADD', 'ATG5', {'sign': -1}), ('FADD', 'RIPK1', {'sign': -1}), ('FADD', 'CASP10', {'sign': -1}), ('FADD', 'CASP8', {'sign': -1}), ('PIDD1', 'CASP2', {'sign': -1}), ('PIDD1', 'IKBKG', {'sign': -1}), ('PIDD1', 'PRKDC', {'sign': -1}), ('PIDD1', 'RIPK1', {'sign': -1}), ('PIDD1', 'CRADD', {'sign': -1}), ('IKBKG', 'IKBKB', {'sign': -1}), ('IKBKG', 'CHUK', {'sign': -1}), ('IKBKG', 'NFKBIA', {'sign': -1}), ('IKBKG', 'NFKBIB', {'sign': -1}), ('IKBKG', 'RELA', {'sign': -1}), ('JAK1', 'IRS1', {'sign': -1}), ('JAK1', 'IRS2', {'sign': -1}), ('JAK1', 'STAT3', {'sign': -1}), ('JAK1', 'FES', {'sign': -1}), ('JAK1', 'STAT6', {'sign': -1}), ('JAK1', 'BTK', {'sign': -1}), ('JAK1', 'STAT5B', {'sign': -1}), ('JAK1', 'IL7R', {'sign': -1}), ('JAK1', 'STAT5A', {'sign': -1}), ('JAK1', 'SOCS3', 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{'sign': -1}), ('RPS6KA3', 'H2BC3', {'sign': -1}), ('RPS6KA3', 'ESR1', {'sign': -1}), ('RPS6KA3', 'GSK3A', {'sign': -1}), ('RPS6KA3', 'EIF2AK2', {'sign': -1}), ('RPS6KA3', 'H3-4', {'sign': -1}), ('RPS6KA3', 'FOS', {'sign': -1}), ('RPS6KA3', 'SRF', {'sign': -1}), ('RPS6KA3', 'RPS6', {'sign': -1}), ('FAS', 'CASP8AP2', {'sign': -1}), ('FAS', 'DAXX', {'sign': -1}), ('FAS', 'FADD', {'sign': -1}), ('FAS', 'RIPK1', {'sign': -1}), ('FAS', 'MAP3K5', {'sign': -1}), ('CASP8AP2', 'CASP8', {'sign': -1}), ('RPS6KA1', 'RPTOR', {'sign': -1}), ('RPS6KA1', 'DAPK1', {'sign': -1}), ('RPS6KA1', 'TSC2', {'sign': -1}), ('RPS6KA1', 'MITF', {'sign': -1}), ('RPS6KA1', 'CREB1', {'sign': -1}), ('RPS6KA1', 'BAD', {'sign': -1}), ('RPS6KA1', 'FOS', {'sign': -1}), ('RPS6KA1', 'GSK3B', {'sign': -1}), ('RPS6KA1', 'EEF2K', {'sign': -1}), ('RPS6KA1', 'WWC1', {'sign': -1}), ('RPS6KA1', 'L1CAM', {'sign': -1}), ('RPS6KA1', 'ETV1', {'sign': -1}), ('RPS6KA1', 'CCT2', {'sign': -1}), ('RPS6KA1', 'RPS6', {'sign': -1}), 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{'sign': -1}), ('INSR', 'PTPN11', {'sign': -1}), ('INSR', 'RASA1', {'sign': -1}), ('INSR', 'VAV1', {'sign': -1}), ('INSR', 'STAT5A', {'sign': -1}), ('ATF2', 'MMP2', {'sign': -1}), ('ATF2', 'GADD45A', {'sign': -1}), ('ATF2', 'ATF3', {'sign': -1}), ('ATF2', 'JUN', {'sign': -1}), ('TP53INP1', 'GABARAPL2', {'sign': -1}), ('TP53INP1', 'GABARAP', {'sign': -1}), ('TP53INP1', 'MAP1LC3A', {'sign': -1}), ('IFIH1', 'MAVS', {'sign': -1}), ('IFIH1', 'TRAF3', {'sign': -1}), ('IFIH1', 'TBK1', {'sign': -1}), ('IFIH1', 'IKBKE', {'sign': -1}), ('MAVS', 'TBK1', {'sign': -1}), ('MAVS', 'IKBKB', {'sign': -1}), ('MAVS', 'TRAF3', {'sign': -1}), ('MAVS', 'IKBKE', {'sign': -1}), ('MAVS', 'IRF3', {'sign': -1}), ('MAVS', 'IRF7', {'sign': -1}), ('MAVS', 'STING1', {'sign': -1}), ('MAVS', 'CASP8', {'sign': -1}), ('DDB1_DDB2', 'XPC', {'sign': -1}), ('NOD2', 'MAP3K14', {'sign': -1}), ('NOD2', 'MAPK1', {'sign': -1}), ('NOD2', 'RIPK2', {'sign': -1}), ('NOD2', 'MAPK14', {'sign': -1}), ('NOD2', 'MAPK8', {'sign': -1}), 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('GSK3B', 'TSC2', {'sign': -1}), ('GSK3B', 'NEFH', {'sign': -1}), ('GSK3B', 'HDAC4', {'sign': -1}), ('GSK3B', 'NFE2L1', {'sign': -1}), ('GSK3B', 'CCND3', {'sign': -1}), ('GSK3B', 'ATXN3', {'sign': -1}), ('GSK3B', 'SNRNP70', {'sign': -1}), ('MAP2K7', 'MAPK8', {'sign': -1}), ('MAP2K7', 'MAPK10', {'sign': -1}), ('MAP2K7', 'MAPK9', {'sign': -1}), ('MAP2K7', 'FADD', {'sign': -1}), ('MAP2K7', 'IRS1', {'sign': -1}), ('MAP2K6', 'MAPK11', {'sign': -1}), ('MAP2K6', 'MAPK12', {'sign': -1}), ('MAP2K6', 'MAPK14', {'sign': -1}), ('MAP2K6', 'MAPK13', {'sign': -1}), ('MAP2K6', 'NFE2L2', {'sign': -1}), ('MAP2K6', 'MAPK8', {'sign': -1}), ('MAP2K6', 'PAK6', {'sign': -1}), ('MAP2K6', 'STAT4', {'sign': -1}), ('ATG14', 'BECN1', {'sign': -1}), ('ATG14', 'PIK3C3', {'sign': -1}), ('SIRT2', 'FOXO1', {'sign': -1}), ('SIRT2', 'H3C12', {'sign': -1}), ('SIRT2', 'KAT2B', {'sign': -1}), ('SIRT2', 'MYOD1', {'sign': -1}), ('RUBCN', 'BECN1', {'sign': -1}), ('RUBCN', 'PIK3C3', {'sign': -1}), ('PPP1CA_PPP1R12A_PPP1R12B', 'MYL12A', {'sign': -1}), ('CARD8', 'CASP9', {'sign': -1}), ('CARD8', 'APAF1', {'sign': -1}), ('SERPINB9', 'CASP1', {'sign': -1}), ('RPS6KB1', 'RPS6', {'sign': -1}), ('RPS6KB1', 'UBTF', {'sign': -1}), ('RPS6KB1', 'MDM2', {'sign': -1}), ('RPS6KB1', 'BAD', {'sign': -1}), ('RPS6KB1', 'EEF2K', {'sign': -1}), ('RPS6KB1', 'URI1', {'sign': -1}), ('RPS6KB1', 'IRS1', {'sign': -1}), ('RPS6KB1', 'PFKFB2', {'sign': -1}), ('RPS6KB1', 'EIF4B', {'sign': -1}), ('RPS6KB1', 'PDCD4', {'sign': -1}), ('RPS6KB1', 'HSPB1', {'sign': -1}), ('RPS6KB1', 'TP63', {'sign': -1}), ('RPS6KB1', 'MRE11', {'sign': -1}), ('RPS6KB1', 'GLI1', {'sign': -1}), ('RPS6KB1', 'ESR1', {'sign': -1}), ('RPS6KB1', 'RICTOR', {'sign': -1}), ('RPS6KB1', 'CAD', {'sign': -1}), ('RPS6KB1', 'MXD1', {'sign': -1}), ('RPS6KB1', 'GSK3B', {'sign': -1}), ('USP3', 'H2AZ1', {'sign': -1}), ('COPS2_COPS3_COPS4_COPS5_COPS6_COPS7A_COPS7B_GPS1', 'NEDD8', {'sign': -1}), ('COPS2_COPS3_COPS4_COPS5_COPS6_COPS7A_COPS7B_GPS1', 'USP15', {'sign': -1}), ('COPS2_COPS3_COPS4_COPS5_COPS6_COPS7A_COPS7B_GPS1', 'CUL1', {'sign': -1}), ('COPS2_COPS3_COPS4_COPS5_COPS6_COPS7A_COPS7B_GPS1', 'CDKN1A', {'sign': -1}), ('COPS2_COPS3_COPS4_COPS5_COPS6_COPS7A_COPS7B_GPS1', 'DDB1', {'sign': -1}), ('COPS2_COPS3_COPS4_COPS5_COPS6_COPS7A_COPS7B_GPS1', 'ERCC8', {'sign': -1}), ('NEDD8', 'CUL2', {'sign': -1}), ('NEDD8', 'CUL4A', {'sign': -1}), ('APEX1', 'TP53', {'sign': -1}), ('APEX1', 'FOSL1', {'sign': -1}), ('APEX1', 'ARNT', {'sign': -1}), ('APEX1', 'TXN', {'sign': -1}), ('APEX1', 'PTH', {'sign': -1}), ('APEX1', 'STAT3', {'sign': -1}), ('APEX1', 'CCNO', {'sign': -1}), ('APEX1', 'EGR1', {'sign': -1}), ('APEX1', 'RELB', {'sign': -1}), ('APEX1', 'FOS', {'sign': -1}), ('CAMKK1', 'CRMP1', {'sign': -1}), ('CAMKK1', 'CAMK1D', {'sign': -1}), ('CAMKK1', 'PRKAA1', {'sign': -1}), ('CAMKK1', 'CAMK4', {'sign': -1}), ('CAMKK1', 'CAMK1', {'sign': -1}), ('CAMKK1', 'AKT1', {'sign': -1}), ('POU2F1', 'H2BC11', {'sign': -1}), ('SFPQ', 'NONO', {'sign': -1}), ('SFPQ', 'TOP1', {'sign': -1}), ('NONO', 'TOP1', {'sign': -1}), ('CUL4A_DDB1_DDB2_RBX1', 'XPC', {'sign': -1}), ('CUL4A_DDB1_DDB2_RBX1', 'TP53', {'sign': -1}), ('CUL4A_DDB1_DDB2_RBX1', 'H3C12', {'sign': -1}), ('CUL4A_DDB1_DDB2_RBX1', 'H4C2', {'sign': -1}), ('CUL4A_DDB1_DDB2_RBX1', 'H2AZ1', {'sign': -1}), ('CUL4A_DDB1_DDB2_RBX1', 'DDB2', {'sign': -1}), ('APLF', 'PARP1', {'sign': -1}), ('PPM1D', 'ATM', {'sign': -1}), ('PPM1D', 'CHEK2', {'sign': -1}), ('PPM1D', 'H2AX', {'sign': -1}), ('PPM1D', 'MDM2', {'sign': -1}), ('PPM1D', 'UNG', {'sign': -1}), ('PPM1D', 'TP53', {'sign': -1}), ('PPM1D', 'CHEK1', {'sign': -1}), ('PPM1D', 'RPS6KA3', {'sign': -1}), ('PPM1D', 'MAPK12', {'sign': -1}), ('PPM1D', 'MAPK14', {'sign': -1}), ('TRIM28', 'STAT3', {'sign': -1}), ('TRIM28', 'TBL1XR1', {'sign': -1}), ('TRIM28', 'STAT1', {'sign': -1}), ('TRIM28', 'MDM2', {'sign': -1}), ('TRIM28', 'SETDB1', {'sign': -1}), ('TRIM28', 'CHD3', {'sign': -1}), ('TRIM28', 'CDKN1A', {'sign': -1}), ('TRIM28', 'GADD45A', {'sign': -1}), ('TRIM28', 'BAX', {'sign': -1}), ('TRIM28', 'BBC3', {'sign': -1}), ('TRIM28', 'PMAIP1', {'sign': -1}), ('CCNA2_CDK2', 'BRCA1', {'sign': -1}), ('CCNA2_CDK2', 'NFYA', {'sign': -1}), ('CCNA2_CDK2', 'CDC23', {'sign': -1}), ('CCNA2_CDK2', 'CDC6', {'sign': -1}), ('CCNA2_CDK2', 'MYBL2', {'sign': -1}), ('CCNA2_CDK2', 'RBBP8', {'sign': -1}), ('CCNA2_CDK2', 'ATRIP', {'sign': -1}), ('CCNA2_CDK2', 'FOXM1', {'sign': -1}), ('CCNA2_CDK2', 'ANAPC11', {'sign': -1}), ('CCNA2_CDK2', 'APC', {'sign': -1}), ('CCNA2_CDK2', 'BRCA2', {'sign': -1}), ('CCNA2_CDK2', 'CEBPB', {'sign': -1}), ('CCNA2_CDK2', 'TP53', {'sign': -1}), ('NOS1', 'NFKBIA', {'sign': -1}), ('NOS1', 'HDAC2', {'sign': -1}), ('ERC1', 'CHUK', {'sign': -1}), ('PPP1R3A', 'GYS1', {'sign': -1}), ('AXIN1', 'MYC', {'sign': -1}), ('AXIN1', 'MAP3K1', {'sign': -1}), ('AXIN1', 'MAP3K4', {'sign': -1}), ('AXIN1', 'CTNNB1', {'sign': -1}), ('AXIN1', 'SMAD3', {'sign': -1}), ('AXIN1', 'CSNK1A1L', {'sign': -1}), ('AXIN1', 'RNF111', {'sign': -1}), ('AXIN1', 'GSK3A', {'sign': -1}), ('AXIN1', 'APC', {'sign': -1}), ('AXIN1', 'SMAD7', {'sign': -1}), ('CSNK1A1', 'PRKN', {'sign': -1}), ('CSNK1A1', 'CTNNB1', {'sign': -1}), ('CSNK1A1', 'CDC25A', {'sign': -1}), ('CSNK1A1', 'CARD11', {'sign': -1}), ('CSNK1A1', 'CREB1', {'sign': -1}), ('CSNK1A1', 'PER1', {'sign': -1}), ('CSNK1A1', 'LEF1', {'sign': -1}), ('CSNK1A1', 'PHLPP1', {'sign': -1}), ('CSNK1A1', 'RHOB', {'sign': -1}), ('CSNK1A1', 'CARM1', {'sign': -1}), ('CSNK1A1', 'IFNAR1', {'sign': -1}), ('CSNK1A1', 'AXIN1', {'sign': -1}), ('CSNK1A1', 'HNRNPC', {'sign': -1}), ('CSNK1A1', 'TP53', {'sign': -1}), ('CSNK1A1', 'TP53TG5', {'sign': -1}), ('CSNK1A1', 'LRP6', {'sign': -1}), ('CSNK1A1', 'GSK3B', {'sign': -1}), ('CSNK1A1', 'NFATC3', {'sign': -1}), ('CSNK1A1', 'FADD', {'sign': -1}), ('CSNK1A1', 'APC_AXIN1_GSK3B', {'sign': -1}), ('CSNK1A1', 'BID', {'sign': -1}), ('CSNK1A1', 'GLI3', {'sign': -1}), ('CSNK1A1', 'SNCA', {'sign': -1}), ('CSNK1A1', 'YWHAZ', {'sign': -1}), ('CSNK1A1', 'DEPTOR', {'sign': -1}), ('CSNK1A1', 'FOXO3', {'sign': -1}), ('CSNK1A1', 'YWHAQ', {'sign': -1}), ('CSNK1A1', 'LGALS3', {'sign': -1}), ('CSNK1A1', 'CTPS2', {'sign': -1}), ('CSNK1A1', 'FOXG1', {'sign': -1}), ('CSNK1A1', 'FOXO1', {'sign': -1}), ('CSNK1A1', 'GLI2', {'sign': -1}), ('CSNK1A1', 'FOXO4', {'sign': -1}), ('CSNK1A1', 'MDM4', {'sign': -1}), ('CSNK1A1', 'APC', {'sign': -1}), ('LRP6', 'AXIN1', {'sign': -1}), ('LRP6', 'APC_AXIN1_GSK3B', {'sign': -1}), ('GNAQ', 'GSK3B', {'sign': -1}), ('GNAQ', 'PLCB1', {'sign': -1}), ('YWHAZ', 'PRKCZ', {'sign': -1}), ('HMGA2', 'ATM', {'sign': -1}), ('HMGA2', 'E4F1', {'sign': -1}), ('HMGA1', 'POU3F1', {'sign': -1}), ('PPP3CA_PPP3R1', 'BAD', {'sign': -1}), ('PPP3CA_PPP3R1', 'NFATC2', {'sign': -1}), ('PPP3CA_PPP3R1', 'NFATC1', {'sign': -1}), ('BMPR2', 'ACVR1', {'sign': -1}), ('BMPR2', 'BMPR1B', {'sign': -1}), ('BMPR2', 'BMPR1A', {'sign': -1}), ('LEF1', 'FAIM2', {'sign': -1}), ('LEF1', 'TLE1', {'sign': -1}), ('LEF1', 'MITF', {'sign': -1}), ('LEF1', 'ALX4', {'sign': -1}), ('FAIM2', 'BAX', {'sign': -1}), ('PPARG', 'KMT5A', {'sign': -1}), ('PPARG', 'CD36', {'sign': -1}), ('PPARG', 'FABP4', {'sign': -1}), ('PPARG', 'KLF15', {'sign': -1}), ('PPARG', 'ADIPOQ', {'sign': -1}), ('PPARG', 'PTGS2', {'sign': -1}), ('PPARG', 'SORBS1', {'sign': -1}), ('PPARG', 'SLC2A4', {'sign': -1}), ('PPARG', 'TBXAS1', {'sign': -1}), ('PPARG', 'NOS2', {'sign': -1}), ('PPARG', 'CDKN1A', {'sign': -1}), ('PPARG', 'GSTA2', {'sign': -1}), ('PPARG', 'NR1H2', {'sign': -1}), ('PPARG', 'NR1H3', {'sign': -1}), ('PPARG', 'RXRG', {'sign': -1}), ('PPARG', 'NR3C1', {'sign': -1}), ('PPARG', 'HDAC1', {'sign': -1}), ('KMT5A', 'H4C2', {'sign': -1}), ('KMT5A', 'TP53', {'sign': -1}), ('NLRC4', 'NOD1', {'sign': -1}), ('NLRC4', 'NOD2', {'sign': -1}), ('ADIPOQ', 'ADIPOR1', {'sign': -1}), ('ADIPOQ', 'ADIPOR2', {'sign': -1}), ('TLX1', 'ALDH1A1', {'sign': -1}), ('TLX1', 'PPP2CA', {'sign': -1}), ('TLX1', 'PPP2CB', {'sign': -1}), ('YWHAQ', 'E2F1', {'sign': -1}), ('YWHAQ', 'MEF2D', {'sign': -1}), ('YWHAQ', 'PRKD1', {'sign': -1}), ('YWHAQ', 'FOXO3', {'sign': -1}), ('YWHAQ', 'CDKN1B', {'sign': -1}), ('YWHAQ', 'CDC25C', {'sign': -1}), ('GPS2_HDAC3_NCOR1_TBL1XR1_TBL1Y', 'DZIP3', {'sign': -1}), ('GPS2_HDAC3_NCOR1_TBL1XR1_TBL1Y', 'NR2F2', {'sign': -1}), ('DZIP3', 'H2AZ1', {'sign': -1}), ('DZIP3', 'SSRP1', {'sign': -1}), ('DZIP3', 'ATXN1', {'sign': -1}), ('DDX17', 'ESR1', {'sign': -1}), ('DDX17', 'MDM2', {'sign': -1}), ('RB1', 'HIF1A', {'sign': -1}), ('RB1', 'E2F1', {'sign': -1}), ('RB1', 'YY1', {'sign': -1}), ('RB1', 'E2F3', {'sign': -1}), ('RB1', 'E2F2', {'sign': -1}), ('RB1', 'TRIP11', {'sign': -1}), ('RB1', 'UBTF', {'sign': -1}), ('RB1', 'MYOD1', {'sign': -1}), ('SNCB', 'TP53', {'sign': -1}), ('PRKAB1', 'NOS3', {'sign': -1}), ('PRKAB1', 'ULK1', {'sign': -1}), ('PRKAB1', 'RPTOR', {'sign': -1}), ('PRKAB1', 'FOXO3', {'sign': -1}), ('PRKAB1', 'TSC2', {'sign': -1}), ('FOXO3', 'BCL2L11', {'sign': -1}), ('FOXO3', 'SCP2', {'sign': -1}), ('FOXO3', 'FASLG', {'sign': -1}), ('FOXO3', 'CDKN1B', {'sign': -1}), ('FOXO3', 'GADD45A', {'sign': -1}), ('FOXO3', 'PINK1', {'sign': -1}), ('FOXO3', 'ATM', {'sign': -1}), ('FOXO3', 'SOD2', {'sign': -1}), ('FOXO3', 'RBL2', {'sign': -1}), ('FOXO3', 'PIK3CA', {'sign': -1}), ('FOXO3', 'ABCB1', {'sign': -1}), ('FOXO3', 'NOS3', {'sign': -1}), ('FOXO3', 'ID1', {'sign': -1}), ('FOXO3', 'G6PC1', {'sign': -1}), ('FOXO3', 'ESR1', {'sign': -1}), ('FOXO3', 'CDKN2D', {'sign': -1}), ('FOXO3', 'CDKN2B', {'sign': -1}), ('FOXO3', 'DUSP6', {'sign': -1}), ('FOXO3', 'DUSP5', {'sign': -1}), ('FOXO3', 'BNIP3L', {'sign': -1}), ('FOXO3', 'BCL6', {'sign': -1}), ('FOXO3', 'CDKN1A', {'sign': -1}), ('FOXO3', 'CAT', {'sign': -1}), ('FOXO3', 'PRDX3', {'sign': -1}), ('FOXO3', 'TNFSF10', {'sign': -1}), ('FOXO3', 'KLF4', {'sign': -1}), ('PRDM1', 'RASD2', {'sign': -1}), ('NR2F2', 'CEBPA', {'sign': -1}), ('NR2F2', 'PPARG', {'sign': -1}), ('NR2F2', 'RXRA', {'sign': -1}), ('NR2F2', 'NR2F1', {'sign': -1}), ('NR2F2', 'THRA', {'sign': -1}), ('NR2F2', 'NR2F6', {'sign': -1}), ('NR2F2', 'NR3C1', {'sign': -1}), ('NR2F2', 'MYOD1', {'sign': -1}), ('CEBPA', 'SLC11A1', {'sign': -1}), ('CEBPA', 'LTF', {'sign': -1}), ('CEBPA', 'ELANE', {'sign': -1}), ('CEBPA', 'LYZ', {'sign': -1}), ('CEBPA', 'CSF2RA', {'sign': -1}), ('CEBPA', 'MPO', {'sign': -1}), ('CEBPA', 'CD14', {'sign': -1}), ('CEBPA', 'SPI1', {'sign': -1}), ('CEBPA', 'CSF1R', {'sign': -1}), ('CEBPA', 'CSF3R', {'sign': -1}), ('PLK3', 'TP53', {'sign': -1}), ('PLK3', 'TOP2A', {'sign': -1}), ('PLK3', 'CDC25C', {'sign': -1}), ('PLK3', 'HIF1A', {'sign': -1}), ('PLK3', 'PTEN', {'sign': -1}), ('PLK3', 'VRK1', {'sign': -1}), ('PLK3', 'SNCA', {'sign': -1}), ('PLK3', 'ATF2', {'sign': -1}), ('PLK3', 'JUN', {'sign': -1}), ('PLK3', 'SNCB', {'sign': -1}), ('PLK3', 'BCL2L1', {'sign': -1}), ('PLK3', 'CDC25A', {'sign': -1}), ('PLK3', 'CHEK2', {'sign': -1}), ('CAMK2A_CAMK2B_CAMK2D_CAMK2G', 'HDAC4', {'sign': -1}), ('CAMK2A_CAMK2B_CAMK2D_CAMK2G', 'HDAC9', {'sign': -1}), ('CAMK2A_CAMK2B_CAMK2D_CAMK2G', 'MAP3K7', {'sign': -1}), ('HDAC9', 'MEF2C', {'sign': -1}), ('SERPINE1', 'LRP1', {'sign': -1}), ('COP1', 'CASP1', {'sign': -1}), ('COP1', 'NLRC4', {'sign': -1}), ('COP1', 'PYCARD', {'sign': -1}), ('COP1', 'NLRP1', {'sign': -1}), ('COP1', 'CASP5', {'sign': -1}), ('COP1', 'NLRP2', {'sign': -1}), ('COP1', 'CARD8', {'sign': -1}), ('TP63', 'FAS', {'sign': -1}), ('ICAM1', 'ITGAL', {'sign': -1}), ('ICAM1', 'ITGAX', {'sign': -1}), ('ICAM1', 'EGFR', {'sign': -1}), ('ICAM1', 'ITGB2', {'sign': -1}), ('CDKN2B', 'CDK4', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'TP53', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'RB1', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'E2F3', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'H4C2', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'CDKN1A', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'GADD45A', {'sign': -1}), ('MAX_MYC', 'NBN', {'sign': -1}), ('BMP7', 'ACVR2B', {'sign': -1}), ('BMP7', 'BMPR2', {'sign': -1}), ('BMP7', 'ACTR2', {'sign': -1}), ('BMP7', 'ACVR2A', {'sign': -1}), ('BMP7', 'ACVR1', {'sign': -1}), ('BMP7', 'BMPR1A_BMPR1B_BMPR2', {'sign': -1}), ('BMP7', 'ACVR1_BMPR2', {'sign': -1}), ('BMP7', 'ACVR1_ACVR2A', {'sign': -1}), ('BMP7', 'ACVR1_ACVR2B', {'sign': -1}), ('BMP7', 'ACVR2A_BMPR1A', {'sign': -1}), ('BMP7', 'ACVR2B_BMPR1A', {'sign': -1}), ('BMP7', 'BMPR1A_BMPR2', {'sign': -1}), ('BMP7', 'ACVR2A_BMPR1B', {'sign': -1}), ('BMP7', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP7', 'BMPR1B_BMPR2', {'sign': -1}), ('BMP7', 'BMPR1B', {'sign': -1}), ('BMP7', 'BMPR1A', {'sign': -1}), ('PPARA', 'FOXO1', {'sign': -1}), ('PPARA', 'LPL', {'sign': -1}), ('PPARA', 'ELOVL7', {'sign': -1}), ('PPARA', 'CRAT', {'sign': -1}), ('PPARA', 'ACOT1', {'sign': -1}), ('PPARA', 'CIDEC', {'sign': -1}), ('PPARA', 'FABP3', {'sign': -1}), ('PPARA', 'FABP4', {'sign': -1}), ('PPARA', 'ACOX1', {'sign': -1}), ('PPARA', 'NR1H2', {'sign': -1}), ('PPARA', 'RXRG', {'sign': -1}), ('RPS6KA5', 'H2AZ1', {'sign': -1}), ('RPS6KA5', 'RELA', {'sign': -1}), ('RPS6KA5', 'HMGN1', {'sign': -1}), ('RPS6KA5', 'H3C12', {'sign': -1}), ('RPS6KA5', 'CREB1', {'sign': -1}), ('RPS6KA5', 'ATF1', {'sign': -1}), ('RPS6KA5', 'EIF4EBP1', {'sign': -1}), ('RPS6KA5', 'STAT3', {'sign': -1}), ('RPS6KA5', 'ETV1', {'sign': -1}), ('RPS6KA5', 'BAD', {'sign': -1}), ('RPS6KA5', 'H2AC15', {'sign': -1}), ('RPS6KA5', 'H3-3A', {'sign': -1}), ('RPS6KA5', 'H2AC25', {'sign': -1}), ('RPS6KA5', 'ELK1', {'sign': -1}), ('RPS6KA5', 'PLA2G4A', {'sign': -1}), ('RPS6KA5', 'TH', {'sign': -1}), ('TAF1', 'BCL2L11', {'sign': -1}), ('TAF1', 'CDKN1B', {'sign': -1}), ('TAF1', 'TP53', {'sign': -1}), ('TAF1', 'GTF2A1', {'sign': -1}), ('CREBBP', 'ASAH2B', {'sign': -1}), ('CREBBP', 'MYB', {'sign': -1}), ('CREBBP', 'NFKB1', {'sign': -1}), ('CREBBP', 'RELB', {'sign': -1}), ('CREBBP', 'CTNNB1', {'sign': -1}), ('CREBBP', 'H3C12', {'sign': -1}), ('CREBBP', 'MMP9', {'sign': -1}), ('CREBBP', 'WRN', {'sign': -1}), ('CREBBP', 'ARNT', {'sign': -1}), ('CREBBP', 'SMAD3', {'sign': -1}), ('CREBBP', 'SMAD2', {'sign': -1}), ('CREBBP', 'STAT6', {'sign': -1}), ('CREBBP', 'H3C13', {'sign': -1}), ('CREBBP', 'HNF1A', {'sign': -1}), ('CREBBP', 'RELA', {'sign': -1}), ('CREBBP', 'NFE2L2', {'sign': -1}), ('CREBBP', 'CSK', {'sign': -1}), ('CREBBP', 'JUN', {'sign': -1}), ('CREBBP', 'ELK1', {'sign': -1}), ('CREBBP', 'TCF7', {'sign': -1}), ('CREBBP', 'IRF9', {'sign': -1}), ('CREBBP', 'MYOD1', {'sign': -1}), ('CREBBP', 'KLF1', {'sign': -1}), ('CREBBP', 'POU1F1', {'sign': -1}), ('CREBBP', 'IFNAR2', {'sign': -1}), ('CREBBP', 'STAT2', {'sign': -1}), ('CREBBP', 'MYBL1', {'sign': -1}), ('CREBBP', 'TP53', {'sign': -1}), ('CREBBP', 'STAT3', {'sign': -1}), ('KAT7', 'H4C2', {'sign': -1}), ('KAT7', 'H3C12', {'sign': -1}), ('KAT7', 'MCM2', {'sign': -1}), ('GTF3C4', 'H3C12', {'sign': -1}), ('NCOA1', 'H4C2', {'sign': -1}), ('NCOA1', 'H3C12', {'sign': -1}), ('NCOA1', 'ESR1', {'sign': -1}), ('CSNK2B', 'TP53', {'sign': -1}), ('CSNK2B', 'CHEK2', {'sign': -1}), ('CSNK2B', 'WEE1', {'sign': -1}), ('CSNK2B', 'TBP', {'sign': -1}), ('CSNK2B', 'NFKBIA', {'sign': -1}), ('CSNK2B', 'SEC63', {'sign': -1}), ('CSNK2B', 'IKZF1', {'sign': -1}), ('CSNK2B', 'EIF5', {'sign': -1}), ('CSNK2B', 'RNF7', {'sign': -1}), ('CSNK2B', 'BID', {'sign': -1}), ('CSNK2B', 'USO1', {'sign': -1}), ('CSNK2B', 'SET', {'sign': -1}), ('CSNK2B', 'CD163', {'sign': -1}), ('CSNK2B', 'CTDP1', {'sign': -1}), ('CSNK2B', 'CTNNB1', {'sign': -1}), ('NCOA3', 'H3C12', {'sign': -1}), ('NCOA3', 'H4C2', 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{'sign': -1}), ('CARM1', 'RELB', {'sign': -1}), ('CARM1', 'PPARG', {'sign': -1}), ('CARM1', 'EP300', {'sign': -1}), ('CARM1', 'SMARCC1', {'sign': -1}), ('CARM1', 'PAX7', {'sign': -1}), ('CARM1', 'CREBBP', {'sign': -1}), ('XIAP', 'CASP3', {'sign': -1}), ('XIAP', 'CASP9', {'sign': -1}), ('XIAP', 'CASP7', {'sign': -1}), ('PRMT6', 'THBS1', {'sign': -1}), ('PRMT6', 'PGR', {'sign': -1}), ('PRMT6', 'ESR1', {'sign': -1}), ('PRMT6', 'H3C12', {'sign': -1}), ('THBS1', 'SDC4', {'sign': -1}), ('THBS1', 'ITGA4', {'sign': -1}), ('THBS1', 'CD47', {'sign': -1}), ('THBS1', 'SDC1', {'sign': -1}), ('THBS1', 'ITGB1', {'sign': -1}), ('THBS1', 'ITGA2B', {'sign': -1}), ('THBS1', 'ITGB3', {'sign': -1}), ('THBS1', 'ITGA6', {'sign': -1}), ('THBS1', 'CD36', {'sign': -1}), ('THBS1', 'ITGA3', {'sign': -1}), ('PGR', 'FOXO1', {'sign': -1}), ('PGR', 'ESR1', {'sign': -1}), ('MRE11_NBN_RAD50', 'ATM', {'sign': -1}), ('MRE11_NBN_RAD50', 'RECQL5', {'sign': -1}), ('MRE11_NBN_RAD50', 'RBBP8', {'sign': -1}), ('KMT5B', 'H4C2', 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('HIC1', 'SIRT1', {'sign': -1}), ('SMARCA4', 'HIC1', {'sign': -1}), ('SMARCA4', 'CDKN1A', {'sign': -1}), ('SMARCA4', 'GADD45A', {'sign': -1}), ('SMARCA4', 'XPC', {'sign': -1}), ('SMARCA4', 'SMARCC2', {'sign': -1}), ('SMARCA4', 'TERT', {'sign': -1}), ('SMARCA4', 'SMARCC1', {'sign': -1}), ('RNF168', 'H2AX', {'sign': -1}), ('SOCS3', 'TRAF6', {'sign': -1}), ('SOCS3', 'MAPK8IP1', {'sign': -1}), ('SOCS3', 'CSF3R', {'sign': -1}), ('SOCS3', 'LIFR', {'sign': -1}), ('SOCS3', 'IL6R', {'sign': -1}), ('SOCS3', 'IL6ST', {'sign': -1}), ('SOCS3', 'JAK2', {'sign': -1}), ('SOCS3', 'STAT5A', {'sign': -1}), ('SOCS3', 'PRLR', {'sign': -1}), ('SOCS3', 'STAT4', {'sign': -1}), ('SOCS3', 'LEPR', {'sign': -1}), ('SOCS3', 'IL12RB1', {'sign': -1}), ('SOCS3', 'RASA1', {'sign': -1}), ('SOCS3', 'IRS1', {'sign': -1}), ('MAPK8IP1', 'MAPK8', {'sign': -1}), ('MAPK8IP1', 'MAP3K10', {'sign': -1}), ('MAPK8IP1', 'MAP3K12', {'sign': -1}), ('MAPK8IP1', 'MAP2K7', {'sign': -1}), ('MAPK8IP1', 'MAP4K1', {'sign': -1}), ('MAPK8IP1', 'TIAM1', {'sign': -1}), ('MAP2K2', 'MAPK3', {'sign': -1}), ('MAP2K2', 'MAPK6', {'sign': -1}), ('MAP2K2', 'MAPK1', {'sign': -1}), ('MAP2K2', 'CASP9', {'sign': -1}), ('BMF', 'BCL2L2', {'sign': -1}), ('BMF', 'BCL2L1', {'sign': -1}), ('BMF', 'MCL1', {'sign': -1}), ('BMF', 'BCL2', {'sign': -1}), ('PPP5C', 'TP53BP1', {'sign': -1}), ('PPP5C', 'PRKDC', {'sign': -1}), ('PPP5C', 'ATM', {'sign': -1}), ('PPP5C', 'MAPT', {'sign': -1}), ('PPP5C', 'MAP3K5', {'sign': -1}), ('PPP5C', 'CDC37', {'sign': -1}), ('PPP5C', 'NR3C1', {'sign': -1}), ('PPP5C', 'CILK1', {'sign': -1}), ('PPP5C', 'RAF1', {'sign': -1}), ('RPA1', 'ATRIP', {'sign': -1}), ('RPA1', 'FEN1', {'sign': -1}), ('RPA1', 'BRIP1', {'sign': -1}), ('RPA1', 'POLA1', {'sign': -1}), ('RPA1_RPA2_RPA3', 'RFWD3', {'sign': -1}), ('RPA1_RPA2_RPA3', 'RECQL', {'sign': -1}), ('RPA1_RPA2_RPA3', 'RAD18', {'sign': -1}), ('RPA1_RPA2_RPA3', 'SMARCAL1', {'sign': -1}), ('SMYD2', 'TP53', {'sign': -1}), ('SMYD2', 'H3C12', {'sign': -1}), ('SETD1A', 'BCL2L11', {'sign': -1}), ('SETD1A', 'H3C12', {'sign': -1}), ('CXCL9', 'CXCR3', {'sign': -1}), ('CXCL9', 'CCR3', {'sign': -1}), ('SETD2', 'H3C12', {'sign': -1}), ('CCL8', 'CCR5', {'sign': -1}), ('CCL8', 'CCR2', {'sign': -1}), ('CCL8', 'ACKR2', {'sign': -1}), ('CCL8', 'CCR1', {'sign': -1}), ('CCL8', 'ACKR4', {'sign': -1}), ('CCL8', 'CCR3', {'sign': -1}), ('CCL4', 'CCR5', {'sign': -1}), ('CCL4', 'CCR1', {'sign': -1}), ('CCL4', 'CCR8', {'sign': -1}), ('CCL4', 'CCR3', {'sign': -1}), ('IL6ST', 'SHC1', {'sign': -1}), ('IL6ST', 'JAK2', {'sign': -1}), ('IL6ST', 'TYK2', {'sign': -1}), ('IL6ST', 'JAK1', {'sign': -1}), ('IL6ST', 'GAB2', {'sign': -1}), ('SETDB2', 'H3C12', {'sign': -1}), ('KMT2E', 'H3C12', {'sign': -1}), ('KMT2E', 'NCR2', {'sign': -1}), ('RIOX1', 'SP7', {'sign': -1}), ('RECQL4', 'APEX1', {'sign': -1}), ('RECQL4', 'POLB', {'sign': -1}), ('RECQL4', 'FEN1', {'sign': -1}), ('GSK3A', 'BCL3', {'sign': -1}), ('GSK3A', 'LRP6', {'sign': -1}), ('GSK3A', 'TSC2', {'sign': -1}), ('GSK3A', 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('SETD7', 'H3C12', {'sign': -1}), ('SETD7', 'TAF10', {'sign': -1}), ('SETD7', 'TP53', {'sign': -1}), ('SETD7', 'ESR1', {'sign': -1}), ('PRDM2', 'H3C12', {'sign': -1}), ('DOT1L', 'H3C12', {'sign': -1}), ('BIRC3', 'CASP7', {'sign': -1}), ('BIRC3', 'CASP9', {'sign': -1}), ('BIRC3', 'MAP3K14', {'sign': -1}), ('BIRC3', 'RIPK1', {'sign': -1}), ('BIRC3', 'CASP3', {'sign': -1}), ('BIRC3', 'BIRC2', {'sign': -1}), ('ATG4D', 'GABARAPL1', {'sign': -1}), ('GABARAPL1', 'SQSTM1', {'sign': -1}), ('EGR1', 'TOPBP1', {'sign': -1}), ('EGR1', 'DUSP1', {'sign': -1}), ('EGR1', 'DUSP4', {'sign': -1}), ('EGR1', 'ID3', {'sign': -1}), ('EGR1', 'CDKN1A', {'sign': -1}), ('EGR1', 'FASLG', {'sign': -1}), ('EGR1', 'PPARG', {'sign': -1}), ('EGR1', 'EGFR', {'sign': -1}), ('EGR1', 'TGFB1', {'sign': -1}), ('EGR1', 'PDGFB', {'sign': -1}), ('EGR1', 'PDGFA', {'sign': -1}), ('EGR1', 'IGF2', {'sign': -1}), ('EGR1', 'TP53', {'sign': -1}), ('EGR1', 'PTEN', {'sign': -1}), ('EGR1', 'PITX1', {'sign': -1}), ('MAP3K5', 'MAP2K3', 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-1}), ('CSNK2A1', 'SET', {'sign': -1}), ('CSNK2A1', 'MCM2', {'sign': -1}), ('CSNK2A1', 'PDCD5', {'sign': -1}), ('CSNK2A1', 'PACS1', {'sign': -1}), ('CSNK2A1', 'HES6', {'sign': -1}), ('CSNK2A1', 'F5', {'sign': -1}), ('CSNK2A1', 'CBX1', {'sign': -1}), ('CSNK2A1', 'FUNDC1', {'sign': -1}), ('CSNK2A1', 'BIK', {'sign': -1}), ('MSH2', 'ATR', {'sign': -1}), ('IL1R1_IL1RAP', 'MYD88', {'sign': -1}), ('IL12A', 'IL12RB1', {'sign': -1}), ('IL12A', 'IL12B', {'sign': -1}), ('IL12A', 'IL12RB2', {'sign': -1}), ('DVL2', 'ARRB2', {'sign': -1}), ('DVL2', 'AXIN1', {'sign': -1}), ('DVL2', 'PI4K2B', {'sign': -1}), ('DVL2', 'LRRK2', {'sign': -1}), ('DVL2', 'RAC1', {'sign': -1}), ('DVL2', 'PARD6A', {'sign': -1}), ('TDP2', 'TOP2A', {'sign': -1}), ('TDP2', 'TOP2B', {'sign': -1}), ('CCDC88C', 'DVL1', {'sign': -1}), ('DVL1', 'DAAM1', {'sign': -1}), ('DVL1', 'RAC1', {'sign': -1}), ('DVL1', 'SMAD3', {'sign': -1}), ('DVL1', 'LRRK2', {'sign': -1}), ('DVL1', 'AXIN1', {'sign': -1}), ('DVL1', 'PI4K2B', {'sign': -1}), ('DVL1', 'CTNNB1', {'sign': -1}), ('DVL1', 'JUN', {'sign': -1}), ('DVL1', 'ROCK1', {'sign': -1}), ('DVL1', 'APC', {'sign': -1}), ('DVL1', 'APC_AXIN1_GSK3B', {'sign': -1}), ('DVL1', 'GSK3B', {'sign': -1}), ('PARP2', 'TOP1', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'H2AZ1', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'H2AX', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'ATM', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'H4C2', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'UBTF', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'TP53', {'sign': -1}), ('KAT5', 'AR', {'sign': -1}), ('KAT5', 'MYC', {'sign': -1}), ('KAT5', 'TP53', {'sign': -1}), ('KAT5', 'H3C12', {'sign': -1}), ('KAT5', 'H2AZ1', {'sign': -1}), ('KAT5', 'H4C2', {'sign': -1}), ('KAT5', 'PRKDC', {'sign': -1}), ('KAT5', 'ATM', {'sign': -1}), ('MYCBP', 'MYC', {'sign': -1}), ('MTNR1A', 'GNAQ', {'sign': -1}), ('MTNR1A', 'GNAI3', {'sign': -1}), ('MTNR1A', 'MAPK1', {'sign': -1}), ('MTNR1A', 'GNAI1', {'sign': -1}), ('GNAI3', 'ADCY5', {'sign': -1}), ('GNAI3', 'ADCY6', {'sign': -1}), ('GNAI3', 'ADCY1', {'sign': -1}), ('CDK11A', 'EIF3F', {'sign': -1}), ('CDK11A', 'CDK11B', {'sign': -1}), ('CDK11B', 'EIF3F', {'sign': -1}), ('CUL4A_DDB1_DTL', 'CDKN1A', {'sign': -1}), ('CUL4A_DDB1_DTL', 'CDT1', {'sign': -1}), ('SMARCB1', 'MYC', {'sign': -1}), ('SMARCB1', 'SMARCA4', {'sign': -1}), ('HDAC3', 'TRIM28', {'sign': -1}), ('HDAC3', 'H3C12', {'sign': -1}), ('HDAC3', 'H4C2', {'sign': -1}), ('HDAC3', 'CDKN1A', {'sign': -1}), ('HDAC3', 'RELA', {'sign': -1}), ('HDAC3', 'CREBBP', {'sign': -1}), ('HDAC3', 'MAFK', {'sign': -1}), ('HDAC3', 'HDAC1', {'sign': -1}), ('HDAC3', 'YY1', {'sign': -1}), ('PTTG1', 'TP53', {'sign': -1}), ('PTTG1', 'ESPL1', {'sign': -1}), ('NSMCE2', 'TERF1', {'sign': -1}), ('NSMCE2', 'TERF2IP', {'sign': -1}), ('NSMCE2', 'TERF2', {'sign': -1}), ('NSMCE2', 'TINF2', {'sign': -1}), ('NSMCE2', 'TSNAX', {'sign': -1}), ('NSMCE2', 'SMC6', {'sign': -1}), ('CD28', 'GRB2', {'sign': -1}), ('CD28', 'PIK3R2', {'sign': -1}), ('CD28', 'CBLB', {'sign': -1}), ('CD28', 'PIK3CG', {'sign': -1}), ('CD86', 'CD28', {'sign': -1}), ('CD86', 'CTLA4', {'sign': -1}), ('CD80', 'CD28', {'sign': -1}), ('CD80', 'CTLA4', {'sign': -1}), ('CD80', 'CD274', {'sign': -1}), ('CARD11', 'MALT1', {'sign': -1}), ('BCL10_CARD11_MALT1', 'IKBKB', {'sign': -1}), ('ANXA1', 'FPR2', {'sign': -1}), ('ANXA1', 'FPR3', {'sign': -1}), ('ANXA1', 'FPR1', {'sign': -1}), ('DDX6', 'ALOX15', {'sign': -1}), ('P4HA1_P4HB', 'AGO2', {'sign': -1}), ('AURKA', 'HDAC6', {'sign': -1}), ('AURKA', 'BRCA1', {'sign': -1}), ('AURKA', 'CENPA', {'sign': -1}), ('AURKA', 'CDC25B', {'sign': -1}), ('AURKA', 'PLK1', {'sign': -1}), ('AURKA', 'AJUBA', {'sign': -1}), ('AURKA', 'TACC1', {'sign': -1}), ('AURKA', 'KIF11', {'sign': -1}), ('AURKA', 'CPEB1', {'sign': -1}), ('AURKA', 'PPP1R1B', {'sign': -1}), ('AURKA', 'TPX2', {'sign': -1}), ('AURKA', 'MAP9', {'sign': -1}), ('AURKA', 'NDEL1', {'sign': -1}), ('AURKA', 'RASSF1', {'sign': -1}), ('AURKA', 'TP53', {'sign': -1}), ('AURKA', 'INCENP', {'sign': -1}), ('AURKA', 'WDR62', {'sign': -1}), ('AURKA', 'FADD', {'sign': -1}), ('AURKA', 'DLGAP5', {'sign': -1}), ('AURKA', 'NEDD9', {'sign': -1}), ('AURKA', 'MBD3', {'sign': -1}), ('AURKA', 'H3C12', {'sign': -1}), ('AURKA', 'LATS2', {'sign': -1}), ('AURKA', 'AURKAIP1', {'sign': -1}), ('AURKA', 'PIN1', {'sign': -1}), ('AURKA', 'KIF4A', {'sign': -1}), ('AURKA', 'TACC3', {'sign': -1}), ('AURKA', 'PARD3', {'sign': -1}), ('AURKA', 'FAF1', {'sign': -1}), ('AURKA', 'CETN2', {'sign': -1}), ('AURKA', 'MAPRE3', {'sign': -1}), ('AURKA', 'NFKBIA', {'sign': -1}), ('HDAC6', 'HSP90B1', {'sign': -1}), ('HDAC6', 'CTTN', {'sign': -1}), ('HDAC6', 'TUBA4B', {'sign': -1}), ('HDAC6', 'ELAVL1', {'sign': -1}), ('HDAC6', 'HSP90AA1', {'sign': -1}), ('HSP90B1', 'LRP1', {'sign': -1}), ('PCBP1', 'ALOX15', {'sign': -1}), ('HNRNPK', 'ALOX15', {'sign': -1}), ('HNRNPK', 'TP53', {'sign': -1}), ('HNRNPK', 'MDM2', {'sign': -1}), ('HNRNPK', 'AR', {'sign': -1}), ('HNRNPK', 'CDKN1A', {'sign': -1}), ('HNRNPK', 'MYC', {'sign': -1}), ('HNRNPK', 'SPN', {'sign': -1}), ('HNRNPK', 'EIF4E', {'sign': -1}), ('HNRNPK', 'TK1', {'sign': -1}), ('TRIM8', 'SOCS1', {'sign': -1}), ('MARCHF5', 'RIGI', {'sign': -1}), ('MARCHF5', 'DNM1L', {'sign': -1}), ('MARCHF5', 'FIS1', {'sign': -1}), ('RIGI', 'MAVS', {'sign': -1}), ('RIGI', 'TRAF3', {'sign': -1}), ('RIGI', 'TBK1', {'sign': -1}), ('RIGI', 'IKBKE', {'sign': -1}), ('ZBTB4', 'CDKN1A', {'sign': -1}), ('DDX5', 'TP53', {'sign': -1}), ('DDX5', 'HDAC1', {'sign': -1}), ('DDX5', 'AR', {'sign': -1}), ('DTX3L', 'H4C2', {'sign': -1}), ('NFKBIZ', 'STAT3', {'sign': -1}), ('SP3', 'IL10', {'sign': -1}), ('SP3', 'HAS2', {'sign': -1}), ('ATF1', 'IL10', {'sign': -1}), ('ATF1', 'SH3RF1', {'sign': -1}), ('ATF1', 'CCDC65', {'sign': -1}), ('ATF1', 'NKX6-1', {'sign': -1}), ('ATF1', 'ARNT2', {'sign': -1}), ('ATF1', 'GOLPH3', {'sign': -1}), ('KDM5D', 'H3C12', {'sign': -1}), ('ASH2L_DPY30_HCFC1_HCFC2_KMT2A_KMT2D_MEN1_RBBP5_WDR5_WDR82', 'H3C12', {'sign': -1}), ('ASH2L_DPY30_KDM6A_KMT2B_KMT2C_NCOA6_PAXIP1_RBBP5_WDR5', 'H3C12', {'sign': -1}), ('KDM5B', 'H3C12', {'sign': -1}), ('KDM5B', 'FOXG1', {'sign': -1}), ('KDM5B', 'PAX9', {'sign': -1}), ('KDM5B', 'CBX4', {'sign': -1}), ('KDM5C', 'H3C12', {'sign': -1}), ('ASH1L', 'H3C12', {'sign': -1}), ('KDM5A', 'H3C12', {'sign': -1}), ('PKMYT1', 'CDK1', {'sign': -1}), ('TNFSF14', 'LTBR', {'sign': -1}), ('TNFSF14', 'TNFRSF14', {'sign': -1}), ('TNFSF14', 'TNFRSF6B', {'sign': -1}), ('LTBR', 'MAP3K14', {'sign': -1}), ('LTBR', 'TRAF2', {'sign': -1}), ('CD40LG', 'CD40', {'sign': -1}), ('CD40', 'TRAF2', {'sign': -1}), ('CD40', 'TRAF3', {'sign': -1}), ('TNFSF13B', 'MAP3K14', {'sign': -1}), ('TNFSF13B', 'TNFRSF13C', {'sign': -1}), ('TNFSF13B', 'TNFRSF13B', {'sign': -1}), ('TNFSF13B', 'TNFRSF17', {'sign': -1}), ('LTA', 'TNFRSF1A', {'sign': -1}), ('LTA', 'LTBR', {'sign': -1}), ('LTA', 'TNFRSF14', {'sign': -1}), ('LTA', 'TNFRSF1B', {'sign': -1}), ('LTB', 'LTBR', {'sign': -1}), ('LTB', 'CD40', {'sign': -1}), ('JUNB', 'BCL2', {'sign': -1}), ('JUNB', 'EGFR', {'sign': -1}), ('JUNB', 'BCL2L1', {'sign': -1}), ('KLF4', 'NANOG', {'sign': -1}), ('PIM1', 'BAD', {'sign': -1}), ('PIM1', 'FLT3', {'sign': -1}), ('PIM1', 'RPS19', {'sign': -1}), ('PIM1', 'FOXO3', {'sign': -1}), ('PIM1', 'CDKN1B', {'sign': -1}), ('PIM1', 'MAP3K5', {'sign': -1}), ('PIM1', 'RELA', {'sign': -1}), ('PIM1', 'MARK3', {'sign': -1}), ('PIM1', 'ABCG2', {'sign': -1}), ('PIM1', 'CDKN1A', {'sign': -1}), ('PIM1', 'MDM2', {'sign': -1}), ('PIM1', 'SKP2', {'sign': -1}), ('PIM1', 'H3C12', {'sign': -1}), ('PIM1', 'MYC', {'sign': -1}), ('PIM1', 'NFATC1', {'sign': -1}), ('NRG1', 'ERBB2', {'sign': -1}), ('NRG1', 'ERBB4', {'sign': -1}), ('NRG1', 'ERBB3', {'sign': -1}), ('ERBB3', 'GRB7', {'sign': -1}), ('ERBB3', 'PIK3R1', {'sign': -1}), ('ERBB3', 'GRB2', {'sign': -1}), ('ERBB3', 'PIK3CG', {'sign': -1}), ('ERBB3', 'PIK3CA', {'sign': -1}), ('ERBB3', 'PIK3CD', {'sign': -1}), ('ERBB3', 'PIK3CB', {'sign': -1}), ('GRB7', 'RND1', {'sign': -1}), ('SKP2', 'FOXO1', {'sign': -1}), ('SKP2', 'MYC', {'sign': -1}), ('SKP2', 'CDKN1B', {'sign': -1}), ('SKP2', 'CDKN1A', {'sign': -1}), ('NR1I2', 'FOXO1', {'sign': -1}), ('NR1I2', 'RXRA', {'sign': -1}), ('CXCL8', 'CXCR1', {'sign': -1}), ('CXCL8', 'CXCR2', {'sign': -1}), ('PIAS1', 'CALCOCO1', {'sign': -1}), ('PIAS1', 'SMAD4', {'sign': -1}), ('PIAS1', 'SOX9', {'sign': -1}), ('PIAS1', 'STAT1', {'sign': -1}), ('PIAS1', 'GLI2', {'sign': -1}), ('PIAS1', 'GLI3', {'sign': -1}), ('PIAS1', 'GLI1', {'sign': -1}), ('PIAS1', 'SATB2', {'sign': -1}), ('NDP', 'FZD4', {'sign': -1}), ('FZD4', 'DVL2', {'sign': -1}), ('FZD4', 'DVL1', {'sign': -1}), ('NOLC1', 'CSNK2A1', {'sign': -1}), ('NOLC1', 'TP53', {'sign': -1}), ('AMBRA1_BECN1_PIK3C3_PIK3R4_SH3GLB1_UVRAG', 'MAP1LC3B', {'sign': -1}), ('PRMT5', 'H4C2', {'sign': -1}), ('PRMT5', 'H2AZ1', {'sign': -1}), ('PRMT5', 'H3C12', {'sign': -1}), ('PRMT5', 'HOXA9', {'sign': -1}), ('APC2', 'CTNNB1', {'sign': -1}), ('APC2', 'AXIN1', {'sign': -1}), ('HDAC2', 'H2AZ1', {'sign': -1}), ('HDAC2', 'H2BC11', {'sign': -1}), ('HDAC2', 'H3C12', {'sign': -1}), ('HDAC2', 'H4C2', {'sign': -1}), ('HDAC2', 'STAT3', {'sign': -1}), ('HDAC2', 'YY1', {'sign': -1}), ('HDAC2', 'CCND1', {'sign': -1}), ('HDAC2', 'CIITA', {'sign': -1}), ('CDC73_CTR9_LEO1_PAF1_SKIC8', 'RNF40', {'sign': -1}), ('RNF40', 'RNF20', {'sign': -1}), ('SUV39H1', 'H3C12', {'sign': -1}), ('MTA1', 'SIX3', {'sign': -1}), ('MTA1', 'WNT1', {'sign': -1}), ('MTA1', 'ESR1', {'sign': -1}), ('MTA1', 'BRCA1', {'sign': -1}), ('SIX3', 'WNT1', {'sign': -1}), ('SIAH1', 'CTNNB1', {'sign': -1}), ('SIAH1', 'HIPK2', {'sign': -1}), ('SIAH1', 'NUMB', {'sign': -1}), ('SIAH1', 'SNCAIP', {'sign': -1}), ('USP22', 'H2AZ1', {'sign': -1}), ('USP22', 'H2BC11', {'sign': -1}), ('USP22', 'SIRT1', {'sign': -1}), ('CDX2', 'CDX4', {'sign': -1}), ('KAT2A_SAP130_SUPT3H_SUPT7L_TADA1_TADA2A_TADA3_TAF10_TAF12_TAF5L_TAF6L_TAF9_TRRAP_USP22', 'H2BC11', {'sign': -1}), ('KAT2A_SAP130_SUPT3H_SUPT7L_TADA1_TADA2A_TADA3_TAF10_TAF12_TAF5L_TAF6L_TAF9_TRRAP_USP22', 'H3C12', {'sign': -1}), ('RNF8_UBE2N', 'H2AZ1', {'sign': -1}), ('RNF8_UBE2N', 'H2AX', {'sign': -1}), ('CSNK1E', 'CTNND1', {'sign': -1}), ('CSNK1E', 'CDH1', {'sign': -1}), ('CSNK1E', 'DVL1', {'sign': -1}), ('CSNK1E', 'PER2', {'sign': -1}), ('CSNK1E', 'CDC25A', {'sign': -1}), ('CSNK1E', 'AXIN1', {'sign': -1}), ('CSNK1E', 'SMO', {'sign': -1}), ('CSNK1E', 'LRP6', {'sign': -1}), ('CSNK1E', 'ROR2', {'sign': -1}), ('CSNK1E', 'PER3', {'sign': -1}), ('CSNK1E', 'EIF4EBP1', {'sign': -1}), ('CSNK1E', 'PER1', {'sign': -1}), ('CSNK1E', 'BID', {'sign': -1}), ('CSNK1E', 'APC', {'sign': -1}), ('CSNK1E', 'DVL2', {'sign': -1}), ('CSNK1E', 'YAP1', {'sign': -1}), ('CSNK1E', 'WWTR1', {'sign': -1}), ('CSNK1E', 'CTNNB1', {'sign': -1}), ('CSNK1E', 'TP53', {'sign': -1}), ('CSNK1E', 'YWHAQ', {'sign': -1}), ('CTNND1', 'CDH1', {'sign': -1}), ('CTNND1', 'CDH3', {'sign': -1}), ('CTNND1', 'CDH2', {'sign': -1}), ('CTNND1', 'CDH5', {'sign': -1}), ('UBE2N', 'TRAF2', {'sign': -1}), ('UBE2N', 'TRAF6', {'sign': -1}), ('UBE2N', 'PCNA', {'sign': -1}), ('UBE2N', 'H2AX', {'sign': -1}), ('UBE2N', 'UBE2V1', {'sign': -1}), ('UBE2N', 'MAP3K7', {'sign': -1}), ('SENP2', 'TCF7L2', {'sign': -1}), ('SMURF2', 'PRICKLE1', {'sign': -1}), ('SMURF2', 'TGFBR1', {'sign': -1}), ('SMURF2', 'SMAD2', {'sign': -1}), ('SMURF2', 'SMAD1', {'sign': -1}), ('SMURF2', 'SKIL', {'sign': -1}), ('SMURF2', 'CTNNB1', {'sign': -1}), ('SMURF2', 'SMAD5', {'sign': -1}), ('SMURF2', 'TGFBR2', {'sign': -1}), ('SMURF1', 'PRICKLE1', {'sign': -1}), ('SMURF1', 'SMAD7', {'sign': -1}), ('SMURF1', 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-1}), ('TGFBR1', 'PIK3R1', {'sign': -1}), ('TGFBR1', 'VPS39', {'sign': -1}), ('TGFBR1', 'PARD6A', {'sign': -1}), ('TGFBR1', 'ACVRL1', {'sign': -1}), ('TGFBR1', 'EIF3I', {'sign': -1}), ('TGFBR1', 'CDC42', {'sign': -1}), ('TGFBR1', 'TRAF6', {'sign': -1}), ('TGFBR1', 'RHOA', {'sign': -1}), ('TGFBR1', 'EEF1A1', {'sign': -1}), ('TGFBR1', 'PIK3R2', {'sign': -1}), ('TGFBR1', 'TGFBR3', {'sign': -1}), ('TGFBR1', 'SMAD1', {'sign': -1}), ('GMNN', 'CDC6', {'sign': -1}), ('GMNN', 'CDT1', {'sign': -1}), ('MAP2K5', 'MAPK7', {'sign': -1}), ('ING2', 'EP300', {'sign': -1}), ('ING2', 'HDAC1', {'sign': -1}), ('PTH', 'PTH2R', {'sign': -1}), ('PTH', 'PTH1R', {'sign': -1}), ('CUL1_RBX1_SKP1_SKP2', 'CDT1', {'sign': -1}), ('CUL1_RBX1_SKP1_SKP2', 'CDKN1A', {'sign': -1}), ('CCNH', 'CDK7', {'sign': -1}), ('BRCA2', 'RAD51', {'sign': -1}), ('BRCA2', 'POLH', {'sign': -1}), ('CENPE', 'BUB1B', {'sign': -1}), ('CDCA8_PRC1', 'CENPE', {'sign': -1}), ('CLK2', 'ATR', {'sign': -1}), ('CLK2', 'PTPN1', {'sign': -1}), 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('SHPRH', 'UBE2V2', {'sign': -1}), ('TGFBR2', 'EIF3I', {'sign': -1}), ('TGFBR2', 'TGFBR1', {'sign': -1}), ('TGFBR2', 'TGFBR3', {'sign': -1}), ('TGFBR2', 'PARD6A', {'sign': -1}), ('TGFBR2', 'ENG', {'sign': -1}), ('TGFBR2', 'SMAD2', {'sign': -1}), ('TGFBR2', 'SMAD3', {'sign': -1}), ('TGFBR2', 'PIK3R1', {'sign': -1}), ('TGFBR2', 'ZFYVE9', {'sign': -1}), ('TGFBR2', 'VPS39', {'sign': -1}), ('TGFBR2', 'TRAF6', {'sign': -1}), ('TGFBR2', 'MAP3K7', {'sign': -1}), ('TGFBR2', 'PIK3CA_PIK3R1', {'sign': -1}), ('TGFBR2', 'PIK3R2', {'sign': -1}), ('CSNK1G2', 'SMAD3', {'sign': -1}), ('CSNK1G2', 'PER1', {'sign': -1}), ('CSNK1G2', 'CERT1', {'sign': -1}), ('CSNK1G2', 'TP53', {'sign': -1}), ('CSNK1G2', 'YWHAQ', {'sign': -1}), ('PARD6A', 'SMURF1', {'sign': -1}), ('PPP2R2A', 'RAF1', {'sign': -1}), ('PPP2R2A', 'KSR1', {'sign': -1}), ('PPP2R2A', 'AKT1', {'sign': -1}), ('PPP2R2A', 'PPP2CA', {'sign': -1}), ('PJA1', 'SPTBN1', {'sign': -1}), ('PJA1', 'EZH2', {'sign': -1}), ('FNTA', 'KRAS', {'sign': -1}), ('FNTA', 'HRAS', {'sign': -1}), ('MEF2C', 'JUN', {'sign': -1}), ('MEF2C', 'MYOD1', {'sign': -1}), ('NEDD4L', 'SMAD2', {'sign': -1}), ('NEDD4L', 'SMAD3', {'sign': -1}), ('NEDD4L', 'SMAD7', {'sign': -1}), ('NEDD4L', 'SCNN1A', {'sign': -1}), ('NEDD4L', 'SCN5A', {'sign': -1}), ('FRS2', 'PTPN11', {'sign': -1}), ('FRS2', 'GRB2', {'sign': -1}), ('FRS2', 'GRAP', {'sign': -1}), ('FRS2', 'CBL', {'sign': -1}), ('TNK2', 'MCF2', {'sign': -1}), ('TNK2', 'SNX9', {'sign': -1}), ('TNK2', 'AKT1', {'sign': -1}), ('TNK2', 'AR', {'sign': -1}), ('TNK2', 'BCAR1', {'sign': -1}), ('MCF2', 'RHOA', {'sign': -1}), ('MCF2', 'CDC42', {'sign': -1}), ('KSR1', 'RAF1', {'sign': -1}), ('PTK6', 'KHDRBS1', {'sign': -1}), ('PTK6', 'STAP2', {'sign': -1}), ('PTK6', 'STAT3', {'sign': -1}), ('PTK6', 'BCAR1', {'sign': -1}), ('PTK6', 'AKT1', {'sign': -1}), ('PTK6', 'ARHGAP5', {'sign': -1}), ('PTK6', 'EPS8', {'sign': -1}), ('PTK6', 'ARAP1', {'sign': -1}), ('PTK6', 'STAT5B', {'sign': -1}), ('PTK6', 'PXN', {'sign': -1}), ('PTK6', 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('PTPN11', 'PIK3R2', {'sign': -1}), ('PTPN11', 'IRS1', {'sign': -1}), ('PTPN11', 'SIRPA', {'sign': -1}), ('PTPN11', 'GRB2', {'sign': -1}), ('PTPN11', 'PIK3R1', {'sign': -1}), ('PTPN11', 'GAB1', {'sign': -1}), ('PTPN11', 'STAT1', {'sign': -1}), ('PTPN11', 'JAK3', {'sign': -1}), ('PTPN11', 'IGF1R', {'sign': -1}), ('PTPN11', 'SPRY1', {'sign': -1}), ('PTPN11', 'PIK3CA', {'sign': -1}), ('PTPN11', 'HRAS', {'sign': -1}), ('PTPN11', 'PTK2', {'sign': -1}), ('PTPN11', 'CTNNA1', {'sign': -1}), ('PTPN11', 'MAP3K5', {'sign': -1}), ('PTPN11', 'KRAS', {'sign': -1}), ('PTPN11', 'ERBB2', {'sign': -1}), ('PTPN11', 'SRC', {'sign': -1}), ('PTPN11', 'NRAS', {'sign': -1}), ('PTPN11', 'MPZL1', {'sign': -1}), ('PTPN11', 'VAV2', {'sign': -1}), ('PTPN11', 'VAV3', {'sign': -1}), ('PTPN11', 'PAG1', {'sign': -1}), ('PTPN11', 'MAP3K4', {'sign': -1}), ('PTPN11', 'KDR', {'sign': -1}), ('HUS1_RAD1_RAD9A', 'APEX1', {'sign': -1}), ('HUS1_RAD1_RAD9A', 'MUTYH', {'sign': -1}), ('HUS1_RAD1_RAD9A', 'TOPBP1', {'sign': -1}), ('HUS1_RAD1_RAD9A', 'POLB', {'sign': -1}), ('ECT2', 'CDC42', {'sign': -1}), ('ECT2', 'RHOA', {'sign': -1}), ('RACGAP1', 'CDC42', {'sign': -1}), ('DIAPH3', 'CENPA', {'sign': -1}), ('TPX2', 'CDCA8', {'sign': -1}), ('NUSAP1', 'CDCA8', {'sign': -1}), ('PLCG2', 'CDKN1A', {'sign': -1}), ('PPP3R1', 'NFATC2', {'sign': -1}), ('PPP3R1', 'NFATC1', {'sign': -1}), ('PPP3R1', 'PPP1R1B', {'sign': -1}), ('PPP3R1', 'GABRA1', {'sign': -1}), ('PPP3R1', 'MAP2', {'sign': -1}), ('PPP3R1', 'MAPT', {'sign': -1}), ('PPP3R1', 'PPP1R1A', {'sign': -1}), ('PPP3R1', 'BAD', {'sign': -1}), ('PPP3R1', 'CREB1', {'sign': -1}), ('CD19', 'VAV1', {'sign': -1}), ('CD19', 'PIK3CA_PIK3R1', {'sign': -1}), ('CD19', 'PIK3R1', {'sign': -1}), ('PIK3AP1', 'PIK3R1', {'sign': -1}), ('MSL2', 'TP53', {'sign': -1}), ('WSB1', 'HIPK2', {'sign': -1}), ('SIAH2', 'HIPK2', {'sign': -1}), ('SIAH2', 'SNCAIP', {'sign': -1}), ('YAP1', 'TP73', {'sign': -1}), ('YAP1', 'SMAD7', {'sign': -1}), ('YAP1', 'RUNX2', {'sign': -1}), ('YAP1', 'CTNNB1', {'sign': -1}), ('YAP1', 'TEAD3', {'sign': -1}), ('YAP1', 'TEAD1', {'sign': -1}), ('YAP1', 'SMAD1', {'sign': -1}), ('YAP1', 'TEAD4', {'sign': -1}), ('YAP1', 'TEAD2', {'sign': -1}), ('SUV39H2', 'H3C12', {'sign': -1}), ('RAD17', 'RAD9A', {'sign': -1}), ('TP53AIP1', 'CYCS', {'sign': -1}), ('FGFR1', 'FRS2', {'sign': -1}), ('FGFR1', 'GRB14', {'sign': -1}), ('FGFR1', 'PDK1', {'sign': -1}), ('FGFR1', 'BCAR1', {'sign': -1}), ('FGFR1', 'LDHA', {'sign': -1}), ('FGFR1', 'SYNCRIP', {'sign': -1}), ('FGFR1', 'CTTN', {'sign': -1}), ('FGFR1', 'AMOTL2', {'sign': -1}), ('FGFR1', 'ACAT1', {'sign': -1}), ('FGFR1', 'PLCG1', {'sign': -1}), ('BORA', 'AURKA', {'sign': -1}), ('INCENP', 'PLK1', {'sign': -1}), ('INCENP', 'AURKA', {'sign': -1}), ('PTPN2', 'STAT3', {'sign': -1}), ('PTPN2', 'STAT1', {'sign': -1}), ('PTPN2', 'KDR', {'sign': -1}), ('PTPN2', 'JAK1', {'sign': -1}), ('PTPN2', 'STAT5A', {'sign': -1}), ('PTPN2', 'INSR', {'sign': -1}), ('PTPN2', 'JAK3', {'sign': -1}), ('PTPN2', 'GJA1', {'sign': -1}), ('PTPN2', 'SHC1', {'sign': -1}), ('PTPN2', 'MET', {'sign': -1}), ('PTPN2', 'EGFR', {'sign': -1}), ('PTPN2', 'FYN', {'sign': -1}), ('PTPN2', 'SRC', {'sign': -1}), ('PTPN2', 'GHR', {'sign': -1}), ('PTPN2', 'PDGFRB', {'sign': -1}), ('PTPN2', 'STAT6', {'sign': -1}), ('PTPN2', 'WASL', {'sign': -1}), ('PTPN2', 'FKBP4', {'sign': -1}), ('PTPN2', 'STAT5B', {'sign': -1}), ('KDR', 'SHC2', {'sign': -1}), ('KDR', 'ANXA5', {'sign': -1}), ('KDR', 'SHC1', {'sign': -1}), ('KDR', 'GRB2', {'sign': -1}), ('KDR', 'PLCG1', {'sign': -1}), ('KDR', 'PTK2', {'sign': -1}), ('NANOS1', 'HDAC2', {'sign': -1}), ('STAT5A', 'AURKA', {'sign': -1}), ('STAT5A', 'CSN2', {'sign': -1}), ('STAT5A', 'BCL2L1', {'sign': -1}), ('PRKCD', 'PRKDC', {'sign': -1}), ('PRKCD', 'STAT3', {'sign': -1}), ('PRKCD', 'ADCY5', {'sign': -1}), ('PRKCD', 'ELAVL1', {'sign': -1}), ('PRKCD', 'ADCY7', {'sign': -1}), ('PRKCD', 'NCF1', {'sign': -1}), ('PRKCD', 'NFE2L2', {'sign': -1}), ('PRKCD', 'STAT1', {'sign': -1}), ('PRKCD', 'FLI1', {'sign': -1}), ('PRKCD', 'ADRB2', {'sign': -1}), ('PRKCD', 'DNM1L', {'sign': -1}), ('PRKCD', 'G6PD', {'sign': -1}), ('PRKCD', 'PA2G4', {'sign': -1}), ('PRKCD', 'MYBPC3', {'sign': -1}), ('PRKCD', 'PRKD1', {'sign': -1}), ('PRKCD', 'CHN2', {'sign': -1}), ('PRKCD', 'DAB2', {'sign': -1}), ('PRKCD', 'SHC1', {'sign': -1}), ('PRKCD', 'GRM5', {'sign': -1}), ('PRKCD', 'HABP4', {'sign': -1}), ('PRKCD', 'IRS1', {'sign': -1}), ('PRKCD', 'PLSCR3', {'sign': -1}), ('PRKCD', 'GSK3A', {'sign': -1}), ('PRKCD', 'CXCR4', {'sign': -1}), ('PRKCD', 'RPS3', {'sign': -1}), ('PRKCD', 'PPP1R14B', {'sign': -1}), ('PRKCD', 'CHAT', {'sign': -1}), ('PRKCD', 'GRK2', {'sign': -1}), ('PRKCD', 'PEBP1', {'sign': -1}), ('PRKCD', 'BDKRB2', {'sign': -1}), ('PRKCD', 'ADRA2A', {'sign': -1}), ('PRKCD', 'BEST1', {'sign': -1}), ('PRKCD', 'KLF5', {'sign': -1}), ('PRKCD', 'HNRNPK', {'sign': -1}), ('PRKCD', 'SLC29A1', {'sign': -1}), ('PRKCD', 'ITGB7', {'sign': -1}), ('PRKCD', 'TNNI3', {'sign': -1}), ('PRKCD', 'MEP1B', {'sign': -1}), ('PRKCD', 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('PRKCD', 'HDAC5', {'sign': -1}), ('PRKCD', 'CTNNB1', {'sign': -1}), ('PRKCD', 'PLD2', {'sign': -1}), ('PRKCD', 'PLSCR1', {'sign': -1}), ('PRKCD', 'TAGLN', {'sign': -1}), ('PRKCD', 'TP53', {'sign': -1}), ('PRKCD', 'KRT8', {'sign': -1}), ('PRKCD', 'BAG3', {'sign': -1}), ('PRKCD', 'CARD9', {'sign': -1}), ('PRKCD', 'MET', {'sign': -1}), ('PRKCD', 'NLRC4', {'sign': -1}), ('DUSP1', 'MAPK14', {'sign': -1}), ('DUSP1', 'FANCI', {'sign': -1}), ('DUSP1', 'MAPK1', {'sign': -1}), ('DUSP1', 'MAPK8', {'sign': -1}), ('DUSP1', 'MAPK3', {'sign': -1}), ('DUSP1', 'MAPK9', {'sign': -1}), ('MAPKAP1_MLST8_MTOR_RICTOR', 'AKT3', {'sign': -1}), ('USF1', 'FOSL1', {'sign': -1}), ('MAPK9', 'CDC25B', {'sign': -1}), ('MAPK9', 'STAT1', {'sign': -1}), ('MAPK9', 'CTNNB1', {'sign': -1}), ('MAPK9', 'MAPK8IP1', {'sign': -1}), ('MAPK9', 'IRS1', {'sign': -1}), ('MAPK9', 'TP53', {'sign': -1}), ('MAPK9', 'MFN2', {'sign': -1}), ('MAPK9', 'NFATC3', {'sign': -1}), ('MAPK9', 'STAT3', {'sign': -1}), ('MAPK9', 'TOB1', {'sign': 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('MFN1', 'BAK1', {'sign': -1}), ('TARBP2', 'DICER1', {'sign': -1}), ('HNF4A', 'APOA1', {'sign': -1}), ('HNF4A', 'F2', {'sign': -1}), ('HNF4A', 'G6PC1', {'sign': -1}), ('HNF4A', 'TTR', {'sign': -1}), ('APOA1', 'ABCA1', {'sign': -1}), ('APOA1', 'LCAT', {'sign': -1}), ('HERC2', 'RNF168', {'sign': -1}), ('HERC2', 'RNF8', {'sign': -1}), ('HERC2', 'XPA', {'sign': -1}), ('FOXA2', 'APOA1', {'sign': -1}), ('FOXA2', 'OTX2', {'sign': -1}), ('EGFR_ERBB3', 'PIK3R1', {'sign': -1}), ('RAD54L', 'MUS81', {'sign': -1}), ('TIMP3', 'MMP14', {'sign': -1}), ('PAX5', 'PDCD1', {'sign': -1}), ('PAX5', 'CD19', {'sign': -1}), ('PAX5', 'CD79A', {'sign': -1}), ('PAX5', 'CSF1R', {'sign': -1}), ('PAX5', 'BLK', {'sign': -1}), ('PAX5', 'TLE4', {'sign': -1}), ('SPI1', 'ITGAM', {'sign': -1}), ('SPI1', 'ITGB2', {'sign': -1}), ('SPI1', 'CSF1', {'sign': -1}), ('SPI1', 'CSF3', {'sign': -1}), ('SPI1', 'CSF2', {'sign': -1}), ('SPI1', 'TAL1', {'sign': -1}), ('SPI1', 'VAV1', {'sign': -1}), ('SPI1', 'PRTN3', {'sign': -1}), ('SPI1', 'ELANE', {'sign': -1}), ('SPI1', 'CSF1R', {'sign': -1}), ('SPI1', 'IRF8', {'sign': -1}), ('CSF1', 'CSF2RA', {'sign': -1}), ('CSF1', 'CSF3R', {'sign': -1}), ('CSF1', 'CSF1R', {'sign': -1}), ('ETS2', 'CDKN2A', {'sign': -1}), ('BCR', 'YWHAQ', {'sign': -1}), ('DUSP5', 'MAPK3', {'sign': -1}), ('DUSP5', 'MAPK1', {'sign': -1}), ('CDCA5', 'SMC3', {'sign': -1}), ('BARD1', 'BRCA1', {'sign': -1}), ('ABI1', 'CBL', {'sign': -1}), ('NDEL1', 'DYNC1H1', {'sign': -1}), ('CBX4', 'CTCF', {'sign': -1}), ('LTF', 'LRP1', {'sign': -1}), ('LTF', 'LRP11', {'sign': -1}), ('IL3', 'CSF2RB', {'sign': -1}), ('IL3', 'IL3RA', {'sign': -1}), ('ELANE', 'F5', {'sign': -1}), ('ELANE', 'F2RL1', {'sign': -1}), ('ELANE', 'F2R', {'sign': -1}), ('ELANE', 'SERPIND1', {'sign': -1}), ('BLK', 'FCGR2A', {'sign': -1}), ('BLK', 'FCGR2C', {'sign': -1}), ('BLK', 'FCGR2B', {'sign': -1}), ('CSF2RA', 'JAK2', {'sign': -1}), ('CD14', 'TLR4', {'sign': -1}), ('CSF3', 'CSF3R', {'sign': -1}), ('CSF3', 'CSF2RA', {'sign': -1}), ('CSF2', 'CSF2RA', {'sign': -1}), ('CSF2', 'CSF3R', {'sign': -1}), ('CSF2', 'CSF2RA_CSF2RB', {'sign': -1}), ('CSF2', 'CSF2RB', {'sign': -1}), ('EEF1E1', 'ATR', {'sign': -1}), ('EEF1E1', 'ATM', {'sign': -1}), ('TIPRL', 'PPP2CA', {'sign': -1}), ('CBX1', 'H3-4', {'sign': -1}), ('CBX1', 'H3C12', {'sign': -1}), ('VCP', 'NPLOC4', {'sign': -1}), ('VCP', 'DERL1', {'sign': -1}), ('VCP', 'UFD1', {'sign': -1}), ('NCL', 'RPA1', {'sign': -1}), ('NCL', 'MYBL1', {'sign': -1}), ('NCL', 'MYB', {'sign': -1}), ('CDCA3', 'WEE1', {'sign': -1}), ('DYNLL2', 'BMF', {'sign': -1}), ('DYNLL2', 'AMBRA1', {'sign': -1}), ('TGFB1', 'NOS2', {'sign': -1}), ('TGFB1', 'TGFBR2', {'sign': -1}), ('TGFB1', 'TGFBR3', {'sign': -1}), ('TGFB1', 'TGFBR1', {'sign': -1}), ('TGFB1', 'TGFBR1_TGFBR2', {'sign': -1}), ('TGFB1', 'EGFR', {'sign': -1}), ('TGFB1', 'SMAD3', {'sign': -1}), ('PSIP1', 'CRYAB', {'sign': -1}), ('PSIP1', 'HSPB1', {'sign': -1}), ('PSIP1', 'ADH4', {'sign': -1}), ('PSIP1', 'PRDX6', {'sign': -1}), ('PSIP1', 'ALDH1A2', {'sign': -1}), ('PSIP1', 'ADH1A', {'sign': -1}), ('PSIP1', 'GCLC', {'sign': -1}), ('CRYAB', 'CRYGS', {'sign': -1}), ('CRYAB', 'CRYGC', {'sign': -1}), ('CRYAB', 'CRYGD', {'sign': -1}), ('ATR_ATRIP', 'RAD17', {'sign': -1}), ('CDKN2A_MDM2', 'TP53', {'sign': -1}), ('PBX1', 'NANOG', {'sign': -1}), ('PBX1', 'MYOD1', {'sign': -1}), ('PBX1', 'HOXB1', {'sign': -1}), ('TNFRSF1B', 'TRAF2', {'sign': -1}), ('TNFRSF1B', 'TRAF1', {'sign': -1}), ('BAG4', 'TNFRSF1A', {'sign': -1}), ('RNF20', 'RNF40', {'sign': -1}), ('MARK1', 'MAP2', {'sign': -1}), ('MARK1', 'MAP4', {'sign': -1}), ('MARK1', 'MAPT', {'sign': -1}), ('MARK1', 'DVL3', {'sign': -1}), ('ERCC5', 'PCNA', {'sign': -1}), ('ERCC5', 'ERCC2', {'sign': -1}), ('INS', 'INSR', {'sign': -1}), ('INS', 'IGF1R', {'sign': -1}), ('NR0B2', 'HNF4A', {'sign': -1}), ('NR0B2', 'AR', {'sign': -1}), ('NR0B2', 'ESR1', {'sign': -1}), ('NR0B2', 'SIRT1', {'sign': -1}), ('NR0B2', 'RXRA', {'sign': -1}), ('NR0B2', 'NR5A2', {'sign': -1}), ('NR0B2', 'RXRB', {'sign': -1}), ('NR0B2', 'ESR2', {'sign': -1}), ('NR0B2', 'NR1I2', {'sign': -1}), ('NR0B2', 'THRA', {'sign': -1}), ('NR0B2', 'THRB', {'sign': -1}), ('NR0B2', 'RARA', {'sign': -1}), ('NR0B2', 'RARB', {'sign': -1}), ('NR0B2', 'PPARA', {'sign': -1}), ('NR0B2', 'NR1H2', {'sign': -1}), ('NR0B2', 'NR1H3', {'sign': -1}), ('NR0B2', 'NR1I3', {'sign': -1}), ('NR0B2', 'ESRRB', {'sign': -1}), ('NR0B2', 'ESRRG', {'sign': -1}), ('NR0B2', 'ESRRA', {'sign': -1}), ('TNFSF9', 'TNFRSF9', {'sign': -1}), ('BAG1', 'BCL2', {'sign': -1}), ('BAG1', 'PPP1R15A', {'sign': -1}), ('BAG1', 'HSPA8', {'sign': -1}), ('NOTCH1_RBPJ', 'HES5', {'sign': -1}), ('INSM1', 'INS', {'sign': -1}), ('MEIS2', 'PAX6', {'sign': -1}), ('CRYAA', 'CRYBB2', {'sign': -1}), ('GADD45B', 'MAP3K4', {'sign': -1}), ('PPP1R15A', 'PPP1CC', {'sign': -1}), ('H1-2', 'LIG3', {'sign': -1}), ('HUS1', 'PCNA', {'sign': -1}), ('MARK2', 'MAPT', {'sign': -1}), ('MARK2', 'DVL3', {'sign': -1}), ('MARK2', 'ARHGEF2', {'sign': -1}), ('MARK2', 'KIF13B', {'sign': -1}), ('MARK2', 'RAB11FIP2', {'sign': -1}), ('MARK2', 'UTRN', {'sign': -1}), ('MARK2', 'PARD3', {'sign': -1}), ('MARK2', 'HDAC7', {'sign': -1}), ('MARK2', 'EIF2S1', {'sign': -1}), ('SEM1', 'BRCA2', {'sign': -1}), ('RHOU', 'PAK1', {'sign': -1}), ('SIRT3', 'XRCC6', {'sign': -1}), ('NAB2', 'EGR1', {'sign': -1}), ('PDGFB', 'PDGFRA', {'sign': -1}), ('PDGFB', 'PDGFRB', {'sign': -1}), ('PDGFA', 'PDGFRA', {'sign': -1}), ('PDGFA', 'PDGFRB', {'sign': -1}), ('NAB1', 'EGR1', {'sign': -1}), ('CD70', 'CD27', {'sign': -1}), ('PRTN3', 'F2RL1', {'sign': -1}), ('PRTN3', 'F2R', {'sign': -1}), ('HNF1B', 'DPP4', {'sign': -1}), ('HNF1B', 'CREB1', {'sign': -1}), ('HNF1B', 'ATF1', {'sign': -1}), ('SPIB', 'XBP1', {'sign': -1}), ('SPIB', 'PRDM1', {'sign': -1}), ('BLVRA', 'HMOX1', {'sign': -1}), ('BLVRA', 'JUND', {'sign': -1}), ('BLVRA', 'PRKCB', {'sign': -1}), ('BLVRA', 'JUN', {'sign': -1}), ('BLVRA', 'ATF2', {'sign': -1}), ('SHH', 'PTCH1', {'sign': -1}), ('SHH', 'PTCH2', {'sign': -1}), ('SHH', 'HHIP', {'sign': -1}), ('SHH', 'BOC', {'sign': -1}), ('SHH', 'CP', {'sign': -1}), ('SHH', 'CDON', {'sign': -1}), ('SHH', 'SMO', {'sign': -1}), ('PTCH1', 'SMO', {'sign': -1}), ('PTCH1', 'CCNB1', {'sign': -1}), ('DHH', 'PTCH1', {'sign': -1}), ('DHH', 'PTCH2', {'sign': -1}), ('DHH', 'HHIP', {'sign': -1}), ('IHH', 'PTCH1', {'sign': -1}), ('IHH', 'PTCH2', {'sign': -1}), ('IHH', 'HHIP', {'sign': -1}), ('NRF1', 'EIF2S1', {'sign': -1}), ('NRF1', 'TFAM', {'sign': -1}), ('NRF1', 'EIF2S2', {'sign': -1}), ('ITCH_NUMB', 'GLI1', {'sign': -1}), ('GNL3', 'TP53', {'sign': -1}), ('RPS6KA2', 'BAD', {'sign': -1}), ('RPS6KA2', 'NFKBIA', {'sign': -1}), ('RPS6KA2', 'L1CAM', {'sign': -1}), ('RPS6KA2', 'NR4A1', {'sign': -1}), ('RPS6KA2', 'CREB1', {'sign': -1}), ('RPS6KA2', 'NFATC4', {'sign': -1}), ('RPS6KA2', 'EEF2K', {'sign': -1}), ('RPS6KA2', 'TSC2', {'sign': -1}), ('FOXD3', 'NANOG', {'sign': -1}), ('POU5F1', 'NANOG', {'sign': -1}), ('BABAM1', 'BRCA1', {'sign': -1}), ('KAT5_UBE2N', 'H2AX', {'sign': -1}), ('EYA2', 'H2AX', {'sign': -1}), ('EYA3', 'H2AX', {'sign': -1}), ('STK36', 'GLI1', {'sign': -1}), ('STK36', 'GLI2', {'sign': -1}), ('BIRC5_LAMTOR5', 'APAF1', {'sign': -1}), ('FUS', 'BCL2L11', {'sign': -1}), ('FUS', 'BCL2L1', {'sign': -1}), ('FUS', 'BCL2', {'sign': -1}), ('FUS', 'MATR3', {'sign': -1}), ('TNF_TNFRSF1A', 'BID', {'sign': -1}), ('TNFRSF1B_TNFSF10', 'BCL2L11', {'sign': -1}), ('RIPK1_TNF_TNFRSF1A_TRADD_TRAF2', 'MAP3K14', {'sign': -1}), ('NOD1_RIPK2', 'CFAP100', {'sign': -1}), ('PIAS3', 'STAT3', {'sign': -1}), ('PIAS3', 'MITF', {'sign': -1}), ('PIAS3', 'SMAD3', {'sign': -1}), ('CHD3_CHD4_GATAD2A_GATAD2B_HDAC1_HDAC2_MBD2_MBD3_MTA1_MTA2_MTA3_RBBP4_RBBP7', 'TGFB1', {'sign': -1}), ('IL24', 'IFNB1', {'sign': -1}), ('IL24', 'IL22RA1', {'sign': -1}), ('IL24', 'IL20RA', {'sign': -1}), ('IL24', 'IL20RB', {'sign': -1}), ('IL24', 'IL20RA_IL20RB', {'sign': -1}), ('IL24', 'IL20RB_IL22RA1', {'sign': -1}), ('ARID4B_BRMS1_HDAC1_HDAC2_ING1_ING2_RBBP4_RBBP7_RBP1_SAP18_SAP30_SIN3A_SUDS3', 'MYC', {'sign': -1}), ('ARID4B_BRMS1_HDAC1_HDAC2_ING1_ING2_RBBP4_RBBP7_RBP1_SAP18_SAP30_SIN3A_SUDS3', 'CCND1', {'sign': -1}), ('CCND3', 'CCNE1', {'sign': -1}), ('CCND3', 'CDK6', {'sign': -1}), ('CCND3', 'CDK4', {'sign': -1}), ('FKBP6', 'GAPDH', {'sign': -1}), ('N4BP1', 'ITCH', {'sign': -1}), ('NOTCH4', 'RBPJ', {'sign': -1}), ('PRKRA', 'EIF2AK2', {'sign': -1}), ('XAF1', 'XIAP', {'sign': -1}), ('XAF1', 'BIRC2', {'sign': -1}), ('XAF1', 'BIRC3', {'sign': -1}), ('RCHY1', 'CDKN1B', {'sign': -1}), ('RCHY1', 'TP53', {'sign': -1}), ('RCHY1', 'HDAC1', {'sign': -1}), ('TP53BP2', 'TP53', {'sign': -1}), ('PPP1R13B', 'TP53', {'sign': -1}), ('WRAP53', 'TP53', {'sign': -1}), ('HOXA5', 'TP53', {'sign': -1}), ('FAAP24_FANCM', 'RPA1', {'sign': -1}), ('CASP12', 'CASP9', {'sign': -1}), ('CASP12', 'CASP7', {'sign': -1}), ('PTPN13', 'FAS', {'sign': -1}), ('PTPN13', 'EFNB1', {'sign': -1}), ('PTPN13', 'TRIP6', {'sign': -1}), ('PTPN13', 'INSR', {'sign': -1}), ('PTPN13', 'PDCD10', {'sign': -1}), ('PTPN13', 'NFKBIA', {'sign': -1}), ('DHX9', 'WRN', {'sign': -1}), ('DAB2', 'AXIN1', {'sign': -1}), ('DAB2', 'PPP1R2', {'sign': -1}), ('DAB2', 'SMAD2', {'sign': -1}), ('DAB2', 'DVL3', {'sign': -1}), ('DAB2', 'TGFBR2', {'sign': -1}), ('DAB2', 'TGFBR1', {'sign': -1}), ('DAB2', 'CSK', {'sign': -1}), ('DAB2', 'LRP6', {'sign': -1}), ('PPP1R2', 'PPP1CA', {'sign': -1}), ('FAAP100', 'FANCA', {'sign': -1}), ('ROR2', 'FLNA', {'sign': -1}), ('ROR2', 'MAGED1', {'sign': -1}), ('ROR2', 'BMPR1B', {'sign': -1}), ('ROR2', 'GRK2', {'sign': -1}), ('ARHGEF2', 'RHOA', {'sign': -1}), ('ARHGEF2', 'RAC1', {'sign': -1}), ('ARRB2', 'GNAI1', {'sign': -1}), ('ARRB2', 'GNAI2', {'sign': -1}), ('ARRB2', 'GNAI3', {'sign': -1}), ('ARRB2', 'ADRB2', {'sign': -1}), ('ARRB2', 'KIF3A', {'sign': -1}), ('HTATIP2', 'TP53', {'sign': -1}), ('RARB', 'RXRG', {'sign': -1}), ('RARB', 'RARG', {'sign': -1}), ('RARB', 'RXRA', {'sign': -1}), ('RARB', 'THRA', {'sign': -1}), ('RARB', 'RXRB', {'sign': -1}), ('RXRG', 'RARA', {'sign': -1}), ('RXRG', 'THRA', {'sign': -1}), ('RXRG', 'VDR', {'sign': -1}), ('RXRG', 'NR4A2', {'sign': -1}), ('WWOX', 'DVL2', {'sign': -1}), ('WWOX', 'SMAD4', {'sign': -1}), ('ARHGEF7', 'RAC1', {'sign': -1}), ('ARHGEF7', 'CDC42', {'sign': -1}), ('ARHGEF7', 'GIT1', {'sign': -1}), ('PTK7', 'CTNNB1', {'sign': -1}), ('FMR1', 'PAK1', {'sign': -1}), ('SOX10', 'RET', {'sign': -1}), ('SOX10', 'PLP1', {'sign': -1}), ('SOX10', 'PDGFRA', {'sign': -1}), ('SOX10', 'MPZ', {'sign': -1}), ('SOX10', 'MITF', {'sign': -1}), ('SOX10', 'MBP', {'sign': -1}), ('SOX10', 'MAG', {'sign': -1}), ('SOX10', 'GJB1', {'sign': -1}), ('SOX10', 'EDNRB', {'sign': -1}), ('SOX10', 'EGR2', {'sign': -1}), ('SOX10', 'DCT', {'sign': -1}), ('SOX10', 'ASCL1', {'sign': -1}), ('SOX10', 'TYR', {'sign': -1}), ('SOX10', 'GJC2', {'sign': -1}), ('SOX10', 'SOX6', {'sign': -1}), ('RAC2', 'PAK3', {'sign': -1}), ('RAC2', 'PAK1', {'sign': -1}), ('PAK3', 'TNNI3', {'sign': -1}), ('PAK3', 'RAF1', {'sign': -1}), ('PAK3', 'CALD1', {'sign': -1}), ('PAK3', 'SYN1', {'sign': -1}), ('PAK3', 'MYO6', {'sign': -1}), ('PAK3', 'CTTN', {'sign': -1}), ('PDGFRA', 'PLCG1', {'sign': -1}), ('PDGFRA', 'CRK', {'sign': -1}), ('PDGFRA', 'SRC', {'sign': -1}), ('PDGFRA', 'PTK2', {'sign': -1}), ('PDGFRA', 'SHC1', {'sign': -1}), ('ARHGEF6', 'PAK1', {'sign': -1}), ('ARHGEF6', 'GIT1', {'sign': -1}), ('ARHGEF6', 'RAC1', {'sign': -1}), ('CIB1', 'PAK1', {'sign': -1}), ('CIB1', 'ITGA2B', {'sign': -1}), ('RILPL2', 'PAK1', {'sign': -1}), ('PAK1IP1', 'PAK1', {'sign': -1}), ('RAC3', 'PAK1', {'sign': -1}), ('RAC3', 'CIB1', {'sign': -1}), ('RHOQ', 'PAK1', {'sign': -1}), ('RHOQ', 'EXOC7', {'sign': -1}), ('CHP1', 'PAK1', {'sign': -1}), ('PPM1E', 'PAK1', {'sign': -1}), ('PPM1F', 'PAK1', {'sign': -1}), ('PPM1F', 'CAMK1', {'sign': -1}), ('PPM1F', 'CAMK2A', {'sign': -1}), ('PPM1F', 'CAMK4', {'sign': -1}), ('NKD1', 'DVL3', {'sign': -1}), ('NKD1', 'CTNNB1', {'sign': -1}), ('ARHGAP32', 'CDC42', {'sign': -1}), ('ARHGAP32', 'CRKL', {'sign': -1}), ('ARHGAP32', 'CRK', {'sign': -1}), ('ARHGAP32', 'RAC1', {'sign': -1}), ('ARHGAP32', 'RHOA', {'sign': -1}), ('ARHGAP32', 'SRC', {'sign': -1}), ('PTPRC', 'LYN', {'sign': -1}), ('PTPRC', 'SKAP1', {'sign': -1}), ('PTPRC', 'JAK3', {'sign': -1}), ('PTPRC', 'JAK1', {'sign': -1}), ('PTPRC', 'JAK2', {'sign': -1}), ('PTPRC', 'LCK', {'sign': -1}), ('PTPRC', 'TYK2', {'sign': -1}), ('PTPRC', 'FYN', {'sign': -1}), ('PTPRC', 'CD247', {'sign': -1}), ('NOTCH3', 'RBPJ', {'sign': -1}), ('GNA13', 'PTK2B', {'sign': -1}), ('GNA13', 'ARHGEF1', {'sign': -1}), ('GNA13', 'RDX', {'sign': -1}), ('GNA13', 'ARHGEF12', {'sign': -1}), ('GNA13', 'ARHGEF11', {'sign': -1}), ('FZD8', 'LRP5', {'sign': -1}), ('FZD8', 'LRP6', {'sign': -1}), ('ABRAXAS1', 'BRCA1', {'sign': -1}), ('PPP6C', 'MAP3K7', {'sign': -1}), ('PTCH2', 'SMO', {'sign': -1}), ('INPP5D', 'TRAF6', {'sign': -1}), ('INPP5D', 'SYK', {'sign': -1}), ('KCNQ3', 'KCNQ2', {'sign': -1}), ('KCNQ2', 'KCNQ3', {'sign': -1}), ('RYK', 'FZD8', {'sign': -1}), ('RYK', 'DVL1', {'sign': -1}), ('RYK', 'DVL2', {'sign': -1}), ('RYK', 'DVL3', {'sign': -1}), ('UBR2', 'RECQL4', {'sign': -1}), ('TGFB3', 'TGFBR2', {'sign': -1}), ('TGFB3', 'TGFBR3', {'sign': -1}), ('TGFB3', 'TGFBR1', {'sign': -1}), ('DUSP16', 'MAPK14', {'sign': -1}), ('DUSP16', 'MAPK8IP1', {'sign': -1}), ('DUSP16', 'MAPK8IP2', {'sign': -1}), ('DUSP16', 'MAPK9', {'sign': -1}), ('DUSP16', 'MAPK10', {'sign': -1}), ('MAP1LC3A', 'SQSTM1', {'sign': -1}), ('MAP1LC3A', 'ATG3', {'sign': -1}), ('TGFB2', 'TGFBR3', {'sign': -1}), ('TGFB2', 'TGFBR2', {'sign': -1}), ('TGFB2', 'TGFBR1', {'sign': -1}), ('SOCS6', 'KIT', {'sign': -1}), ('MALT1', 'TAB2', {'sign': -1}), ('VAV3', 'RHOA', {'sign': -1}), ('VAV3', 'RAC1', {'sign': -1}), ('EID2', 'SMAD3', {'sign': -1}), ('WNT3A', 'RYK', {'sign': -1}), ('WNT3A', 'FZD1', {'sign': -1}), ('WNT3A', 'LRP6', {'sign': -1}), ('WNT3A', 'FZD6', {'sign': -1}), ('WNT3A', 'FZD8', {'sign': -1}), ('WNT3A', 'FZD3', {'sign': -1}), ('WNT3A', 'LRP5', {'sign': -1}), ('WNT3A', 'FZD2', {'sign': -1}), ('WNT3A', 'FZD5', {'sign': -1}), ('WNT3A', 'FZD7', {'sign': 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{'sign': -1}), ('PSEN1', 'CTNNB1', {'sign': -1}), ('PSEN1', 'APH1A_NCSTN_PSEN1_PSENEN', {'sign': -1}), ('IL1RN', 'IL1R1', {'sign': -1}), ('IL1RN', 'IL1R2', {'sign': -1}), ('FOXH1', 'SMAD2', {'sign': -1}), ('ARHGAP31', 'RAC1', {'sign': -1}), ('WNT7A', 'FZD5', {'sign': -1}), ('WNT7A', 'FZD7', {'sign': -1}), ('WNT7A', 'LRP6', {'sign': -1}), ('WNT7A', 'FZD9', {'sign': -1}), ('WNT7A', 'FZD10', {'sign': -1}), ('SMAD1', 'DVL1', {'sign': -1}), ('SMAD1', 'SMAD4', {'sign': -1}), ('SMAD1', 'RUNX2', {'sign': -1}), ('GAB1', 'PLCG1', {'sign': -1}), ('GAB1', 'ARHGAP32', {'sign': -1}), ('GAB1', 'PIK3CA', {'sign': -1}), ('GAB1', 'CRKL', {'sign': -1}), ('VPS39', 'SMAD4', {'sign': -1}), ('SNW1', 'RBPJ', {'sign': -1}), ('CCN3', 'NOTCH1', {'sign': -1}), ('ERBIN', 'SMAD3', {'sign': -1}), ('ERBIN', 'SMAD2', {'sign': -1}), ('ERBIN', 'NOD2', {'sign': -1}), ('ERBIN', 'RIPK2', {'sign': -1}), ('ZFYVE9', 'TGFBR1', {'sign': -1}), ('ZFYVE9', 'SMAD2', {'sign': -1}), ('ZFYVE9', 'SMAD3', {'sign': -1}), ('TAX1BP1', 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{'sign': -1}), ('BMP2', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP2', 'BMPR1B_BMPR2', {'sign': -1}), ('BMP2', 'ACVR2A', {'sign': -1}), ('BMP2', 'ACVR1', {'sign': -1}), ('BMP2', 'BMPR1B', {'sign': -1}), ('GDF5', 'BMPR2', {'sign': -1}), ('GDF5', 'ACVR2B', {'sign': -1}), ('GDF5', 'BMPR1B', {'sign': -1}), ('GDF5', 'ACVR2A_BMPR1A', {'sign': -1}), ('GDF5', 'ACVR2B_BMPR1A', {'sign': -1}), ('GDF5', 'BMPR1A_BMPR2', {'sign': -1}), ('GDF5', 'ACVR2A_BMPR1B', {'sign': -1}), ('GDF5', 'ACVR2B_BMPR1B', {'sign': -1}), ('GDF5', 'BMPR1B_BMPR2', {'sign': -1}), ('GDF5', 'ACVR2A', {'sign': -1}), ('GDF5', 'BMPR1A', {'sign': -1}), ('GDF5', 'ROR2', {'sign': -1}), ('ACVR2B', 'ACVR1B', {'sign': -1}), ('ACVR2B', 'BMPR1A', {'sign': -1}), ('ACVR2B', 'ACVR1', {'sign': -1}), ('ACVR2B', 'BMPR1B', {'sign': -1}), ('ACVR2B', 'ACVRL1', {'sign': -1}), ('ACVR2B', 'ACVR1C', {'sign': -1}), ('IFNAR2', 'JAK1', {'sign': -1}), ('IFNAR2', 'TYK2', {'sign': -1}), ('IL21R', 'JAK1', {'sign': -1}), ('IL21R', 'JAK3', {'sign': -1}), ('GH1', 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'NEUROD1', {'sign': -1}), ('MAP3K10', 'TCF3', {'sign': -1}), ('MAP3K10', 'DYRK2', {'sign': -1}), ('ACVR1', 'SMAD1', {'sign': -1}), ('ACVR1', 'SMAD5', {'sign': -1}), ('ACVRL1', 'SMAD1', {'sign': -1}), ('BMPR1B', 'SMAD5', {'sign': -1}), ('BMPR1B', 'SMAD1', {'sign': -1}), ('BMPR1B', 'SMAD9', {'sign': -1}), ('BMPR1B', 'STAMBP', {'sign': -1}), ('SMAD5', 'SMAD4', {'sign': -1}), ('DUSP8', 'MAPK14', {'sign': -1}), ('DUSP8', 'MAPK8', {'sign': -1}), ('WNT8A', 'FZD7', {'sign': -1}), ('WNT8A', 'FZD8', {'sign': -1}), ('WNT8A', 'LRP5', {'sign': -1}), ('FZD7', 'DVL1', {'sign': -1}), ('AREG', 'EGFR', {'sign': -1}), ('AREG', 'ERBB2', {'sign': -1}), ('HBEGF', 'EGFR', {'sign': -1}), ('HBEGF', 'ERBB4', {'sign': -1}), ('NRG4', 'ERBB4', {'sign': -1}), ('BAMBI', 'BMPR1A', {'sign': -1}), ('BAMBI', 'TGFBR1', {'sign': -1}), ('BAMBI', 'BMPR1B', {'sign': -1}), ('BAMBI', 'ACVRL1', {'sign': -1}), ('BMPR1A', 'SMAD9', {'sign': -1}), ('BMPR1A', 'SMAD1', {'sign': -1}), ('BMPR1A', 'FAM83G', {'sign': -1}), ('BMPR1A', 'BMPR1B', {'sign': -1}), ('MAPK8IP3', 'MAP3K11', {'sign': -1}), ('MAPK8IP3', 'MAP2K7', {'sign': -1}), ('MAPK8IP3', 'MAP2K4', {'sign': -1}), ('MAPK8IP3', 'MAP3K1', {'sign': -1}), ('MAPK8IP3', 'MAPK9', {'sign': -1}), ('OSMR', 'IL6ST', {'sign': -1}), ('OSMR', 'JAK2', {'sign': -1}), ('OSMR', 'JAK1', {'sign': -1}), ('SHOC2', 'KRAS', {'sign': -1}), ('DLL3', 'NOTCH1', {'sign': -1}), ('DLL3', 'NOTCH2', {'sign': -1}), ('DLL3', 'NOTCH3', {'sign': -1}), ('DLL3', 'NOTCH4', {'sign': -1}), ('IL23A', 'IL12RB1', {'sign': -1}), ('IL23A', 'IL23R', {'sign': -1}), ('IL23A', 'IL12RB1_IL23R', {'sign': -1}), ('MAPK12', 'SNTA1', {'sign': -1}), ('MAPK12', 'CARM1', {'sign': -1}), ('MAPK12', 'MAPT', {'sign': -1}), ('MAPK12', 'KRT8', {'sign': -1}), ('MAPK12', 'ATF2', {'sign': -1}), ('MAPK12', 'SH3BP5', {'sign': -1}), ('MAPK12', 'RCSD1', {'sign': -1}), ('MAPK12', 'MEF2A', {'sign': -1}), ('MAPK12', 'MEF2C', {'sign': -1}), ('MAPK12', 'MAPKAPK5', {'sign': -1}), ('CNTF', 'CRLF1', {'sign': -1}), ('CNTF', 'CNTFR', {'sign': -1}), ('CNTF', 'LIFR', {'sign': -1}), ('CNTF', 'IL6ST', {'sign': -1}), ('CRLF1', 'CNTFR', {'sign': -1}), ('CISH', 'STAT5A', {'sign': -1}), ('CISH', 'PRLR', {'sign': -1}), ('CISH', 'LEPR', {'sign': -1}), ('MAP3K20', 'MAP2K7', {'sign': -1}), ('MAP3K20', 'MAP2K5', {'sign': -1}), ('MAP3K20', 'MAP2K4', {'sign': -1}), ('MAP3K20', 'MAP2K3', {'sign': -1}), ('MAP3K20', 'MAP2K6', {'sign': -1}), ('PIK3CG', 'RAC1', {'sign': -1}), ('PIK3CG', 'TPM2', {'sign': -1}), ('IL23R', 'JAK2', {'sign': -1}), ('IL23R', 'TYK2', {'sign': -1}), ('MAPK8IP2', 'MAPK14', {'sign': -1}), ('MAPK8IP2', 'MAPK8', {'sign': -1}), ('MAPK8IP2', 'MAPK13', {'sign': -1}), ('MAPK8IP2', 'MAPK10', {'sign': -1}), ('MAPK8IP2', 'MAPK9', {'sign': -1}), ('MAPK8IP2', 'MAP2K7', {'sign': -1}), ('MAPK8IP2', 'MAPK8IP1', {'sign': -1}), ('NCSTN', 'PSEN1', {'sign': -1}), ('NCSTN', 'APH1A', {'sign': -1}), ('NCSTN', 'PSEN2', {'sign': -1}), ('GRB10', 'NEDD4', {'sign': -1}), ('GRB10', 'ABL1', {'sign': -1}), ('IL20RA', 'TYK2', {'sign': -1}), ('IL20RA', 'JAK1', {'sign': -1}), ('IL22RA1', 'TYK2', {'sign': -1}), ('IL22RA1', 'JAK1', {'sign': -1}), ('DISP1', 'SHH', {'sign': -1}), ('APH1A', 'PSEN1', {'sign': -1}), ('APH1A', 'PSEN2', {'sign': -1}), ('APH1A', 'PSENEN', {'sign': -1}), ('LRIG1', 'CBL', {'sign': -1}), ('LRIG1', 'ERBB3', {'sign': -1}), ('LRIG1', 'ERBB2', {'sign': -1}), ('LRIG1', 'ERBB4', {'sign': -1}), ('PPP4C', 'IRS4', {'sign': -1}), ('PPP4C', 'FOXO3', {'sign': -1}), ('PPP4C', 'NDEL1', {'sign': -1}), ('PPP4C', 'BANF1', {'sign': -1}), ('PPP4C', 'HDAC3', {'sign': -1}), ('PPP4C', 'RELA', {'sign': -1}), ('PPP4C', 'H2AX', {'sign': -1}), ('IL31', 'OSMR', {'sign': -1}), ('IL31', 'IL31RA', {'sign': -1}), ('IL31', 'IL31RA_OSMR', {'sign': -1}), ('OSM', 'OSMR', {'sign': -1}), ('OSM', 'LIFR', {'sign': -1}), ('OSM', 'IL6ST', {'sign': -1}), ('OSM', 'IL6ST_OSMR', {'sign': -1}), ('OSM', 'IL6ST_LIFR', {'sign': -1}), ('IL21', 'IL21R', {'sign': -1}), ('IL21', 'IL2RG', {'sign': -1}), ('AMHR2', 'ACVR1', {'sign': -1}), ('AMHR2', 'BMPR1B', {'sign': -1}), ('INHBA', 'ACVR2B', {'sign': -1}), ('INHBA', 'ACTR2', {'sign': -1}), ('INHBA', 'ACVR2A', {'sign': -1}), ('INHBA', 'ACVR1B_ACVR2A', {'sign': -1}), ('INHBA', 'ACVR1B_ACVR2B', {'sign': -1}), ('INHBA', 'ACVR1', {'sign': -1}), ('INHBA', 'BAMBI', {'sign': -1}), ('INHBA', 'ACVR1B', {'sign': -1}), ('BMP6', 'ACVR2B', {'sign': -1}), ('BMP6', 'BMPR2', {'sign': -1}), ('BMP6', 'AMHR2', {'sign': -1}), ('BMP6', 'ACVR1_ACVR2A', {'sign': -1}), ('BMP6', 'ACVR1_ACVR2B', {'sign': -1}), ('BMP6', 'ACVR1_BMPR2', {'sign': -1}), ('BMP6', 'ACVR2A_BMPR1A', {'sign': -1}), ('BMP6', 'ACVR2B_BMPR1A', {'sign': -1}), ('BMP6', 'BMPR1A_BMPR2', {'sign': -1}), ('BMP6', 'ACVR2A_BMPR1B', {'sign': -1}), ('BMP6', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP6', 'BMPR1B_BMPR2', {'sign': -1}), ('BMP6', 'ACVR2A', {'sign': -1}), ('BMP6', 'ACVR1', {'sign': -1}), ('BMP6', 'BMPR1A', {'sign': -1}), ('BMP6', 'BMPR1B', {'sign': -1}), ('GDF6', 'BMPR2', {'sign': -1}), ('GDF6', 'BMPR1A', {'sign': -1}), ('GDF6', 'ACVR2A_BMPR1A', {'sign': -1}), ('GDF6', 'ACVR2B_BMPR1A', {'sign': -1}), ('GDF6', 'BMPR1A_BMPR2', {'sign': -1}), ('GDF6', 'ACVR2A_BMPR1B', {'sign': -1}), ('GDF6', 'ACVR2B_BMPR1B', {'sign': -1}), ('GDF6', 'BMPR1B_BMPR2', {'sign': -1}), ('PPP4R3A', 'PPP4C', {'sign': -1}), ('CDO1', 'SHH', {'sign': -1}), ('IL20', 'IL22RA1', {'sign': -1}), ('IL20', 'IL20RA', {'sign': -1}), ('IL20', 'IL20RB', {'sign': -1}), ('IL20', 'IL20RA_IL20RB', {'sign': -1}), ('IL20', 'IL20RB_IL22RA1', {'sign': -1}), ('IL26', 'IL20RA', {'sign': -1}), ('IL26', 'IL10RB', {'sign': -1}), ('IL19', 'IL20RA', {'sign': -1}), ('IL19', 'IL20RB', {'sign': -1}), ('IL19', 'IL20RA_IL20RB', {'sign': -1}), ('IL27', 'IL27RA', {'sign': -1}), ('GPC3', 'SHH', {'sign': -1}), ('MFAP5', 'NOTCH1', {'sign': -1}), ('DAB1', 'NOTCH1', {'sign': -1}), ('CTF1', 'IL6ST', {'sign': -1}), ('CTF1', 'LIFR', {'sign': -1}), ('CTF1', 'IL6ST_LIFR', {'sign': -1}), ('IL31RA', 'JAK2', {'sign': -1}), ('IL31RA', 'JAK1', {'sign': -1}), ('MTMR4', 'SMAD2', {'sign': -1}), ('MTMR4', 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{'sign': -1}), ('RXRB', 'VDR', {'sign': -1}), ('RXRB', 'THRB', {'sign': -1}), ('RXRB', 'NR2F1', {'sign': -1}), ('RXRB', 'NR2F2', {'sign': -1}), ('RXRB', 'PPARD', {'sign': -1}), ('RXRB', 'NR1H2', {'sign': -1}), ('RXRB', 'PPARA', {'sign': -1}), ('RXRB', 'NRIP1', {'sign': -1}), ('NR1H3', 'PPARA', {'sign': -1}), ('NR1H3', 'PPARD', {'sign': -1}), ('ESR2', 'RARA', {'sign': -1}), ('NR1H2', 'PPARA', {'sign': -1}), ('NR1H2', 'PPARG', {'sign': -1}), ('NR1H2', 'RXRA', {'sign': -1}), ('NR1H2', 'PPARD', {'sign': -1}), ('NR4A2', 'NR4A3', {'sign': -1}), ('NR4A2', 'RXRA', {'sign': -1}), ('NR4A2', 'RXRB', {'sign': -1}), ('NR4A2', 'RXRG', {'sign': -1}), ('NR4A2', 'NR3C1', {'sign': -1}), ('NR4A2', 'NR4A1', {'sign': -1}), ('NR4A3', 'NR4A2', {'sign': -1}), ('NR4A3', 'NR3C1', {'sign': -1}), ('NR4A3', 'NR4A1', {'sign': -1}), ('UBE2O', 'SMAD6', {'sign': -1}), ('USP4', 'BRAP', {'sign': -1}), ('PEA15', 'MAPK3', {'sign': -1}), ('PEA15', 'MAPK1', {'sign': -1}), ('IFNLR1', 'TYK2', {'sign': -1}), ('IFNLR1', 'JAK1', {'sign': -1}), ('MAP4K2', 'MAP3K1', {'sign': -1}), ('MPL', 'JAK2', {'sign': -1}), ('MPL', 'TYK2', {'sign': -1}), ('THPO', 'MPL', {'sign': -1}), ('CNTFR', 'JAK1', {'sign': -1}), ('DUSP2', 'MAPK1', {'sign': -1}), ('DUSP2', 'MAPK14', {'sign': -1}), ('SHC3', 'GRB2', {'sign': -1}), ('MAP4K4', 'MAP3K1', {'sign': -1}), ('MAP4K4', 'MAP3K7', {'sign': -1}), ('NRG2', 'ERBB3', {'sign': -1}), ('NRG2', 'ERBB4', {'sign': -1}), ('LEP', 'LEPR', {'sign': -1}), ('MAP4K5', 'MAP3K1', {'sign': -1}), ('MAP4K5', 'GSK3B', {'sign': -1}), ('LAMTOR3', 'MAPK3', {'sign': -1}), ('LAMTOR3', 'MAP2K1', {'sign': -1}), ('LAMTOR3', 'MAPK1', {'sign': -1}), ('TAOK1', 'MAP2K3', {'sign': -1}), ('TAOK1', 'STK3', {'sign': -1}), ('TAOK1', 'STK4', {'sign': -1}), ('ACVR1C', 'SMAD3', {'sign': -1}), ('ACVR1C', 'SMAD2', {'sign': -1}), ('DUSP9', 'MAPK1', {'sign': -1}), ('DUSP9', 'MAPK3', {'sign': -1}), ('DUSP9', 'MAPK14', {'sign': -1}), ('WIF1', 'WNT8A', {'sign': -1}), ('BTC', 'EGFR', {'sign': -1}), ('BTC', 'ERBB4', {'sign': -1}), 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('LTC4S', 'NOTCH1', {'sign': -1}), ('LTC4S', 'MEF2C', {'sign': -1}), ('LTC4S', 'CTNNB1', {'sign': -1}), ('LTC4S', 'CDK8', {'sign': -1}), ('LTC4S', 'RBPJ', {'sign': -1}), ('LTC4S', 'TP53', {'sign': -1}), ('MAPK13', 'RCSD1', {'sign': -1}), ('MAPK13', 'EEF2K', {'sign': -1}), ('MAPK13', 'STMN1', {'sign': -1}), ('MAPK13', 'PRKD1', {'sign': -1}), ('MAPK13', 'KRT8', {'sign': -1}), ('MAPK13', 'TP53', {'sign': -1}), ('MAPK13', 'MAPT', {'sign': -1}), ('MAPK13', 'MAPKAPK5', {'sign': -1}), ('MAP4K3', 'MAP3K1', {'sign': -1}), ('MAP4K3', 'PRKCQ', {'sign': -1}), ('MAP3K13', 'MAP2K7', {'sign': -1}), ('SH2B1', 'JAK2', {'sign': -1}), ('CSNK1A1L', 'CTNNB1', {'sign': -1}), ('CSNK1A1L', 'GLI1', {'sign': -1}), ('CSNK1A1L', 'GLI3', {'sign': -1}), ('CSNK1A1L', 'GLIS2', {'sign': -1}), ('CSNK1A1L', 'LRP6', {'sign': -1}), ('CSNK1A1L', 'GLI2', {'sign': -1}), ('EXTL1', 'SHH', {'sign': -1}), ('DUSP19', 'MAPK8', {'sign': -1}), ('UBR5', 'PGR', {'sign': -1}), ('ELP1', 'MAPK8', {'sign': -1}), ('SPAG9', 'MAP2K4', {'sign': -1}), ('SPAG9', 'MAX', {'sign': -1}), ('SPAG9', 'MAP3K3', {'sign': -1}), ('SPAG9', 'MAPK14', {'sign': -1}), ('CBY1', 'CTNNB1', {'sign': -1}), ('BHLHE41', 'RBPJ', {'sign': -1}), ('IL20RB', 'TYK2', {'sign': -1}), ('IL20RB', 'JAK1', {'sign': -1}), ('CNKSR2', 'RAF1', {'sign': -1}), ('FZD3', 'CXCL1', {'sign': -1}), ('FZD3', 'DVL1', {'sign': -1}), ('PPP1CC', 'TGFBR1', {'sign': -1}), ('PPP1CC', 'CAMK2A', {'sign': -1}), ('PPP1CC', 'BCL2', {'sign': -1}), ('PPP1CC', 'AXIN1', {'sign': -1}), ('PPP1CC', 'CDK9', {'sign': -1}), ('PPP1CC', 'MDM2', {'sign': -1}), ('PPP1CC', 'IFIH1', {'sign': -1}), ('PPP1CC', 'EIF2S1', {'sign': -1}), ('PPP1CC', 'TP53', {'sign': -1}), ('PPP1CC', 'AKT1', {'sign': -1}), ('PPP1CC', 'CASP2', {'sign': -1}), ('PPP1CC', 'IKZF1', {'sign': -1}), ('PPP1CC', 'NOS3', {'sign': -1}), ('PPP1CC', 'CDC25C', {'sign': -1}), ('WDR83', 'RAF1', {'sign': -1}), ('WDR83', 'MAPK3', {'sign': -1}), ('WDR83', 'MAP2K1', {'sign': -1}), ('WWP1', 'SMAD7', {'sign': -1}), ('WWP1', 'SMAD2', {'sign': -1}), ('WWP1', 'TGFBR1', {'sign': -1}), ('TPBG', 'EGFR', {'sign': -1}), ('TGIF1', 'WWP1', {'sign': -1}), ('POFUT1', 'MFNG', {'sign': -1}), ('POFUT1', 'LFNG', {'sign': -1}), ('POFUT1', 'GALM', {'sign': -1}), ('POFUT1', 'NOTCH1', {'sign': -1}), ('NEURL1', 'JAG1', {'sign': -1}), ('MTSS1', 'GLI1', {'sign': -1}), ('MTSS1', 'GLIS2', {'sign': -1}), ('MTSS1', 'SUFU', {'sign': -1}), ('MTSS1', 'RAC1', {'sign': -1}), ('GRK6', 'SMO', {'sign': -1}), ('GRK6', 'LRP6', {'sign': -1}), ('GRK6', 'TYRO3', {'sign': -1}), ('GRK6', 'SLC9A3R1', {'sign': -1}), ('GRK6', 'LTB4R', {'sign': -1}), ('GRK6', 'BDKRB2', {'sign': -1}), ('GRK6', 'CXCR4', {'sign': -1}), ('DISP2', 'SHH', {'sign': -1}), ('DISP3', 'SHH', {'sign': -1}), ('TRIM33', 'SMAD4', {'sign': -1}), ('TRIM33', 'SMAD3', {'sign': -1}), ('TRIM33', 'SMAD2', {'sign': -1}), ('CNKSR1', 'RAF1', {'sign': -1}), ('CNKSR1', 'RASSF1', {'sign': -1}), ('SPOP', 'CUL3', {'sign': -1}), ('SPOP', 'GLI2', {'sign': -1}), ('SPOP', 'NCOA3', {'sign': -1}), ('SPOP', 'GLI3', {'sign': -1}), ('SPOP', 'DAXX', {'sign': -1}), ('SPOP', 'PDX1', {'sign': -1}), ('CUL3', 'GLIS2', {'sign': -1}), ('CUL3', 'KCTD10', {'sign': -1}), ('CUL3', 'TNFAIP1', {'sign': -1}), ('CUL3', 'HSF2', {'sign': -1}), ('CUL3', 'KCTD13', {'sign': -1}), ('MIB2', 'JAG2', {'sign': -1}), ('RAB11A', 'JAG1', {'sign': -1}), ('RANBP3', 'CTNNB1', {'sign': -1}), ('RANBP3', 'SMAD2', {'sign': -1}), ('RANBP3', 'SMAD3', {'sign': -1}), ('SNX9', 'EGFR', {'sign': -1}), ('SNX9', 'DNM2', {'sign': -1}), ('SNX9', 'DNM1', {'sign': -1}), ('ACTR2', 'ACVR1B', {'sign': -1}), ('GDF11', 'ACTR2', {'sign': -1}), ('GDF11', 'ACVR2B', {'sign': -1}), ('GDF11', 'ACVR1B', {'sign': -1}), ('GDF11', 'ACVR2A', {'sign': -1}), ('GDF1', 'ACTR2', {'sign': -1}), ('BMP15', 'ACTR2', {'sign': -1}), ('BMP15', 'BMPR2', {'sign': -1}), ('BMP15', 'BMPR1B_BMPR2', {'sign': -1}), ('BMP15', 'BMPR1B', {'sign': -1}), ('NODAL', 'ACVR2B', {'sign': -1}), ('NODAL', 'ACVR1C', {'sign': -1}), ('NODAL', 'ACVR1B', {'sign': -1}), ('NODAL', 'ACVR1B_ACVR2B', {'sign': -1}), ('NODAL', 'ACVR1C_ACVR2A', {'sign': -1}), ('NODAL', 'ACVR1C_ACVR2B', {'sign': -1}), ('NODAL', 'ACVR2A', {'sign': -1}), ('NUMBL', 'ITCH', {'sign': -1}), ('SOCS2', 'IGF1R', {'sign': -1}), ('SOCS2', 'LEPR', {'sign': -1}), ('SOCS2', 'EPOR', {'sign': -1}), ('CTDSP1', 'SMAD1', {'sign': -1}), ('CTDSP1', 'SMAD3', {'sign': -1}), ('CTDSP1', 'SMAD2', {'sign': -1}), ('CTDSP1', 'POLR2A', {'sign': -1}), ('CTDSP1', 'TWIST1', {'sign': -1}), ('CTDSP2', 'SMAD1', {'sign': -1}), ('CTDSP2', 'SMAD3', {'sign': -1}), ('CTDSP2', 'SMAD2', {'sign': -1}), ('BCL9', 'CTNNB1', {'sign': -1}), ('BCL9', 'PYGO1', {'sign': -1}), ('CTDNEP1', 'BMPR1A', {'sign': -1}), ('CTDNEP1', 'LPIN1', {'sign': -1}), ('IFNK', 'IFNAR1', {'sign': -1}), ('IFNK', 'IFNAR2', {'sign': -1}), ('IL36G', 'IFNAR1', {'sign': -1}), ('IL36G', 'IFNAR2', {'sign': -1}), ('IFNL2', 'IL10RB', {'sign': -1}), ('IFNL2', 'IFNLR1', {'sign': -1}), ('IFNL3', 'IL10RB', {'sign': -1}), ('IFNL3', 'IFNLR1', {'sign': -1}), ('MDK', 'NOTCH2', {'sign': -1}), ('MDK', 'ALK', {'sign': -1}), ('INPPL1', 'MAPK8IP1', {'sign': -1}), ('HHAT', 'SHH', {'sign': -1}), ('MFAP2', 'NOTCH1', {'sign': -1}), ('CDK8', 'NOTCH1', {'sign': -1}), ('CDK8', 'SMAD1', {'sign': -1}), ('CDK8', 'SMAD3', {'sign': -1}), ('CDK8', 'E2F1', {'sign': -1}), ('CDK8', 'CCNH', {'sign': -1}), ('PTPRT', 'STAT3', {'sign': -1}), ('PTPRT', 'PXN', {'sign': -1}), ('FKBP1A', 'TGFBR1', {'sign': -1}), ('FKBP1A', 'PPP3R1', {'sign': -1}), ('LRRFIP2', 'DVL3', {'sign': -1}), ('CAPRIN2', 'LRP6', {'sign': -1}), ('PDGFD', 'PDGFRB', {'sign': -1}), ('GRB14', 'INSR', {'sign': -1}), ('FGF6', 'FGFR2', {'sign': -1}), ('FGF6', 'FGFR4', {'sign': -1}), ('FGF17', 'FGFR2', {'sign': -1}), ('FGF17', 'FGFR1', {'sign': -1}), ('FGF17', 'FGFR3', {'sign': -1}), ('FGF17', 'FGFR4', {'sign': -1}), ('FGF18', 'FGFR2', {'sign': -1}), ('FGF18', 'FGFR1', {'sign': -1}), ('FGF18', 'FGFR3', {'sign': -1}), ('FGF18', 'FGFR4', {'sign': -1}), ('FGF22', 'FGFR2', {'sign': -1}), ('FGF22', 'FGFR1', {'sign': 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('CXCL13', 'CXCR3', {'sign': -1}), ('CXCL13', 'CCR10', {'sign': -1}), ('POMC', 'OPRD1', {'sign': -1}), ('POMC', 'OPRK1', {'sign': -1}), ('POMC', 'MC1R', {'sign': -1}), ('POMC', 'MC3R', {'sign': -1}), ('POMC', 'MC4R', {'sign': -1}), ('POMC', 'MC5R', {'sign': -1}), ('POMC', 'MC2R', {'sign': -1}), ('POMC', 'OPRM1', {'sign': -1}), ('OPRD1', 'GNAO1', {'sign': -1}), ('OPRD1', 'GNAI3', {'sign': -1}), ('OPRD1', 'GNAI1', {'sign': -1}), ('PDYN', 'OPRD1', {'sign': -1}), ('PDYN', 'OPRK1', {'sign': -1}), ('PDYN', 'OPRM1', {'sign': -1}), ('PENK', 'OPRD1', {'sign': -1}), ('PENK', 'MRGPRX1', {'sign': -1}), ('PENK', 'OPRM1', {'sign': -1}), ('PENK', 'OPRK1', {'sign': -1}), ('PENK', 'OGFR', {'sign': -1}), ('EDA', 'EDAR', {'sign': -1}), ('EDA', 'EDA2R', {'sign': -1}), ('EDNRA', 'GNAQ', {'sign': -1}), ('EDNRA', 'GNA11', {'sign': -1}), ('EDN3', 'EDNRB', {'sign': -1}), ('FGF19', 'FGFR4', {'sign': -1}), ('FGF19', 'FGFR1', {'sign': -1}), ('FGF19', 'FGFR2', {'sign': -1}), ('FGF19', 'FGFR3', {'sign': -1}), 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{'sign': -1}), ('PSAP', 'GPR37L1', {'sign': -1}), ('PSAP', 'LRP1', {'sign': -1}), ('RSPO1', 'LGR4', {'sign': -1}), ('RSPO1', 'LGR5', {'sign': -1}), ('RSPO1', 'LGR6', {'sign': -1}), ('RSPO1', 'ZNRF3', {'sign': -1}), ('RSPO1', 'LRP6', {'sign': -1}), ('RSPO1', 'RNF43', {'sign': -1}), ('RSPO2', 'LGR4', {'sign': -1}), ('RSPO2', 'LGR5', {'sign': -1}), ('RSPO2', 'LGR6', {'sign': -1}), ('RSPO3', 'LGR4', {'sign': -1}), ('RSPO3', 'LGR5', {'sign': -1}), ('RSPO3', 'LGR6', {'sign': -1}), ('RSPO3', 'SDC4', {'sign': -1}), ('RSPO4', 'LGR4', {'sign': -1}), ('RSPO4', 'LGR5', {'sign': -1}), ('RSPO4', 'LGR6', {'sign': -1}), ('OPRK1', 'GNAO1', {'sign': -1}), ('OPRK1', 'GNAI3', {'sign': -1}), ('KISS1', 'KISS1R', {'sign': -1}), ('CGB5', 'LHCGR', {'sign': -1}), ('LHB', 'LHCGR', {'sign': -1}), ('PMCH', 'MCHR1', {'sign': -1}), ('PMCH', 'MCHR2', {'sign': -1}), ('MC1R', 'GNAS', {'sign': -1}), ('AGRP', 'MC3R', {'sign': -1}), ('AGRP', 'MC4R', {'sign': -1}), ('AGRP', 'MC5R', {'sign': -1}), ('AGRP', 'MC1R', {'sign': 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('NPW', 'NPBWR1', {'sign': -1}), ('NPW', 'NPBWR2', {'sign': -1}), ('NPFF', 'NPFFR1', {'sign': -1}), ('NPFF', 'NPFFR2', {'sign': -1}), ('NPVF', 'NPFFR1', {'sign': -1}), ('NPVF', 'NPFFR2', {'sign': -1}), ('NPS', 'NPSR1', {'sign': -1}), ('NTS', 'NTSR1', {'sign': -1}), ('NTS', 'NTSR2', {'sign': -1}), ('OXT', 'OXTR', {'sign': -1}), ('OXT', 'AVPR1A', {'sign': -1}), ('OXT', 'AVPR1B', {'sign': -1}), ('OXT', 'AVPR2', {'sign': -1}), ('OXTR', 'GNAS', {'sign': -1}), ('OXTR', 'GNAI1', {'sign': -1}), ('OXTR', 'GNAQ', {'sign': -1}), ('AVP', 'OXTR', {'sign': -1}), ('AVP', 'AVPR1A', {'sign': -1}), ('AVP', 'AVPR1B', {'sign': -1}), ('AVP', 'AVPR2', {'sign': -1}), ('HCRT', 'HCRTR1', {'sign': -1}), ('HCRT', 'HCRTR2', {'sign': -1}), ('ADCYAP1', 'ADCYAP1R1', {'sign': -1}), ('ADCYAP1', 'VIPR1', {'sign': -1}), ('ADCYAP1', 'VIPR2', {'sign': -1}), ('VIP', 'ADCYAP1R1', {'sign': -1}), ('VIP', 'SCTR', {'sign': -1}), ('VIP', 'VIPR1', {'sign': -1}), ('VIP', 'VIPR2', {'sign': -1}), ('PROK1', 'PROKR1', {'sign': -1}), 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{'sign': -1}), ('YWHAH', 'CDKN1B', {'sign': -1}), ('RIMS1', 'YWHAH', {'sign': -1}), ('RIMS1', 'RAB3A', {'sign': -1}), ('RIMS1', 'UNC13B', {'sign': -1}), ('RIMS1', 'SYT1', {'sign': -1}), ('SYT1', 'STX3', {'sign': -1}), ('SYT1', 'SNAP25', {'sign': -1}), ('RAPGEF4', 'RIMS1', {'sign': -1}), ('HTR1A', 'GNAI3', {'sign': -1}), ('CAMK1', 'SYN1', {'sign': -1}), ('CAMK1', 'CREB1', {'sign': -1}), ('CAMK1', 'NUMB', {'sign': -1}), ('CAMK1', 'HDAC5', {'sign': -1}), ('CAMK1', 'DNM1L', {'sign': -1}), ('CAMK1', 'CDKN1B', {'sign': -1}), ('CAMK1', 'GCM1', {'sign': -1}), ('CAMK1', 'NOS1', {'sign': -1}), ('CAMK1', 'PPME1', {'sign': -1}), ('CAMK1', 'ATF1', {'sign': -1}), ('RAP1A', 'RALGDS', {'sign': -1}), ('RAP1A', 'BRAF', {'sign': -1}), ('RAP1A', 'RAF1', {'sign': -1}), ('NLGN1', 'DLG4', {'sign': -1}), ('NLGN1', 'NRXN2', {'sign': -1}), ('NLGN1', 'NRXN1', {'sign': -1}), ('NLGN1', 'NRXN3', {'sign': -1}), ('CREM', 'KCNIP3', {'sign': -1}), ('CREM', 'CREB1', {'sign': -1}), ('KCNIP3', 'CREB1', {'sign': -1}), ('KCNIP3', 'KCND2', {'sign': -1}), ('MINK1', 'MAPK14', {'sign': -1}), ('MINK1', 'PRICKLE1', {'sign': -1}), ('CARD14', 'EIF4E', {'sign': -1}), ('CAMK4', 'CREB1', {'sign': -1}), ('CAMK4', 'NOS1', {'sign': -1}), ('CAMK4', 'CREM', {'sign': -1}), ('CAMK4', 'HDAC4', {'sign': -1}), ('CAMK4', 'CREBBP', {'sign': -1}), ('CAMK4', 'HDAC5', {'sign': -1}), ('CAMK4', 'PHB2', {'sign': -1}), ('CAMK4', 'STMN1', {'sign': -1}), ('CAMK4', 'HNRNPL', {'sign': -1}), ('CHRM2', 'GNAI3', {'sign': -1}), ('CHRM2', 'GNB2', {'sign': -1}), ('CHRM2', 'GNAO1', {'sign': -1}), ('GRIN2A', 'PLCG1', {'sign': -1}), ('GRIN2A', 'DLG3', {'sign': -1}), ('DRD1', 'GNAS', {'sign': -1}), ('DRD1', 'GNAI3', {'sign': -1}), ('HTR2A', 'GNAQ', {'sign': -1}), ('HTR2A', 'GNAI1', {'sign': -1}), ('PTAFR', 'GNAO1', {'sign': -1}), ('PTAFR', 'GNAQ', {'sign': -1}), ('PTAFR', 'GNB2', {'sign': -1}), ('PTAFR', 'GNAI3', {'sign': -1}), ('CHRM1', 'GNAQ', {'sign': -1}), ('CHRM1', 'GNA11', {'sign': -1}), ('CHRM1', 'GNB2', {'sign': -1}), ('DRD2', 'GNAI3', {'sign': -1}), ('DRD2', 'GNAO1', {'sign': -1}), ('DRD2', 'GNAZ', {'sign': -1}), ('RBP1', 'SHC1', {'sign': -1}), ('BCAP31', 'CASP8', {'sign': -1}), ('BCAP31', 'BCL2', {'sign': -1}), ('BCAP31', 'BCL2L1', {'sign': -1}), ('ANP32A', 'APAF1', {'sign': -1}), ('FER', 'CTNNB1', {'sign': -1}), ('FER', 'AR', {'sign': -1}), ('FER', 'JUP', {'sign': -1}), ('FER', 'PECAM1', {'sign': -1}), ('FER', 'STAT3', {'sign': -1}), ('FER', 'CTTN', {'sign': -1}), ('EEF2K', 'EEF2', {'sign': -1}), ('L1CAM', 'EZR', {'sign': -1}), ('L1CAM', 'NRP1', {'sign': -1}), ('L1CAM', 'PLXNA1', {'sign': -1}), ('CNR1', 'GNB2', {'sign': -1}), ('CNR1', 'GNAI3', {'sign': -1}), ('CNR1', 'GNAO1', {'sign': -1}), ('CNR1', 'GNAI1', {'sign': -1}), ('CNR1', 'HCRTR1', {'sign': -1}), ('RPH3A', 'RAB3A', {'sign': -1}), ('ADORA1', 'GNAI3', {'sign': -1}), ('ADORA1', 'GNAO1', {'sign': -1}), ('ADORA1', 'GNAZ', {'sign': -1}), ('ADRA1A', 'GNAQ', {'sign': -1}), ('ADRA2A', 'GNAI3', {'sign': -1}), ('ADRA2A', 'GNAO1', {'sign': -1}), ('ADRA2A', 'GNAI1', {'sign': -1}), ('AKAP5', 'PRKACA', {'sign': -1}), ('PKN1', 'PPP1R14A', {'sign': -1}), ('PKN1', 'MAPK14', {'sign': -1}), ('PKN1', 'PGAM1', {'sign': -1}), ('PKN1', 'FOXO1', {'sign': -1}), ('PKN1', 'SNAI1', {'sign': -1}), ('PKN1', 'MARCKS', {'sign': -1}), ('PKN1', 'RAF1', {'sign': -1}), ('PKN1', 'ARHGEF2', {'sign': -1}), ('PKN1', 'EGFR', {'sign': -1}), ('PKN1', 'MAPT', {'sign': -1}), ('PKN1', 'PGM1', {'sign': -1}), ('RAPGEF2', 'RAP1A', {'sign': -1}), ('STX3', 'CACNA1B', {'sign': -1}), ('SPRY1', 'SOS1', {'sign': -1}), ('ADORA2A', 'GNAS', {'sign': -1}), ('ARHGAP1', 'CDC42', {'sign': -1}), ('ARHGAP1', 'RHOA', {'sign': -1}), ('ARHGEF1', 'RHOA', {'sign': -1}), ('CYTH2', 'ARF1', {'sign': -1}), ('CYTH2', 'ARF6', {'sign': -1}), ('ARF1', 'PLD1', {'sign': -1}), ('ARF1', 'PLD2', {'sign': -1}), ('NRCAM', 'ANK1', {'sign': -1}), ('NRCAM', 'ANK2', {'sign': -1}), ('RASGRF1', 'NRAS', {'sign': -1}), ('RASGRF1', 'RAC1', {'sign': -1}), ('RASA4', 'NRAS', {'sign': -1}), ('RAPGEF3', 'RAP1A', {'sign': -1}), ('RAPGEF3', 'RAP1B', {'sign': -1}), ('RGS2', 'GNAQ', {'sign': -1}), ('ANAPC1', 'CTNNB1', {'sign': -1}), ('ANAPC1', 'PTTG1', {'sign': -1}), ('ARFGEF2', 'ARF1', {'sign': -1}), ('ARFGAP1', 'ARF1', {'sign': -1}), ('RGS4', 'GNAQ', {'sign': -1}), ('RGS19', 'GNAQ', {'sign': -1}), ('F2RL1', 'GNB2', {'sign': -1}), ('F2RL1', 'GNAQ', {'sign': -1}), ('PRSS1', 'F2RL1', {'sign': -1}), ('WNT6', 'FZD1', {'sign': -1}), ('WNT6', 'LRP5', {'sign': -1}), ('CHRM4', 'EEF1A2', {'sign': -1}), ('CHRM4', 'GNAI3', {'sign': -1}), ('HOMER2', 'RYR1', {'sign': -1}), ('COX5B', 'APAF1', {'sign': -1}), ('NAIP', 'CASP9', {'sign': -1}), ('HPCA', 'NAIP', {'sign': -1}), ('EPB41', 'DLG1', {'sign': -1}), ('EPB41', 'NUMA1', {'sign': -1}), ('SHANK1', 'ARHGEF7', {'sign': -1}), ('SHANK1', 'ADGRL1', {'sign': -1}), ('NFASC', 'ANK1', {'sign': -1}), ('NFASC', 'NRCAM', {'sign': -1}), ('SRP54', 'SRPRA', {'sign': -1}), ('PTPRA', 'FYN', {'sign': -1}), ('PTPRA', 'LYN', {'sign': -1}), ('PTPRA', 'BCAR1', {'sign': -1}), ('PTPRA', 'INSR', {'sign': -1}), ('PKIA', 'PRKACA', {'sign': -1}), ('SERPINB2', 'PPP1CC', {'sign': -1}), ('PPP1R1A', 'PPP1CC', {'sign': -1}), ('DLGAP1', 'SHANK1', {'sign': -1}), ('DLGAP1', 'DLG4', {'sign': -1}), ('DLGAP1', 'SHANK2', {'sign': -1}), ('RELN', 'ITGB1', {'sign': -1}), ('RELN', 'VLDLR', {'sign': -1}), ('RELN', 'LRP8', {'sign': -1}), ('RELN', 'ITGA3', {'sign': -1}), ('SV2A', 'SYT1', {'sign': -1}), ('CNR2', 'GNAI3', {'sign': -1}), ('CNR2', 'GNAO1', {'sign': -1}), ('GRM7', 'GNB2', {'sign': -1}), ('PICK1', 'GRM7', {'sign': -1}), ('PICK1', 'ASIC1', {'sign': -1}), ('PICK1', 'BNC1', {'sign': -1}), ('PICK1', 'GRIA2', {'sign': -1}), ('SRI', 'RYR1', {'sign': -1}), ('DOC2A', 'UNC13B', {'sign': -1}), ('RIT2', 'POU4F1', {'sign': -1}), ('DRD3', 'GNAI3', {'sign': -1}), ('DRD3', 'GNAO1', {'sign': -1}), ('DRD3', 'GRB2', {'sign': -1}), ('DRD3', 'GNAI1', {'sign': -1}), ('STK24', 'STK38', {'sign': -1}), ('STK24', 'STK38L', {'sign': -1}), ('AP1B1', 'CLTA', {'sign': -1}), ('AP1B1', 'DNM1', {'sign': -1}), ('VTN', 'ITGB1', {'sign': -1}), ('VTN', 'ITGA8_ITGB1', {'sign': -1}), ('VTN', 'ITGA5', {'sign': -1}), ('VTN', 'ITGA8', {'sign': -1}), ('VTN', 'ITGAV', {'sign': -1}), ('VTN', 'KDR', {'sign': -1}), ('VTN', 'ITGB3', {'sign': -1}), ('VTN', 'ITGB6', {'sign': -1}), ('VTN', 'ITGB8', {'sign': -1}), ('FGA', 'ITGB1', {'sign': -1}), ('FGA', 'ITGAX', {'sign': -1}), ('FGA', 'ITGB2', {'sign': -1}), ('RAP2A', 'RALGDS', {'sign': -1}), ('RPS6KB2', 'PDCD4', {'sign': -1}), ('RPS6KB2', 'MXD1', {'sign': -1}), ('RPS6KB2', 'RPS6', {'sign': -1}), ('PTMA', 'KEAP1', {'sign': -1}), ('CSNK2A2', 'NFKBIA', {'sign': -1}), ('CSNK2A2', 'AQP4', {'sign': -1}), ('CSNK2A2', 'PPP1R1B', {'sign': -1}), ('CSNK2A2', 'PPP1R8', {'sign': -1}), ('CSNK2A2', 'EIF2B5', {'sign': -1}), ('CSNK2A2', 'HDAC1', {'sign': -1}), ('CSNK2A2', 'IL16', {'sign': -1}), ('CSNK2A2', 'NOL3', {'sign': -1}), ('CSNK2A2', 'XRCC1', {'sign': -1}), ('CSNK2A2', 'SPIB', {'sign': -1}), ('CSNK2A2', 'MYF5', {'sign': -1}), ('CSNK2A2', 'BID', {'sign': -1}), ('CSNK2A2', 'UBE2R2', {'sign': -1}), ('CSNK2A2', 'PTEN', {'sign': -1}), ('CSNK2A2', 'PTPRC', {'sign': -1}), ('CSNK2A2', 'PPP1R2', {'sign': -1}), ('CSNK2A2', 'GTF2A1L', {'sign': -1}), ('CSNK2A2', 'HSPH1', {'sign': -1}), ('CSNK2A2', 'HDAC2', {'sign': -1}), ('CSNK2A2', 'WAS', {'sign': -1}), ('CSNK2A2', 'TCF7L2', {'sign': -1}), ('CSNK2A2', 'GTF2A1', {'sign': -1}), ('CSNK2A2', 'KLF1', {'sign': -1}), ('CSNK2A2', 'CTDP1', {'sign': -1}), ('CSNK2A2', 'CDC37', {'sign': -1}), ('CSNK2A2', 'ARRB2', {'sign': -1}), ('CSNK2A2', 'NKX3-1', {'sign': -1}), ('CSNK2A2', 'EIF4EBP1', {'sign': -1}), ('CSNK2A2', 'SET', {'sign': -1}), ('CSNK2A2', 'CCAR2', {'sign': -1}), ('CSNK2A2', 'HSF1', {'sign': -1}), ('CSNK2A2', 'CTNNB1', {'sign': -1}), ('CSNK2A2', 'RELA', {'sign': -1}), ('CSNK2A2', 'TP53', {'sign': -1}), ('UBE2V1', 'TRAF6', {'sign': -1}), ('DHX58', 'RIGI', {'sign': -1}), ('DHX58', 'MAVS', {'sign': -1}), ('DHX58', 'IFIH1', {'sign': -1}), ('ZBP1', 'TBK1', {'sign': -1}), ('ZBP1', 'RIPK3', {'sign': -1}), ('CARD17P', 'NLRC4', {'sign': -1}), ('CARD17P', 'PYCARD', {'sign': -1}), ('CARD17P', 'CASP1', {'sign': -1}), ('CARD17P', 'NLRP1', {'sign': -1}), ('CARD17P', 'CASP5', {'sign': -1}), ('CARD17P', 'NLRP2', {'sign': -1}), ('CARD17P', 'CARD8', {'sign': -1}), ('NOD1', 'DEFB4A', {'sign': -1}), ('NOD1', 'DEFB104A', {'sign': -1}), ('NOD1', 'MAPK8', {'sign': -1}), ('NOD1', 'RIPK2', {'sign': -1}), ('NOD1', 'ATG16L1', {'sign': -1}), ('CARD9', 'MAPK14', {'sign': -1}), ('CARD9', 'BCL10', {'sign': -1}), ('RNF125', 'RIGI', {'sign': -1}), ('RNF125', 'IFIH1', {'sign': -1}), ('SAR1A', 'SEC23A', {'sign': -1}), ('SAR1A', 'SEC24A', {'sign': -1}), ('CASP4', 'CASP1', {'sign': -1}), ('IFNA17', 'IFNAR1', {'sign': -1}), ('IFNA17', 'IFNAR2', {'sign': -1}), ('MAGI2', 'PTEN', {'sign': -1}), ('SNTA1', 'NOS1', {'sign': -1}), ('SLC9A3R2', 'PLCB3', {'sign': -1}), ('MAGI3', 'PTEN', {'sign': -1}), ('GOPC', 'CFTR', {'sign': -1}), ('GOPC', 'BECN1', {'sign': -1}), ('GOPC', 'ADRB1', {'sign': -1}), ('ARVCF', 'ERBIN', {'sign': -1}), ('ARVCF', 'CDH1', {'sign': -1}), ('ARVCF', 'CDH2', {'sign': -1}), ('MOB1A', 'LATS2', {'sign': -1}), ('MOB1A', 'LATS1', {'sign': -1}), ('NTF4', 'NTRK2', {'sign': -1}), ('NTF4', 'NTRK1', {'sign': -1}), ('NTF4', 'NGFR', {'sign': -1}), ('NTF4', 'BEX3', {'sign': -1}), ('MBL2', 'MASP2', {'sign': -1}), ('MBL2', 'MASP1', {'sign': -1}), ('MASP2', 'C2', {'sign': -1}), ('MASP2', 'C4A', {'sign': -1}), ('MASP2', 'C4B', {'sign': -1}), ('PRKAA1', 'FOXO3', {'sign': -1}), ('PRKAA1', 'EP300', {'sign': -1}), ('PRKAA1', 'PFKFB2', {'sign': -1}), ('PRKAA1', 'RAF1', {'sign': -1}), ('PRKAA1', 'ZNF692', {'sign': -1}), ('PRKAA1', 'PIAS1', {'sign': -1}), ('PRKAA1', 'EEF2K', {'sign': -1}), ('PRKAA1', 'SYN1', {'sign': -1}), ('PRKAA1', 'ULK1', {'sign': -1}), ('PRKAA1', 'GLI1', {'sign': -1}), ('PRKAA1', 'CRTC2', {'sign': -1}), ('PRKAA1', 'CFTR', {'sign': -1}), ('PRKAA1', 'CRY1', {'sign': -1}), ('PRKAA1', 'PRPS1', {'sign': -1}), ('PRKAA1', 'MFF', {'sign': -1}), ('PRKAA1', 'LIPE', {'sign': -1}), ('PRKAA1', 'NOS3', {'sign': -1}), ('PRKAA1', 'CTBP1', {'sign': -1}), ('PRKAA1', 'RB1', {'sign': -1}), ('PRKAA1', 'POU2F1', {'sign': -1}), ('PRKAA1', 'HDAC7', {'sign': -1}), ('PRKAA1', 'SREBF1', {'sign': -1}), ('PRKAA1', 'KLC2', {'sign': -1}), ('PRKAA1', 'CDKN1B', {'sign': -1}), ('PRKAA1', 'HDAC5', {'sign': -1}), ('PRKAA1', 'HNF4A', {'sign': -1}), ('PRKAA1', 'PRKAB1', {'sign': -1}), ('PRKAA1', 'PPARGC1A', {'sign': -1}), ('PRKAA1', 'ACSS2', {'sign': -1}), ('PRKAA1', 'ALDH2', {'sign': -1}), ('PRKAA1', 'DDIT3', {'sign': -1}), ('PRKAA1', 'MLXIPL', {'sign': -1}), ('PRKAA1', 'TET2', {'sign': -1}), ('PRKAA1', 'SNAI1', {'sign': -1}), ('PRKAA1', 'GAPDH', {'sign': -1}), ('PRKAA1', 'GFPT1', {'sign': -1}), ('PRKAA1', 'ACACA', {'sign': -1}), ('PRKAA1', 'PRPS2', {'sign': -1}), ('PRKAA1', 'KPNA2', {'sign': -1}), ('PRKAA1', 'RPTOR', {'sign': -1}), ('PRKAA1', 'RRN3', {'sign': -1}), ('PRKAA1', 'PFKFB3', {'sign': -1}), ('PRKAA1', 'DNMT1', {'sign': -1}), ('PRKAA1', 'NR2C2', {'sign': -1}), ('PRKAA1', 'TBC1D1', {'sign': -1}), ('PRKAA1', 'GBF1', {'sign': -1}), ('PRKAA1', 'TP53', {'sign': -1}), ('PRKAA1', 'TSC2', {'sign': -1}), ('PRKAA1', 'ACACB', {'sign': -1}), ('PRKAA1', 'MTOR', {'sign': -1}), ('FAAP100_FAAP24_FANCA_FANCB_FANCC_FANCE_FANCF_FANCG_FANCL_FANCM', 'FANCD2', {'sign': -1}), ('JDP2', 'ATF2', {'sign': -1}), ('JDP2', 'JUN', {'sign': -1}), ('MSC', 'TCF3', {'sign': -1}), ('CLK1', 'PTPN1', {'sign': -1}), ('CLK1', 'RBM17', {'sign': -1}), ('CLK1', 'ABL1', {'sign': -1}), ('NF2', 'LATS1', {'sign': -1}), ('NF2', 'LATS2', {'sign': -1}), ('CDK12', 'POLR2A', {'sign': -1}), ('SIK2', 'CDK5R1', {'sign': -1}), ('SIK2', 'IRS1', {'sign': -1}), ('SIK2', 'CRTC2', {'sign': -1}), ('SIK2', 'CEP250', {'sign': -1}), ('PHKG2', 'PYGL', {'sign': -1}), ('PHKG2', 'PYGM', {'sign': -1}), ('PHKG2', 'PYGB', {'sign': -1}), ('APC_AXIN1_GSK3B', 'CTNNB1', {'sign': -1}), ('WDR48', 'USP1', {'sign': -1}), ('PRPF4B', 'KLF13', {'sign': -1}), ('PRPF4B', 'ELK1', {'sign': -1}), ('RAE1', 'NUP98', {'sign': -1}), ('SEMA3C', 'NRP2', {'sign': -1}), 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{'sign': -1}), ('NSMCE3', 'NSMCE1', {'sign': -1}), ('SERPINA1', 'LRP1', {'sign': -1}), ('ASAP1', 'ARF1', {'sign': -1}), ('FGF13', 'SCN5A', {'sign': -1}), ('FGF13', 'SCN8A', {'sign': -1}), ('PDXP', 'CFL1', {'sign': -1}), ('CDK2AP1', 'CDK2', {'sign': -1}), ('MMP10', 'HAPLN1', {'sign': -1}), ('HTR6', 'GNAQ', {'sign': -1}), ('FBXO38', 'KLF7', {'sign': -1}), ('TSSK4', 'CREB1', {'sign': -1}), ('DOCK8', 'CDC42', {'sign': -1}), ('TRIM32', 'DTNBP1', {'sign': -1}), ('LARP4B', 'PABPC1', {'sign': -1}), ('RNF180', 'ZIC2', {'sign': -1}), ('G3BP2', 'NFKBIA', {'sign': -1}), ('IST1', 'SPAST', {'sign': -1}), ('DPP3', 'KEAP1', {'sign': -1}), ('ASB2', 'FLNA', {'sign': -1}), ('CD55', 'ADGRE5', {'sign': -1}), ('NTN4', 'UNC5A', {'sign': -1}), ('NTN4', 'DCC', {'sign': -1}), ('SRGAP3', 'WASF1', {'sign': -1}), ('SEPTIN4', 'XIAP', {'sign': -1}), ('MTCH2', 'BID', {'sign': -1}), ('POU2AF1', 'POU2F2', {'sign': -1}), ('POU2AF1', 'POU2F1', {'sign': -1}), ('RPGRIP1', 'RPGR', {'sign': -1}), ('PELI3', 'IRAK1', {'sign': -1}), ('SPATA13', 'CDC42', {'sign': -1}), ('PEX3', 'PEX19', {'sign': -1}), ('PTX3', 'CFH', {'sign': -1}), ('VAC14', 'FIG4', {'sign': -1}), ('RWDD3', 'HIF1A', {'sign': -1}), ('ICAM3', 'ITGB2', {'sign': -1}), ('SRSF3', 'NXF1', {'sign': -1}), ('AP2M1', 'EGFR', {'sign': -1}), ('PPP2R1A', 'PPP2CA', {'sign': -1}), ('PPP2R1A', 'SGO1', {'sign': -1}), ('PPP2R1A', 'PPP2CB', {'sign': -1}), ('USP24', 'DDB2', {'sign': -1}), ('CEBPE', 'CEBPG', {'sign': -1}), ('VEGFD', 'KDR', {'sign': -1}), ('VEGFD', 'FLT4', {'sign': -1}), ('VEGFD', 'NRP2', {'sign': -1}), ('KHK', 'PRPS1', {'sign': -1}), ('CDH8', 'CTNNB1', {'sign': -1}), ('CDH5', 'CTNNB1', {'sign': -1}), ('DACT1', 'DVL2', {'sign': -1}), ('CCN2', 'LRP6', {'sign': -1}), ('CCN2', 'ITGAM', {'sign': -1}), ('CCN2', 'ITGB2', {'sign': -1}), ('SEMA3B', 'NRP1', {'sign': -1}), ('SEMA3B', 'NRP2', {'sign': -1}), ('TNFSF4', 'TNFRSF4', {'sign': -1}), ('TOPORS', 'TP53', {'sign': -1}), ('SH3BP4', 'TFRC', {'sign': -1}), ('ADA', 'ADORA1', {'sign': -1}), ('TRIP12', 'CDKN2A', {'sign': -1}), ('WLS', 'WNT3A', {'sign': -1}), ('CHAMP1', 'MAD2L2', {'sign': -1}), ('SND1', 'STAT6', {'sign': -1}), ('PSMA5', 'XBP1', {'sign': -1}), ('ZIC3', 'GLI3', {'sign': -1}), ('PLAU', 'PLAUR', {'sign': -1}), ('PLAU', 'LRP1', {'sign': -1}), ('KCNIP4', 'KCND2', {'sign': -1}), ('CCNY', 'CDK14', {'sign': -1}), ('CDK14', 'LRP6', {'sign': -1}), ('UBQLN2', 'HNRNPU', {'sign': -1}), ('UBQLN2', 'HNRNPA1', {'sign': -1}), ('RNF182', 'ATP6V0C', {'sign': -1}), ('TNFRSF13C', 'TRAF3', {'sign': -1}), ('TRH', 'TRHR', {'sign': -1}), ('TMED10', 'PSEN1', {'sign': -1}), ('CDH9', 'CTNNB1', {'sign': -1}), ('NCAM1', 'FGFR1', {'sign': -1}), ('NCAM1', 'ROBO1', {'sign': -1}), ('NCAM1', 'ROBO3', {'sign': -1}), ('EPGN', 'EGFR', {'sign': -1}), ('EPGN', 'ERBB4', {'sign': -1}), ('EAF2', 'ELL', {'sign': -1}), ('SAFB', 'FUS', {'sign': -1}), ('EAF1', 'ELL', {'sign': -1}), ('MMP13', 'COL2A1', {'sign': -1}), ('MMP13', 'F12', {'sign': -1}), ('MMP13', 'LRP1', {'sign': -1}), ('MAP3K6', 'MAP3K5', {'sign': -1}), ('TET3', 'OGT', {'sign': -1}), ('MEX3B', 'SNUPN', {'sign': -1}), ('FBXL15', 'SMURF1', {'sign': -1}), ('TRIM27', 'PIK3C2B', {'sign': -1}), ('TTBK2', 'KIF2A', {'sign': -1}), ('BAG3', 'HSPA8', {'sign': -1}), ('SRP19', 'SRP54', {'sign': -1}), ('PSPN', 'GFRA4', {'sign': -1}), ('PSPN', 'RET', {'sign': -1}), ('RGMA', 'NEO1', {'sign': -1}), ('KPNA1', 'KPNB1', {'sign': -1}), ('CTTNBP2', 'CTTN', {'sign': -1}), ('PAWR', 'WT1', {'sign': -1}), ('CCNF', 'CCP110', {'sign': -1}), ('NDFIP1', 'NEDD4', {'sign': -1}), ('PHF21A', 'KDM1A', {'sign': -1}), ('EIF4H', 'EIF4A1', {'sign': -1}), ('RPL10', 'YES1', {'sign': -1}), ('SETBP1', 'SET', {'sign': -1}), ('ZNF521', 'EBF1', {'sign': -1}), ('MNAT1', 'ESR1', {'sign': -1}), ('NGLY1', 'RAD23B', {'sign': -1}), ('PHACTR1', 'PPP1CA', {'sign': -1}), ('GPI', 'AMFR', {'sign': -1}), ('PATZ1', 'RNF4', {'sign': -1}), ('HPN', 'F7', {'sign': -1}), ('SRSF7', 'NXF1', {'sign': -1}), ('SS18L1', 'CREBBP', {'sign': -1}), ('ITGAL_ITGB2', 'ICAM1', {'sign': -1}), ('CDKL5', 'AMPH', {'sign': -1}), ('PCSK2', 'IAPP', {'sign': -1}), ('DLK2', 'NOTCH1', {'sign': -1}), ('CTTNBP2NL', 'STRN', {'sign': -1}), ('HSPG2', 'PTPRS', {'sign': -1}), ('HSPG2', 'ITGA2', {'sign': -1}), ('COL5A1', 'SDC3', {'sign': -1}), ('PAX1', 'MEOX1', {'sign': -1}), ('PAX1', 'MEOX2', {'sign': -1}), ('TPSAB1', 'F2RL1', {'sign': -1}), ('PEX12', 'PEX5', {'sign': -1}), ('PEX2', 'PEX5', {'sign': -1}), ('THBS2', 'CD47', {'sign': -1}), ('THBS2', 'ITGA4', {'sign': -1}), ('THBS2', 'ITGB1', {'sign': -1}), ('THBS2', 'ITGA6', {'sign': -1}), ('CLCC1', 'PIGBOS1', {'sign': -1}), ('CD274', 'PDCD1', {'sign': -1}), ('VRK3', 'BANF1', {'sign': -1}), ('DHPS', 'EIF5A', {'sign': -1}), ('AKAP9', 'TRIP10', {'sign': -1}), ('MLF1', 'COPS3', {'sign': -1}), ('VPS4A', 'CHMP2A', {'sign': -1}), ('RAMAC', 'RNMT', {'sign': -1}), ('STON2', 'SYT1', {'sign': -1}), ('OMG', 'LINGO1', {'sign': -1}), ('OMG', 'TNFRSF1B', {'sign': -1}), ('TTF2', 'CDC5L', {'sign': -1}), ('CDC5L', 'HNRNPM', {'sign': -1}), ('NEK1', 'VDAC1', {'sign': -1}), ('CTNNA3', 'CTNNB1', {'sign': -1}), ('CDH7', 'CTNNB1', {'sign': -1}), ('KANK1', 'BAIAP2', {'sign': -1}), ('UBASH3B', 'CBL', {'sign': -1}), ('LMO2', 'TAL1', {'sign': -1}), ('GUCA2B', 'GUCY2C', {'sign': -1}), ('DLGAP2', 'DLG4', {'sign': -1}), ('KRT14', 'TRADD', {'sign': -1}), ('TFPI', 'VLDLR', {'sign': -1}), ('TFPI', 'LRP1', {'sign': -1}), ('PKP2', 'DSP', {'sign': -1}), ('TMOD1', 'TPM3', {'sign': -1}), ('SEPTIN12', 'SEPTIN6', {'sign': -1}), ('MRAP', 'MC2R', {'sign': -1}), ('SMAD3_SMAD4', 'FOS_JUN', {'sign': -1}), ('IRF2BP2', 'IRF2', {'sign': -1}), ('IRF2BP1', 'IRF2', {'sign': -1}), ('ITGAD_ITGB2', 'VCAM1', {'sign': -1}), ('VCAM1', 'ITGA4_ITGB1', {'sign': -1}), ('VCAM1', 'ITGA4', {'sign': -1}), ('VCAM1', 'ITGB1', {'sign': -1}), ('VCAM1', 'ITGB2', {'sign': -1}), ('VCAM1', 'ITGAD', {'sign': -1}), ('LNX1', 'NUMB', {'sign': -1}), ('ADAM12', 'SDC4', {'sign': -1}), ('ADAM12', 'ITGB1', {'sign': -1}), ('ADAM12', 'ITGA9', {'sign': -1}), ('INHA', 'TGFBR3', {'sign': -1}), ('INHA', 'ACVR2B', {'sign': -1}), ('INHA', 'ACVR2A', {'sign': -1}), ('PCGF2', 'HSF2', {'sign': -1}), ('ADAMTS13', 'VWF', {'sign': -1}), ('RNF19B', 'UCKL1', {'sign': -1}), ('UBE2L3', 'RNF19B', {'sign': -1}), ('PCSK1', 'IAPP', {'sign': -1}), ('PAK5', 'BAD', {'sign': -1}), ('SIL1', 'HSPA5', {'sign': -1}), ('POGZ', 'CBX5', {'sign': -1}), ('HOXD11', 'MEIS1', {'sign': -1}), ('STOM', 'SLC2A1', {'sign': -1}), ('ARPC2', 'ACTB', {'sign': -1}), ('PTPRO', 'PXN', {'sign': -1}), ('BMP5', 'ACVR1_ACVR2A', {'sign': -1}), ('BMP5', 'ACVR1_ACVR2B', {'sign': -1}), ('BMP5', 'ACVR1_BMPR2', {'sign': -1}), ('BMP5', 'ACVR2A_BMPR1A', {'sign': -1}), ('BMP5', 'ACVR2B_BMPR1A', {'sign': -1}), ('BMP5', 'BMPR1A_BMPR2', {'sign': -1}), ('BMP5', 'ACVR2A_BMPR1B', {'sign': -1}), ('BMP5', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP5', 'BMPR1B_BMPR2', {'sign': -1}), ('BMP5', 'BMPR1A', {'sign': -1}), ('BMP8A', 'ACVR1_ACVR2A', {'sign': -1}), ('BMP8A', 'ACVR1_ACVR2B', {'sign': -1}), ('BMP8A', 'ACVR1_BMPR2', {'sign': -1}), ('BMP8A', 'ACVR2A_BMPR1A', {'sign': -1}), ('BMP8A', 'ACVR2B_BMPR1A', {'sign': -1}), ('BMP8A', 'BMPR1A_BMPR2', {'sign': -1}), ('BMP8A', 'ACVR2A_BMPR1B', {'sign': -1}), ('BMP8A', 'ACVR2B_BMPR1B', {'sign': -1}), ('BMP8A', 'BMPR1B_BMPR2', {'sign': -1}), ('CCL18', 'CCR3', {'sign': -1}), ('CCL18', 'CCR8', {'sign': -1}), ('CCL18', 'CCR1', {'sign': -1}), ('CCL28', 'CCR10', {'sign': -1}), ('CCL28', 'CCR3', {'sign': -1}), ('CCL28', 'ACKR2', {'sign': -1}), ('CD48', 'CD244', {'sign': -1}), ('CD58', 'CD2', {'sign': -1}), ('FGF16', 'FGFR1', {'sign': -1}), ('FGF16', 'FGFR2', {'sign': -1}), ('FGF16', 'FGFR3', {'sign': -1}), ('FGF16', 'FGFR4', {'sign': -1}), ('FGF20', 'FGFR1', {'sign': -1}), ('FGF20', 'FGFR2', {'sign': -1}), ('FGF20', 'FGFR3', {'sign': -1}), ('FGF20', 'FGFR4', {'sign': -1}), ('FGF21', 'FGFR1', {'sign': -1}), ('FGF21', 'FGFR3', {'sign': -1}), ('FGF21', 'FGFR4', {'sign': -1}), ('FGF21', 'FGFR2', {'sign': -1}), ('GDF7', 'ACVR2A_BMPR1A', {'sign': -1}), ('GDF7', 'ACVR2B_BMPR1A', {'sign': -1}), ('GDF7', 'BMPR1A_BMPR2', {'sign': -1}), ('GDF7', 'ACVR2A_BMPR1B', {'sign': -1}), ('GDF7', 'ACVR2B_BMPR1B', {'sign': -1}), ('GDF7', 'BMPR1B_BMPR2', {'sign': -1}), ('GDF7', 'BMPR2', {'sign': -1}), ('GDF7', 'BMPR1A', {'sign': -1}), ('GDF7', 'ACVR2A', {'sign': -1}), ('GH2', 'GHR', {'sign': -1}), ('HLA-A', 'KIR3DL2', {'sign': -1}), ('HLA-A', 'KIR3DL1', {'sign': -1}), ('HLA-A', 'KLRD1', {'sign': -1}), ('HLA-B', 'KIR3DL1', {'sign': -1}), ('HLA-B', 'KIR3DL2', {'sign': -1}), ('HLA-B', 'KIR2DL3', {'sign': -1}), ('HLA-B', 'KLRD1', {'sign': -1}), ('HLA-C', 'KIR2DL1', {'sign': -1}), ('HLA-C', 'KIR2DL2', {'sign': -1}), ('HLA-C', 'KIR2DL3', {'sign': -1}), ('HLA-C', 'KIR2DS1', {'sign': -1}), ('HLA-C', 'KIR2DS4', {'sign': -1}), ('HLA-C', 'KIR2DS2', {'sign': -1}), ('IL25', 'IL17RB', {'sign': -1}), ('IL36RN', 'IL1RL2', {'sign': -1}), ('MICB', 'KLRK1', {'sign': -1}), ('NCR3LG1', 'NCR3', {'sign': -1}), ('NECTIN3', 'TIGIT', {'sign': -1}), ('PDCD1LG2', 'PDCD1', {'sign': -1}), ('PF4', 'CXCR3', {'sign': -1}), ('PF4', 'FGFR2', {'sign': -1}), ('PF4', 'LDLR', {'sign': -1}), ('PF4', 'THBD', {'sign': -1}), ('PF4', 'PROCR', {'sign': -1}), ('PF4V1', 'CXCR3', {'sign': -1}), ('PGF', 'FLT1', {'sign': -1}), ('PGF', 'NRP1', {'sign': -1}), ('TNFSF12', 'TNFRSF12A', {'sign': -1}), ('TNFSF18', 'TNFRSF18', {'sign': -1}), ('TNFSF8', 'TNFRSF8', {'sign': -1}), ('MADCAM1', 'ITGA4', {'sign': -1}), ('MADCAM1', 'ITGB7', {'sign': -1}), ('DKK4', 'LRP6', {'sign': -1}), ('DKK4', 'LRP5', {'sign': -1}), ('EBI3', 'IL27RA', {'sign': -1}), ('EBI3', 'IL6ST', {'sign': -1}), ('ICAM5', 'ITGAL', {'sign': -1}), ('ICAM5', 'ITGB2', {'sign': -1}), ('COMP', 'ITGB3', {'sign': -1}), ('LAMB1', 'ITGB1', {'sign': -1}), ('LAMB1', 'ITGA6', {'sign': -1}), ('LAMB1', 'ITGB4', {'sign': -1}), ('LAMB1', 'CD151', {'sign': -1}), ('ULBP1', 'KLRK1', {'sign': -1}), ('HRG', 'ERBB3', {'sign': -1}), ('IFNA7', 'IFNAR2', {'sign': -1}), ('IFNA7', 'IFNAR1', {'sign': -1}), ('IL17C', 'IL17RE', {'sign': -1}), ('LAMA5', 'ITGA6', {'sign': -1}), ('LAMA5', 'ITGB4', {'sign': -1}), ('LAMA5', 'CD151', {'sign': -1}), ('LAMC1', 'ITGA6', {'sign': -1}), ('LAMC1', 'ITGB4', {'sign': -1}), ('IL36A', 'IL1RL2', {'sign': -1}), ('LAMC2', 'ITGA6', {'sign': -1}), ('LAMC2', 'ITGB1', {'sign': -1}), ('LAMC2', 'ITGA3', {'sign': -1}), ('LAMC2', 'ITGB4', {'sign': -1}), ('NID1', 'PTPRF', {'sign': -1}), ('ADAM2', 'ITGB1', {'sign': -1}), ('ADAM2', 'ITGA6', {'sign': -1}), ('INHBE', 'ACVR2B', {'sign': -1}), ('INHBE', 'ACVR2A', {'sign': -1}), ('HDC', 'HRH1', {'sign': -1}), ('HDC', 'HRH2', {'sign': -1}), ('HDC', 'HRH3', {'sign': -1}), ('HDC', 'HRH4', {'sign': -1}), ('INHBB', 'ACVR2B', {'sign': -1}), ('INHBB', 'ACVR1B', {'sign': -1}), ('INHBB', 'ACVR2A', {'sign': -1}), ('INHBB', 'ACVR1C', {'sign': -1}), ('INHBB', 'ACVR1', {'sign': -1}), ('PCSK9', 'LDLR', {'sign': -1}), ('SEMA3E', 'PLXND1', {'sign': -1}), ('INHBC', 'ACVR2B', {'sign': -1}), ('INHBC', 'ACVR2A', {'sign': -1}), ('INHBC', 'ACVR1', {'sign': -1}), ('INHBC', 'ACVR1B', {'sign': -1}), ('CSH1', 'PRLR', {'sign': -1}), ('SEMA6D', 'PLXNA1', {'sign': -1}), ('SEMA6D', 'KDR', {'sign': -1}), ('SLIT3', 'ROBO2', {'sign': -1}), ('SLIT3', 'ROBO1', {'sign': -1}), ('CXCL14', 'CXCR4', {'sign': -1}), ('ICAM4', 'ITGAM', {'sign': -1}), ('ICAM4', 'ITGAL', {'sign': -1}), ('ICAM4', 'ITGB3', {'sign': -1}), ('ICAM4', 'ITGAV', {'sign': -1}), ('ICAM4', 'ITGA2B', {'sign': -1}), ('ICAM4', 'ITGB2', {'sign': -1}), ('GDF9', 'BMPR1B', {'sign': -1}), ('GDF9', 'ACVR2A', {'sign': -1}), ('GDF9', 'BMPR1A', {'sign': -1}), ('GDF9', 'BMPR2', {'sign': -1}), ('GDF9', 'TGFBR1', {'sign': -1}), ('ZG16B', 'CXCR4', {'sign': -1}), ('LAMA1', 'ITGA7', {'sign': -1}), ('LAMA1', 'ITGB8', {'sign': -1}), ('LAMA1', 'ITGA2', {'sign': -1}), ('LAMA1', 'RPSA', {'sign': -1}), ('LAMB3', 'ITGA6', {'sign': -1}), ('LAMB3', 'ITGB4', {'sign': -1}), ('CCN1', 'ITGAM', {'sign': -1}), ('CCN1', 'ITGB3', {'sign': -1}), ('CCN1', 'ITGA5', {'sign': -1}), ('CCN1', 'ITGB2', {'sign': -1}), ('LAMA2', 'ITGA7', {'sign': -1}), ('LAMA2', 'ITGB4', {'sign': -1}), ('LAMA2', 'RPSA', {'sign': -1}), ('LAMA2', 'ITGB1', {'sign': -1}), ('LAMA2', 'ITGA6', {'sign': -1}), ('LAMA2', 'DAG1', {'sign': -1}), ('LAMA3', 'ITGB4', {'sign': -1}), ('LAMB2', 'ITGB4', {'sign': -1}), ('LAMB2', 'RPSA', {'sign': -1}), ('RAET1L', 'KLRK1', {'sign': -1}), ('ULBP3', 'KLRK1', {'sign': -1}), ('RAET1E', 'KLRK1', {'sign': -1}), ('RAET1G', 'KLRK1', {'sign': -1}), ('SERPINE2', 'LRP1', {'sign': -1}), ('LRPAP1', 'LRP1', {'sign': -1}), ('LRPAP1', 'VLDLR', {'sign': -1}), ('RNASE2', 'TLR2', {'sign': -1}), ('SOST', 'LRP6', {'sign': -1}), ('SOST', 'LRP5', {'sign': -1}), ('CD24', 'SELP', {'sign': -1}), ('IFNA16', 'IFNAR1', {'sign': -1}), ('IFNA16', 'IFNAR2', {'sign': -1}), ('IFNA14', 'IFNAR1', {'sign': -1}), ('IFNA14', 'IFNAR2', {'sign': -1}), ('IFNA4', 'IFNAR1', {'sign': -1}), ('IFNA4', 'IFNAR2', {'sign': -1}), ('IFNA5', 'IFNAR1', {'sign': -1}), ('IFNA5', 'IFNAR2', {'sign': -1}), ('IFNA6', 'IFNAR1', {'sign': -1}), ('IFNA6', 'IFNAR2', {'sign': -1}), ('IFNA10', 'IFNAR1', {'sign': -1}), ('IFNA10', 'IFNAR2', {'sign': -1}), ('IFNA8', 'IFNAR1', {'sign': -1}), ('IFNA8', 'IFNAR2', {'sign': -1}), ('IFNE', 'IFNAR1', {'sign': -1}), ('IFNE', 'IFNAR2', {'sign': -1}), ('IFNA21', 'IFNAR1', {'sign': -1}), ('IFNA21', 'IFNAR2', {'sign': -1}), ('IFNA2', 'IFNAR1', {'sign': -1}), ('IFNA2', 'IFNAR2', {'sign': -1}), ('IL17F', 'IL17RC', {'sign': -1}), ('IL17F', 'IL17RA', {'sign': -1}), ('CHAD', 'ITGA2', {'sign': -1}), ('CHAD', 'ITGB1', {'sign': -1}), ('TAC4', 'TACR1', {'sign': -1}), ('LEFTY2', 'ACVR2B', {'sign': -1}), ('ICAM2', 'ITGAL', {'sign': -1}), ('ICAM2', 'ITGB2', {'sign': -1}), ('CD59', 'CD2', {'sign': -1}), ('CXCL17', 'GPR35', {'sign': -1}), ('NAMPT', 'INSR', {'sign': -1}), ('ENHO', 'GPR19', {'sign': -1}), ('BAG6', 'NCR3', {'sign': -1}), ('HLA-F', 'KIR3DL1', {'sign': -1}), ('HLA-F', 'KIR3DL2', {'sign': -1}), ('HLA-E', 'KLRC1', {'sign': -1}), ('HLA-E', 'KLRC2', {'sign': -1}), ('HLA-E', 'KLRD1', {'sign': -1}), ('ADAM23', 'ITGA5', {'sign': -1}), ('ADAM23', 'ITGB3', {'sign': -1}), ('COL5A3', 'SDC3', {'sign': -1}), ('LEAP2', 'GHSR', {'sign': -1}), ('NXPH3', 'NRXN1', {'sign': -1}), ('NXPH3', 'NRXN2', {'sign': -1}), ('NXPH3', 'NRXN3', {'sign': -1}), ('PODXL2', 'SELL', {'sign': -1}), ('PRND', 'RPSA', {'sign': -1}), ('PTDSS1', 'JMJD6', {'sign': -1}), ('PTDSS1', 'SCARB1', {'sign': -1}), ('SERPING1', 'LRP1', {'sign': -1}), ('TFF2', 'CXCR4', {'sign': -1}), ('GPR15LG', 'GPR15', {'sign': -1}), ('DUSP18', 'CD151', {'sign': -1}), ('CDK19', 'EIF3F', {'sign': -1}), ('PTP4A1', 'ATF7', {'sign': -1}), ('PTPRU', 'CTNNB1', {'sign': -1}), ('PTPRM', 'CTNND1', {'sign': -1}), ('HIPK4', 'TP53', {'sign': -1}), ('FRK', 'PTEN', {'sign': -1}), ('MYT1', 'CDK1', {'sign': -1}), ('ENPEP', 'CCK', {'sign': -1}), ('ADAMTS1', 'VCAN', {'sign': -1}), ('MMP26', 'MMP9', {'sign': -1}), ('FCGR3A', 'LCK', {'sign': -1}), ('TASP1', 'GTF2A1', {'sign': -1}), ('NAA10', 'HIF1A', {'sign': -1}), ('ECE1', 'EDN1', {'sign': -1}), ('CSNK1G3', 'TP53', {'sign': -1}), ('CSNK1G3', 'YWHAQ', {'sign': -1})])" + " source target sign\n", + "0 CALM1 TRPC1 -1\n", + "1 CALM3 TRPC1 -1\n", + "2 CALM2 TRPC1 -1\n", + "3 CAV1 TRPC1 1\n", + "4 MDFI TRPC1 -1\n", + "... ... ... ...\n", + "13253 SYK NFKBIA 1\n", + "13254 MAPK3 GATA4 1\n", + "13255 GRK5 CXCR4 1\n", + "13256 SLK RHOA -1\n", + "13257 AKT1 SKP2 1\n", + "\n", + "[13258 rows x 3 columns]" ] }, - "execution_count": 12, + "execution_count": 11, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "graph.edges(data=True)" + "network" ] }, { "cell_type": "code", - "execution_count": 24, + "execution_count": 12, "metadata": {}, - "outputs": [ - { - "ename": "AttributeError", - "evalue": "module 'networkcommons._methods.causal' has no attribute 'convert_cornetograph'", - "output_type": "error", - "traceback": [ - "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", - "\u001b[0;31mKeyError\u001b[0m Traceback (most recent call last)", - "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:159\u001b[0m, in \u001b[0;36mLazyModule.__getattribute__\u001b[0;34m(self, attr)\u001b[0m\n\u001b[1;32m 158\u001b[0m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[0;32m--> 159\u001b[0m _callable \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mtype\u001b[39;49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m)\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_lazy_import_callables\u001b[49m\u001b[43m[\u001b[49m\u001b[43mattr\u001b[49m\u001b[43m]\u001b[49m\n\u001b[1;32m 160\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mReturning lazy-callable \u001b[39m\u001b[38;5;124m'\u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m'\u001b[39m\u001b[38;5;124m.\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;241m.\u001b[39mformat(attr))\n", - "\u001b[0;31mKeyError\u001b[0m: 'causal'", - "\nDuring handling of the above exception, another exception occurred:\n", - "\u001b[0;31mAttributeError\u001b[0m Traceback (most recent call last)", - "Cell \u001b[0;32mIn[24], line 1\u001b[0m\n\u001b[0;32m----> 1\u001b[0m importlib\u001b[38;5;241m.\u001b[39mreload(\u001b[43mnc\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mmethods\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mcausal\u001b[49m)\n", - "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:167\u001b[0m, in \u001b[0;36mLazyModule.__getattribute__\u001b[0;34m(self, attr)\u001b[0m\n\u001b[1;32m 162\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m (\u001b[38;5;167;01mAttributeError\u001b[39;00m, \u001b[38;5;167;01mKeyError\u001b[39;00m) \u001b[38;5;28;01mas\u001b[39;00m err:\n\u001b[1;32m 163\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mProceeding to load module \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m, \u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 164\u001b[0m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mfrom requested value \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 165\u001b[0m \u001b[38;5;241m.\u001b[39mformat(\u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\n\u001b[1;32m 166\u001b[0m \u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124m__name__\u001b[39m\u001b[38;5;124m\"\u001b[39m), attr))\n\u001b[0;32m--> 167\u001b[0m \u001b[43m_load_module\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m)\u001b[49m\n\u001b[1;32m 168\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mReturning value \u001b[39m\u001b[38;5;124m'\u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m'\u001b[39m\u001b[38;5;124m.\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;241m.\u001b[39mformat(\u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\n\u001b[1;32m 169\u001b[0m \u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(attr)))\n\u001b[1;32m 170\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(attr)\n", - "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:536\u001b[0m, in \u001b[0;36m_load_module\u001b[0;34m(module)\u001b[0m\n\u001b[1;32m 533\u001b[0m cached_data \u001b[38;5;241m=\u001b[39m _clean_lazymodule(module)\n\u001b[1;32m 534\u001b[0m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[1;32m 535\u001b[0m \u001b[38;5;66;03m# Get Python to do the real import!\u001b[39;00m\n\u001b[0;32m--> 536\u001b[0m \u001b[43mreload_module\u001b[49m\u001b[43m(\u001b[49m\u001b[43mmodule\u001b[49m\u001b[43m)\u001b[49m \n\u001b[1;32m 537\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m:\n\u001b[1;32m 538\u001b[0m \u001b[38;5;66;03m# Loading failed. We reset our lazy state.\u001b[39;00m\n\u001b[1;32m 539\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mFailed to load module \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m. Resetting...\u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 540\u001b[0m \u001b[38;5;241m.\u001b[39mformat(modname))\n", - "File \u001b[0;32m/usr/lib/python3.10/importlib/__init__.py:169\u001b[0m, in \u001b[0;36mreload\u001b[0;34m(module)\u001b[0m\n\u001b[1;32m 167\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m spec \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m:\n\u001b[1;32m 168\u001b[0m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mModuleNotFoundError\u001b[39;00m(\u001b[38;5;124mf\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mspec not found for the module \u001b[39m\u001b[38;5;132;01m{\u001b[39;00mname\u001b[38;5;132;01m!r}\u001b[39;00m\u001b[38;5;124m\"\u001b[39m, name\u001b[38;5;241m=\u001b[39mname)\n\u001b[0;32m--> 169\u001b[0m \u001b[43m_bootstrap\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_exec\u001b[49m\u001b[43m(\u001b[49m\u001b[43mspec\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mmodule\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 170\u001b[0m \u001b[38;5;66;03m# The module may have replaced itself in sys.modules!\u001b[39;00m\n\u001b[1;32m 171\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m sys\u001b[38;5;241m.\u001b[39mmodules[name]\n", - "File \u001b[0;32m:619\u001b[0m, in \u001b[0;36m_exec\u001b[0;34m(spec, module)\u001b[0m\n", - "File \u001b[0;32m:883\u001b[0m, in \u001b[0;36mexec_module\u001b[0;34m(self, module)\u001b[0m\n", - "File \u001b[0;32m:241\u001b[0m, in \u001b[0;36m_call_with_frames_removed\u001b[0;34m(f, *args, **kwds)\u001b[0m\n", - "File \u001b[0;32m~/networkcommons/networkcommons/methods.py:1\u001b[0m\n\u001b[0;32m----> 1\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n", - "File \u001b[0;32m~/networkcommons/networkcommons/_methods/__init__.py:21\u001b[0m\n\u001b[1;32m 16\u001b[0m \u001b[38;5;124;03m\"\"\"\u001b[39;00m\n\u001b[1;32m 17\u001b[0m \u001b[38;5;124;03mNetwork based inference methods and network operations.\u001b[39;00m\n\u001b[1;32m 18\u001b[0m \u001b[38;5;124;03m\"\"\"\u001b[39;00m\n\u001b[1;32m 20\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mgraph\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n\u001b[0;32m---> 21\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mcausal\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n\u001b[1;32m 22\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mmoon\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n", - "\u001b[0;31mAttributeError\u001b[0m: module 'networkcommons._methods.causal' has no attribute 'convert_cornetograph'" - ] - } - ], + "outputs": [], "source": [ - "importlib.reload(nc.methods.causal)" + "graph = nc.utils.network_from_df(network)" ] }, { - "cell_type": "code", - "execution_count": 20, + "cell_type": "markdown", "metadata": {}, - "outputs": [ - { - "ename": "AttributeError", - "evalue": "module 'networkcommons._methods.causal' has no attribute 'convert_cornetograph'", - "output_type": "error", - "traceback": [ - "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", - "\u001b[0;31mKeyError\u001b[0m Traceback (most recent call last)", - "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:159\u001b[0m, in \u001b[0;36mLazyModule.__getattribute__\u001b[0;34m(self, attr)\u001b[0m\n\u001b[1;32m 158\u001b[0m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[0;32m--> 159\u001b[0m _callable \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mtype\u001b[39;49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m)\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_lazy_import_callables\u001b[49m\u001b[43m[\u001b[49m\u001b[43mattr\u001b[49m\u001b[43m]\u001b[49m\n\u001b[1;32m 160\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mReturning lazy-callable \u001b[39m\u001b[38;5;124m'\u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m'\u001b[39m\u001b[38;5;124m.\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;241m.\u001b[39mformat(attr))\n", - "\u001b[0;31mKeyError\u001b[0m: 'causal'", - "\nDuring handling of the above exception, another exception occurred:\n", - "\u001b[0;31mAttributeError\u001b[0m Traceback (most recent call last)", - "Cell \u001b[0;32mIn[20], line 1\u001b[0m\n\u001b[0;32m----> 1\u001b[0m corneto_graph \u001b[38;5;241m=\u001b[39m \u001b[43mnc\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mmethods\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mcausal\u001b[49m\u001b[38;5;241m.\u001b[39mto_cornetograph(graph)\n", - "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:167\u001b[0m, in \u001b[0;36mLazyModule.__getattribute__\u001b[0;34m(self, attr)\u001b[0m\n\u001b[1;32m 162\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m (\u001b[38;5;167;01mAttributeError\u001b[39;00m, \u001b[38;5;167;01mKeyError\u001b[39;00m) \u001b[38;5;28;01mas\u001b[39;00m err:\n\u001b[1;32m 163\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mProceeding to load module \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m, \u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 164\u001b[0m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mfrom requested value \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 165\u001b[0m \u001b[38;5;241m.\u001b[39mformat(\u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\n\u001b[1;32m 166\u001b[0m \u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124m__name__\u001b[39m\u001b[38;5;124m\"\u001b[39m), attr))\n\u001b[0;32m--> 167\u001b[0m \u001b[43m_load_module\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[43m)\u001b[49m\n\u001b[1;32m 168\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mReturning value \u001b[39m\u001b[38;5;124m'\u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m'\u001b[39m\u001b[38;5;124m.\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;241m.\u001b[39mformat(\u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\n\u001b[1;32m 169\u001b[0m \u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(attr)))\n\u001b[1;32m 170\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28msuper\u001b[39m(LazyModule, \u001b[38;5;28mself\u001b[39m)\u001b[38;5;241m.\u001b[39m\u001b[38;5;21m__getattribute__\u001b[39m(attr)\n", - "File \u001b[0;32m~/.cache/pypoetry/virtualenvs/networkcommons-DX9y6Uxu-py3.10/lib/python3.10/site-packages/lazy_import/__init__.py:536\u001b[0m, in \u001b[0;36m_load_module\u001b[0;34m(module)\u001b[0m\n\u001b[1;32m 533\u001b[0m cached_data \u001b[38;5;241m=\u001b[39m _clean_lazymodule(module)\n\u001b[1;32m 534\u001b[0m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[1;32m 535\u001b[0m \u001b[38;5;66;03m# Get Python to do the real import!\u001b[39;00m\n\u001b[0;32m--> 536\u001b[0m \u001b[43mreload_module\u001b[49m\u001b[43m(\u001b[49m\u001b[43mmodule\u001b[49m\u001b[43m)\u001b[49m \n\u001b[1;32m 537\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m:\n\u001b[1;32m 538\u001b[0m \u001b[38;5;66;03m# Loading failed. We reset our lazy state.\u001b[39;00m\n\u001b[1;32m 539\u001b[0m logger\u001b[38;5;241m.\u001b[39mdebug(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mFailed to load module \u001b[39m\u001b[38;5;132;01m{}\u001b[39;00m\u001b[38;5;124m. Resetting...\u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 540\u001b[0m \u001b[38;5;241m.\u001b[39mformat(modname))\n", - "File \u001b[0;32m/usr/lib/python3.10/importlib/__init__.py:169\u001b[0m, in \u001b[0;36mreload\u001b[0;34m(module)\u001b[0m\n\u001b[1;32m 167\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m spec \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m:\n\u001b[1;32m 168\u001b[0m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mModuleNotFoundError\u001b[39;00m(\u001b[38;5;124mf\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mspec not found for the module \u001b[39m\u001b[38;5;132;01m{\u001b[39;00mname\u001b[38;5;132;01m!r}\u001b[39;00m\u001b[38;5;124m\"\u001b[39m, name\u001b[38;5;241m=\u001b[39mname)\n\u001b[0;32m--> 169\u001b[0m \u001b[43m_bootstrap\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_exec\u001b[49m\u001b[43m(\u001b[49m\u001b[43mspec\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mmodule\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 170\u001b[0m \u001b[38;5;66;03m# The module may have replaced itself in sys.modules!\u001b[39;00m\n\u001b[1;32m 171\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m sys\u001b[38;5;241m.\u001b[39mmodules[name]\n", - "File \u001b[0;32m:619\u001b[0m, in \u001b[0;36m_exec\u001b[0;34m(spec, module)\u001b[0m\n", - "File \u001b[0;32m:883\u001b[0m, in \u001b[0;36mexec_module\u001b[0;34m(self, module)\u001b[0m\n", - "File \u001b[0;32m:241\u001b[0m, in \u001b[0;36m_call_with_frames_removed\u001b[0;34m(f, *args, **kwds)\u001b[0m\n", - "File \u001b[0;32m~/networkcommons/networkcommons/methods.py:1\u001b[0m\n\u001b[0;32m----> 1\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n", - "File \u001b[0;32m~/networkcommons/networkcommons/_methods/__init__.py:21\u001b[0m\n\u001b[1;32m 16\u001b[0m \u001b[38;5;124;03m\"\"\"\u001b[39;00m\n\u001b[1;32m 17\u001b[0m \u001b[38;5;124;03mNetwork based inference methods and network operations.\u001b[39;00m\n\u001b[1;32m 18\u001b[0m \u001b[38;5;124;03m\"\"\"\u001b[39;00m\n\u001b[1;32m 20\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mgraph\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n\u001b[0;32m---> 21\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mcausal\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n\u001b[1;32m 22\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mnetworkcommons\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01m_methods\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mmoon\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m \u001b[38;5;241m*\u001b[39m\n", - "\u001b[0;31mAttributeError\u001b[0m: module 'networkcommons._methods.causal' has no attribute 'convert_cornetograph'" - ] - } - ], "source": [ - "corneto_graph = nc.methods.causal.to_cornetograph(graph)" + "Afatinib targets EGFR by inhibition, so we will create a source dictionary containing the origin of perturbation, EGFR, and the sign of the perturbation (negative, therefore -1)." ] }, { "cell_type": "code", - "execution_count": 40, + "execution_count": 13, "metadata": {}, "outputs": [], "source": [ - "G = corneto_graph_to_networkx(cornetoG, skip_unsupported_edges=True)" + "source_df = pd.DataFrame({'source': ['EGFR'], \n", + " 'sign': [-1]}, columns=['source', 'sign'])\n", + "source_df.set_index('source', inplace=True)\n", + "sources = source_df['sign'].to_dict()" ] }, { - "cell_type": "code", - "execution_count": 41, + "cell_type": "markdown", "metadata": {}, - "outputs": [ - { - "data": { - "text/plain": [ - "{'__edge_type': 'directed',\n", - " 'sign': -1,\n", - " '__source_attr': {'CALM1': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}}" - ] - }, - "execution_count": 41, - "metadata": {}, - "output_type": "execute_result" - } - ], "source": [ - "networkxG.get_edge_data('CALM1', 'TRPC1')" + "### 2.1 CORNETO" ] }, { "cell_type": "code", - "execution_count": 43, + "execution_count": 14, "metadata": {}, - "outputs": [ - { - "data": { - "text/plain": [ - "13172" - ] - }, - "execution_count": 43, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ - "len(networkxG.edges())" + "corneto_graph = nc.methods.to_cornetograph(graph)" ] }, { @@ -727,4040 +747,135 @@ "metadata": {}, "outputs": [ { - "data": { - "text/plain": [ - "[{'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CALM1': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CALM3': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CALM2': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CAV1': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'MDFI': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'ITPR2': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'STIM1': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TRPC1': {'__value': {}}},\n", - " '__target_attr': {'TRPC3': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TRPC3': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TRPC1': {'__value': {}}},\n", - " '__target_attr': {'TRPC4': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TRPC4': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TRPC1': {'__value': {}}},\n", - " '__target_attr': {'TRPC5': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TRPC5': {'__value': {}}},\n", - " '__target_attr': {'TRPC1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TRPC1': {'__value': {}}},\n", - " '__target_attr': {'TRPC6': {'__value': {}}}},\n", - 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" {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'PYCARD': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'PTK2': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'PTEN': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'PRKAB1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'SGK1': {'__value': {}}},\n", - " '__target_attr': {'FOXO3': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'PRDM1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CHUK_IKBKB_IKBKG': {'__value': {}}},\n", - " '__target_attr': {'FOXO3': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'PPM1J': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'AKT1': {'__value': {}}},\n", - " '__target_attr': {'FOXO1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'NR2F2': {'__value': {}}},\n", - " '__target_attr': {'CEBPA': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'PLK3': {'__value': {}}},\n", - " '__target_attr': {'TP53': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CAMK2A_CAMK2B_CAMK2D_CAMK2G': {'__value': {}}},\n", - " '__target_attr': {'HDAC4': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'NR2F2': {'__value': {}}},\n", - " '__target_attr': {'PPARG': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'GPS2_HDAC3_NCOR1_TBL1XR1_TBL1Y': {'__value': {}}},\n", - " '__target_attr': {'NR2F2': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CAMK2A_CAMK2B_CAMK2D_CAMK2G': {'__value': {}}},\n", - " '__target_attr': {'HDAC9': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'E2F1': {'__value': {}}},\n", - " '__target_attr': {'CCNB1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'E2F1': {'__value': {}}},\n", - " '__target_attr': {'CASP7': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'SERPINE1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'SERPINB5': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'SFN': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'SESN1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'RPS27L': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'COP1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'S100A2': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'SCN3B': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'SCD': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'MIR17HG': {'__value': {}}},\n", - " '__target_attr': {'CCND1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'TP73': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'TP63': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'GSK3B': {'__value': {}}},\n", - " '__target_attr': {'CCND1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'STEAP3': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'SLC38A2': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'ETS1': {'__value': {}}},\n", - " '__target_attr': {'STAT1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'STAT1': {'__value': {}}},\n", - " '__target_attr': {'ICAM1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'SH2D1A': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'TNFRSF10C': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'MAX_MYC_ZMIZ1': {'__value': {}}},\n", - " '__target_attr': {'CDKN2B': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'TNFRSF10A': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'TGFA': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1': {'__value': {}}},\n", - " '__target_attr': {'TP53': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TP53': {'__value': {}}},\n", - " '__target_attr': {'TAP1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'AXIN1': {'__value': {}}},\n", - " '__target_attr': {'MYC': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'GSK3B': {'__value': {}}},\n", - " '__target_attr': {'MYC': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'PPP2CA_PPP2R5A_PTPA': {'__value': {}}},\n", - " '__target_attr': {'MYC': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'MAX_MYC': {'__value': {}}},\n", - " '__target_attr': {'NBN': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'MIR22HG': {'__value': {}}},\n", - " '__target_attr': {'BMP7': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'MIR22HG': {'__value': {}}},\n", - " '__target_attr': {'PPARA': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'IKBKG': {'__value': {}}},\n", - " '__target_attr': {'IKBKB': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CHEK1': {'__value': {}}},\n", - " '__target_attr': {'CDC25A': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'RPS6KA5': {'__value': {}}},\n", - " '__target_attr': {'H2AZ1': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'TAF1': {'__value': {}}},\n", - " '__target_attr': {'BCL2L11': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CREBBP': {'__value': {}}},\n", - " '__target_attr': {'ASAH2B': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'KAT7': {'__value': {}}},\n", - " '__target_attr': {'H4C2': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'KAT7': {'__value': {}}},\n", - " '__target_attr': {'H3C12': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CASP8': {'__value': {}}},\n", - " '__target_attr': {'CASP6': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'GTF3C4': {'__value': {}}},\n", - " '__target_attr': {'H3C12': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'CSNK2A1_CSNK2B': {'__value': {}}},\n", - " '__target_attr': {'TOP2A': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'NCOA1': {'__value': {}}},\n", - " '__target_attr': {'H4C2': {'__value': {}}}},\n", - " {'__edge_type': 'directed',\n", - " 'interaction': -1,\n", - " '__source_attr': {'NCOA1': {'__value': {}}},\n", - " '__target_attr': {'H3C12': {'__value': {}}}},\n", - " ...]" - ] - }, - "execution_count": 15, - "metadata": {}, - "output_type": "execute_result" + "name": "stdout", + "output_type": "stream", + "text": [ + "(CORNETO) Jul 04 02:00:54 AM - INFO : 1/1 inputs mapped to the graph\n", + "(CORNETO) Jul 04 02:00:54 AM - INFO : 16/25 outputs mapped to the graph\n", + "(CORNETO) Jul 04 02:00:54 AM - INFO : Pruning the graph with size: V x E = (4946, 13172)...\n", + "(CORNETO) Jul 04 02:00:55 AM - INFO : Finished. Final size: V x E = (1185, 5787).\n", + "(CORNETO) Jul 04 02:00:55 AM - INFO : 1/1 inputs after pruning.\n", + "(CORNETO) Jul 04 02:00:55 AM - INFO : 9/16 outputs after pruning.\n", + "(CORNETO) Jul 04 02:00:55 AM - INFO : Converting into a flow graph...\n", + "(CORNETO) Jul 04 02:00:55 AM - INFO : Creating a network flow problem...\n", + "(CORNETO) Jul 04 02:00:56 AM - INFO : Preprocess completed.\n", + "===============================================================================\n", + " CVXPY \n", + " v1.5.2 \n", + "===============================================================================\n", + "(CVXPY) Jul 04 02:00:56 AM: Your problem has 26883 variables, 65452 constraints, and 0 parameters.\n", + "(CVXPY) Jul 04 02:00:56 AM: It is compliant with the following grammars: DCP, DQCP\n", + "(CVXPY) Jul 04 02:00:56 AM: (If you need to solve this problem multiple times, but with different data, consider using parameters.)\n", + "(CVXPY) Jul 04 02:00:56 AM: CVXPY will first compile your problem; then, it will invoke a numerical solver to obtain a solution.\n", + "(CVXPY) Jul 04 02:00:56 AM: Your problem is compiled with the CPP canonicalization backend.\n", + "-------------------------------------------------------------------------------\n", + " Compilation \n", + "-------------------------------------------------------------------------------\n", + "(CVXPY) Jul 04 02:00:56 AM: Compiling problem (target solver=GUROBI).\n", + "(CVXPY) Jul 04 02:00:56 AM: Reduction chain: CvxAttr2Constr -> Qp2SymbolicQp -> QpMatrixStuffing -> GUROBI\n", + "(CVXPY) Jul 04 02:00:56 AM: Applying reduction CvxAttr2Constr\n", + "(CVXPY) Jul 04 02:00:56 AM: Applying reduction Qp2SymbolicQp\n", + "(CVXPY) Jul 04 02:00:56 AM: Applying reduction QpMatrixStuffing\n", + "(CVXPY) Jul 04 02:00:56 AM: Applying reduction GUROBI\n", + "(CVXPY) Jul 04 02:00:56 AM: Finished problem compilation (took 1.435e-01 seconds).\n", + "-------------------------------------------------------------------------------\n", + " Numerical solver \n", + "-------------------------------------------------------------------------------\n", + "(CVXPY) Jul 04 02:00:56 AM: Invoking solver GUROBI to obtain a solution.\n", + "Set parameter Username\n", + "Academic license - for non-commercial use only - expires 2025-07-03\n", + "Set parameter QCPDual to value 1\n", + "Gurobi Optimizer version 11.0.2 build v11.0.2rc0 (linux64 - \"Ubuntu 22.04.1 LTS\")\n", + "\n", + "CPU model: 11th Gen Intel(R) Core(TM) i7-1165G7 @ 2.80GHz, instruction set [SSE2|AVX|AVX2|AVX512]\n", + "Thread count: 4 physical cores, 8 logical processors, using up to 8 threads\n", + "\n", + "Optimize a model with 65452 rows, 26883 columns and 152766 nonzeros\n", + "Model fingerprint: 0x57ca586c\n", + "Variable types: 7022 continuous, 19861 integer (19861 binary)\n", + "Coefficient statistics:\n", + " Matrix range [1e-03, 1e+03]\n", + " Objective range [1e-02, 1e+00]\n", + " Bounds range [1e+00, 1e+00]\n", + " RHS range [1e-03, 1e+03]\n", + "Presolve removed 29163 rows and 2375 columns\n", + "Presolve time: 0.38s\n", + "Presolved: 36289 rows, 24508 columns, 108473 nonzeros\n", + "Variable types: 6589 continuous, 17919 integer (17919 binary)\n", + "Deterministic concurrent LP optimizer: primal and dual simplex\n", + "Showing primal log only...\n", + "\n", + "Concurrent spin time: 0.00s\n", + "\n", + "Solved with dual simplex\n", + "Extra simplex iterations after uncrush: 4\n", + "\n", + "Root relaxation: objective -9.758317e+00, 1232 iterations, 0.23 seconds (0.16 work units)\n", + "\n", + " Nodes | Current Node | Objective Bounds | Work\n", + " Expl Unexpl | Obj Depth IntInf | Incumbent BestBd Gap | It/Node Time\n", + "\n", + " 0 0 -9.75832 0 72 - -9.75832 - - 1s\n", + " 0 0 -9.74833 0 76 - -9.74833 - - 1s\n", + "H 0 0 -0.9700000 -9.74833 905% - 1s\n", + "H 0 0 -1.8700000 -9.74833 421% - 1s\n", + "H 0 0 -1.9300000 -9.74833 405% - 1s\n", + " 0 0 -9.74360 0 153 -1.93000 -9.74360 405% - 2s\n", + " 0 0 -9.74000 0 161 -1.93000 -9.74000 405% - 2s\n", + " 0 0 -9.74000 0 143 -1.93000 -9.74000 405% - 2s\n", + " 0 0 -9.74000 0 153 -1.93000 -9.74000 405% - 3s\n", + " 0 0 -9.74000 0 187 -1.93000 -9.74000 405% - 3s\n", + " 0 0 -9.73700 0 164 -1.93000 -9.73700 405% - 4s\n", + " 0 0 -9.73667 0 184 -1.93000 -9.73667 404% - 4s\n", + " 0 0 -9.73500 0 195 -1.93000 -9.73500 404% - 4s\n", + "H 0 0 -8.7500000 -9.73500 11.3% - 5s\n", + " 0 0 -9.73500 0 192 -8.75000 -9.73500 11.3% - 5s\n", + " 0 0 -9.73500 0 180 -8.75000 -9.73500 11.3% - 5s\n", + " 0 0 -9.73500 0 124 -8.75000 -9.73500 11.3% - 6s\n", + "H 0 0 -9.6900000 -9.73500 0.46% - 7s\n", + " 0 2 -9.73500 0 124 -9.69000 -9.73500 0.46% - 8s\n", + "H 29 30 -9.7200000 -9.73500 0.15% 202 9s\n", + " 72 33 -9.73000 9 64 -9.72000 -9.73500 0.15% 105 10s\n", + " 708 93 -9.73000 20 11 -9.72000 -9.73000 0.10% 21.1 15s\n", + " 1778 29 -9.73000 24 54 -9.72000 -9.73000 0.10% 14.9 20s\n", + "\n", + "Cutting planes:\n", + " Learned: 4\n", + " Gomory: 6\n", + " Cover: 13\n", + " Implied bound: 91\n", + " MIR: 11\n", + " Inf proof: 28\n", + " Zero half: 23\n", + " RLT: 12\n", + " Relax-and-lift: 2\n", + "\n", + "Explored 2131 nodes (48215 simplex iterations) in 22.68 seconds (20.45 work units)\n", + "Thread count was 8 (of 8 available processors)\n", + "\n", + "Solution count 6: -9.72 -9.69 -8.75 ... -0.97\n", + "No other solutions better than -9.72\n", + "\n", + "Optimal solution found (tolerance 1.00e-04)\n", + "Best objective -9.720000000000e+00, best bound -9.720000000000e+00, gap 0.0000%\n", + "-------------------------------------------------------------------------------\n", + " Summary \n", + "-------------------------------------------------------------------------------\n", + "(CVXPY) Jul 04 02:01:19 AM: Problem status: optimal\n", + "(CVXPY) Jul 04 02:01:19 AM: Optimal value: 1.628e+01\n", + "(CVXPY) Jul 04 02:01:19 AM: Compilation took 1.435e-01 seconds\n", + "(CVXPY) Jul 04 02:01:19 AM: Solver (including time spent in interface) took 2.326e+01 seconds\n", + "(CORNETO) Jul 04 02:01:19 AM - INFO : Finished in 24.88 s.\n" + ] } ], "source": [ - "G.get_attr_edges()" - ] - }, - { - "cell_type": "code", - "execution_count": 14, - "metadata": {}, - "outputs": [], - "source": [ - "G = cn.Graph.from_sif(\"network.csv\", delimiter=\",\", has_header=True, column_order=[0,2,1])\n", - "# corneto_network = nc.methods.causal.run_corneto_carnival(G, sources, measurements, betaWeight=0.01)" + "corneto_network = nc.methods.run_corneto_carnival(corneto_graph, sources, measurements, betaWeight=0.01, solver='GUROBI')" ] }, { "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [] - }, - { - "cell_type": "code", - "execution_count": 13, + "execution_count": 16, "metadata": {}, "outputs": [ { @@ -4781,243 +896,309 @@ "\n", "\n", - "\n", "\n", - "\n", - "\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", "\n", - "RAC1\n", - "\n", + "AKT1\n", + "\n", "\n", - "\n", + "\n", "\n", - "MAP3K10\n", - "\n", + "GSK3A\n", + "\n", "\n", - "\n", + "\n", "\n", - "RAC1->MAP3K10\n", - "\n", - "\n", + "AKT1->GSK3A\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "AKT1\n", - "\n", + "PEA15\n", + "\n", "\n", - "\n", + "\n", "\n", - "RAC1->AKT1\n", - "\n", - "\n", + "AKT1->PEA15\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "NEUROD1\n", - "\n", + "RARA\n", + "\n", "\n", - "\n", + "\n", "\n", - "MAP3K10->NEUROD1\n", - "\n", - "\n", + "AKT1->RARA\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "RARA\n", - "\n", + "YAP1\n", + "\n", "\n", - "\n", + "\n", "\n", - "AKT1->RARA\n", - "\n", - "\n", + "AKT1->YAP1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "CDK2\n", - "\n", + "BCL3\n", + "\n", "\n", - "\n", + "\n", "\n", - "AKT1->CDK2\n", - "\n", - "\n", + "GSK3A->BCL3\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "FOXO3\n", - "\n", + "MAPK1\n", + "\n", "\n", - "\n", + "\n", "\n", - "AKT1->FOXO3\n", - "\n", - "\n", + "PEA15->MAPK1\n", + "\n", + "\n", "\n", "\n", "\n", "THRA\n", - "\n", + "\n", "\n", "\n", "\n", "RARA->THRA\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "ID3\n", - "\n", + "RUNX2\n", + "\n", "\n", - "\n", + "\n", "\n", - "CDK2->ID3\n", - "\n", - "\n", + "YAP1->RUNX2\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "ATM\n", - "\n", + "PPP2R5C\n", + "\n", "\n", - "\n", + "\n", "\n", - "FOXO3->ATM\n", - "\n", - "\n", + "MAPK1->PPP2R5C\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "DUSP5\n", - "\n", + "NCOA6\n", + "\n", "\n", - "\n", + "\n", "\n", - "FOXO3->DUSP5\n", - "\n", - "\n", + "MAPK1->NCOA6\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "TP53\n", + "\n", + "\n", + "\n", + "\n", + "MAPK1->TP53\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "RARB\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "THRA->RARB\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "HIPK2\n", - "\n", + "\n", + "\n", + "SIAH1\n", + "\n", "\n", - "\n", - "\n", - "ATM->HIPK2\n", - "\n", - "\n", + "\n", + "\n", + "TP53->SIAH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFYB\n", + "\n", + "\n", + "\n", + "\n", + "TP53->NFYB\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKCZ\n", + "\n", + "\n", + "\n", + "\n", + "PRKCZ->AKT1\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK3\n", - "\n", + "\n", "\n", - "\n", - "\n", - "DUSP5->MAPK3\n", - "\n", - "\n", + "\n", + "\n", + "PRKCZ->MAPK3\n", + "\n", + "\n", "\n", - "\n", - "\n", - "MAPK1\n", - "\n", + "\n", + "\n", + "FOXO3\n", + "\n", "\n", - "\n", - "\n", - "DUSP5->MAPK1\n", - "\n", - "\n", + "\n", + "\n", + "MAPK3->FOXO3\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAZ\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK3->MAZ\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "RUNX2\n", - "\n", - "\n", - "\n", - "\n", - "MAPK3->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "NCOA6\n", - "\n", + "RBL2\n", + "\n", "\n", - "\n", + "\n", "\n", - "MAPK1->NCOA6\n", - "\n", - "\n", + "FOXO3->RBL2\n", + "\n", + "\n", "\n", - "\n", - "\n", - "STAT3\n", - "\n", + "\n", + "\n", + "E2F5\n", + "\n", "\n", - "\n", - "\n", - "MAPK1->STAT3\n", - "\n", - "\n", + "\n", + "\n", + "RBL2->E2F5\n", + "\n", + "\n", "\n", - "\n", - "\n", - "PTK2\n", - "\n", + "\n", + "\n", + "HIPK2\n", + "\n", "\n", - "\n", - "\n", - "PTK2->RAC1\n", - "\n", - "\n", + "\n", + "\n", + "SIAH1->HIPK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDC42\n", + "\n", + "\n", + "\n", + "\n", + "CDC42->PRKCZ\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K10\n", + "\n", + "\n", + "\n", + "\n", + "CDC42->MAP3K10\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NEUROD1\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K10->NEUROD1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "VAV2\n", + "\n", + "\n", + "\n", + "\n", + "VAV2->CDC42\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR\n", - "\n", + "\n", "\n", - "\n", - "\n", - "EGFR->PTK2\n", - "\n", - "\n", + "\n", + "\n", + "EGFR->VAV2\n", + "\n", + "\n", "\n", "\n", "\n" ], "text/plain": [ - ">" + ">" ] }, "metadata": {}, @@ -5025,41 +1206,24 @@ } ], "source": [ - "a = nc.visualize_graph_simple(corneto_network, sources, measurements, is_sign_consistent=False)\n", + "a = nc.visual.visualize_graph_simple(corneto_network, sources, measurements, is_sign_consistent=False)\n", "style = \"\"\n", "display(HTML(style))\n", "display(a)" ] }, - { - "cell_type": "code", - "execution_count": 14, - "metadata": {}, - "outputs": [], - "source": [ - "import networkx as nx\n", - "nx.to_pandas_edgelist(corneto_network)[['source', 'target', 'sign']].to_csv('corneto_network.csv', index=False)" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [] - }, { "cell_type": "markdown", "metadata": {}, "source": [ - "### 2.2 Baseline methods: shortest paths, all paths, sign consistency, Personalised PageRank" + "### 2.2 Topological methods: shortest paths, all paths, sign consistency, Personalised PageRank" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ - "NetworkCommons also includes several baseline methods. These methods follow very simple assumptions, and therefore are well suited to be compared against more advanced methodologies." + "NetworkCommons also includes several topological methods. These methods follow very simple assumptions, and therefore are well suited to be compared against more advanced methodologies." ] }, { @@ -5073,16 +1237,36 @@ }, { "cell_type": "code", - "execution_count": 15, + "execution_count": 17, "metadata": {}, "outputs": [], "source": [ - "shortest_path_network, shortest_paths_list = nc.run_shortest_paths(graph, sources, measurements)" + "shortest_path_network, shortest_paths_list = nc.methods.run_shortest_paths(graph, sources, measurements)" ] }, { "cell_type": "code", - "execution_count": 16, + "execution_count": 18, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "OutEdgeDataView([('CALM1', 'TRPC1', {'sign': -1}), ('CALM1', 'TRPC3', {'sign': -1}), ('CALM1', 'TRPC6', {'sign': 1}), ('CALM1', 'TRPV1', {'sign': 1}), ('CALM1', 'TRPV4', {'sign': 1}), ('CALM1', 'TRPV5', {'sign': -1}), ('CALM1', 'TRPV6', {'sign': -1}), ('CALM1', 'DAPK1', {'sign': 1}), ('CALM1', 'MYLK', {'sign': 1}), ('CALM1', 'MYLK2', {'sign': 1}), ('CALM1', 'CAMK2A', {'sign': 1}), ('CALM1', 'IQGAP1', {'sign': 1}), ('CALM1', 'ATP2B1', {'sign': 1}), ('CALM1', 'NOS1', {'sign': 1}), ('CALM1', 'CAMK4', {'sign': 1}), ('CALM1', 'ADCY1', {'sign': 1}), ('CALM1', 'EEF2K', {'sign': 1}), ('CALM1', 'CAMKK2', {'sign': 1}), ('CALM1', 'UNC13B', {'sign': 1}), ('CALM1', 'GRIN2A', {'sign': -1}), ('CALM1', 'ITPR1', {'sign': -1}), ('CALM1', 'RASGRF1', {'sign': 1}), ('CALM1', 'MARCKS', {'sign': -1}), ('CALM1', 'ADD1', {'sign': 1}), ('CALM1', 'AKAP5', {'sign': -1}), ('CALM1', 'PDE1A', {'sign': 1}), ('CALM1', 'PDE1B', {'sign': 1}), ('CALM1', 'PDE1C', {'sign': 1}), ('CALM1', 'RYR1', {'sign': 1}), ('CALM1', 'GRM7', {'sign': -1}), ('CALM1', 'RAC1', {'sign': 1}), ('CALM1', 'RIT2', {'sign': 1}), ('CALM1', 'NOS3', {'sign': 1}), ('CALM1', 'CAMKK1', {'sign': 1}), ('TRPC1', 'TRPC3', {'sign': 1}), ('TRPC1', 'TRPC4', {'sign': 1}), ('TRPC1', 'TRPC5', {'sign': 1}), ('TRPC1', 'TRPC6', {'sign': -1}), ('TRPC1', 'PKD2', {'sign': 1}), ('TRPC1', 'TRPV4', {'sign': 1}), ('TRPC1', 'TRPV6', {'sign': -1}), ('CALM3', 'TRPC1', {'sign': -1}), ('CALM3', 'TRPC3', {'sign': -1}), ('CALM3', 'TRPC6', {'sign': 1}), ('CALM3', 'TRPV1', {'sign': 1}), ('CALM3', 'TRPV4', {'sign': 1}), ('CALM3', 'TRPV5', {'sign': -1}), ('CALM3', 'TRPV6', {'sign': -1}), ('CALM3', 'MYLK', {'sign': 1}), ('CALM3', 'MYLK2', {'sign': 1}), ('CALM3', 'CAMK2A', {'sign': 1}), ('CALM3', 'IQGAP1', {'sign': 1}), ('CALM3', 'NOS1', {'sign': 1}), ('CALM3', 'CAMK4', {'sign': 1}), ('CALM3', 'ADCY1', {'sign': 1}), ('CALM3', 'PPP3R1', {'sign': 1}), ('CALM3', 'EEF2K', {'sign': 1}), ('CALM3', 'CAMKK2', {'sign': 1}), ('CALM3', 'UNC13B', {'sign': 1}), ('CALM3', 'GRIN2A', {'sign': -1}), ('CALM3', 'ITPR1', {'sign': -1}), ('CALM3', 'RASGRF1', {'sign': 1}), ('CALM3', 'DAPK1', {'sign': 1}), ('CALM3', 'MARCKS', {'sign': -1}), ('CALM3', 'PDE1A', {'sign': 1}), ('CALM3', 'PDE1B', {'sign': 1}), ('CALM3', 'PDE1C', {'sign': 1}), ('CALM3', 'GRM7', {'sign': -1}), ('CALM3', 'RAC1', {'sign': 1}), ('CALM3', 'RIT2', {'sign': 1}), ('CALM3', 'NOS3', {'sign': 1}), ('CALM2', 'TRPC1', {'sign': -1}), ('CALM2', 'TRPC3', {'sign': -1}), ('CALM2', 'TRPC6', {'sign': 1}), ('CALM2', 'TRPV1', {'sign': 1}), ('CALM2', 'TRPV4', {'sign': 1}), ('CALM2', 'TRPV5', {'sign': -1}), ('CALM2', 'TRPV6', {'sign': -1}), ('CALM2', 'MYLK', {'sign': 1}), ('CALM2', 'MYLK2', {'sign': 1}), ('CALM2', 'CAMK2A', {'sign': 1}), ('CALM2', 'IQGAP1', {'sign': 1}), ('CALM2', 'NOS1', {'sign': 1}), ('CALM2', 'CAMK4', {'sign': 1}), ('CALM2', 'ADCY1', {'sign': 1}), ('CALM2', 'EEF2K', {'sign': 1}), ('CALM2', 'CAMKK2', {'sign': 1}), ('CALM2', 'UNC13B', {'sign': 1}), ('CALM2', 'GRIN2A', {'sign': -1}), ('CALM2', 'ITPR1', {'sign': -1}), ('CALM2', 'RASGRF1', {'sign': 1}), ('CALM2', 'DAPK1', {'sign': 1}), ('CALM2', 'MARCKS', {'sign': -1}), ('CALM2', 'PDE1A', {'sign': 1}), ('CALM2', 'PDE1B', {'sign': 1}), ('CALM2', 'PDE1C', {'sign': 1}), ('CALM2', 'GRM7', {'sign': -1}), ('CALM2', 'RAC1', {'sign': 1}), ('CALM2', 'RIT2', {'sign': 1}), ('CALM2', 'NOS3', {'sign': 1}), ('CAV1', 'TRPC1', {'sign': 1}), ('CAV1', 'PDGFRA', {'sign': 1}), ('CAV1', 'PDGFRB', {'sign': 1}), ('CAV1', 'LRP6', {'sign': 1}), ('MDFI', 'TRPC1', {'sign': -1}), ('MDFI', 'MYOD1', {'sign': -1}), ('MDFI', 'MYOG', {'sign': -1}), ('MDFI', 'MYF5', {'sign': -1}), ('ITPR2', 'TRPC1', {'sign': 1}), ('STIM1', 'TRPC1', {'sign': 1}), ('TRPC3', 'TRPC1', {'sign': 1}), ('TRPC4', 'TRPC1', {'sign': 1}), ('TRPC5', 'TRPC1', {'sign': 1}), ('TRPC5', 'TRPC6', {'sign': -1}), ('PKD2', 'TRPC1', {'sign': 1}), ('PKD2', 'TRPV4', {'sign': 1}), ('TRPV4', 'TRPC1', {'sign': 1}), ('TRPV6', 'TRPV5', {'sign': 1}), ('EPOR', 'TRPC3', {'sign': 1}), ('EPOR', 'PIK3R1', {'sign': 1}), ('ITPR1', 'TRPC3', {'sign': 1}), ('ITPR3', 'TRPC3', {'sign': 1}), ('ITPR3', 'TRPV4', {'sign': 1}), ('ORAI1', 'TRPC3', {'sign': 1}), ('PRKG1', 'TRPC3', {'sign': -1}), ('PRKG1', 'TRPC7', {'sign': 1}), ('PRKG1', 'PPP1R12A', {'sign': -1}), ('PRKG1', 'FHOD1', {'sign': 1}), ('PRKG1', 'SRF', {'sign': 1}), ('PRKG1', 'RGS2', {'sign': 1}), ('PRKG1', 'SEPTIN3', {'sign': 1}), ('PRKG1', 'LASP1', {'sign': -1}), ('PRKG1', 'SF1', {'sign': -1}), ('PRKG1', 'HSPB1', {'sign': -1}), ('PRKG1', 'HRH1', {'sign': -1}), ('PRKG1', 'CFTR', {'sign': 1}), ('PRKG1', 'PPP1R17', {'sign': 1}), ('PRKG1', 'TNNI3', {'sign': 1}), ('PRKG1', 'VASP', {'sign': -1}), ('PRKG1', 'PLCB3', {'sign': -1}), ('PRKG1', 'GTF2I', {'sign': 1}), ('PRKG1', 'SLC6A4', {'sign': 1}), ('PRKG1', 'PTS', {'sign': 1}), ('PRKG1', 'TTN', {'sign': 1}), ('PRKG1', 'PDE5A', {'sign': 1}), ('PRKG1', 'IRAG1', {'sign': 1}), ('TRPM4', 'TRPC3', {'sign': -1}), ('SLC9A3R1', 'TRPC4', {'sign': 1}), ('SLC9A3R1', 'ADRB2', {'sign': 1}), ('SLC9A3R1', 'CFTR', {'sign': 1}), ('FYN', 'TRPC6', {'sign': 1}), ('FYN', 'TRPV4', {'sign': 1}), ('FYN', 'DOK1', {'sign': 1}), ('FYN', 'TXK', {'sign': 1}), ('FYN', 'ITPR1', {'sign': 1}), ('FYN', 'SIT1', {'sign': 1}), ('FYN', 'CD247', {'sign': 1}), ('FYN', 'CTLA4', {'sign': -1}), ('FYN', 'LCP2', {'sign': 1}), ('FYN', 'VAV1', {'sign': 1}), ('FYN', 'FYB1', {'sign': 1}), ('FYN', 'SKAP1', {'sign': 1}), ('FYN', 'TRAT1', {'sign': 1}), ('FYN', 'WAS', {'sign': 1}), ('FYN', 'SYK', {'sign': 1}), ('FYN', 'SH3BP2', {'sign': 1}), ('FYN', 'PIK3R1', {'sign': 1}), ('FYN', 'PIK3R2', {'sign': 1}), ('FYN', 'NFE2L2', {'sign': -1}), ('FYN', 'CD79A', {'sign': 1}), ('FYN', 'CBL', {'sign': 1}), ('FYN', 'BCAR1', {'sign': 1}), ('FYN', 'KIT', {'sign': 1}), ('FYN', 'SHC1', {'sign': 1}), ('FYN', 'GRIN2A', {'sign': 1}), ('FYN', 'CTNNB1', {'sign': 1}), ('FYN', 'PTK2', {'sign': 1}), ('FYN', 'TUBA1B', {'sign': 1}), ('FYN', 'PLCG1', {'sign': 1}), ('FYN', 'DLG2', {'sign': 1}), ('FYN', 'DLG4', {'sign': 1}), ('FYN', 'GRIN2B', {'sign': 1}), ('FYN', 'SLAMF1', {'sign': 1}), ('FYN', 'GRB10', {'sign': -1}), ('FYN', 'PGD', {'sign': 1}), ('FYN', 'FCGR2A', {'sign': 1}), ('FYN', 'SCN5A', {'sign': -1}), ('FYN', 'CD79B', {'sign': 1}), ('FYN', 'TGFB1I1', {'sign': 1}), ('FYN', 'KIRREL1', {'sign': 1}), ('FYN', 'ACP1', {'sign': 1}), ('FYN', 'TOM1L1', {'sign': 1}), ('FYN', 'ARHGAP33', {'sign': -1}), 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1}), ('CDK2', 'ID2', {'sign': -1}), ('CDK2', 'MYOD1', {'sign': -1}), ('CDK2', 'HIRA', {'sign': 1}), ('CDK2', 'UBTF', {'sign': 1}), ('CDK2', 'NCOA1', {'sign': 1}), ('CDK2', 'NR1I2', {'sign': -1}), ('CDK2', 'BARD1', {'sign': 1}), ('CDK2', 'E2F1', {'sign': 1}), ('CDK2', 'H1-5', {'sign': 1}), ('HBP1', 'MYC', {'sign': -1}), ('RPL11', 'TRRAP', {'sign': -1}), ('RPL11', 'MYC', {'sign': -1}), ('RPL11', 'MDM2', {'sign': -1}), ('TRRAP', 'MYC', {'sign': 1}), ('PTPN12', 'PIN1', {'sign': 1}), ('PTPN12', 'PTK2', {'sign': -1}), ('PTPN12', 'WAS', {'sign': -1}), ('PTPN12', 'JAK2', {'sign': -1}), ('PTPN12', 'PSTPIP1', {'sign': -1}), ('PTPN12', 'SHC1', {'sign': -1}), ('PTPN12', 'GIT2', {'sign': -1}), ('PTPN12', 'INSR', {'sign': -1}), ('PTPN12', 'BCAR1', {'sign': -1}), ('PTPN12', 'PTK2B', {'sign': -1}), ('PTPN12', 'ABL1', {'sign': -1}), ('PTPN12', 'SRC', {'sign': -1}), ('PTPN12', 'PXN', {'sign': -1}), ('PTPN12', 'NEDD9', {'sign': -1}), ('PDPK1', 'PAK1', {'sign': 1}), ('PDPK1', 'PRKCG', {'sign': 1}), 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1}), ('BECN1', 'PIK3C3', {'sign': 1}), ('BECN1', 'ZWINT', {'sign': 1}), ('PIK3R4', 'PIK3C3', {'sign': 1}), ('TIAM1', 'RAC1', {'sign': 1}), ('HRAS', 'TIAM1', {'sign': 1}), ('HRAS', 'PLCE1', {'sign': 1}), ('HRAS', 'SHC1', {'sign': 1}), ('HRAS', 'RAF1', {'sign': 1}), ('HRAS', 'BRAF', {'sign': 1}), ('HRAS', 'PIK3CD', {'sign': 1}), ('HRAS', 'PIK3CB', {'sign': 1}), ('HRAS', 'PIK3CG', {'sign': 1}), ('HRAS', 'ARAF', {'sign': 1}), ('HRAS', 'PIK3CA', {'sign': 1}), ('HRAS', 'SDC2', {'sign': 1}), ('ATG10', 'ATG12', {'sign': 1}), ('ATG10', 'ATG5', {'sign': 1}), ('ATG12', 'ATG5', {'sign': 1}), ('RPTOR', 'MTOR', {'sign': -1}), ('AKT1S1', 'RPTOR', {'sign': -1}), ('DAPK1', 'CAMKK2', {'sign': -1}), ('DAPK1', 'MAPK6', {'sign': -1}), ('DAPK1', 'MCM3', {'sign': 1}), ('DAPK1', 'TP53', {'sign': 1}), ('DAPK1', 'PRKD1', {'sign': 1}), ('DAPK1', 'BECN1', {'sign': 1}), ('DAPK1', 'STX1A', {'sign': -1}), ('DAPK1', 'RPS6', {'sign': -1}), ('DAPK1', 'DAPK3', {'sign': 1}), ('DAPK1', 'TSC2', {'sign': -1}), ('DAPK1', 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1}), ('APEX1', 'PTH', {'sign': -1}), ('APEX1', 'STAT3', {'sign': 1}), ('APEX1', 'CCNO', {'sign': 1}), ('APEX1', 'EGR1', {'sign': 1}), ('APEX1', 'RELB', {'sign': 1}), ('APEX1', 'FOS', {'sign': 1}), ('CAMKK1', 'CRMP1', {'sign': 1}), ('CAMKK1', 'CAMK1D', {'sign': 1}), ('CAMKK1', 'PRKAA1', {'sign': 1}), ('CAMKK1', 'CAMK4', {'sign': 1}), ('CAMKK1', 'CAMK1', {'sign': 1}), ('CAMKK1', 'AKT1', {'sign': 1}), ('POU2F1', 'H2BC11', {'sign': 1}), ('SFPQ', 'NONO', {'sign': 1}), ('SFPQ', 'TOP1', {'sign': 1}), ('NONO', 'TOP1', {'sign': 1}), ('CUL4A_DDB1_DDB2_RBX1', 'XPC', {'sign': 1}), ('CUL4A_DDB1_DDB2_RBX1', 'TP53', {'sign': -1}), ('CUL4A_DDB1_DDB2_RBX1', 'H3C12', {'sign': 1}), ('CUL4A_DDB1_DDB2_RBX1', 'H4C2', {'sign': 1}), ('CUL4A_DDB1_DDB2_RBX1', 'H2AZ1', {'sign': 1}), ('CUL4A_DDB1_DDB2_RBX1', 'DDB2', {'sign': -1}), ('APLF', 'PARP1', {'sign': 1}), ('PPM1D', 'ATM', {'sign': -1}), ('PPM1D', 'CHEK2', {'sign': -1}), ('PPM1D', 'H2AX', {'sign': -1}), ('PPM1D', 'MDM2', {'sign': 1}), ('PPM1D', 'UNG', 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1}), ('HMGA2', 'E4F1', {'sign': -1}), ('HMGA1', 'POU3F1', {'sign': 1}), ('PPP3CA_PPP3R1', 'BAD', {'sign': 1}), ('PPP3CA_PPP3R1', 'NFATC2', {'sign': 1}), ('PPP3CA_PPP3R1', 'NFATC1', {'sign': 1}), ('BMPR2', 'ACVR1', {'sign': 1}), ('BMPR2', 'BMPR1B', {'sign': 1}), ('BMPR2', 'BMPR1A', {'sign': 1}), ('LEF1', 'FAIM2', {'sign': 1}), ('LEF1', 'TLE1', {'sign': 1}), ('LEF1', 'MITF', {'sign': 1}), ('LEF1', 'ALX4', {'sign': 1}), ('FAIM2', 'BAX', {'sign': -1}), ('PPARG', 'KMT5A', {'sign': 1}), ('PPARG', 'CD36', {'sign': 1}), ('PPARG', 'FABP4', {'sign': 1}), ('PPARG', 'KLF15', {'sign': 1}), ('PPARG', 'ADIPOQ', {'sign': 1}), ('PPARG', 'PTGS2', {'sign': 1}), ('PPARG', 'SORBS1', {'sign': 1}), ('PPARG', 'SLC2A4', {'sign': 1}), ('PPARG', 'TBXAS1', {'sign': -1}), ('PPARG', 'NOS2', {'sign': -1}), ('PPARG', 'CDKN1A', {'sign': 1}), ('PPARG', 'GSTA2', {'sign': 1}), ('PPARG', 'NR1H2', {'sign': 1}), ('PPARG', 'NR1H3', {'sign': 1}), ('PPARG', 'RXRG', {'sign': 1}), ('PPARG', 'NR3C1', {'sign': 1}), ('PPARG', 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('RB1', 'UBTF', {'sign': -1}), ('RB1', 'MYOD1', {'sign': 1}), ('SNCB', 'TP53', {'sign': -1}), ('PRKAB1', 'NOS3', {'sign': 1}), ('PRKAB1', 'ULK1', {'sign': 1}), ('PRKAB1', 'RPTOR', {'sign': -1}), ('PRKAB1', 'FOXO3', {'sign': 1}), ('PRKAB1', 'TSC2', {'sign': 1}), ('FOXO3', 'BCL2L11', {'sign': -1}), ('FOXO3', 'SCP2', {'sign': 1}), ('FOXO3', 'FASLG', {'sign': 1}), ('FOXO3', 'CDKN1B', {'sign': 1}), ('FOXO3', 'GADD45A', {'sign': 1}), ('FOXO3', 'PINK1', {'sign': 1}), ('FOXO3', 'ATM', {'sign': 1}), ('FOXO3', 'SOD2', {'sign': 1}), ('FOXO3', 'RBL2', {'sign': 1}), ('FOXO3', 'PIK3CA', {'sign': 1}), ('FOXO3', 'ABCB1', {'sign': 1}), ('FOXO3', 'NOS3', {'sign': -1}), ('FOXO3', 'ID1', {'sign': -1}), ('FOXO3', 'G6PC1', {'sign': 1}), ('FOXO3', 'ESR1', {'sign': 1}), ('FOXO3', 'CDKN2D', {'sign': 1}), ('FOXO3', 'CDKN2B', {'sign': 1}), ('FOXO3', 'DUSP6', {'sign': 1}), ('FOXO3', 'DUSP5', {'sign': 1}), ('FOXO3', 'BNIP3L', {'sign': 1}), ('FOXO3', 'BCL6', {'sign': 1}), ('FOXO3', 'CDKN1A', {'sign': 1}), ('FOXO3', 'CAT', {'sign': 1}), ('FOXO3', 'PRDX3', {'sign': 1}), ('FOXO3', 'TNFSF10', {'sign': 1}), ('FOXO3', 'KLF4', {'sign': 1}), ('PRDM1', 'RASD2', {'sign': -1}), ('NR2F2', 'CEBPA', {'sign': -1}), ('NR2F2', 'PPARG', {'sign': -1}), ('NR2F2', 'RXRA', {'sign': 1}), ('NR2F2', 'NR2F1', {'sign': 1}), ('NR2F2', 'THRA', {'sign': 1}), ('NR2F2', 'NR2F6', {'sign': 1}), ('NR2F2', 'NR3C1', {'sign': 1}), ('NR2F2', 'MYOD1', {'sign': -1}), ('CEBPA', 'SLC11A1', {'sign': 1}), ('CEBPA', 'LTF', {'sign': 1}), ('CEBPA', 'ELANE', {'sign': 1}), ('CEBPA', 'LYZ', {'sign': 1}), ('CEBPA', 'CSF2RA', {'sign': 1}), ('CEBPA', 'MPO', {'sign': 1}), ('CEBPA', 'CD14', {'sign': 1}), ('CEBPA', 'SPI1', {'sign': 1}), ('CEBPA', 'CSF1R', {'sign': 1}), ('CEBPA', 'CSF3R', {'sign': 1}), ('PLK3', 'TP53', {'sign': 1}), ('PLK3', 'TOP2A', {'sign': 1}), ('PLK3', 'CDC25C', {'sign': 1}), ('PLK3', 'HIF1A', {'sign': -1}), ('PLK3', 'PTEN', {'sign': -1}), ('PLK3', 'VRK1', {'sign': 1}), ('PLK3', 'SNCA', {'sign': -1}), ('PLK3', 'ATF2', {'sign': 1}), ('PLK3', 'JUN', {'sign': 1}), ('PLK3', 'SNCB', {'sign': -1}), ('PLK3', 'BCL2L1', {'sign': 1}), ('PLK3', 'CDC25A', {'sign': -1}), ('PLK3', 'CHEK2', {'sign': 1}), ('CAMK2A_CAMK2B_CAMK2D_CAMK2G', 'HDAC4', {'sign': -1}), ('CAMK2A_CAMK2B_CAMK2D_CAMK2G', 'HDAC9', {'sign': 1}), ('CAMK2A_CAMK2B_CAMK2D_CAMK2G', 'MAP3K7', {'sign': 1}), ('HDAC9', 'MEF2C', {'sign': -1}), ('SERPINE1', 'LRP1', {'sign': 1}), ('COP1', 'CASP1', {'sign': -1}), ('COP1', 'NLRC4', {'sign': -1}), ('COP1', 'PYCARD', {'sign': -1}), ('COP1', 'NLRP1', {'sign': -1}), ('COP1', 'CASP5', {'sign': -1}), ('COP1', 'NLRP2', {'sign': -1}), ('COP1', 'CARD8', {'sign': -1}), ('TP63', 'FAS', {'sign': 1}), ('ICAM1', 'ITGAL', {'sign': 1}), ('ICAM1', 'ITGAX', {'sign': 1}), ('ICAM1', 'EGFR', {'sign': 1}), ('ICAM1', 'ITGB2', {'sign': 1}), ('CDKN2B', 'CDK4', {'sign': -1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'TP53', {'sign': 1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'RB1', {'sign': 1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'E2F3', {'sign': 1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'H4C2', {'sign': 1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'CDKN1A', {'sign': 1}), ('ACTL6A_ACTL6B_ARID1A_ARID1B_ARID2_PBRM1_SMARCA2_SMARCA4_SMARCB1_SMARCC1_SMARCC2_SMARCD1_SMARCD2_SMARCD3_SMARCE1', 'GADD45A', {'sign': 1}), ('MAX_MYC', 'NBN', {'sign': 1}), ('BMP7', 'ACVR2B', {'sign': 1}), ('BMP7', 'BMPR2', {'sign': 1}), ('BMP7', 'ACTR2', {'sign': 1}), ('BMP7', 'ACVR2A', {'sign': 1}), ('BMP7', 'ACVR1', {'sign': 1}), ('BMP7', 'BMPR1A_BMPR1B_BMPR2', {'sign': 1}), ('BMP7', 'ACVR1_BMPR2', {'sign': 1}), ('BMP7', 'ACVR1_ACVR2A', {'sign': 1}), ('BMP7', 'ACVR1_ACVR2B', {'sign': 1}), ('BMP7', 'ACVR2A_BMPR1A', {'sign': 1}), ('BMP7', 'ACVR2B_BMPR1A', {'sign': 1}), ('BMP7', 'BMPR1A_BMPR2', {'sign': 1}), ('BMP7', 'ACVR2A_BMPR1B', {'sign': 1}), ('BMP7', 'ACVR2B_BMPR1B', {'sign': 1}), ('BMP7', 'BMPR1B_BMPR2', {'sign': 1}), ('BMP7', 'BMPR1B', {'sign': 1}), ('BMP7', 'BMPR1A', {'sign': 1}), ('PPARA', 'FOXO1', {'sign': -1}), ('PPARA', 'LPL', {'sign': 1}), ('PPARA', 'ELOVL7', {'sign': 1}), ('PPARA', 'CRAT', {'sign': 1}), ('PPARA', 'ACOT1', {'sign': 1}), ('PPARA', 'CIDEC', {'sign': 1}), ('PPARA', 'FABP3', {'sign': 1}), ('PPARA', 'FABP4', {'sign': 1}), ('PPARA', 'ACOX1', {'sign': 1}), ('PPARA', 'NR1H2', {'sign': 1}), ('PPARA', 'RXRG', {'sign': 1}), ('RPS6KA5', 'H2AZ1', {'sign': -1}), ('RPS6KA5', 'RELA', {'sign': 1}), ('RPS6KA5', 'HMGN1', {'sign': 1}), ('RPS6KA5', 'H3C12', {'sign': 1}), ('RPS6KA5', 'CREB1', {'sign': 1}), ('RPS6KA5', 'ATF1', {'sign': 1}), ('RPS6KA5', 'EIF4EBP1', {'sign': -1}), ('RPS6KA5', 'STAT3', {'sign': 1}), ('RPS6KA5', 'ETV1', {'sign': 1}), ('RPS6KA5', 'BAD', {'sign': -1}), ('RPS6KA5', 'H2AC15', {'sign': -1}), ('RPS6KA5', 'H3-3A', {'sign': 1}), ('RPS6KA5', 'H2AC25', {'sign': -1}), ('RPS6KA5', 'ELK1', {'sign': 1}), ('RPS6KA5', 'PLA2G4A', {'sign': 1}), ('RPS6KA5', 'TH', {'sign': 1}), ('TAF1', 'BCL2L11', {'sign': 1}), ('TAF1', 'CDKN1B', {'sign': 1}), ('TAF1', 'TP53', {'sign': -1}), ('TAF1', 'GTF2A1', {'sign': 1}), ('CREBBP', 'ASAH2B', {'sign': 1}), ('CREBBP', 'MYB', {'sign': 1}), ('CREBBP', 'NFKB1', {'sign': 1}), ('CREBBP', 'RELB', {'sign': 1}), ('CREBBP', 'CTNNB1', {'sign': 1}), ('CREBBP', 'H3C12', {'sign': 1}), ('CREBBP', 'MMP9', {'sign': 1}), ('CREBBP', 'WRN', {'sign': 1}), ('CREBBP', 'ARNT', {'sign': 1}), ('CREBBP', 'SMAD3', {'sign': 1}), ('CREBBP', 'SMAD2', {'sign': 1}), ('CREBBP', 'STAT6', {'sign': 1}), ('CREBBP', 'H3C13', {'sign': 1}), ('CREBBP', 'HNF1A', {'sign': 1}), ('CREBBP', 'RELA', {'sign': 1}), ('CREBBP', 'NFE2L2', {'sign': 1}), ('CREBBP', 'CSK', {'sign': 1}), ('CREBBP', 'JUN', {'sign': 1}), ('CREBBP', 'ELK1', {'sign': 1}), ('CREBBP', 'TCF7', {'sign': -1}), ('CREBBP', 'IRF9', {'sign': 1}), ('CREBBP', 'MYOD1', {'sign': 1}), ('CREBBP', 'KLF1', {'sign': 1}), ('CREBBP', 'POU1F1', {'sign': 1}), ('CREBBP', 'IFNAR2', {'sign': 1}), ('CREBBP', 'STAT2', {'sign': 1}), ('CREBBP', 'MYBL1', {'sign': 1}), ('CREBBP', 'TP53', {'sign': 1}), ('CREBBP', 'STAT3', {'sign': 1}), ('KAT7', 'H4C2', {'sign': 1}), ('KAT7', 'H3C12', {'sign': 1}), ('KAT7', 'MCM2', {'sign': 1}), ('GTF3C4', 'H3C12', {'sign': 1}), ('NCOA1', 'H4C2', {'sign': 1}), ('NCOA1', 'H3C12', {'sign': 1}), ('NCOA1', 'ESR1', {'sign': 1}), ('CSNK2B', 'TP53', {'sign': 1}), ('CSNK2B', 'CHEK2', {'sign': -1}), ('CSNK2B', 'WEE1', {'sign': 1}), ('CSNK2B', 'TBP', {'sign': 1}), ('CSNK2B', 'NFKBIA', {'sign': -1}), ('CSNK2B', 'SEC63', {'sign': 1}), ('CSNK2B', 'IKZF1', {'sign': -1}), ('CSNK2B', 'EIF5', {'sign': 1}), ('CSNK2B', 'RNF7', {'sign': 1}), ('CSNK2B', 'BID', {'sign': 1}), ('CSNK2B', 'USO1', {'sign': 1}), ('CSNK2B', 'SET', {'sign': -1}), ('CSNK2B', 'CD163', {'sign': 1}), ('CSNK2B', 'CTDP1', {'sign': -1}), ('CSNK2B', 'CTNNB1', {'sign': 1}), ('NCOA3', 'H3C12', {'sign': 1}), ('NCOA3', 'H4C2', {'sign': 1}), ('DYRK2', 'TP53', {'sign': 1}), ('DYRK2', 'GLI3', {'sign': -1}), ('DYRK2', 'GLI2', {'sign': -1}), ('DYRK2', 'GYS1', {'sign': -1}), ('DYRK2', 'H2BC11', {'sign': 1}), ('DYRK2', 'SIAH2', {'sign': 1}), ('DYRK2', 'DPYSL3', {'sign': 1}), ('DYRK2', 'KATNA1', {'sign': -1}), ('DYRK2', 'JUN', {'sign': -1}), ('GDE1', 'PPM1D', {'sign': -1}), ('GDE1', 'CCNE1', {'sign': -1}), ('GDE1', 'CCND1', {'sign': -1}), ('RUNX1', 'IER3', {'sign': 1}), ('RUNX1', 'CD4', {'sign': 1}), ('RUNX1', 'CSF1R', {'sign': 1}), ('RUNX1', 'MIR17HG', {'sign': -1}), ('RUNX1', 'IL3', {'sign': 1}), ('RUNX1', 'BLK', {'sign': 1}), ('RUNX1', 'ELANE', {'sign': 1}), ('RUNX1', 'MPO', {'sign': 1}), ('RUNX1', 'CSF2RA', {'sign': 1}), ('IER3', 'PPP2R5C', {'sign': -1}), ('NCOA2', 'H3C12', {'sign': 1}), ('NCOA2', 'H4C2', {'sign': 1}), ('NCOA2', 'AR', {'sign': 1}), ('NCOA2', 'PPARG', {'sign': 1}), ('NCOA2', 'RXRA', {'sign': 1}), ('NCOA2', 'RARA', {'sign': 1}), ('NCOA2', 'NR3C1', {'sign': 1}), ('TLR5', 'MYD88', {'sign': 1}), ('KDM3B', 'H3C12', {'sign': -1}), ('RIPK2', 'BCL10', {'sign': 1}), ('RIPK2', 'IKBKB', {'sign': 1}), ('RIPK2', 'MAP3K7', {'sign': 1}), ('RIPK2', 'MAPK14', {'sign': 1}), ('RIPK2', 'MAPK8', {'sign': 1}), ('RIPK2', 'IRF5', {'sign': 1}), ('KDM3A', 'H3C12', {'sign': 1}), ('KDM3A', 'AR', {'sign': 1}), ('CLOCK', 'H3C12', {'sign': 1}), ('KDM4C', 'H3C12', {'sign': -1}), ('KDM4C', 'AR', {'sign': 1}), ('KDM4B', 'H3C12', {'sign': -1}), ('KDM4A', 'BCL2L11', {'sign': -1}), ('KDM4A', 'AR', {'sign': 1}), ('KDM4A', 'H1-4', {'sign': 1}), ('APC_CDC20', 'CCNB1', {'sign': -1}), ('APC_CDC20', 'PTTG1', {'sign': -1}), ('RFWD3', 'RPA1', {'sign': 1}), ('RFWD3', 'TP53', {'sign': 1}), ('RFWD3', 'MDM2', {'sign': 1}), ('CCNT1_CCNT2_CDK9', 'POLR2A', {'sign': 1}), ('CCNT1_CCNT2_CDK9', 'RB1', {'sign': 1}), ('HIF1A', 'BNIP3', {'sign': 1}), ('APIP', 'APAF1', {'sign': -1}), ('ESCO1', 'KDM1A', {'sign': 1}), ('ESCO1', 'RAD21', {'sign': 1}), ('ESCO1', 'SMC3', {'sign': 1}), ('KDM1A', 'H3C12', {'sign': 1}), ('KDM1A', 'TP53', {'sign': -1}), ('KDM1A', 'CHRNA1', {'sign': -1}), ('KDM1A', 'CDKN1C', {'sign': -1}), ('KDM1A', 'ACTB', {'sign': -1}), ('KDM1A', 'SCN1A', {'sign': -1}), ('KDM1A', 'SCN2A', {'sign': -1}), ('KDM1A', 'SCN3A', {'sign': -1}), ('KDM1A', 'AR', {'sign': 1}), ('KDM1A', 'KLK3', {'sign': 1}), ('KDM1A', 'H3-4', {'sign': 1}), ('TNFAIP3', 'IKBKG', {'sign': -1}), ('TNFAIP3', 'BECN1', {'sign': -1}), ('TNFAIP3', 'RIPK1', {'sign': -1}), ('TNFAIP3', 'TBK1', {'sign': -1}), ('TNFAIP3', 'IKBKE', {'sign': -1}), ('TNFAIP3', 'TRADD', {'sign': -1}), ('TNFAIP3', 'TRAF6', {'sign': -1}), ('PPP4C_PPP4R1', 'H2AX', {'sign': -1}), ('PPP4C_PPP4R1', 'HDAC3', {'sign': -1}), ('IL1B', 'IL1R2', {'sign': -1}), ('IL1B', 'IL1R1', {'sign': 1}), ('IL1B', 'IL1RAP', {'sign': 1}), ('IL1B', 'IL1R1_IL1RAP', {'sign': 1}), ('IL18', 'IL18R1', {'sign': 1}), ('IL18', 'IL18R1_IL18RAP', {'sign': 1}), ('IL18', 'IL1RAPL1', {'sign': 1}), ('IL18', 'IL18RAP', {'sign': 1}), ('ABL2', 'WASL', {'sign': 1}), ('ABL2', 'PDGFRB', {'sign': -1}), ('ABL2', 'NFKBIB', {'sign': 1}), ('ABL2', 'GPX1', {'sign': 1}), ('ABL2', 'CTTN', {'sign': 1}), ('ABL2', 'CAT', {'sign': 1}), ('ABL2', 'SORBS2', {'sign': 1}), ('ABL2', 'SIVA1', {'sign': 1}), ('ABL2', 'RIN1', {'sign': 1}), ('ABL2', 'RAPH1', {'sign': 1}), ('ABL2', 'LGALS3', {'sign': 1}), ('ABL2', 'CEBPB', {'sign': 1}), ('ABL2', 'PSMA7', {'sign': -1}), ('ABL2', 'CRK', {'sign': -1}), ('WRN', 'NEIL1', {'sign': 1}), ('WRN', 'RAD52', {'sign': 1}), ('WRN', 'FEN1', {'sign': 1}), ('WRN', 'POLD4', {'sign': 1}), ('CAPNS1', 'CAPN2', {'sign': 1}), ('XRCC5', 'DDB2', {'sign': 1}), ('XRCC5', 'ATRIP', {'sign': 1}), ('VEGFA', 'FLT1', {'sign': 1}), ('VEGFA', 'KDR', {'sign': 1}), ('VEGFA', 'NRP1', {'sign': 1}), ('VEGFA', 'NRP2', {'sign': 1}), ('KMT2B', 'RELB', {'sign': 1}), ('KMT2B', 'H3C12', {'sign': 1}), ('KMT2D', 'RELB', {'sign': 1}), ('KMT2D', 'H3C12', {'sign': 1}), ('KMT2D', 'ESR1', {'sign': 1}), ('CARM1', 'H3C12', {'sign': 1}), ('CARM1', 'RELB', {'sign': 1}), ('CARM1', 'PPARG', {'sign': 1}), ('CARM1', 'EP300', {'sign': 1}), ('CARM1', 'SMARCC1', {'sign': 1}), ('CARM1', 'PAX7', {'sign': 1}), ('CARM1', 'CREBBP', {'sign': 1}), ('XIAP', 'CASP3', {'sign': -1}), ('XIAP', 'CASP9', {'sign': -1}), ('XIAP', 'CASP7', {'sign': -1}), ('PRMT6', 'THBS1', {'sign': -1}), ('PRMT6', 'PGR', {'sign': 1}), ('PRMT6', 'ESR1', {'sign': 1}), ('PRMT6', 'H3C12', {'sign': -1}), ('THBS1', 'SDC4', {'sign': 1}), ('THBS1', 'ITGA4', {'sign': 1}), ('THBS1', 'CD47', {'sign': 1}), ('THBS1', 'SDC1', {'sign': 1}), ('THBS1', 'ITGB1', {'sign': 1}), ('THBS1', 'ITGA2B', {'sign': 1}), ('THBS1', 'ITGB3', {'sign': 1}), ('THBS1', 'ITGA6', {'sign': 1}), ('THBS1', 'CD36', {'sign': 1}), ('THBS1', 'ITGA3', {'sign': 1}), ('PGR', 'FOXO1', {'sign': 1}), ('PGR', 'ESR1', {'sign': 1}), ('MRE11_NBN_RAD50', 'ATM', {'sign': 1}), ('MRE11_NBN_RAD50', 'RECQL5', {'sign': 1}), ('MRE11_NBN_RAD50', 'RBBP8', {'sign': 1}), ('KMT5B', 'H4C2', {'sign': 1}), ('KMT5B', 'H3-4', {'sign': 1}), ('ATRIP', 'BRCA1', {'sign': 1}), ('KMT2A', 'RELB', {'sign': 1}), ('KMT2A', 'H3C12', {'sign': 1}), ('KMT2A', 'CDKN2C', {'sign': 1}), ('KMT2A', 'CDKN1B', {'sign': 1}), ('KMT2A', 'HOXA7', {'sign': 1}), ('KMT2A', 'MEIS1', {'sign': 1}), ('KMT2A', 'FOXC2', {'sign': 1}), ('KMT2A', 'HOXA1', {'sign': 1}), ('KMT2A', 'FOXC1', {'sign': 1}), ('KMT2A', 'MYC', {'sign': 1}), ('KMT2A', 'HOXC8', {'sign': 1}), ('KMT2A', 'HOXA9', {'sign': 1}), ('KMT2A', 'HOXA11', {'sign': 1}), ('KMT2A', 'HOXA10', {'sign': 1}), ('KMT2A', 'KAT8', {'sign': 1}), ('KMT2A', 'RUNX1', {'sign': 1}), ('PPM1A', 'PRKAG1', {'sign': -1}), ('PPM1A', 'SMAD2', {'sign': -1}), ('PPM1A', 'SMAD3', {'sign': 1}), ('PPM1A', 'SMAD1', {'sign': 1}), ('PPM1A', 'IKBKB', {'sign': -1}), ('PPM1A', 'PAK1', {'sign': -1}), ('PPM1A', 'AXIN1', {'sign': -1}), ('PPM1A', 'CDK9', {'sign': -1}), ('PPM1A', 'MAPK14', {'sign': -1}), ('PPM1A', 'PIK3R1', {'sign': 1}), ('PPM1A', 'MAP2K6', {'sign': -1}), ('PPM1A', 'MAP2K4', {'sign': -1}), ('BRD4', 'CDK9', {'sign': 1}), ('BRD4', 'MYC', {'sign': -1}), ('BRD4', 'POLR2A', {'sign': 1}), ('CDK9', 'RB1', {'sign': 1}), ('CDK9', 'POLR2A', {'sign': 1}), ('CDK9', 'SMAD3', {'sign': -1}), ('CDK9', 'TP53', {'sign': 1}), ('CDK9', 'NCOA2', {'sign': 1}), ('CDK9', 'SMAD1', {'sign': -1}), ('CDK9', 'RCHY1', {'sign': -1}), ('CDK9', 'SUPT5H', {'sign': 1}), ('MBD1', 'SETDB1', {'sign': 1}), ('SETDB1', 'H3C12', {'sign': -1}), ('CUL1_FBXW7_RBX1_SKP1', 'KMT5A', {'sign': 1}), ('CUL1_FBXW7_RBX1_SKP1', 'MYBL2', {'sign': -1}), ('CUL1_FBXW7_RBX1_SKP1', 'MYC', {'sign': -1}), ('CUL1_FBXW7_RBX1_SKP1', 'CDKN1B', {'sign': -1}), ('CUL1_FBXW7_RBX1_SKP1', 'FBXO5', {'sign': -1}), ('CUL1_FBXW7_RBX1_SKP1', 'A1BG', {'sign': -1}), ('CUL1_FBXW7_RBX1_SKP1', 'NOTCH1', {'sign': -1}), ('CUL1_FBXW7_RBX1_SKP1', 'CCNE2', {'sign': -1}), ('HSPB1', 'SP1', {'sign': 1}), ('HSPB1', 'UBE2N', {'sign': 1}), ('HSPB1', 'AR', {'sign': -1}), ('HSPB1', 'NFKBIA', {'sign': -1}), ('HIC1', 'SIRT1', {'sign': 1}), ('SMARCA4', 'HIC1', {'sign': 1}), ('SMARCA4', 'CDKN1A', {'sign': 1}), ('SMARCA4', 'GADD45A', {'sign': 1}), ('SMARCA4', 'XPC', {'sign': 1}), ('SMARCA4', 'SMARCC2', {'sign': 1}), ('SMARCA4', 'TERT', {'sign': 1}), ('SMARCA4', 'SMARCC1', {'sign': 1}), ('RNF168', 'H2AX', {'sign': 1}), ('SOCS3', 'TRAF6', {'sign': -1}), ('SOCS3', 'MAPK8IP1', {'sign': -1}), ('SOCS3', 'CSF3R', {'sign': 1}), ('SOCS3', 'LIFR', {'sign': -1}), ('SOCS3', 'IL6R', {'sign': -1}), ('SOCS3', 'IL6ST', {'sign': -1}), ('SOCS3', 'JAK2', {'sign': 1}), ('SOCS3', 'STAT5A', {'sign': 1}), ('SOCS3', 'PRLR', {'sign': 1}), ('SOCS3', 'STAT4', {'sign': 1}), ('SOCS3', 'LEPR', {'sign': 1}), ('SOCS3', 'IL12RB1', {'sign': 1}), ('SOCS3', 'RASA1', {'sign': 1}), ('SOCS3', 'IRS1', {'sign': -1}), ('MAPK8IP1', 'MAPK8', {'sign': -1}), ('MAPK8IP1', 'MAP3K10', {'sign': 1}), ('MAPK8IP1', 'MAP3K12', {'sign': 1}), ('MAPK8IP1', 'MAP2K7', {'sign': 1}), ('MAPK8IP1', 'MAP4K1', {'sign': 1}), ('MAPK8IP1', 'TIAM1', {'sign': 1}), ('MAP2K2', 'MAPK3', {'sign': 1}), ('MAP2K2', 'MAPK6', {'sign': 1}), ('MAP2K2', 'MAPK1', {'sign': 1}), ('MAP2K2', 'CASP9', {'sign': -1}), ('BMF', 'BCL2L2', {'sign': -1}), ('BMF', 'BCL2L1', {'sign': -1}), ('BMF', 'MCL1', {'sign': -1}), ('BMF', 'BCL2', {'sign': -1}), ('PPP5C', 'TP53BP1', {'sign': -1}), ('PPP5C', 'PRKDC', {'sign': -1}), ('PPP5C', 'ATM', {'sign': 1}), ('PPP5C', 'MAPT', {'sign': -1}), ('PPP5C', 'MAP3K5', {'sign': -1}), ('PPP5C', 'CDC37', {'sign': -1}), ('PPP5C', 'NR3C1', {'sign': -1}), ('PPP5C', 'CILK1', {'sign': -1}), ('PPP5C', 'RAF1', {'sign': -1}), ('RPA1', 'ATRIP', {'sign': 1}), ('RPA1', 'FEN1', {'sign': 1}), ('RPA1', 'BRIP1', {'sign': 1}), ('RPA1', 'POLA1', {'sign': 1}), ('RPA1_RPA2_RPA3', 'RFWD3', {'sign': 1}), ('RPA1_RPA2_RPA3', 'RECQL', {'sign': 1}), ('RPA1_RPA2_RPA3', 'RAD18', {'sign': 1}), ('RPA1_RPA2_RPA3', 'SMARCAL1', {'sign': 1}), ('SMYD2', 'TP53', {'sign': -1}), ('SMYD2', 'H3C12', {'sign': 1}), ('SETD1A', 'BCL2L11', {'sign': 1}), ('SETD1A', 'H3C12', {'sign': 1}), ('CXCL9', 'CXCR3', {'sign': 1}), ('CXCL9', 'CCR3', {'sign': -1}), ('SETD2', 'H3C12', {'sign': 1}), ('CCL8', 'CCR5', {'sign': 1}), ('CCL8', 'CCR2', {'sign': 1}), ('CCL8', 'ACKR2', {'sign': 1}), ('CCL8', 'CCR1', {'sign': 1}), ('CCL8', 'ACKR4', {'sign': 1}), ('CCL8', 'CCR3', {'sign': 1}), ('CCL4', 'CCR5', {'sign': 1}), ('CCL4', 'CCR1', {'sign': -1}), ('CCL4', 'CCR8', {'sign': 1}), ('CCL4', 'CCR3', {'sign': 1}), ('IL6ST', 'SHC1', {'sign': 1}), ('IL6ST', 'JAK2', {'sign': 1}), ('IL6ST', 'TYK2', {'sign': 1}), ('IL6ST', 'JAK1', {'sign': 1}), ('IL6ST', 'GAB2', {'sign': 1}), ('SETDB2', 'H3C12', {'sign': 1}), ('KMT2E', 'H3C12', {'sign': 1}), ('KMT2E', 'NCR2', {'sign': 1}), ('RIOX1', 'SP7', {'sign': -1}), ('RECQL4', 'APEX1', {'sign': 1}), ('RECQL4', 'POLB', {'sign': 1}), ('RECQL4', 'FEN1', {'sign': 1}), ('GSK3A', 'BCL3', {'sign': -1}), ('GSK3A', 'LRP6', {'sign': 1}), ('GSK3A', 'TSC2', {'sign': 1}), ('GSK3A', 'LTC4S', {'sign': 1}), ('GSK3A', 'MITF', {'sign': 1}), ('GSK3A', 'CREB1', {'sign': 1}), ('GSK3A', 'CTNNB1', {'sign': -1}), ('GSK3A', 'ANAPC1', {'sign': 1}), ('GSK3A', 'SERPINB2', {'sign': 1}), ('GSK3A', 'JUN', {'sign': -1}), ('GSK3A', 'MAPT', {'sign': -1}), ('GSK3A', 'PSEN1', {'sign': -1}), ('GSK3A', 'EIF2B5', {'sign': -1}), ('GSK3A', 'GPSM3', {'sign': -1}), ('GSK3A', 'UNG', {'sign': -1}), ('GSK3A', 'CAMKK2', {'sign': -1}), ('GSK3A', 'NIFK', {'sign': 1}), ('GSK3A', 'MCL1', {'sign': -1}), ('GSK3A', 'MAFA', {'sign': 1}), ('GSK3A', 'GATA6', {'sign': -1}), ('GSK3A', 'SFPQ', {'sign': -1}), ('GSK3A', 'RELA', {'sign': 1}), ('GSK3A', 'GYS1', {'sign': -1}), ('GSK3A', 'NBR1', {'sign': -1}), ('GSK3A', 'ARHGAP31', {'sign': 1}), ('GSK3A', 'MYC', {'sign': -1}), ('BCL3', 'NFKB2', {'sign': 1}), ('BCL3', 'NFKB1', {'sign': 1}), ('BCL3', 'HDAC1', {'sign': 1}), ('BCL3', 'HDAC3', {'sign': 1}), ('CTBP1', 'ELK3', {'sign': -1}), ('CTBP1', 'TCF7L2', {'sign': -1}), ('CTBP1', 'ZEB2', {'sign': 1}), ('SETD7', 'H3C12', {'sign': 1}), ('SETD7', 'TAF10', {'sign': 1}), ('SETD7', 'TP53', {'sign': 1}), ('SETD7', 'ESR1', {'sign': 1}), ('PRDM2', 'H3C12', {'sign': -1}), ('DOT1L', 'H3C12', {'sign': 1}), ('BIRC3', 'CASP7', {'sign': -1}), ('BIRC3', 'CASP9', {'sign': -1}), ('BIRC3', 'MAP3K14', {'sign': -1}), ('BIRC3', 'RIPK1', {'sign': 1}), ('BIRC3', 'CASP3', {'sign': -1}), ('BIRC3', 'BIRC2', {'sign': 1}), ('ATG4D', 'GABARAPL1', {'sign': 1}), ('GABARAPL1', 'SQSTM1', {'sign': 1}), ('EGR1', 'TOPBP1', {'sign': 1}), ('EGR1', 'DUSP1', {'sign': 1}), ('EGR1', 'DUSP4', {'sign': 1}), ('EGR1', 'ID3', {'sign': 1}), ('EGR1', 'CDKN1A', {'sign': 1}), ('EGR1', 'FASLG', {'sign': 1}), ('EGR1', 'PPARG', {'sign': 1}), ('EGR1', 'EGFR', {'sign': 1}), ('EGR1', 'TGFB1', {'sign': 1}), ('EGR1', 'PDGFB', {'sign': 1}), ('EGR1', 'PDGFA', {'sign': 1}), ('EGR1', 'IGF2', {'sign': 1}), ('EGR1', 'TP53', {'sign': 1}), ('EGR1', 'PTEN', {'sign': 1}), ('EGR1', 'PITX1', {'sign': 1}), ('MAP3K5', 'MAP2K3', {'sign': 1}), ('MAP3K5', 'MAP2K4', {'sign': 1}), ('MAP3K5', 'MAP2K7', {'sign': 1}), ('MAP3K5', 'MAP2K6', {'sign': 1}), ('MAP3K5', 'ZNF622', {'sign': 1}), ('MAP3K5', 'CDKN1A', {'sign': 1}), ('MAP3K5', 'MAPK8', {'sign': 1}), ('MAP3K5', 'MAPK14', {'sign': 1}), ('MAP3K5', 'TNNT2', {'sign': 1}), ('GABARAP', 'DVL2', {'sign': -1}), ('GABARAP', 'TBC1D25', {'sign': 1}), ('GABARAP', 'GPHN', {'sign': 1}), ('DFFA', 'DFFB', {'sign': -1}), ('ATG4A', 'GABARAPL2', {'sign': 1}), ('GABARAPL2', 'SQSTM1', {'sign': 1}), ('EIF2A', 'ATF4', {'sign': 1}), ('TAB2', 'MAP3K7', {'sign': 1}), ('TAB1', 'MAP3K7', {'sign': 1}), ('WDFY3', 'ATG12', {'sign': 1}), ('WDFY3', 'SQSTM1', {'sign': 1}), ('WDFY3', 'ATG5', {'sign': 1}), ('WDFY3', 'GABARAP', {'sign': -1}), ('DAXX', 'MAP3K5', {'sign': 1}), ('DAXX', 'TGFBR2', {'sign': 1}), ('DAXX', 'AIRE', {'sign': -1}), ('DAXX', 'MDM2', {'sign': 1}), ('SQSTM1', 'NTRK1', {'sign': 1}), ('SQSTM1', 'NTRK2', {'sign': 1}), ('SQSTM1', 'KEAP1', {'sign': -1}), ('ARNT_HIF1A', 'GAPDH', {'sign': 1}), ('ARNT_HIF1A', 'CP', {'sign': 1}), ('ARNT_HIF1A', 'EPO', {'sign': 1}), ('ARNT_HIF1A', 'VEGFA', {'sign': 1}), ('ARNT_HIF1A', 'SLC2A1', {'sign': 1}), ('ARNT_HIF1A', 'CA9', {'sign': 1}), ('ARNT_HIF1A', 'ERCC6', {'sign': 1}), ('ARNT_HIF1A', 'FLT1', {'sign': 1}), ('ARNT_HIF1A', 'SERPINE1', {'sign': 1}), ('ARNT_HIF1A', 'NOS2', {'sign': 1}), ('ARNT_HIF1A', 'ADRA1B', {'sign': 1}), ('ARNT_HIF1A', 'ADM', {'sign': 1}), ('ARNT_HIF1A', 'EDN1', {'sign': 1}), ('ARNT_HIF1A', 'HMOX1', {'sign': 1}), ('ARNT_HIF1A', 'TFRC', {'sign': 1}), ('ARNT_HIF1A', 'TF', {'sign': 1}), ('ARNT_HIF1A', 'CDKN1A', {'sign': 1}), ('ARNT_HIF1A', 'PGK1', {'sign': 1}), ('ARNT_HIF1A', 'PKM', {'sign': 1}), ('ARNT_HIF1A', 'LDHA', {'sign': 1}), ('ARNT_HIF1A', 'PFKL', {'sign': 1}), ('ARNT_HIF1A', 'HK2', {'sign': 1}), ('ARNT_HIF1A', 'IGF2', {'sign': 1}), ('ARNT_HIF1A', 'HK1', {'sign': 1}), ('ARNT_HIF1A', 'SLC2A3', {'sign': 1}), ('ARNT_HIF1A', 'ENO1', {'sign': 1}), ('ARNT_HIF1A', 'AK3', {'sign': 1}), ('ARNT_HIF1A', 'IGFBP1', {'sign': 1}), ('ARNT_HIF1A', 'ALDOC', {'sign': 1}), ('ARNT_HIF1A', 'ALDOA', {'sign': 1}), ('EGF', 'EGFR', {'sign': 1}), ('EGF', 'ERBB2', {'sign': 1}), ('EGF', 'EGFR_ERBB2', {'sign': 1}), ('VMP1', 'BECN1', {'sign': 1}), ('IL1R1', 'IRAK2', {'sign': 1}), ('IL1R1', 'IRAK1', {'sign': 1}), ('IL1R1', 'PIK3R1', {'sign': 1}), ('IL1R1', 'MYD88', {'sign': 1}), ('AMBRA1', 'BECN1', {'sign': 1}), ('PDGFRA_PDGFRB', 'GRB2', {'sign': 1}), ('RAB7A', 'FYCO1', {'sign': 1}), ('FYCO1', 'MAP1LC3A', {'sign': 1}), ('FYCO1', 'MAP1LC3B', {'sign': 1}), ('FASLG', 'FAS', {'sign': 1}), ('FASLG', 'TNFRSF6B', {'sign': 1}), ('RARA', 'CASP9', {'sign': 1}), ('RARA', 'RARG', {'sign': 1}), ('RARA', 'BTG2', {'sign': 1}), ('RARA', 'IER3', {'sign': 1}), ('RARA', 'GPRC5A', {'sign': 1}), ('RARA', 'RXRA', {'sign': 1}), ('RARA', 'ESR2', {'sign': 1}), ('RARA', 'CTNNB1', {'sign': 1}), ('RARA', 'NR4A1', {'sign': 1}), ('RARA', 'THRA', {'sign': 1}), ('RARA', 'NRIP1', {'sign': 1}), ('RARA', 'EGFR', {'sign': 1}), ('DAP3', 'CYCS', {'sign': 1}), ('RARG', 'HAS2', {'sign': 1}), ('RARG', 'RXRB', {'sign': 1}), ('RARG', 'THRA', {'sign': 1}), ('SUPT20H', 'ATG9A', {'sign': 1}), ('RAB33B', 'ATG16L1', {'sign': 1}), ('GOLGA3', 'GOPC', {'sign': 1}), ('LMNA', 'SUN2', {'sign': 1}), ('CISD2', 'BCL2', {'sign': 1}), ('BCL6', 'TP53', {'sign': -1}), ('BCL6', 'ZBTB17', {'sign': -1}), ('BCL6', 'ATR', {'sign': -1}), ('GDF15', 'GFRAL', {'sign': 1}), ('CRADD', 'RIPK1', {'sign': 1}), ('CRADD', 'CASP2', {'sign': 1}), ('HSP90AB1', 'KEAP1', {'sign': -1}), ('HSPA8', 'CFTR', {'sign': -1}), ('LIF', 'LIFR', {'sign': 1}), ('LIF', 'IL6ST', {'sign': 1}), ('LIF', 'IL6ST_LIFR', {'sign': 1}), ('RNF144B', 'CDKN1A', {'sign': -1}), ('HMGB1', 'BECN1', {'sign': -1}), ('HMGB1', 'AGER', {'sign': 1}), ('HMGB1', 'TLR4', {'sign': 1}), ('HMGB1', 'HOXD9', {'sign': 1}), ('HMGB1', 'TLR9', {'sign': -1}), ('HMGB1', 'TLR2', {'sign': 1}), ('BECN1_PIK3C3_PIK3R4_UVRAG', 'ATG9A', {'sign': 1}), ('FBXO5', 'ANAPC11', {'sign': -1}), ('FBXO5', 'FZR1', {'sign': -1}), ('FBXO5', 'CDC20', {'sign': -1}), ('FBXO5', 'ANAPC7', {'sign': -1}), ('EVI5', 'FBXO5', {'sign': 1}), ('ZBTB17', 'CDKN1A', {'sign': -1}), ('UBE2M', 'CUL2', {'sign': 1}), ('UBE2M', 'CUL1', {'sign': 1}), ('CUL2_ELOB_ELOC_RBX1_VHL', 'HIF1A', {'sign': -1}), ('EGLN1', 'HIF1A', {'sign': -1}), ('EGLN3', 'HIF1A', {'sign': -1}), ('EGLN2', 'HIF1A', {'sign': -1}), ('VHL', 'HIF1A', {'sign': -1}), ('VHL', 'CARD9', {'sign': -1}), ('RUNX3', 'CD4', {'sign': 1}), ('CD4', 'LCK', {'sign': 1}), ('CD4', 'CCR5', {'sign': 1}), ('MYB', 'GATA3', {'sign': 1}), ('MYB', 'KIT', {'sign': 1}), ('MYB', 'MYC', {'sign': 1}), ('MYB', 'COL1A2', {'sign': 1}), ('MYB', 'COL1A1', {'sign': 1}), ('PALB2', 'BRCA2', {'sign': 1}), ('PALB2', 'POLH', {'sign': 1}), ('PALB2', 'RAD51', {'sign': 1}), ('EP300', 'MYB', {'sign': 1}), ('EP300', 'HDAC6', {'sign': -1}), ('EP300', 'TP53', {'sign': 1}), ('EP300', 'H3C12', {'sign': 1}), ('EP300', 'CTNNB1', {'sign': 1}), ('EP300', 'H2BC11', {'sign': 1}), ('EP300', 'H2AZ1', {'sign': 1}), ('EP300', 'RECQL4', {'sign': -1}), ('EP300', 'BCL6', {'sign': -1}), ('EP300', 'WRN', {'sign': 1}), ('EP300', 'DDX17', {'sign': 1}), ('EP300', 'NBN', {'sign': 1}), ('EP300', 'DDX5', {'sign': 1}), ('EP300', 'H2AX', {'sign': 1}), ('EP300', 'H4C2', {'sign': 1}), ('EP300', 'PARP1', {'sign': 1}), ('EP300', 'TDG', {'sign': 1}), ('EP300', 'SMAD2', {'sign': 1}), ('EP300', 'FEN1', {'sign': -1}), ('EP300', 'HMGN1', {'sign': -1}), ('EP300', 'HIF1A', {'sign': 1}), ('EP300', 'ARNT', {'sign': 1}), ('EP300', 'APEX1', {'sign': 1}), ('EP300', 'SMAD3', {'sign': 1}), ('EP300', 'H3C13', {'sign': 1}), ('EP300', 'STAT6', {'sign': 1}), ('EP300', 'ZBTB16', {'sign': 1}), ('EP300', 'TP63', {'sign': 1}), ('EP300', 'STAT3', {'sign': 1}), ('EP300', 'STAT5A', {'sign': 1}), ('EP300', 'SMAD7', {'sign': 1}), ('EP300', 'SMAD4', {'sign': 1}), ('EP300', 'RELA', {'sign': 1}), ('EP300', 'RUNX2', {'sign': 1}), ('EP300', 'MEF2D', {'sign': 1}), ('EP300', 'DUSP1', {'sign': 1}), ('EP300', 'MEF2A', {'sign': 1}), ('EP300', 'MN1', {'sign': 1}), ('EP300', 'KPNA2', {'sign': 1}), ('EP300', 'MEF2C', {'sign': 1}), ('EP300', 'SMAD1', {'sign': 1}), ('EP300', 'MYOD1', {'sign': 1}), ('EP300', 'AR', {'sign': 1}), ('EP300', 'RB1', {'sign': 1}), ('COL1A2', 'ITGA11_ITGB1', {'sign': 1}), ('COL1A2', 'ITGA1_ITGB1', {'sign': 1}), ('COL1A2', 'CD44', {'sign': 1}), ('COL1A2', 'ITGB1', {'sign': 1}), ('COL1A2', 'ITGA11', {'sign': 1}), ('COL1A2', 'ITGB3', {'sign': 1}), ('COL1A2', 'ITGA2B', {'sign': 1}), ('COL1A2', 'ITGA2', {'sign': 1}), ('COL1A1', 'ITGB1', {'sign': 1}), ('COL1A1', 'ITGA2_ITGB1', {'sign': 1}), ('COL1A1', 'DDR1', {'sign': 1}), ('COL1A1', 'ITGA1_ITGB1', {'sign': 1}), ('COL1A1', 'ITGA11_ITGB1', {'sign': 1}), ('COL1A1', 'DDR2', {'sign': 1}), ('COL1A1', 'ITGA5', {'sign': 1}), ('COL1A1', 'CD44', {'sign': 1}), ('COL1A1', 'ITGA11', {'sign': 1}), ('COL1A1', 'ITGA2', {'sign': 1}), ('PAXIP1', 'ATM', {'sign': 1}), ('PAXIP1', 'TP53BP1', {'sign': 1}), ('PAXIP1', 'PAX2', {'sign': 1}), ('NLK', 'MYB', {'sign': -1}), ('NLK', 'TCF7L2', {'sign': -1}), ('NLK', 'LEF1', {'sign': -1}), ('NLK', 'TCF4', {'sign': -1}), ('NLK', 'STAT3', {'sign': 1}), ('NLK', 'SMAD4', {'sign': -1}), ('TIMELESS', 'ATR', {'sign': 1}), ('TIMELESS', 'TIPIN', {'sign': 1}), ('TIMELESS', 'ATM', {'sign': 1}), ('TIMELESS', 'CHEK1', {'sign': 1}), ('TIMELESS', 'CRY1', {'sign': 1}), ('RAD18_UBE2B', 'TP53BP1', {'sign': 1}), ('RAD18_UBE2B', 'PCNA', {'sign': 1}), ('SSBP1', 'TP53', {'sign': 1}), ('RECQL5', 'RAD51', {'sign': -1}), ('RORA', 'BMAL1', {'sign': 1}), ('RORB', 'BMAL1', {'sign': 1}), ('RORC', 'BMAL1', {'sign': 1}), ('RORC', 'EIF4EBP1', {'sign': -1}), ('NR1D1', 'BMAL1', {'sign': -1}), ('NR1D2', 'BMAL1', {'sign': -1}), ('PER3', 'BMAL1', {'sign': -1}), ('CAND1', 'CUL1', {'sign': -1}), ('CAND1', 'CUL4A', {'sign': -1}), ('CUL1', 'ARIH1', {'sign': 1}), ('CUL1', 'RNF7', {'sign': 1}), ('CUL1', 'CTNNB1', {'sign': -1}), ('CUL1', 'CDKN1B', {'sign': -1}), ('GLRX', 'ACTA1', {'sign': 1}), ('GLRX', 'GAPDH', {'sign': -1}), ('GLRX', 'IRF3', {'sign': 1}), ('GLRX', 'IKBKB', {'sign': 1}), ('GLRX', 'MAP3K5', {'sign': -1}), ('GLRX', 'NFYA', {'sign': 1}), ('EDN1', 'EDNRA', {'sign': 1}), ('EDN1', 'EDNRB', {'sign': 1}), ('POU3F2', 'GNRH1', {'sign': 1}), ('GNRH1', 'CAMK2A', {'sign': 1}), ('GNRH1', 'CAMK2B', {'sign': 1}), ('GNRH1', 'GNRHR', {'sign': 1}), ('PNPLA8', 'PTGS2', {'sign': 1}), ('GNRHR', 'GNAS', {'sign': 1}), ('GNRHR', 'GNA11', {'sign': 1}), ('GNRHR', 'GNAI1', {'sign': 1}), ('GNRHR', 'CTNNB1', {'sign': 1}), ('GNRHR', 'APBA1', {'sign': 1}), ('GNRHR', 'SNAP25', {'sign': 1}), ('GNRHR', 'MMP14', {'sign': 1}), ('GNRHR', 'MMP15', {'sign': 1}), ('GNRHR', 'MMP9', {'sign': -1}), ('GNRHR', 'TIMP2', {'sign': 1}), ('GNRHR', 'SCG2', {'sign': 1}), ('GNRHR', 'TIMP1', {'sign': -1}), ('GNRHR', 'TIMP3', {'sign': -1}), ('NR5A1', 'GNRHR', {'sign': 1}), ('PPP3CA_PPP3CB_PPP3CC_PPP3R1_PPP3R2', 'DNM1L', {'sign': 1}), ('PPP3CA_PPP3CB_PPP3CC_PPP3R1_PPP3R2', 'DAPK2', {'sign': 1}), ('FKBP4', 'PPP3CA', {'sign': -1}), ('FKBP4', 'AR', {'sign': 1}), ('LRP5', 'GSK3B', {'sign': -1}), ('LRP5', 'AXIN1', {'sign': 1}), ('FZD5', 'LRP6', {'sign': 1}), ('USP15', 'RBX1', {'sign': 1}), ('USP15', 'BRAP', {'sign': 1}), ('RBX1', 'CUL1', {'sign': 1}), ('RBX1', 'NFKBIA', {'sign': -1}), ('RBX1', 'NFE2L2', {'sign': -1}), ('COPS5', 'MYC', {'sign': 1}), ('COPS5', 'HIF1A', {'sign': 1}), ('COPS5', 'MDM2', {'sign': 1}), ('COPS5', 'JUN', {'sign': 1}), ('COPS5', 'CDKN1B', {'sign': -1}), ('COPS5', 'SMAD4', {'sign': -1}), ('COPS5', 'FOS', {'sign': 1}), ('COPS5', 'NCOA1', {'sign': 1}), ('COPS5', 'TYK2', {'sign': 1}), ('NKRF', 'NFKB2', {'sign': -1}), ('NKRF', 'NFKB1', {'sign': -1}), ('NKRF', 'RELA', {'sign': -1}), ('NKRF', 'REL', {'sign': -1}), ('NFKB2', 'RELB', {'sign': 1}), ('REL', 'IL12A', {'sign': 1}), ('TWIST1', 'TIMP1', {'sign': -1}), ('TWIST1', 'CDH1', {'sign': -1}), ('TWIST1', 'RELA', {'sign': -1}), ('TWIST1', 'AKT2', {'sign': 1}), ('TWIST1', 'VEGFA', {'sign': 1}), ('TWIST1', 'MDM2', {'sign': 1}), ('TWIST1', 'CDKN2A', {'sign': -1}), ('FRAT1', 'GSK3B', {'sign': -1}), ('FRAT2', 'GSK3B', {'sign': -1}), ('PRICKLE1', 'DVL3', {'sign': -1}), ('DVL3', 'FRAT1', {'sign': 1}), ('DVL3', 'CSNK1G1', {'sign': 1}), ('DVL3', 'RAC1', {'sign': 1}), ('DVL3', 'LRRK2', {'sign': 1}), ('DVL3', 'PIP5K1A', {'sign': 1}), ('F2', 'F13A1', {'sign': 1}), ('F2', 'F8', {'sign': 1}), ('F2', 'F2R', {'sign': 1}), ('F2', 'F2RL1', {'sign': 1}), ('F2', 'F5', {'sign': 1}), ('F2', 'F2RL3', {'sign': 1}), ('F2', 'F2RL2', {'sign': 1}), ('F2', 'THBD', {'sign': 1}), ('F2', 'GP9', {'sign': 1}), ('CSNK2A1', 'CDH1', {'sign': 1}), ('CSNK2A1', 'CTNNB1', {'sign': 1}), ('CSNK2A1', 'PRKDC', {'sign': 1}), ('CSNK2A1', 'LEF1', {'sign': 1}), ('CSNK2A1', 'MUSK', {'sign': 1}), ('CSNK2A1', 'NFKBIA', {'sign': -1}), ('CSNK2A1', 'MDC1', {'sign': 1}), ('CSNK2A1', 'PSEN2', {'sign': 1}), ('CSNK2A1', 'EXOSC9', {'sign': 1}), ('CSNK2A1', 'BID', {'sign': 1}), ('CSNK2A1', 'SSRP1', {'sign': -1}), ('CSNK2A1', 'PPP1R1B', {'sign': 1}), ('CSNK2A1', 'CASP2', {'sign': -1}), ('CSNK2A1', 'TOP2A', {'sign': 1}), ('CSNK2A1', 'PPP1R8', {'sign': 1}), ('CSNK2A1', 'MRE11', {'sign': 1}), ('CSNK2A1', 'VDR', {'sign': 1}), ('CSNK2A1', 'TELO2', {'sign': -1}), ('CSNK2A1', 'EIF5', {'sign': 1}), ('CSNK2A1', 'GRIN2B', {'sign': -1}), ('CSNK2A1', 'G3BP1', {'sign': -1}), ('CSNK2A1', 'SRF', {'sign': 1}), ('CSNK2A1', 'HNRNPC', {'sign': -1}), ('CSNK2A1', 'WAS', {'sign': 1}), ('CSNK2A1', 'KLF1', {'sign': 1}), ('CSNK2A1', 'PDCL', {'sign': 1}), ('CSNK2A1', 'TCOF1', {'sign': 1}), ('CSNK2A1', 'MAZ', {'sign': 1}), ('CSNK2A1', 'CALM1', {'sign': -1}), ('CSNK2A1', 'CDC34', {'sign': -1}), ('CSNK2A1', 'PIAS1', {'sign': 1}), ('CSNK2A1', 'IGFBP3', {'sign': 1}), ('CSNK2A1', 'NR1H3', {'sign': -1}), ('CSNK2A1', 'ACE', {'sign': 1}), ('CSNK2A1', 'SEC63', {'sign': 1}), ('CSNK2A1', 'TP53', {'sign': 1}), ('CSNK2A1', 'TERF1', {'sign': 1}), ('CSNK2A1', 'TWIST1', {'sign': 1}), ('CSNK2A1', 'SNCA', {'sign': 1}), ('CSNK2A1', 'CBX5', {'sign': 1}), ('CSNK2A1', 'XRCC1', {'sign': 1}), ('CSNK2A1', 'STX1A', {'sign': 1}), ('CSNK2A1', 'IFI16', {'sign': 1}), ('CSNK2A1', 'SPTBN1', {'sign': -1}), ('CSNK2A1', 'CARD9', {'sign': -1}), ('CSNK2A1', 'VTN', {'sign': 1}), ('CSNK2A1', 'CD5', {'sign': 1}), ('CSNK2A1', 'MME', {'sign': -1}), ('CSNK2A1', 'ANP32B', {'sign': 1}), ('CSNK2A1', 'HSPH1', {'sign': -1}), ('CSNK2A1', 'EIF4EBP1', {'sign': -1}), ('CSNK2A1', 'NPHP1', {'sign': 1}), ('CSNK2A1', 'DEK', {'sign': 1}), ('CSNK2A1', 'PTEN', {'sign': -1}), ('CSNK2A1', 'MYH9', {'sign': 1}), ('CSNK2A1', 'PKD2', {'sign': 1}), ('CSNK2A1', 'HCLS1', {'sign': 1}), ('CSNK2A1', 'CCAR2', {'sign': 1}), ('CSNK2A1', 'MAPK9', {'sign': 1}), ('CSNK2A1', 'HDAC1', {'sign': 1}), ('CSNK2A1', 'FKBP4', {'sign': -1}), ('CSNK2A1', 'TFAP2A', {'sign': 1}), ('CSNK2A1', 'HDAC2', {'sign': 1}), ('CSNK2A1', 'AQP4', {'sign': -1}), ('CSNK2A1', 'GTF2A1L', {'sign': 1}), ('CSNK2A1', 'PTGES3', {'sign': 1}), ('CSNK2A1', 'EIF2S2', {'sign': 1}), ('CSNK2A1', 'C1R', {'sign': -1}), ('CSNK2A1', 'PPP1R2', {'sign': 1}), ('CSNK2A1', 'ARNT', {'sign': -1}), ('CSNK2A1', 'CDC27', {'sign': 1}), ('CSNK2A1', 'YY1', {'sign': 1}), ('CSNK2A1', 'RANGAP1', {'sign': 1}), ('CSNK2A1', 'EGR1', {'sign': -1}), ('CSNK2A1', 'ATF1', {'sign': 1}), ('CSNK2A1', 'PML', {'sign': -1}), ('CSNK2A1', 'LIG1', {'sign': 1}), ('CSNK2A1', 'TLE1', {'sign': 1}), ('CSNK2A1', 'MEF2C', {'sign': 1}), ('CSNK2A1', 'SSB', {'sign': 1}), ('CSNK2A1', 'TNFAIP1', {'sign': 1}), ('CSNK2A1', 'EIF4G2', {'sign': 1}), ('CSNK2A1', 'ESR1', {'sign': -1}), ('CSNK2A1', 'HSP90AB1', {'sign': -1}), ('CSNK2A1', 'PTPRC', {'sign': 1}), ('CSNK2A1', 'JUN', {'sign': -1}), ('CSNK2A1', 'APEX1', {'sign': 1}), ('CSNK2A1', 'PIN4', {'sign': -1}), ('CSNK2A1', 'TTI1', {'sign': -1}), ('CSNK2A1', 'EIF2B5', {'sign': 1}), ('CSNK2A1', 'GTF2A1', {'sign': 1}), ('CSNK2A1', 'DDIT3', {'sign': -1}), ('CSNK2A1', 'CAPZA1', {'sign': 1}), ('CSNK2A1', 'NOL3', {'sign': 1}), ('CSNK2A1', 'RIGI', {'sign': -1}), ('CSNK2A1', 'DAXX', {'sign': 1}), ('CSNK2A1', 'STARD10', {'sign': -1}), ('CSNK2A1', 'AKT1', {'sign': 1}), ('CSNK2A1', 'WASF2', {'sign': -1}), ('CSNK2A1', 'SHOX', {'sign': 1}), ('CSNK2A1', 'IL16', {'sign': 1}), ('CSNK2A1', 'SNAI1', {'sign': 1}), ('CSNK2A1', 'BRMS1', {'sign': -1}), ('CSNK2A1', 'TCF7L2', {'sign': 1}), ('CSNK2A1', 'FOSB', {'sign': 1}), ('CSNK2A1', 'UBE2R2', {'sign': 1}), ('CSNK2A1', 'SLK', {'sign': -1}), ('CSNK2A1', 'RRN3', {'sign': -1}), ('CSNK2A1', 'HMGN1', {'sign': -1}), ('CSNK2A1', 'FAF1', {'sign': -1}), ('CSNK2A1', 'CTDP1', {'sign': -1}), ('CSNK2A1', 'MYF5', {'sign': 1}), ('CSNK2A1', 'HMOX2', {'sign': 1}), ('CSNK2A1', 'MAX', {'sign': -1}), ('CSNK2A1', 'VAMP4', {'sign': 1}), ('CSNK2A1', 'IKZF1', {'sign': -1}), ('CSNK2A1', 'CDC25B', {'sign': 1}), ('CSNK2A1', 'CAV2', {'sign': 1}), ('CSNK2A1', 'YWHAQ', {'sign': -1}), ('CSNK2A1', 'PIP4K2A', {'sign': 1}), ('CSNK2A1', 'ARRB2', {'sign': 1}), ('CSNK2A1', 'HOXB7', {'sign': -1}), ('CSNK2A1', 'CFTR', {'sign': 1}), ('CSNK2A1', 'EIF3J', {'sign': 1}), ('CSNK2A1', 'ABCC1', {'sign': 1}), ('CSNK2A1', 'SPIB', {'sign': -1}), ('CSNK2A1', 'MYB', {'sign': -1}), ('CSNK2A1', 'CLIP1', {'sign': 1}), ('CSNK2A1', 'CDC25C', {'sign': -1}), ('CSNK2A1', 'RELA', {'sign': 1}), ('CSNK2A1', 'NKX2-5', {'sign': 1}), ('CSNK2A1', 'SP1', {'sign': -1}), ('CSNK2A1', 'SLBP', {'sign': -1}), ('CSNK2A1', 'SEPTIN2', {'sign': -1}), ('CSNK2A1', 'HSF1', {'sign': 1}), ('CSNK2A1', 'RNF7', {'sign': 1}), ('CSNK2A1', 'CDC37', {'sign': 1}), ('CSNK2A1', 'OTUD5', {'sign': 1}), ('CSNK2A1', 'HDAC3', {'sign': 1}), ('CSNK2A1', 'TSPY1', {'sign': 1}), ('CSNK2A1', 'CTNNA1', {'sign': -1}), ('CSNK2A1', 'CORO1C', {'sign': 1}), ('CSNK2A1', 'PRPF3', {'sign': 1}), ('CSNK2A1', 'GPI', {'sign': -1}), ('CSNK2A1', 'CCNF', {'sign': -1}), ('CSNK2A1', 'AMPH', {'sign': -1}), ('CSNK2A1', 'SET', {'sign': -1}), ('CSNK2A1', 'MCM2', {'sign': 1}), ('CSNK2A1', 'PDCD5', {'sign': 1}), ('CSNK2A1', 'PACS1', {'sign': 1}), ('CSNK2A1', 'HES6', {'sign': 1}), ('CSNK2A1', 'F5', {'sign': -1}), ('CSNK2A1', 'CBX1', {'sign': -1}), ('CSNK2A1', 'FUNDC1', {'sign': -1}), ('CSNK2A1', 'BIK', {'sign': 1}), ('MSH2', 'ATR', {'sign': 1}), ('IL1R1_IL1RAP', 'MYD88', {'sign': 1}), ('IL12A', 'IL12RB1', {'sign': 1}), ('IL12A', 'IL12B', {'sign': 1}), ('IL12A', 'IL12RB2', {'sign': 1}), ('DVL2', 'ARRB2', {'sign': 1}), ('DVL2', 'AXIN1', {'sign': 1}), ('DVL2', 'PI4K2B', {'sign': 1}), ('DVL2', 'LRRK2', {'sign': 1}), ('DVL2', 'RAC1', {'sign': 1}), ('DVL2', 'PARD6A', {'sign': 1}), ('TDP2', 'TOP2A', {'sign': -1}), ('TDP2', 'TOP2B', {'sign': -1}), ('CCDC88C', 'DVL1', {'sign': -1}), ('DVL1', 'DAAM1', {'sign': 1}), ('DVL1', 'RAC1', {'sign': 1}), ('DVL1', 'SMAD3', {'sign': 1}), ('DVL1', 'LRRK2', {'sign': 1}), ('DVL1', 'AXIN1', {'sign': -1}), ('DVL1', 'PI4K2B', {'sign': 1}), ('DVL1', 'CTNNB1', {'sign': 1}), ('DVL1', 'JUN', {'sign': 1}), ('DVL1', 'ROCK1', {'sign': 1}), ('DVL1', 'APC', {'sign': -1}), ('DVL1', 'APC_AXIN1_GSK3B', {'sign': -1}), ('DVL1', 'GSK3B', {'sign': -1}), ('PARP2', 'TOP1', {'sign': -1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'H2AZ1', {'sign': 1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'H2AX', {'sign': 1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'ATM', {'sign': 1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'H4C2', {'sign': 1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'UBTF', {'sign': 1}), ('ACTA1_ACTL6A_ALKBH3_BRD2_BRD8_DMAP1_EP400_EPC1_ING3_KAT5_MORF4L1_MRGBP_RUVBL1_RUVBL2_TRRAP_VPS72_YEATS4', 'TP53', {'sign': 1}), ('KAT5', 'AR', {'sign': 1}), ('KAT5', 'MYC', {'sign': 1}), ('KAT5', 'TP53', {'sign': 1}), ('KAT5', 'H3C12', {'sign': 1}), ('KAT5', 'H2AZ1', {'sign': 1}), ('KAT5', 'H4C2', {'sign': 1}), ('KAT5', 'PRKDC', {'sign': 1}), ('KAT5', 'ATM', {'sign': 1}), ('MYCBP', 'MYC', {'sign': 1}), ('MTNR1A', 'GNAQ', {'sign': 1}), ('MTNR1A', 'GNAI3', {'sign': 1}), ('MTNR1A', 'MAPK1', {'sign': 1}), ('MTNR1A', 'GNAI1', {'sign': 1}), ('GNAI3', 'ADCY5', {'sign': -1}), ('GNAI3', 'ADCY6', {'sign': -1}), ('GNAI3', 'ADCY1', {'sign': -1}), ('CDK11A', 'EIF3F', {'sign': -1}), ('CDK11A', 'CDK11B', {'sign': 1}), ('CDK11B', 'EIF3F', {'sign': -1}), ('CUL4A_DDB1_DTL', 'CDKN1A', {'sign': -1}), ('CUL4A_DDB1_DTL', 'CDT1', {'sign': -1}), ('SMARCB1', 'MYC', {'sign': 1}), ('SMARCB1', 'SMARCA4', {'sign': 1}), ('HDAC3', 'TRIM28', {'sign': 1}), ('HDAC3', 'H3C12', {'sign': -1}), ('HDAC3', 'H4C2', {'sign': -1}), ('HDAC3', 'CDKN1A', {'sign': 1}), ('HDAC3', 'RELA', {'sign': -1}), ('HDAC3', 'CREBBP', {'sign': -1}), ('HDAC3', 'MAFK', {'sign': -1}), ('HDAC3', 'HDAC1', {'sign': 1}), ('HDAC3', 'YY1', {'sign': -1}), ('PTTG1', 'TP53', {'sign': -1}), ('PTTG1', 'ESPL1', {'sign': -1}), ('NSMCE2', 'TERF1', {'sign': 1}), ('NSMCE2', 'TERF2IP', {'sign': 1}), ('NSMCE2', 'TERF2', {'sign': 1}), ('NSMCE2', 'TINF2', {'sign': 1}), ('NSMCE2', 'TSNAX', {'sign': 1}), ('NSMCE2', 'SMC6', {'sign': 1}), ('CD28', 'GRB2', {'sign': 1}), ('CD28', 'PIK3R2', {'sign': 1}), ('CD28', 'CBLB', {'sign': -1}), ('CD28', 'PIK3CG', {'sign': 1}), ('CD86', 'CD28', {'sign': 1}), ('CD86', 'CTLA4', {'sign': 1}), ('CD80', 'CD28', {'sign': 1}), ('CD80', 'CTLA4', {'sign': 1}), ('CD80', 'CD274', {'sign': 1}), ('CARD11', 'MALT1', {'sign': 1}), ('BCL10_CARD11_MALT1', 'IKBKB', {'sign': 1}), ('ANXA1', 'FPR2', {'sign': 1}), ('ANXA1', 'FPR3', {'sign': 1}), ('ANXA1', 'FPR1', {'sign': 1}), ('DDX6', 'ALOX15', {'sign': -1}), ('P4HA1_P4HB', 'AGO2', {'sign': 1}), ('AURKA', 'HDAC6', {'sign': 1}), ('AURKA', 'BRCA1', {'sign': 1}), ('AURKA', 'CENPA', {'sign': 1}), ('AURKA', 'CDC25B', {'sign': 1}), ('AURKA', 'PLK1', {'sign': 1}), ('AURKA', 'AJUBA', {'sign': 1}), ('AURKA', 'TACC1', {'sign': 1}), ('AURKA', 'KIF11', {'sign': 1}), ('AURKA', 'CPEB1', {'sign': 1}), ('AURKA', 'PPP1R1B', {'sign': -1}), ('AURKA', 'TPX2', {'sign': 1}), ('AURKA', 'MAP9', {'sign': 1}), ('AURKA', 'NDEL1', {'sign': 1}), ('AURKA', 'RASSF1', {'sign': -1}), ('AURKA', 'TP53', {'sign': -1}), ('AURKA', 'INCENP', {'sign': 1}), ('AURKA', 'WDR62', {'sign': 1}), ('AURKA', 'FADD', {'sign': 1}), ('AURKA', 'DLGAP5', {'sign': 1}), ('AURKA', 'NEDD9', {'sign': 1}), ('AURKA', 'MBD3', {'sign': 1}), ('AURKA', 'H3C12', {'sign': 1}), ('AURKA', 'LATS2', {'sign': 1}), ('AURKA', 'AURKAIP1', {'sign': 1}), ('AURKA', 'PIN1', {'sign': -1}), ('AURKA', 'KIF4A', {'sign': 1}), ('AURKA', 'TACC3', {'sign': 1}), ('AURKA', 'PARD3', {'sign': 1}), ('AURKA', 'FAF1', {'sign': -1}), ('AURKA', 'CETN2', {'sign': 1}), ('AURKA', 'MAPRE3', {'sign': 1}), ('AURKA', 'NFKBIA', {'sign': -1}), ('HDAC6', 'HSP90B1', {'sign': 1}), ('HDAC6', 'CTTN', {'sign': 1}), ('HDAC6', 'TUBA4B', {'sign': -1}), ('HDAC6', 'ELAVL1', {'sign': -1}), ('HDAC6', 'HSP90AA1', {'sign': 1}), ('HSP90B1', 'LRP1', {'sign': 1}), ('PCBP1', 'ALOX15', {'sign': -1}), ('HNRNPK', 'ALOX15', {'sign': -1}), ('HNRNPK', 'TP53', {'sign': 1}), ('HNRNPK', 'MDM2', {'sign': 1}), ('HNRNPK', 'AR', {'sign': -1}), ('HNRNPK', 'CDKN1A', {'sign': 1}), ('HNRNPK', 'MYC', {'sign': 1}), ('HNRNPK', 'SPN', {'sign': -1}), ('HNRNPK', 'EIF4E', {'sign': 1}), ('HNRNPK', 'TK1', {'sign': -1}), ('TRIM8', 'SOCS1', {'sign': -1}), ('MARCHF5', 'RIGI', {'sign': 1}), ('MARCHF5', 'DNM1L', {'sign': -1}), ('MARCHF5', 'FIS1', {'sign': -1}), ('RIGI', 'MAVS', {'sign': 1}), ('RIGI', 'TRAF3', {'sign': -1}), ('RIGI', 'TBK1', {'sign': 1}), ('RIGI', 'IKBKE', {'sign': 1}), ('ZBTB4', 'CDKN1A', {'sign': -1}), ('DDX5', 'TP53', {'sign': 1}), ('DDX5', 'HDAC1', {'sign': 1}), ('DDX5', 'AR', {'sign': 1}), ('DTX3L', 'H4C2', {'sign': 1}), ('NFKBIZ', 'STAT3', {'sign': -1}), ('SP3', 'IL10', {'sign': 1}), ('SP3', 'HAS2', {'sign': 1}), ('ATF1', 'IL10', {'sign': 1}), ('ATF1', 'SH3RF1', {'sign': 1}), ('ATF1', 'CCDC65', {'sign': 1}), ('ATF1', 'NKX6-1', {'sign': 1}), ('ATF1', 'ARNT2', {'sign': 1}), ('ATF1', 'GOLPH3', {'sign': 1}), ('KDM5D', 'H3C12', {'sign': -1}), ('ASH2L_DPY30_HCFC1_HCFC2_KMT2A_KMT2D_MEN1_RBBP5_WDR5_WDR82', 'H3C12', {'sign': 1}), ('ASH2L_DPY30_KDM6A_KMT2B_KMT2C_NCOA6_PAXIP1_RBBP5_WDR5', 'H3C12', {'sign': 1}), ('KDM5B', 'H3C12', {'sign': -1}), ('KDM5B', 'FOXG1', {'sign': 1}), ('KDM5B', 'PAX9', {'sign': 1}), ('KDM5B', 'CBX4', {'sign': 1}), ('KDM5C', 'H3C12', {'sign': -1}), ('ASH1L', 'H3C12', {'sign': 1}), ('KDM5A', 'H3C12', {'sign': -1}), ('PKMYT1', 'CDK1', {'sign': -1}), ('TNFSF14', 'LTBR', {'sign': 1}), ('TNFSF14', 'TNFRSF14', {'sign': 1}), ('TNFSF14', 'TNFRSF6B', {'sign': 1}), ('LTBR', 'MAP3K14', {'sign': 1}), ('LTBR', 'TRAF2', {'sign': 1}), ('CD40LG', 'CD40', {'sign': 1}), ('CD40', 'TRAF2', {'sign': 1}), ('CD40', 'TRAF3', {'sign': 1}), ('TNFSF13B', 'MAP3K14', {'sign': 1}), ('TNFSF13B', 'TNFRSF13C', {'sign': 1}), ('TNFSF13B', 'TNFRSF13B', {'sign': 1}), ('TNFSF13B', 'TNFRSF17', {'sign': 1}), ('LTA', 'TNFRSF1A', {'sign': 1}), ('LTA', 'LTBR', {'sign': 1}), ('LTA', 'TNFRSF14', {'sign': 1}), ('LTA', 'TNFRSF1B', {'sign': 1}), ('LTB', 'LTBR', {'sign': 1}), ('LTB', 'CD40', {'sign': 1}), ('JUNB', 'BCL2', {'sign': -1}), ('JUNB', 'EGFR', {'sign': 1}), ('JUNB', 'BCL2L1', {'sign': -1}), ('KLF4', 'NANOG', {'sign': 1}), ('PIM1', 'BAD', {'sign': -1}), ('PIM1', 'FLT3', {'sign': 1}), ('PIM1', 'RPS19', {'sign': 1}), ('PIM1', 'FOXO3', {'sign': -1}), ('PIM1', 'CDKN1B', {'sign': -1}), ('PIM1', 'MAP3K5', {'sign': -1}), ('PIM1', 'RELA', {'sign': 1}), ('PIM1', 'MARK3', {'sign': -1}), ('PIM1', 'ABCG2', {'sign': 1}), ('PIM1', 'CDKN1A', {'sign': 1}), ('PIM1', 'MDM2', {'sign': 1}), ('PIM1', 'SKP2', {'sign': 1}), ('PIM1', 'H3C12', {'sign': 1}), ('PIM1', 'MYC', {'sign': 1}), ('PIM1', 'NFATC1', {'sign': 1}), ('NRG1', 'ERBB2', {'sign': 1}), ('NRG1', 'ERBB4', {'sign': 1}), ('NRG1', 'ERBB3', {'sign': 1}), ('ERBB3', 'GRB7', {'sign': 1}), ('ERBB3', 'PIK3R1', {'sign': 1}), ('ERBB3', 'GRB2', {'sign': 1}), ('ERBB3', 'PIK3CG', {'sign': 1}), ('ERBB3', 'PIK3CA', {'sign': 1}), ('ERBB3', 'PIK3CD', {'sign': 1}), ('ERBB3', 'PIK3CB', {'sign': 1}), ('GRB7', 'RND1', {'sign': 1}), ('SKP2', 'FOXO1', {'sign': 1}), ('SKP2', 'MYC', {'sign': -1}), ('SKP2', 'CDKN1B', {'sign': -1}), ('SKP2', 'CDKN1A', {'sign': -1}), ('NR1I2', 'FOXO1', {'sign': 1}), ('NR1I2', 'RXRA', {'sign': 1}), ('CXCL8', 'CXCR1', {'sign': 1}), ('CXCL8', 'CXCR2', {'sign': 1}), ('PIAS1', 'CALCOCO1', {'sign': -1}), ('PIAS1', 'SMAD4', {'sign': 1}), ('PIAS1', 'SOX9', {'sign': 1}), ('PIAS1', 'STAT1', {'sign': 1}), ('PIAS1', 'GLI2', {'sign': 1}), ('PIAS1', 'GLI3', {'sign': -1}), ('PIAS1', 'GLI1', {'sign': 1}), ('PIAS1', 'SATB2', {'sign': -1}), ('NDP', 'FZD4', {'sign': 1}), ('FZD4', 'DVL2', {'sign': 1}), ('FZD4', 'DVL1', {'sign': 1}), ('NOLC1', 'CSNK2A1', {'sign': -1}), ('NOLC1', 'TP53', {'sign': 1}), ('AMBRA1_BECN1_PIK3C3_PIK3R4_SH3GLB1_UVRAG', 'MAP1LC3B', {'sign': 1}), ('PRMT5', 'H4C2', {'sign': -1}), ('PRMT5', 'H2AZ1', {'sign': -1}), ('PRMT5', 'H3C12', {'sign': 1}), ('PRMT5', 'HOXA9', {'sign': 1}), ('APC2', 'CTNNB1', {'sign': 1}), ('APC2', 'AXIN1', {'sign': 1}), ('HDAC2', 'H2AZ1', {'sign': -1}), ('HDAC2', 'H2BC11', {'sign': -1}), ('HDAC2', 'H3C12', {'sign': -1}), ('HDAC2', 'H4C2', {'sign': -1}), ('HDAC2', 'STAT3', {'sign': 1}), ('HDAC2', 'YY1', {'sign': -1}), ('HDAC2', 'CCND1', {'sign': -1}), ('HDAC2', 'CIITA', {'sign': -1}), ('CDC73_CTR9_LEO1_PAF1_SKIC8', 'RNF40', {'sign': 1}), ('RNF40', 'RNF20', {'sign': 1}), ('SUV39H1', 'H3C12', {'sign': -1}), ('MTA1', 'SIX3', {'sign': -1}), ('MTA1', 'WNT1', {'sign': 1}), ('MTA1', 'ESR1', {'sign': -1}), ('MTA1', 'BRCA1', {'sign': -1}), ('SIX3', 'WNT1', {'sign': -1}), ('SIAH1', 'CTNNB1', {'sign': -1}), ('SIAH1', 'HIPK2', {'sign': -1}), ('SIAH1', 'NUMB', {'sign': -1}), ('SIAH1', 'SNCAIP', {'sign': -1}), ('USP22', 'H2AZ1', {'sign': 1}), ('USP22', 'H2BC11', {'sign': 1}), ('USP22', 'SIRT1', {'sign': 1}), ('CDX2', 'CDX4', {'sign': 1}), ('KAT2A_SAP130_SUPT3H_SUPT7L_TADA1_TADA2A_TADA3_TAF10_TAF12_TAF5L_TAF6L_TAF9_TRRAP_USP22', 'H2BC11', {'sign': -1}), ('KAT2A_SAP130_SUPT3H_SUPT7L_TADA1_TADA2A_TADA3_TAF10_TAF12_TAF5L_TAF6L_TAF9_TRRAP_USP22', 'H3C12', {'sign': 1}), ('RNF8_UBE2N', 'H2AZ1', {'sign': 1}), ('RNF8_UBE2N', 'H2AX', {'sign': 1}), ('CSNK1E', 'CTNND1', {'sign': 1}), ('CSNK1E', 'CDH1', {'sign': -1}), ('CSNK1E', 'DVL1', {'sign': 1}), ('CSNK1E', 'PER2', {'sign': -1}), ('CSNK1E', 'CDC25A', {'sign': -1}), ('CSNK1E', 'AXIN1', {'sign': 1}), ('CSNK1E', 'SMO', {'sign': 1}), ('CSNK1E', 'LRP6', {'sign': 1}), ('CSNK1E', 'ROR2', {'sign': 1}), ('CSNK1E', 'PER3', {'sign': -1}), ('CSNK1E', 'EIF4EBP1', {'sign': -1}), ('CSNK1E', 'PER1', {'sign': -1}), ('CSNK1E', 'BID', {'sign': 1}), ('CSNK1E', 'APC', {'sign': 1}), ('CSNK1E', 'DVL2', {'sign': 1}), ('CSNK1E', 'YAP1', {'sign': -1}), ('CSNK1E', 'WWTR1', {'sign': -1}), ('CSNK1E', 'CTNNB1', {'sign': -1}), ('CSNK1E', 'TP53', {'sign': 1}), ('CSNK1E', 'YWHAQ', {'sign': 1}), ('CTNND1', 'CDH1', {'sign': 1}), ('CTNND1', 'CDH3', {'sign': 1}), ('CTNND1', 'CDH2', {'sign': 1}), ('CTNND1', 'CDH5', {'sign': 1}), ('UBE2N', 'TRAF2', {'sign': 1}), ('UBE2N', 'TRAF6', {'sign': 1}), ('UBE2N', 'PCNA', {'sign': 1}), ('UBE2N', 'H2AX', {'sign': 1}), ('UBE2N', 'UBE2V1', {'sign': 1}), ('UBE2N', 'MAP3K7', {'sign': -1}), ('SENP2', 'TCF7L2', {'sign': -1}), ('SMURF2', 'PRICKLE1', {'sign': -1}), ('SMURF2', 'TGFBR1', {'sign': 1}), ('SMURF2', 'SMAD2', {'sign': 1}), ('SMURF2', 'SMAD1', {'sign': 1}), ('SMURF2', 'SKIL', {'sign': 1}), ('SMURF2', 'CTNNB1', {'sign': 1}), ('SMURF2', 'SMAD5', {'sign': -1}), ('SMURF2', 'TGFBR2', {'sign': -1}), ('SMURF1', 'PRICKLE1', {'sign': -1}), ('SMURF1', 'SMAD7', {'sign': 1}), ('SMURF1', 'TGFBR1', {'sign': 1}), ('SMURF1', 'RHOA', {'sign': -1}), ('SMURF1', 'SMAD3', {'sign': 1}), ('SMURF1', 'SMAD2', {'sign': 1}), ('SMURF1', 'BMPR1A', {'sign': -1}), ('SMURF1', 'SMAD1', {'sign': -1}), ('SMURF1', 'RUNX2', {'sign': -1}), ('SMURF1', 'SMAD5', {'sign': -1}), ('SMURF1', 'TGFBR2', {'sign': -1}), ('SMURF1', 'SMAD6', {'sign': -1}), ('SMURF1', 'BMPR2', {'sign': -1}), ('DIXDC1', 'AXIN1', {'sign': -1}), ('DIXDC1', 'MAP3K4', {'sign': -1}), ('DIXDC1', 'DVL1', {'sign': 1}), ('RCOR1', 'KDM1A', {'sign': 1}), ('RCOR1', 'REST', {'sign': 1}), ('NKIRAS1', 'NFKBIA', {'sign': 1}), ('BACH1', 'NFE2L2', {'sign': -1}), ('BACH1', 'NQO1', {'sign': -1}), ('BACH1', 'MAFK', {'sign': 1}), ('NKIRAS2', 'NFKBIB', {'sign': 1}), ('NFKBIB', 'NFKB1', {'sign': -1}), ('ERO1A', 'ERP44', {'sign': 1}), ('NGF', 'NTRK1', {'sign': 1}), ('NGF', 'NGFR', {'sign': 1}), ('CEBPB', 'RUNX2', {'sign': 1}), ('CEBPB', 'FOXO1', {'sign': 1}), ('CEBPB', 'E2F4', {'sign': 1}), ('CEBPB', 'ORM1', {'sign': 1}), ('CEBPB', 'HSP90AA1', {'sign': 1}), ('CEBPB', 'STAT3', {'sign': 1}), ('CEBPB', 'LBP', {'sign': 1}), ('CEBPB', 'CREB1', {'sign': 1}), ('ACAA2', 'BNIP3', {'sign': -1}), ('BMI1', 'CDKN2A', {'sign': -1}), ('BMI1', 'RNF2', {'sign': 1}), ('CEBPA_FOXO1', 'ADIPOQ', {'sign': 1}), ('CEBPA_FOXO1', 'PCK1', {'sign': 1}), ('ING1', 'CDKN1A', {'sign': 1}), ('ING1', 'CCNB1', {'sign': -1}), ('ING1', 'HDAC1', {'sign': 1}), ('FBXO31', 'CCND1', {'sign': -1}), ('STAT6', 'RETNLB', {'sign': 1}), ('STAT6', 'CLEC7A', {'sign': 1}), ('STAT6', 'CHIA', {'sign': 1}), ('STAT6', 'THY1', {'sign': 1}), ('STAT6', 'NFIL3', {'sign': 1}), ('STAT6', 'ARG1', {'sign': 1}), ('STAT6', 'GATA3', {'sign': 1}), ('STAT6', 'RHOA', {'sign': 1}), ('STAT6', 'STAT1', {'sign': -1}), ('IL4R', 'JAK1', {'sign': 1}), ('IL4R', 'JAK3', {'sign': 1}), ('IL4R', 'IRS2', {'sign': 1}), ('IL4R', 'IRS1', {'sign': 1}), ('IL4R', 'JAK2', {'sign': 1}), ('IL4R', 'IL2RG', {'sign': 1}), ('RPS6KA4', 'FOS', {'sign': 1}), ('RPS6KA4', 'CREB1', {'sign': 1}), ('RPS6KA4', 'RELA', {'sign': 1}), ('RPS6KA4', 'HMGN1', {'sign': 1}), ('RPS6KA4', 'H3C12', {'sign': 1}), ('RPS6KA4', 'ATF1', {'sign': 1}), ('FOS', 'NFAT5', {'sign': 1}), ('FOS', 'CGA', {'sign': 1}), ('FOS', 'JUN', {'sign': 1}), ('IL4', 'IL4R', {'sign': 1}), ('IL4', 'IL13RA1', {'sign': 1}), ('IL4', 'IL2RG', {'sign': 1}), ('USP17L2', 'CDC25A', {'sign': 1}), ('JAK3', 'FES', {'sign': 1}), ('JAK3', 'IL7R', {'sign': 1}), ('JAK3', 'IRS1', {'sign': 1}), ('JAK3', 'SOCS3', {'sign': 1}), ('JAK3', 'JAK1', {'sign': 1}), ('JAK3', 'IRS2', {'sign': 1}), ('JAK3', 'STAT3', {'sign': 1}), ('JAK3', 'STAT5A', {'sign': 1}), ('JAK3', 'STAM', {'sign': 1}), ('JAK3', 'PTK2B', {'sign': 1}), ('JAK3', 'STAT1', {'sign': 1}), ('JAK3', 'DBP', {'sign': 1}), ('JAK3', 'STAT2', {'sign': 1}), ('JAK3', 'STAT5B', {'sign': 1}), ('JAK3', 'SIGLEC10', {'sign': 1}), ('JAK3', 'PLD2', {'sign': 1}), ('NEK11', 'CDC25A', {'sign': -1}), ('IL3RA', 'JAK2', {'sign': 1}), ('PIAS4', 'STAT1', {'sign': -1}), ('PIAS4', 'IKBKG', {'sign': 1}), ('PIAS4', 'TCF7L2', {'sign': 1}), ('PIAS4', 'TCF4', {'sign': 1}), ('PIAS4', 'BRCA1', {'sign': 1}), ('PIAS4', 'SMAD3', {'sign': 1}), ('PIAS4', 'SMAD4', {'sign': 1}), ('PIAS4', 'RPA2', {'sign': 1}), ('H3-4', 'TP53BP1', {'sign': 1}), ('BTK', 'TIRAP', {'sign': -1}), ('BTK', 'GTF2I', {'sign': 1}), ('BTK', 'PLCG2', {'sign': 1}), ('BTK', 'PIK3AP1', {'sign': 1}), ('BTK', 'PLCG1', {'sign': 1}), ('BTK', 'DAPP1', {'sign': 1}), ('BTK', 'STAT5A', {'sign': 1}), ('BTK', 'BMX', {'sign': 1}), ('BTK', 'NFKBIA', {'sign': 1}), ('KMT5C', 'H4C2', {'sign': 1}), ('SIRT7', 'POLR1B', {'sign': 1}), ('PRKAA2_PRKAB2_PRKAG2', 'EEF2', {'sign': -1}), ('EIF2AK4', 'EIF2S1', {'sign': -1}), ('EIF2AK4', 'EIF2A', {'sign': -1}), ('EIF2AK4', 'MARS1', {'sign': -1}), ('EIF2AK1', 'EIF2S1', {'sign': -1}), ('MKNK2', 'EIF4E', {'sign': 1}), ('MKNK1', 'EIF4E', {'sign': 1}), ('MKNK1', 'SPRY2', {'sign': -1}), ('MKNK1', 'PLA2G4A', {'sign': 1}), ('HSPA5', 'ERN2', {'sign': -1}), ('HSPA5', 'EIF2AK3', {'sign': -1}), ('HSPA5', 'ERN1', {'sign': -1}), ('HSPA5', 'ATF6', {'sign': -1}), ('EIF2AK3', 'NFE2L2', {'sign': 1}), ('EIF2AK3', 'BIRC3', {'sign': 1}), ('EIF2AK3', 'BIRC2', {'sign': 1}), ('EIF2AK3', 'SLC7A1', {'sign': 1}), ('EIF2AK3', 'ATF4', {'sign': 1}), ('EIF2AK3', 'EIF2A', {'sign': -1}), ('EIF2AK3', 'APAF1', {'sign': -1}), ('EIF2AK3', 'EIF2S1', {'sign': -1}), ('ATF4', 'FUS', {'sign': 1}), ('MAPK11', 'ATF2', {'sign': 1}), ('MAPK11', 'MAPKAPK5', {'sign': 1}), ('MAPK11', 'RPS6KA5', {'sign': 1}), ('MAPK11', 'SMAD2', {'sign': 1}), ('MAPK11', 'TWIST1', {'sign': 1}), ('MAPK11', 'EGFR', {'sign': -1}), ('MAPK11', 'PIAS2', {'sign': 1}), ('MAPK11', 'TP53', {'sign': 1}), ('MAPK11', 'HBP1', {'sign': 1}), ('MAPK11', 'TCF3', {'sign': 1}), ('MAPK11', 'KRT8', {'sign': 1}), ('CDK5RAP3', 'CDK1', {'sign': 1}), ('CDK5RAP3', 'CHEK1', {'sign': -1}), ('ERN1', 'XBP1', {'sign': 1}), ('ERN1', 'MAPK8', {'sign': 1}), ('ERN1', 'TRAF2', {'sign': 1}), ('TIMD4', 'HAVCR1', {'sign': 1}), ('GHR', 'JAK2', {'sign': 1}), ('GHR', 'TYK2', {'sign': 1}), ('GHR', 'JAK1', {'sign': 1}), ('PRLR', 'JAK2', {'sign': 1}), ('LEPR', 'JAK2', {'sign': 1}), ('LEPR', 'STAT3', {'sign': 1}), ('LEPR', 'JAK1', {'sign': 1}), ('LEPR', 'TYK2', {'sign': 1}), ('LEPR', 'PTPN11', {'sign': 1}), ('IL5RA', 'JAK2', {'sign': 1}), ('IL5RA', 'SOX4', {'sign': 1}), ('CSF3R', 'JAK1', {'sign': 1}), ('CSF3R', 'TYK2', {'sign': 1}), ('CSF3R', 'JAK2', {'sign': 1}), ('LIFR', 'IL6ST', {'sign': 1}), ('LIFR', 'JAK2', {'sign': 1}), ('LIFR', 'TYK2', {'sign': 1}), ('LIFR', 'JAK1', {'sign': 1}), ('IL6R', 'IL6ST', {'sign': 1}), ('SENP3', 'SUMO2', {'sign': -1}), ('SENP3', 'EP300', {'sign': 1}), ('SUMO2', 'KDM1A', {'sign': 1}), ('SUMO2', 'RCOR1', {'sign': 1}), ('SUMO2', 'RARA', {'sign': 1}), ('SUMO2', 'ELF4', {'sign': -1}), ('GNB2', 'DVL1', {'sign': -1}), ('GNB2', 'KCNJ3', {'sign': 1}), ('GNB2', 'PLCB1', {'sign': 1}), ('GNB2', 'GRK2', {'sign': 1}), ('GNB2', 'ADCY2', {'sign': 1}), ('GNB2', 'CACNA1B', {'sign': -1}), ('NET1', 'RHOA', {'sign': 1}), ('DAAM1', 'RHO', {'sign': 1}), ('DAAM1', 'PFN1', {'sign': 1}), ('DAAM1', 'RHOA', {'sign': 1}), ('ARHGEF18', 'RHOA', {'sign': 1}), ('CEBPB_FOXO1', 'WNT10B', {'sign': -1}), ('CEBPB_FOXO1', 'PRL', {'sign': 1}), ('WNT10B', 'FZD5', {'sign': 1}), ('WNT10B', 'LRP5', {'sign': 1}), ('WNT10B', 'FZD1', {'sign': 1}), ('WNT10B', 'LRP6', {'sign': 1}), ('ERG', 'WNT11', {'sign': 1}), ('WNT11', 'MUSK', {'sign': 1}), ('WNT11', 'FZD7', {'sign': 1}), ('WNT11', 'FZD3', {'sign': 1}), ('GRHL3', 'ARHGEF19', {'sign': 1}), ('ARHGEF19', 'RHOA', {'sign': 1}), ('ARHGEF19', 'CDC42', {'sign': 1}), ('ARHGEF19', 'RAC1', {'sign': 1}), ('GNAO1', 'DVL1', {'sign': 1}), ('INVS', 'DVL1', {'sign': -1}), ('CUL1_FBXW7_PRKN', 'CCNE1', {'sign': -1}), ('BAG2', 'STUB1', {'sign': 1}), ('BAG2', 'RAF1', {'sign': 1}), ('BAG2', 'BCL2', {'sign': 1}), ('STUB1', 'MKKS', {'sign': -1}), ('STUB1', 'LIG3', {'sign': -1}), ('STUB1', 'XRCC1', {'sign': -1}), ('STUB1', 'POLB', {'sign': -1}), ('STUB1', 'SMAD5', {'sign': -1}), ('STUB1', 'SMAD1', {'sign': -1}), ('STUB1', 'TAL1', {'sign': -1}), ('STUB1', 'HIF1A', {'sign': -1}), ('TCF3', 'MYOD1', {'sign': 1}), ('TCL1A', 'AKT3', {'sign': 1}), ('TCL1A', 'AKT1', {'sign': 1}), ('TCL1A', 'AKT2', {'sign': 1}), ('SMARCA2', 'SMARCC2', {'sign': 1}), ('SMAD6', 'TGFBR1', {'sign': 1}), ('SMAD6', 'SMAD1', {'sign': 1}), ('SMAD6', 'SMAD3', {'sign': 1}), ('SMAD6', 'SMAD2', {'sign': 1}), ('SMAD6', 'BMPR1A', {'sign': 1}), ('SMAD6', 'ACVR1', {'sign': 1}), ('SMAD6', 'BMPR1B', {'sign': 1}), ('SMAD6', 'TAB1', {'sign': 1}), ('SMAD6', 'HOXC8', {'sign': 1}), ('SMAD6', 'PELI1', {'sign': 1}), ('SMAD6', 'MAP3K7', {'sign': -1}), ('SCYL2', 'FZD5', {'sign': -1}), ('CXXC5', 'DVL1', {'sign': -1}), ('CXXC4', 'DVL1', {'sign': -1}), ('KLHL12', 'DVL1', {'sign': -1}), ('SDC4', 'DVL1', {'sign': 1}), ('ANKRD6', 'CSNK1E', {'sign': 1}), ('ANKRD6', 'DVL1', {'sign': 1}), ('ANKRD6', 'DVL2', {'sign': 1}), ('CSNK1D', 'PER2', {'sign': -1}), ('CSNK1D', 'AXIN1', {'sign': 1}), ('CSNK1D', 'APC2', {'sign': 1}), ('CSNK1D', 'GSK3B', {'sign': 1}), ('CSNK1D', 'DVL1', {'sign': 1}), ('CSNK1D', 'CTNNB1', {'sign': 1}), ('CSNK1D', 'LRP6', {'sign': 1}), ('CSNK1D', 'KIR3DL1', {'sign': 1}), ('CSNK1D', 'DVL2', {'sign': 1}), ('CSNK1D', 'WWTR1', {'sign': -1}), ('CSNK1D', 'PSEN2', {'sign': 1}), ('CSNK1D', 'HIF1A', {'sign': -1}), ('CSNK1D', 'ZNF322', {'sign': -1}), ('CSNK1D', 'TP53', {'sign': 1}), ('CSNK1D', 'MAPT', {'sign': -1}), ('CSNK1D', 'YAP1', {'sign': -1}), ('CSNK1D', 'MDM2', {'sign': -1}), ('CSNK1D', 'PER1', {'sign': -1}), ('CSNK1D', 'NCOA3', {'sign': 1}), ('CSNK1D', 'PER3', {'sign': -1}), ('CSNK1D', 'PRH2', {'sign': 1}), ('CSNK1D', 'UHRF1', {'sign': 1}), ('CSNK1D', 'CDK5', {'sign': 1}), ('CSNK1D', 'LEF1', {'sign': -1}), ('CSNK1D', 'GJA1', {'sign': 1}), ('CSNK1D', 'APC', {'sign': 1}), ('CSNK1D', 'YWHAQ', {'sign': 1}), ('ARRB1', 'DVL1', {'sign': 1}), ('ARRB1', 'DVL2', {'sign': 1}), ('ARRB1', 'MDM2', {'sign': 1}), ('ARRB1', 'SMO', {'sign': 1}), ('ARRB1', 'GNAI1', {'sign': -1}), ('ARRB1', 'GNAI2', {'sign': -1}), ('ARRB1', 'GNAI3', {'sign': -1}), ('ARRB1', 'ADRB2', {'sign': -1}), ('ARRB1', 'PDE4D', {'sign': 1}), ('PSMA6', 'XBP1', {'sign': -1}), ('SSRP1_SUPT16H', 'H2AX', {'sign': 1}), ('SSRP1_SUPT16H', 'CSNK2A1', {'sign': 1}), ('EHMT2', 'H3C12', {'sign': -1}), ('EHMT2', 'DNMT3B', {'sign': 1}), ('EHMT2', 'DNMT3A', {'sign': 1}), ('EHMT1', 'H3C12', {'sign': -1}), ('EHMT1', 'CCND1', {'sign': 1}), ('KAT6A', 'H3C12', {'sign': 1}), ('KAT6A', 'RUNX1', {'sign': 1}), ('DNMT3A', 'TDG', {'sign': 1}), ('JARID2', 'EHMT1', {'sign': 1}), ('JARID2', 'GATA4', {'sign': -1}), ('JARID2', 'NKX2-5', {'sign': -1}), ('KDM6A', 'H3C12', {'sign': 1}), ('KDM6A', 'RB1', {'sign': 1}), ('KDM6B', 'H3C12', {'sign': 1}), ('TRDMT1', 'CCPG1', {'sign': -1}), ('UHRF1', 'DNMT1', {'sign': 1}), ('UHRF1', 'TOP2A', {'sign': 1}), ('KAT2A', 'H3C12', {'sign': 1}), ('KAT2A', 'SOCS1', {'sign': 1}), ('KAT2A', 'SMAD3', {'sign': 1}), ('KAT2A', 'SMAD2', {'sign': 1}), ('KAT2A', 'SMAD7', {'sign': 1}), ('MEN1', 'KMT2A', {'sign': 1}), ('MEN1', 'HOXC6', {'sign': 1}), ('MEN1', 'HOXC8', {'sign': 1}), ('MEN1', 'HOXC9', {'sign': 1}), ('MEN1', 'TERT', {'sign': -1}), ('MEN1', 'DBF4', {'sign': -1}), ('MEN1', 'JUND', {'sign': -1}), ('MEN1', 'FANCD2', {'sign': 1}), ('MEN1', 'RELA', {'sign': -1}), ('PHF8', 'H3C12', {'sign': 1}), ('SETD1B', 'H3C12', {'sign': 1}), ('GZMA', 'SET', {'sign': -1}), ('GZMA', 'IL1B', {'sign': 1}), ('GZMA', 'APEX1', {'sign': -1}), ('GZMA', 'HMGB2', {'sign': -1}), ('SET', 'NME1', {'sign': -1}), ('SET', 'PPP2CA', {'sign': -1}), ('GZMB', 'CASP3', {'sign': 1}), ('GZMB', 'TUBA4B', {'sign': 1}), ('GZMB', 'BID', {'sign': 1}), ('GZMB', 'CASP7', 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1}), ('GDF5', 'ACVR2B_BMPR1B', {'sign': 1}), ('GDF5', 'BMPR1B_BMPR2', {'sign': 1}), ('GDF5', 'ACVR2A', {'sign': 1}), ('GDF5', 'BMPR1A', {'sign': 1}), ('GDF5', 'ROR2', {'sign': 1}), ('ACVR2B', 'ACVR1B', {'sign': 1}), ('ACVR2B', 'BMPR1A', {'sign': 1}), ('ACVR2B', 'ACVR1', {'sign': 1}), ('ACVR2B', 'BMPR1B', {'sign': 1}), ('ACVR2B', 'ACVRL1', {'sign': 1}), ('ACVR2B', 'ACVR1C', {'sign': 1}), ('IFNAR2', 'JAK1', {'sign': 1}), ('IFNAR2', 'TYK2', {'sign': 1}), ('IL21R', 'JAK1', {'sign': 1}), ('IL21R', 'JAK3', {'sign': 1}), ('GH1', 'PRLR', {'sign': 1}), ('GH1', 'GHR', {'sign': 1}), ('IFNGR2', 'JAK1', {'sign': 1}), ('IFNGR2', 'JAK2', {'sign': 1}), ('TSLP', 'CRLF2', {'sign': 1}), ('TSLP', 'IL7R', {'sign': 1}), ('CRLF2', 'JAK2', {'sign': 1}), ('IRF9', 'IFNAR2', {'sign': 1}), ('IFNA13', 'IFNAR1', {'sign': 1}), ('IFNA13', 'IFNAR2', {'sign': 1}), ('IFNA13', 'IFNAR1_IFNAR2', {'sign': 1}), ('IL15', 'IL15RA', {'sign': 1}), ('IL15', 'IL2RG', {'sign': 1}), ('IL15', 'IL2RB', {'sign': 1}), ('IL15RA', 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1}), ('EFNA3', 'EPHA2', {'sign': 1}), ('EFNA3', 'EPHA4', {'sign': 1}), ('EFNA3', 'EPHB1', {'sign': 1}), ('EFNA4', 'EPHA6', {'sign': 1}), ('EFNA4', 'EPHA4', {'sign': 1}), ('EFNA4', 'EPHA7', {'sign': 1}), ('EFNA4', 'EPHA8', {'sign': 1}), ('EFNA4', 'EPHA2', {'sign': 1}), ('EFNA4', 'EPHA3', {'sign': 1}), ('EFNA4', 'EPHA5', {'sign': 1}), ('EPHA4', 'NGEF', {'sign': 1}), ('EPHA4', 'ARHGEF15', {'sign': 1}), ('EPHA4', 'FYN', {'sign': 1}), ('EPHA3', 'CRK', {'sign': 1}), ('EPHA3', 'SRC', {'sign': 1}), ('EPHA3', 'FYN', {'sign': 1}), ('EFNB2', 'EPHB4', {'sign': 1}), ('EFNB2', 'EPHB2', {'sign': 1}), ('EFNB2', 'EPHB1', {'sign': 1}), ('EFNB2', 'EPHB3', {'sign': 1}), ('EFNB2', 'EPHA3', {'sign': 1}), ('EFNB2', 'EPHA4', {'sign': 1}), ('NGEF', 'RHOA', {'sign': 1}), ('LTK', 'IRS1', {'sign': 1}), ('LTK', 'PIK3CG', {'sign': 1}), ('LTK', 'CBL', {'sign': 1}), ('LTK', 'SHC1', {'sign': 1}), ('LTK', 'PLCG1', {'sign': 1}), ('LTK', 'RAF1', {'sign': 1}), ('TEK', 'TNIP2', {'sign': 1}), ('TEK', 'DOK2', {'sign': 1}), 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{'sign': 1}), ('FNTB', 'KRAS', {'sign': 1}), ('GRID2IP', 'GRID2', {'sign': 1}), ('GRK4', 'BDKRB2', {'sign': -1}), ('EPN1', 'EGFR', {'sign': -1}), ('RRAGD', 'RPTOR', {'sign': 1}), ('MYCBP2', 'AR', {'sign': -1}), ('MYCBP2', 'MYC', {'sign': -1}), ('CHRM3', 'GNAQ', {'sign': 1}), ('FAM20C', 'FGF23', {'sign': -1}), ('FGF23', 'FGFR1', {'sign': 1}), ('FGF23', 'FGFR3', {'sign': 1}), ('FGF23', 'FGFR4', {'sign': 1}), ('FGF23', 'FGFR2', {'sign': 1}), ('FGF23', 'PHEX', {'sign': -1}), ('MEGF10', 'ABCA1', {'sign': 1}), ('SLN', 'ATP2A1', {'sign': -1}), ('HECTD3', 'TRIOBP', {'sign': -1}), ('ZNF462', 'PBX1', {'sign': -1}), ('UBE2D1', 'TRIM2', {'sign': 1}), ('UBE2D1', 'MGRN1', {'sign': 1}), ('SEMA4D', 'PLXNB1', {'sign': 1}), ('SEMA4D', 'PLXNB2', {'sign': 1}), ('SEMA4D', 'MET', {'sign': 1}), ('TNFRSF25', 'TRADD', {'sign': 1}), ('PRKAR1A', 'PRKACA', {'sign': -1}), ('KLHL8', 'RAPSN', {'sign': -1}), ('STK17A', 'TP53', {'sign': 1}), ('TAF12', 'ATF7', {'sign': 1}), ('ZNF76', 'TBP', {'sign': -1}), ('WNT2B', 'LRP5', {'sign': 1}), ('WNT2B', 'FZD4', {'sign': 1}), ('CRP', 'OLR1', {'sign': 1}), ('FCN3', 'MASP1', {'sign': 1}), ('FCN2', 'MASP1', {'sign': 1}), ('FCN2', 'MASP2', {'sign': 1}), ('PRKG2', 'HSPB1', {'sign': -1}), ('PRKG2', 'HCN2', {'sign': -1}), ('PRKG2', 'PLCB3', {'sign': -1}), ('PRKG2', 'PTS', {'sign': 1}), ('SIM2', 'ARNT', {'sign': 1}), ('LOX', 'EFEMP2', {'sign': 1}), ('CAMK1G', 'EIF4G3', {'sign': 1}), ('PDP2', 'SMAD1', {'sign': -1}), ('PDP2', 'PDHA1', {'sign': 1}), ('TSC22D3', 'NFKB2', {'sign': -1}), ('TSC22D3', 'RELA', {'sign': -1}), ('ZMIZ1', 'NOTCH1', {'sign': 1}), ('ZMIZ1', 'AR', {'sign': 1}), ('RTN4', 'LINGO1', {'sign': 1}), ('RTN4', 'TNFRSF19', {'sign': 1}), ('RTN4', 'RTN4R', {'sign': 1}), ('CNTN6', 'NOTCH1', {'sign': 1}), ('CDR2', 'MYC', {'sign': 1}), ('CBFB', 'RUNX1', {'sign': 1}), ('OTULIN', 'UBC', {'sign': 1}), ('CAPRIN1', 'G3BP1', {'sign': 1}), ('EIF2B2', 'EIF2S1', {'sign': 1}), ('MMP25', 'MMP2', {'sign': 1}), ('HDLBP', 'CTCF', {'sign': 1}), ('NRTN', 'RET', {'sign': 1}), ('NRTN', 'GFRA1', {'sign': 1}), ('NRTN', 'GFRA2', {'sign': 1}), ('MRTFB', 'SRF', {'sign': 1}), ('LRSAM1', 'TSG101', {'sign': -1}), ('SOCS5', 'EGFR', {'sign': -1}), ('FSTL3', 'MSTN', {'sign': -1}), ('FGG', 'VTN', {'sign': -1}), ('FBXW2', 'GCM1', {'sign': -1}), ('USP5', 'UBB', {'sign': 1}), ('USP5', 'UBC', {'sign': 1}), ('AAK1', 'NUMB', {'sign': 1}), ('AAK1', 'AP1M1', {'sign': 1}), ('AAK1', 'AP2M1', {'sign': 1}), ('TPH1', 'HTR7', {'sign': 1}), ('TPH1', 'HTR1A', {'sign': 1}), ('TPH1', 'HTR1F', {'sign': 1}), ('TPH1', 'HTR2C', {'sign': 1}), ('TPH1', 'HTR4', {'sign': 1}), ('TPH1', 'HTR6', {'sign': 1}), ('TPH1', 'HTR1B', {'sign': 1}), ('TPH1', 'HTR2A', {'sign': 1}), ('TPH1', 'HTR2B', {'sign': 1}), ('TPH1', 'HTR5A', {'sign': 1}), ('TPH1', 'HTR1E', {'sign': 1}), ('UBE3C', 'CAND2', {'sign': -1}), ('RNF19A', 'SNCAIP', {'sign': 1}), ('RNF19A', 'CASR', {'sign': -1}), ('BTAF1', 'TBP', {'sign': 1}), ('CDK20', 'CDK2', {'sign': 1}), ('CDK20', 'CILK1', {'sign': 1}), ('POU4F2', 'ESR1', {'sign': 1}), ('MYLIP', 'LDLR', {'sign': -1}), ('UCHL3', 'UBA52', {'sign': 1}), ('UCHL3', 'RPS27A', {'sign': 1}), ('SCAF11', 'PSEN1', {'sign': 1}), ('PSENEN', 'PSEN1', {'sign': 1}), ('FGF12', 'SCN1A', {'sign': -1}), ('FGF12', 'SCN5A', {'sign': -1}), ('GTF2A2', 'TBP', {'sign': 1}), ('POU3F4', 'POU3F3', {'sign': 1}), ('POU3F4', 'POU3F2', {'sign': 1}), ('RABGGTB', 'RAB5A', {'sign': 1}), ('RABGGTB', 'RAB3A', {'sign': 1}), ('S1PR5', 'GNAI1', {'sign': 1}), ('UNC80', 'NALCN', {'sign': 1}), ('RITA1', 'RBPJ', {'sign': -1}), ('PEX26', 'PEX6', {'sign': 1}), ('PEX6', 'PEX1', {'sign': 1}), ('GTF2H1', 'E2F1', {'sign': -1}), ('NSD2', 'AR', {'sign': 1}), ('GUCA2A', 'GUCY2C', {'sign': 1}), ('NSMCE3', 'NSMCE1', {'sign': 1}), ('SERPINA1', 'LRP1', {'sign': 1}), ('ASAP1', 'ARF1', {'sign': -1}), ('FGF13', 'SCN5A', {'sign': -1}), ('FGF13', 'SCN8A', {'sign': -1}), ('PDXP', 'CFL1', {'sign': -1}), ('CDK2AP1', 'CDK2', {'sign': -1}), ('MMP10', 'HAPLN1', {'sign': -1}), ('HTR6', 'GNAQ', {'sign': 1}), ('FBXO38', 'KLF7', {'sign': 1}), ('TSSK4', 'CREB1', {'sign': 1}), ('DOCK8', 'CDC42', {'sign': 1}), ('TRIM32', 'DTNBP1', {'sign': -1}), ('LARP4B', 'PABPC1', {'sign': 1}), ('RNF180', 'ZIC2', {'sign': -1}), ('G3BP2', 'NFKBIA', {'sign': -1}), ('IST1', 'SPAST', {'sign': 1}), ('DPP3', 'KEAP1', {'sign': -1}), ('ASB2', 'FLNA', {'sign': -1}), ('CD55', 'ADGRE5', {'sign': 1}), ('NTN4', 'UNC5A', {'sign': 1}), ('NTN4', 'DCC', {'sign': 1}), ('SRGAP3', 'WASF1', {'sign': 1}), ('SEPTIN4', 'XIAP', {'sign': -1}), ('MTCH2', 'BID', {'sign': 1}), ('POU2AF1', 'POU2F2', {'sign': 1}), ('POU2AF1', 'POU2F1', {'sign': 1}), ('RPGRIP1', 'RPGR', {'sign': -1}), ('PELI3', 'IRAK1', {'sign': 1}), ('SPATA13', 'CDC42', {'sign': 1}), ('PEX3', 'PEX19', {'sign': 1}), ('PTX3', 'CFH', {'sign': 1}), ('VAC14', 'FIG4', {'sign': 1}), ('RWDD3', 'HIF1A', {'sign': 1}), ('ICAM3', 'ITGB2', {'sign': 1}), ('SRSF3', 'NXF1', {'sign': 1}), ('AP2M1', 'EGFR', {'sign': -1}), ('PPP2R1A', 'PPP2CA', {'sign': 1}), ('PPP2R1A', 'SGO1', {'sign': 1}), ('PPP2R1A', 'PPP2CB', {'sign': 1}), ('USP24', 'DDB2', {'sign': 1}), ('CEBPE', 'CEBPG', {'sign': 1}), ('VEGFD', 'KDR', {'sign': 1}), ('VEGFD', 'FLT4', {'sign': 1}), ('VEGFD', 'NRP2', {'sign': 1}), ('KHK', 'PRPS1', {'sign': 1}), ('CDH8', 'CTNNB1', {'sign': 1}), ('CDH5', 'CTNNB1', {'sign': 1}), ('DACT1', 'DVL2', {'sign': -1}), ('CCN2', 'LRP6', {'sign': 1}), ('CCN2', 'ITGAM', {'sign': 1}), ('CCN2', 'ITGB2', {'sign': 1}), ('SEMA3B', 'NRP1', {'sign': 1}), ('SEMA3B', 'NRP2', {'sign': 1}), ('TNFSF4', 'TNFRSF4', {'sign': 1}), ('TOPORS', 'TP53', {'sign': -1}), ('SH3BP4', 'TFRC', {'sign': -1}), ('ADA', 'ADORA1', {'sign': 1}), ('TRIP12', 'CDKN2A', {'sign': -1}), ('WLS', 'WNT3A', {'sign': 1}), ('CHAMP1', 'MAD2L2', {'sign': 1}), ('SND1', 'STAT6', {'sign': 1}), ('PSMA5', 'XBP1', {'sign': -1}), ('ZIC3', 'GLI3', {'sign': 1}), ('PLAU', 'PLAUR', {'sign': 1}), ('PLAU', 'LRP1', {'sign': 1}), ('KCNIP4', 'KCND2', {'sign': 1}), ('CCNY', 'CDK14', {'sign': 1}), ('CDK14', 'LRP6', {'sign': 1}), ('UBQLN2', 'HNRNPU', {'sign': 1}), ('UBQLN2', 'HNRNPA1', {'sign': 1}), ('RNF182', 'ATP6V0C', {'sign': -1}), ('TNFRSF13C', 'TRAF3', {'sign': -1}), ('TRH', 'TRHR', {'sign': 1}), ('TMED10', 'PSEN1', {'sign': 1}), ('CDH9', 'CTNNB1', {'sign': 1}), ('NCAM1', 'FGFR1', {'sign': 1}), ('NCAM1', 'ROBO1', {'sign': 1}), ('NCAM1', 'ROBO3', {'sign': 1}), ('EPGN', 'EGFR', {'sign': 1}), ('EPGN', 'ERBB4', {'sign': 1}), ('EAF2', 'ELL', {'sign': 1}), ('SAFB', 'FUS', {'sign': 1}), ('EAF1', 'ELL', {'sign': 1}), ('MMP13', 'COL2A1', {'sign': -1}), ('MMP13', 'F12', {'sign': -1}), ('MMP13', 'LRP1', {'sign': 1}), ('MAP3K6', 'MAP3K5', {'sign': 1}), ('TET3', 'OGT', {'sign': 1}), ('MEX3B', 'SNUPN', {'sign': -1}), ('FBXL15', 'SMURF1', {'sign': -1}), ('TRIM27', 'PIK3C2B', {'sign': -1}), ('TTBK2', 'KIF2A', {'sign': -1}), ('BAG3', 'HSPA8', {'sign': 1}), ('SRP19', 'SRP54', {'sign': 1}), ('PSPN', 'GFRA4', {'sign': 1}), ('PSPN', 'RET', {'sign': 1}), ('RGMA', 'NEO1', {'sign': -1}), ('KPNA1', 'KPNB1', {'sign': 1}), ('CTTNBP2', 'CTTN', {'sign': 1}), ('PAWR', 'WT1', {'sign': -1}), ('CCNF', 'CCP110', {'sign': -1}), ('NDFIP1', 'NEDD4', {'sign': 1}), ('PHF21A', 'KDM1A', {'sign': -1}), ('EIF4H', 'EIF4A1', {'sign': 1}), ('RPL10', 'YES1', {'sign': -1}), ('SETBP1', 'SET', {'sign': 1}), ('ZNF521', 'EBF1', {'sign': -1}), ('MNAT1', 'ESR1', {'sign': 1}), ('NGLY1', 'RAD23B', {'sign': 1}), ('PHACTR1', 'PPP1CA', {'sign': 1}), ('GPI', 'AMFR', {'sign': 1}), ('PATZ1', 'RNF4', {'sign': -1}), ('HPN', 'F7', {'sign': 1}), ('SRSF7', 'NXF1', {'sign': 1}), ('SS18L1', 'CREBBP', {'sign': 1}), ('ITGAL_ITGB2', 'ICAM1', {'sign': 1}), ('CDKL5', 'AMPH', {'sign': -1}), ('PCSK2', 'IAPP', {'sign': 1}), ('DLK2', 'NOTCH1', {'sign': -1}), ('CTTNBP2NL', 'STRN', {'sign': 1}), ('HSPG2', 'PTPRS', {'sign': 1}), ('HSPG2', 'ITGA2', {'sign': 1}), ('COL5A1', 'SDC3', {'sign': 1}), ('PAX1', 'MEOX1', {'sign': 1}), ('PAX1', 'MEOX2', {'sign': 1}), ('TPSAB1', 'F2RL1', {'sign': 1}), ('PEX12', 'PEX5', {'sign': 1}), ('PEX2', 'PEX5', {'sign': -1}), ('THBS2', 'CD47', {'sign': 1}), ('THBS2', 'ITGA4', {'sign': 1}), ('THBS2', 'ITGB1', {'sign': 1}), ('THBS2', 'ITGA6', {'sign': 1}), ('CLCC1', 'PIGBOS1', {'sign': 1}), ('CD274', 'PDCD1', {'sign': 1}), ('VRK3', 'BANF1', {'sign': -1}), ('DHPS', 'EIF5A', {'sign': 1}), ('AKAP9', 'TRIP10', {'sign': 1}), ('MLF1', 'COPS3', {'sign': 1}), ('VPS4A', 'CHMP2A', {'sign': 1}), ('RAMAC', 'RNMT', {'sign': 1}), ('STON2', 'SYT1', {'sign': 1}), ('OMG', 'LINGO1', {'sign': 1}), ('OMG', 'TNFRSF1B', {'sign': 1}), ('TTF2', 'CDC5L', {'sign': 1}), ('CDC5L', 'HNRNPM', {'sign': 1}), ('NEK1', 'VDAC1', {'sign': -1}), ('CTNNA3', 'CTNNB1', {'sign': 1}), ('CDH7', 'CTNNB1', {'sign': 1}), ('KANK1', 'BAIAP2', {'sign': -1}), ('UBASH3B', 'CBL', {'sign': -1}), ('LMO2', 'TAL1', {'sign': 1}), ('GUCA2B', 'GUCY2C', {'sign': 1}), ('DLGAP2', 'DLG4', {'sign': 1}), ('KRT14', 'TRADD', {'sign': -1}), ('TFPI', 'VLDLR', {'sign': 1}), ('TFPI', 'LRP1', {'sign': 1}), ('PKP2', 'DSP', {'sign': 1}), ('TMOD1', 'TPM3', {'sign': -1}), ('SEPTIN12', 'SEPTIN6', {'sign': -1}), ('MRAP', 'MC2R', {'sign': 1}), ('SMAD3_SMAD4', 'FOS_JUN', {'sign': 1}), ('IRF2BP2', 'IRF2', {'sign': 1}), ('IRF2BP1', 'IRF2', {'sign': 1}), ('ITGAD_ITGB2', 'VCAM1', {'sign': 1}), ('VCAM1', 'ITGA4_ITGB1', {'sign': 1}), ('VCAM1', 'ITGA4', {'sign': 1}), ('VCAM1', 'ITGB1', {'sign': 1}), ('VCAM1', 'ITGB2', {'sign': 1}), ('VCAM1', 'ITGAD', {'sign': 1}), ('LNX1', 'NUMB', {'sign': -1}), ('ADAM12', 'SDC4', {'sign': 1}), ('ADAM12', 'ITGB1', {'sign': 1}), ('ADAM12', 'ITGA9', {'sign': 1}), ('INHA', 'TGFBR3', {'sign': -1}), ('INHA', 'ACVR2B', {'sign': 1}), ('INHA', 'ACVR2A', {'sign': 1}), ('PCGF2', 'HSF2', {'sign': -1}), ('ADAMTS13', 'VWF', {'sign': -1}), ('RNF19B', 'UCKL1', {'sign': -1}), ('UBE2L3', 'RNF19B', {'sign': 1}), ('PCSK1', 'IAPP', {'sign': 1}), ('PAK5', 'BAD', {'sign': -1}), ('SIL1', 'HSPA5', {'sign': 1}), ('POGZ', 'CBX5', {'sign': -1}), ('HOXD11', 'MEIS1', {'sign': 1}), ('STOM', 'SLC2A1', {'sign': -1}), ('ARPC2', 'ACTB', {'sign': 1}), ('PTPRO', 'PXN', {'sign': -1}), ('BMP5', 'ACVR1_ACVR2A', {'sign': 1}), ('BMP5', 'ACVR1_ACVR2B', {'sign': 1}), ('BMP5', 'ACVR1_BMPR2', {'sign': 1}), ('BMP5', 'ACVR2A_BMPR1A', {'sign': 1}), ('BMP5', 'ACVR2B_BMPR1A', {'sign': 1}), ('BMP5', 'BMPR1A_BMPR2', {'sign': 1}), ('BMP5', 'ACVR2A_BMPR1B', {'sign': 1}), ('BMP5', 'ACVR2B_BMPR1B', {'sign': 1}), ('BMP5', 'BMPR1B_BMPR2', {'sign': 1}), ('BMP5', 'BMPR1A', {'sign': 1}), ('BMP8A', 'ACVR1_ACVR2A', {'sign': 1}), ('BMP8A', 'ACVR1_ACVR2B', {'sign': 1}), ('BMP8A', 'ACVR1_BMPR2', {'sign': 1}), ('BMP8A', 'ACVR2A_BMPR1A', {'sign': 1}), ('BMP8A', 'ACVR2B_BMPR1A', {'sign': 1}), ('BMP8A', 'BMPR1A_BMPR2', {'sign': 1}), ('BMP8A', 'ACVR2A_BMPR1B', {'sign': 1}), ('BMP8A', 'ACVR2B_BMPR1B', {'sign': 1}), ('BMP8A', 'BMPR1B_BMPR2', {'sign': 1}), ('CCL18', 'CCR3', {'sign': -1}), ('CCL18', 'CCR8', {'sign': 1}), ('CCL18', 'CCR1', {'sign': -1}), ('CCL28', 'CCR10', {'sign': 1}), ('CCL28', 'CCR3', {'sign': 1}), ('CCL28', 'ACKR2', {'sign': 1}), ('CD48', 'CD244', {'sign': 1}), ('CD58', 'CD2', {'sign': 1}), ('FGF16', 'FGFR1', {'sign': 1}), ('FGF16', 'FGFR2', {'sign': 1}), ('FGF16', 'FGFR3', {'sign': 1}), ('FGF16', 'FGFR4', {'sign': 1}), ('FGF20', 'FGFR1', {'sign': 1}), ('FGF20', 'FGFR2', {'sign': 1}), ('FGF20', 'FGFR3', {'sign': 1}), ('FGF20', 'FGFR4', {'sign': 1}), ('FGF21', 'FGFR1', {'sign': 1}), ('FGF21', 'FGFR3', {'sign': 1}), ('FGF21', 'FGFR4', {'sign': 1}), ('FGF21', 'FGFR2', {'sign': 1}), ('GDF7', 'ACVR2A_BMPR1A', {'sign': 1}), ('GDF7', 'ACVR2B_BMPR1A', {'sign': 1}), ('GDF7', 'BMPR1A_BMPR2', {'sign': 1}), ('GDF7', 'ACVR2A_BMPR1B', {'sign': 1}), ('GDF7', 'ACVR2B_BMPR1B', {'sign': 1}), ('GDF7', 'BMPR1B_BMPR2', {'sign': 1}), ('GDF7', 'BMPR2', {'sign': 1}), ('GDF7', 'BMPR1A', {'sign': 1}), ('GDF7', 'ACVR2A', {'sign': 1}), ('GH2', 'GHR', {'sign': 1}), ('HLA-A', 'KIR3DL2', {'sign': 1}), ('HLA-A', 'KIR3DL1', {'sign': 1}), ('HLA-A', 'KLRD1', {'sign': 1}), ('HLA-B', 'KIR3DL1', {'sign': 1}), ('HLA-B', 'KIR3DL2', {'sign': 1}), ('HLA-B', 'KIR2DL3', {'sign': 1}), ('HLA-B', 'KLRD1', {'sign': 1}), ('HLA-C', 'KIR2DL1', {'sign': 1}), ('HLA-C', 'KIR2DL2', {'sign': 1}), ('HLA-C', 'KIR2DL3', {'sign': 1}), ('HLA-C', 'KIR2DS1', {'sign': 1}), ('HLA-C', 'KIR2DS4', {'sign': 1}), ('HLA-C', 'KIR2DS2', {'sign': 1}), ('IL25', 'IL17RB', {'sign': 1}), ('IL36RN', 'IL1RL2', {'sign': -1}), ('MICB', 'KLRK1', {'sign': 1}), ('NCR3LG1', 'NCR3', {'sign': 1}), ('NECTIN3', 'TIGIT', {'sign': 1}), ('PDCD1LG2', 'PDCD1', {'sign': 1}), ('PF4', 'CXCR3', {'sign': 1}), ('PF4', 'FGFR2', {'sign': 1}), ('PF4', 'LDLR', {'sign': 1}), ('PF4', 'THBD', {'sign': 1}), ('PF4', 'PROCR', {'sign': 1}), ('PF4V1', 'CXCR3', {'sign': 1}), ('PGF', 'FLT1', {'sign': 1}), ('PGF', 'NRP1', {'sign': 1}), ('TNFSF12', 'TNFRSF12A', {'sign': 1}), ('TNFSF18', 'TNFRSF18', {'sign': 1}), ('TNFSF8', 'TNFRSF8', {'sign': 1}), ('MADCAM1', 'ITGA4', {'sign': 1}), ('MADCAM1', 'ITGB7', {'sign': 1}), ('DKK4', 'LRP6', {'sign': -1}), ('DKK4', 'LRP5', {'sign': -1}), ('EBI3', 'IL27RA', {'sign': 1}), ('EBI3', 'IL6ST', {'sign': 1}), ('ICAM5', 'ITGAL', {'sign': 1}), ('ICAM5', 'ITGB2', {'sign': 1}), ('COMP', 'ITGB3', {'sign': 1}), ('LAMB1', 'ITGB1', {'sign': 1}), ('LAMB1', 'ITGA6', {'sign': 1}), ('LAMB1', 'ITGB4', {'sign': 1}), ('LAMB1', 'CD151', {'sign': 1}), ('ULBP1', 'KLRK1', {'sign': 1}), ('HRG', 'ERBB3', {'sign': 1}), ('IFNA7', 'IFNAR2', {'sign': 1}), ('IFNA7', 'IFNAR1', {'sign': 1}), ('IL17C', 'IL17RE', {'sign': 1}), ('LAMA5', 'ITGA6', {'sign': 1}), ('LAMA5', 'ITGB4', {'sign': 1}), ('LAMA5', 'CD151', {'sign': 1}), ('LAMC1', 'ITGA6', {'sign': 1}), ('LAMC1', 'ITGB4', {'sign': 1}), ('IL36A', 'IL1RL2', {'sign': 1}), ('LAMC2', 'ITGA6', {'sign': 1}), ('LAMC2', 'ITGB1', {'sign': 1}), ('LAMC2', 'ITGA3', {'sign': 1}), ('LAMC2', 'ITGB4', {'sign': 1}), ('NID1', 'PTPRF', {'sign': 1}), ('ADAM2', 'ITGB1', {'sign': 1}), ('ADAM2', 'ITGA6', {'sign': 1}), ('INHBE', 'ACVR2B', {'sign': 1}), ('INHBE', 'ACVR2A', {'sign': 1}), ('HDC', 'HRH1', {'sign': 1}), ('HDC', 'HRH2', {'sign': 1}), ('HDC', 'HRH3', {'sign': 1}), ('HDC', 'HRH4', {'sign': 1}), ('INHBB', 'ACVR2B', {'sign': 1}), ('INHBB', 'ACVR1B', {'sign': 1}), ('INHBB', 'ACVR2A', {'sign': 1}), ('INHBB', 'ACVR1C', {'sign': 1}), ('INHBB', 'ACVR1', {'sign': 1}), ('PCSK9', 'LDLR', {'sign': -1}), ('SEMA3E', 'PLXND1', {'sign': 1}), ('INHBC', 'ACVR2B', {'sign': 1}), ('INHBC', 'ACVR2A', {'sign': 1}), ('INHBC', 'ACVR1', {'sign': 1}), ('INHBC', 'ACVR1B', {'sign': 1}), ('CSH1', 'PRLR', {'sign': 1}), ('SEMA6D', 'PLXNA1', {'sign': 1}), ('SEMA6D', 'KDR', {'sign': 1}), ('SLIT3', 'ROBO2', {'sign': 1}), ('SLIT3', 'ROBO1', {'sign': 1}), ('CXCL14', 'CXCR4', {'sign': 1}), ('ICAM4', 'ITGAM', {'sign': 1}), ('ICAM4', 'ITGAL', {'sign': 1}), ('ICAM4', 'ITGB3', {'sign': 1}), ('ICAM4', 'ITGAV', {'sign': 1}), ('ICAM4', 'ITGA2B', {'sign': 1}), ('ICAM4', 'ITGB2', {'sign': 1}), ('GDF9', 'BMPR1B', {'sign': 1}), ('GDF9', 'ACVR2A', {'sign': 1}), ('GDF9', 'BMPR1A', {'sign': 1}), ('GDF9', 'BMPR2', {'sign': 1}), ('GDF9', 'TGFBR1', {'sign': 1}), ('ZG16B', 'CXCR4', {'sign': 1}), ('LAMA1', 'ITGA7', {'sign': 1}), ('LAMA1', 'ITGB8', {'sign': 1}), ('LAMA1', 'ITGA2', {'sign': 1}), ('LAMA1', 'RPSA', {'sign': 1}), ('LAMB3', 'ITGA6', {'sign': 1}), ('LAMB3', 'ITGB4', {'sign': 1}), ('CCN1', 'ITGAM', {'sign': 1}), ('CCN1', 'ITGB3', {'sign': 1}), ('CCN1', 'ITGA5', {'sign': 1}), ('CCN1', 'ITGB2', {'sign': 1}), ('LAMA2', 'ITGA7', {'sign': 1}), ('LAMA2', 'ITGB4', {'sign': 1}), ('LAMA2', 'RPSA', {'sign': 1}), ('LAMA2', 'ITGB1', {'sign': 1}), ('LAMA2', 'ITGA6', {'sign': 1}), ('LAMA2', 'DAG1', {'sign': 1}), ('LAMA3', 'ITGB4', {'sign': 1}), ('LAMB2', 'ITGB4', {'sign': 1}), ('LAMB2', 'RPSA', {'sign': 1}), ('RAET1L', 'KLRK1', {'sign': 1}), ('ULBP3', 'KLRK1', {'sign': 1}), ('RAET1E', 'KLRK1', {'sign': 1}), ('RAET1G', 'KLRK1', {'sign': 1}), ('SERPINE2', 'LRP1', {'sign': 1}), ('LRPAP1', 'LRP1', {'sign': 1}), ('LRPAP1', 'VLDLR', {'sign': -1}), ('RNASE2', 'TLR2', {'sign': 1}), ('SOST', 'LRP6', {'sign': 1}), ('SOST', 'LRP5', {'sign': 1}), ('CD24', 'SELP', {'sign': 1}), ('IFNA16', 'IFNAR1', {'sign': 1}), ('IFNA16', 'IFNAR2', {'sign': 1}), ('IFNA14', 'IFNAR1', {'sign': 1}), ('IFNA14', 'IFNAR2', {'sign': 1}), ('IFNA4', 'IFNAR1', {'sign': 1}), ('IFNA4', 'IFNAR2', {'sign': 1}), ('IFNA5', 'IFNAR1', {'sign': 1}), ('IFNA5', 'IFNAR2', {'sign': 1}), ('IFNA6', 'IFNAR1', {'sign': 1}), ('IFNA6', 'IFNAR2', {'sign': 1}), ('IFNA10', 'IFNAR1', {'sign': 1}), ('IFNA10', 'IFNAR2', {'sign': 1}), ('IFNA8', 'IFNAR1', {'sign': 1}), ('IFNA8', 'IFNAR2', {'sign': 1}), ('IFNE', 'IFNAR1', {'sign': 1}), ('IFNE', 'IFNAR2', {'sign': 1}), ('IFNA21', 'IFNAR1', {'sign': 1}), ('IFNA21', 'IFNAR2', {'sign': 1}), ('IFNA2', 'IFNAR1', {'sign': 1}), ('IFNA2', 'IFNAR2', {'sign': 1}), ('IL17F', 'IL17RC', {'sign': 1}), ('IL17F', 'IL17RA', {'sign': 1}), ('CHAD', 'ITGA2', {'sign': 1}), ('CHAD', 'ITGB1', {'sign': 1}), ('TAC4', 'TACR1', {'sign': 1}), ('LEFTY2', 'ACVR2B', {'sign': 1}), ('ICAM2', 'ITGAL', {'sign': 1}), ('ICAM2', 'ITGB2', {'sign': 1}), ('CD59', 'CD2', {'sign': -1}), ('CXCL17', 'GPR35', {'sign': 1}), ('NAMPT', 'INSR', {'sign': 1}), ('ENHO', 'GPR19', {'sign': 1}), ('BAG6', 'NCR3', {'sign': 1}), ('HLA-F', 'KIR3DL1', {'sign': 1}), ('HLA-F', 'KIR3DL2', {'sign': 1}), ('HLA-E', 'KLRC1', {'sign': 1}), ('HLA-E', 'KLRC2', {'sign': 1}), ('HLA-E', 'KLRD1', {'sign': 1}), ('ADAM23', 'ITGA5', {'sign': 1}), ('ADAM23', 'ITGB3', {'sign': 1}), ('COL5A3', 'SDC3', {'sign': 1}), ('LEAP2', 'GHSR', {'sign': -1}), ('NXPH3', 'NRXN1', {'sign': 1}), ('NXPH3', 'NRXN2', {'sign': 1}), ('NXPH3', 'NRXN3', {'sign': 1}), ('PODXL2', 'SELL', {'sign': 1}), ('PRND', 'RPSA', {'sign': 1}), ('PTDSS1', 'JMJD6', {'sign': 1}), ('PTDSS1', 'SCARB1', {'sign': 1}), ('SERPING1', 'LRP1', {'sign': 1}), ('TFF2', 'CXCR4', {'sign': 1}), ('GPR15LG', 'GPR15', {'sign': 1}), ('DUSP18', 'CD151', {'sign': 1}), ('CDK19', 'EIF3F', {'sign': 1}), ('PTP4A1', 'ATF7', {'sign': -1}), ('PTPRU', 'CTNNB1', {'sign': -1}), ('PTPRM', 'CTNND1', {'sign': 1}), ('HIPK4', 'TP53', {'sign': 1}), ('FRK', 'PTEN', {'sign': -1}), ('MYT1', 'CDK1', {'sign': -1}), ('ENPEP', 'CCK', {'sign': -1}), ('ADAMTS1', 'VCAN', {'sign': 1}), ('MMP26', 'MMP9', {'sign': 1}), ('FCGR3A', 'LCK', {'sign': 1}), ('TASP1', 'GTF2A1', {'sign': 1}), ('NAA10', 'HIF1A', {'sign': 1}), ('ECE1', 'EDN1', {'sign': 1}), ('CSNK1G3', 'TP53', {'sign': 1}), ('CSNK1G3', 'YWHAQ', {'sign': 1})])" + ] + }, + "execution_count": 18, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "graph.edges(data=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 19, "metadata": {}, "outputs": [ { @@ -5103,429 +1287,653 @@ "\n", "\n", - "\n", "\n", - "\n", - "\n", - "\n", + "\n", + "\n", + "\n", "\n", "\n", "EGFR\n", - "\n", + "\n", "\n", - "\n", + "\n", "\n", - "PTPN1\n", - "\n", + "MAP2K1\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->PTPN1\n", - "\n", - "\n", + "EGFR->MAP2K1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "MAP2K1\n", - "\n", + "ESR1\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->MAP2K1\n", - "\n", - "\n", + "EGFR->ESR1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", + "PTPN1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTPN1\n", + "\n", + "\n", + "\n", + "\n", + "\n", "VAV2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->VAV2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PIK3R1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PIK3R1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CALM2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->CALM2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CALM1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->CALM1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CALM3\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->CALM3\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PTK2\n", - "\n", + "\n", "\n", "\n", - "\n", - "EGFR->PTK2\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "STAT3\n", - "\n", - "\n", - "\n", "\n", - "EGFR->STAT3\n", - "\n", - "\n", + "EGFR->PTK2\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "PCNA\n", - "\n", + "E2F1\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->PCNA\n", - "\n", - "\n", + "EGFR->E2F1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "ERBB2\n", - "\n", + "PRKDC\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->ERBB2\n", - "\n", - "\n", + "EGFR->PRKDC\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "BCAR1\n", - "\n", + "PCNA\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->BCAR1\n", - "\n", - "\n", + "EGFR->PCNA\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "ESR1\n", - "\n", + "ERBB2\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->ESR1\n", - "\n", - "\n", + "EGFR->ERBB2\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "ABL1\n", - "\n", + "BCAR1\n", + "\n", "\n", - "\n", + "\n", "\n", - "PTPN1->ABL1\n", - "\n", - "\n", + "EGFR->BCAR1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "MAPK3\n", - "\n", + "SHC1\n", + "\n", "\n", - "\n", + "\n", "\n", - "MAP2K1->MAPK3\n", - "\n", - "\n", + "EGFR->SHC1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "MAPK1\n", - "\n", + "CTNNB1\n", + "\n", "\n", - "\n", + "\n", "\n", - "MAP2K1->MAPK1\n", - "\n", - "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "RAC1\n", - "\n", + "CCND1\n", + "\n", "\n", - "\n", + "\n", "\n", + "EGFR->CCND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PKIA\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PKIA\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3\n", + "\n", + "\n", + "\n", + "\n", + "MAP2K1->MAPK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK1\n", + "\n", + "\n", + "\n", + "\n", + "MAP2K1->MAPK1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RARA\n", + "\n", + "\n", + "\n", + "\n", + "ESR1->RARA\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "ABL1\n", + "\n", + "\n", + "\n", + "\n", + "PTPN1->ABL1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKCD\n", + "\n", + "\n", + "\n", + "\n", + "PTPN1->PRKCD\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CAPN1\n", + "\n", + "\n", + "\n", + "\n", + "PTPN1->CAPN1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAC1\n", + "\n", + "\n", + "\n", + "\n", "VAV2->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDC42\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "VAV2->CDC42\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PIK3R1->RAC1\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "AKT1\n", + "\n", + "\n", + "\n", + "\n", + "PIK3R1->AKT1\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CALM2->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CALM1->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CALM3->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PTK2->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "EGR1\n", - "\n", + "\n", + "\n", + "TP53\n", + "\n", "\n", - "\n", - "\n", - "STAT3->EGR1\n", - "\n", - "\n", + "\n", + "\n", + "E2F1->TP53\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKDC->AKT1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKDC->TP53\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "EP300\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "PCNA->EP300\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDK1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "ERBB2->CDK1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "SMAD3\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "BCAR1->SMAD3\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "RARA\n", - "\n", + "\n", + "\n", + "FOXO3\n", + "\n", "\n", - "\n", - "\n", - "ESR1->RARA\n", - "\n", - "\n", + "\n", + "\n", + "SHC1->FOXO3\n", + "\n", + "\n", "\n", - "\n", - "\n", - "HIPK2\n", - "\n", + "\n", + "\n", + "CTNNB1->FOXO3\n", + "\n", + "\n", "\n", - "\n", - "\n", - "ABL1->HIPK2\n", - "\n", - "\n", + "\n", + "\n", + "CDK4\n", + "\n", + "\n", + "\n", + "\n", + "CCND1->CDK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK6\n", + "\n", + "\n", + "\n", + "\n", + "CCND1->CDK6\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKACA\n", + "\n", + "\n", + "\n", + "\n", + "PKIA->PRKACA\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAZ\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK3->MAZ\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "RUNX2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK3->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "NCOA6\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK1->NCOA6\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "THRA\n", + "\n", + "\n", + "\n", + "\n", + "RARA->THRA\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "HIPK2\n", + "\n", + "\n", + "\n", + "\n", + "ABL1->HIPK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "GSK3A\n", + "\n", + "\n", + "\n", + "\n", + "PRKCD->GSK3A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CAPN1->GSK3A\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K10\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "RAC1->MAP3K10\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDC42->MAP3K10\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "ID3\n", - "\n", + "\n", + "\n", + "AKT1->GSK3A\n", + "\n", + "\n", "\n", - "\n", - "\n", - "EGR1->ID3\n", - "\n", - "\n", + "\n", + "\n", + "NFYB\n", + "\n", + "\n", + "\n", + "\n", + "TP53->NFYB\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "EP300->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDK1->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "SMAD3->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "THRA\n", - "\n", + "\n", + "\n", + "RBL2\n", + "\n", "\n", - "\n", - "\n", - "RARA->THRA\n", - "\n", - "\n", + "\n", + "\n", + "FOXO3->RBL2\n", + "\n", + "\n", "\n", - "\n", - "\n", - "NEUROD1\n", - "\n", + "\n", + "\n", + "CDK4->RBL2\n", + "\n", + "\n", "\n", - "\n", - "\n", - "MAP3K10->NEUROD1\n", - "\n", - "\n", + "\n", + "\n", + "CDK6->RBL2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKACA->GSK3A\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "RARB\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "THRA->RARB\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCL3\n", + "\n", + "\n", + "\n", + "\n", + "GSK3A->BCL3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NEUROD1\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K10->NEUROD1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "E2F5\n", + "\n", + "\n", + "\n", + "\n", + "RBL2->E2F5\n", + "\n", + "\n", "\n", "\n", "\n" ], "text/plain": [ - ">" + ">" ] }, "metadata": {}, @@ -5533,31 +1941,51 @@ } ], "source": [ - "a = nc.visualize_graph_simple(shortest_path_network, sources, measurements, is_sign_consistent=False)\n", + "a = nc.visual.visualize_graph_simple(shortest_path_network, sources, measurements, is_sign_consistent=False)\n", "style = \"\"\n", "display(HTML(style))\n", "display(a)" ] }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "We can use the signs of the network to add an additional layer of constrain to the problem by removing the paths which are not coherent in terms of sign. The algorithm computes an overall sign of the path by multiplying the signs of the edges contained in said path, and then evaluates whether perturbation_sign * path_sign = measurement_sign. If it does not, the path is discarded." - ] - }, { "cell_type": "code", - "execution_count": 17, + "execution_count": 20, "metadata": {}, - "outputs": [], - "source": [ - "shortest_sc_network, shortest_sc_list = nc.run_sign_consistency(shortest_path_network, shortest_paths_list, sources, measurements)" - ] + "outputs": [ + { + "data": { + "text/plain": [ + "OutEdgeDataView([('EGFR', 'MAP2K1', {'sign': 1}), ('EGFR', 'ESR1', {'sign': 1}), ('EGFR', 'PTPN1', {'sign': 1}), ('EGFR', 'VAV2', {'sign': 1}), ('EGFR', 'PIK3R1', {'sign': 1}), ('EGFR', 'CALM2', {'sign': -1}), ('EGFR', 'CALM1', {'sign': -1}), ('EGFR', 'CALM3', {'sign': -1}), ('EGFR', 'PTK2', {'sign': 1}), ('EGFR', 'E2F1', {'sign': 1}), ('EGFR', 'PRKDC', {'sign': 1}), ('EGFR', 'PCNA', {'sign': 1}), ('EGFR', 'ERBB2', {'sign': 1}), ('EGFR', 'BCAR1', {'sign': -1}), ('EGFR', 'SHC1', {'sign': 1}), ('EGFR', 'CTNNB1', {'sign': 1}), ('EGFR', 'CCND1', {'sign': 1}), ('EGFR', 'PKIA', {'sign': 1}), ('MAP2K1', 'MAPK3', {'sign': 1}), ('MAP2K1', 'MAPK1', {'sign': 1}), ('MAPK3', 'MAZ', {'sign': 1}), ('MAPK3', 'RUNX2', {'sign': 1}), ('ESR1', 'RARA', {'sign': 1}), ('RARA', 'THRA', {'sign': 1}), ('THRA', 'RARB', {'sign': 1}), ('PTPN1', 'ABL1', {'sign': -1}), ('PTPN1', 'PRKCD', {'sign': -1}), ('PTPN1', 'CAPN1', {'sign': -1}), ('ABL1', 'HIPK2', {'sign': 1}), ('VAV2', 'RAC1', {'sign': 1}), ('VAV2', 'CDC42', {'sign': 1}), ('RAC1', 'MAP3K10', {'sign': 1}), ('MAP3K10', 'NEUROD1', {'sign': 1}), ('PIK3R1', 'RAC1', {'sign': 1}), ('PIK3R1', 'AKT1', {'sign': 1}), ('CALM2', 'RAC1', {'sign': 1}), ('CALM1', 'RAC1', {'sign': 1}), ('CALM3', 'RAC1', {'sign': 1}), ('PTK2', 'RAC1', {'sign': 1}), ('CDC42', 'MAP3K10', {'sign': 1}), ('E2F1', 'TP53', {'sign': 1}), ('TP53', 'NFYB', {'sign': -1}), ('PRKDC', 'TP53', {'sign': 1}), ('PRKDC', 'AKT1', {'sign': 1}), ('PCNA', 'EP300', {'sign': -1}), ('EP300', 'RUNX2', {'sign': 1}), ('ERBB2', 'CDK1', {'sign': -1}), ('CDK1', 'RUNX2', {'sign': 1}), ('BCAR1', 'SMAD3', {'sign': -1}), ('SMAD3', 'RUNX2', {'sign': -1}), ('SHC1', 'FOXO3', {'sign': -1}), ('FOXO3', 'RBL2', {'sign': 1}), ('RBL2', 'E2F5', {'sign': 1}), ('CTNNB1', 'FOXO3', {'sign': 1}), ('CCND1', 'CDK4', {'sign': 1}), ('CCND1', 'CDK6', {'sign': 1}), ('CDK4', 'RBL2', {'sign': -1}), ('CDK6', 'RBL2', {'sign': -1}), ('MAPK1', 'NCOA6', {'sign': 1}), ('AKT1', 'GSK3A', {'sign': -1}), ('GSK3A', 'BCL3', {'sign': -1}), ('PRKCD', 'GSK3A', {'sign': -1}), ('CAPN1', 'GSK3A', {'sign': 1}), ('PKIA', 'PRKACA', {'sign': -1}), ('PRKACA', 'GSK3A', {'sign': -1})])" + ] + }, + "execution_count": 20, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "shortest_path_network.edges(data=True)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "We can use the signs of the network to add an additional layer of constrain to the problem by removing the paths which are not coherent in terms of sign. The algorithm computes an overall sign of the path by multiplying the signs of the edges contained in said path, and then evaluates whether perturbation_sign * path_sign = measurement_sign. If it does not, the path is discarded." + ] }, { "cell_type": "code", - "execution_count": 18, + "execution_count": 21, + "metadata": {}, + "outputs": [], + "source": [ + "shortest_sc_network, shortest_sc_list = nc.methods.run_sign_consistency(shortest_path_network, shortest_paths_list, sources, measurements)" + ] + }, + { + "cell_type": "code", + "execution_count": 22, "metadata": {}, "outputs": [ { @@ -5578,207 +2006,445 @@ "\n", "\n", - "\n", "\n", - "\n", - "\n", - "\n", + "\n", + "\n", + "\n", "\n", "\n", "EGFR\n", - "\n", + "\n", "\n", - "\n", + "\n", "\n", + "MAP2K1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->MAP2K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "ESR1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->ESR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", "VAV2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->VAV2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PIK3R1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PIK3R1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PTK2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PTK2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PCNA\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PCNA\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "ERBB2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->ERBB2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "BCAR1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->BCAR1\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SHC1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->SHC1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CCND1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CCND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPN1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTPN1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PKIA\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PKIA\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3\n", + "\n", + "\n", + "\n", + "\n", + "MAP2K1->MAPK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RARA\n", + "\n", + "\n", + "\n", + "\n", + "ESR1->RARA\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "RAC1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "VAV2->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDC42\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "VAV2->CDC42\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PIK3R1->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PTK2->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "EP300\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "PCNA->EP300\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDK1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "ERBB2->CDK1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "SMAD3\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "BCAR1->SMAD3\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "FOXO3\n", + "\n", + "\n", + "\n", + "\n", + "SHC1->FOXO3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK4\n", + "\n", + "\n", + "\n", + "\n", + "CCND1->CDK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK6\n", + "\n", + "\n", + "\n", + "\n", + "CCND1->CDK6\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKCD\n", + "\n", + "\n", + "\n", + "\n", + "PTPN1->PRKCD\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKACA\n", + "\n", + "\n", + "\n", + "\n", + "PKIA->PRKACA\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAZ\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3->MAZ\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "THRA\n", + "\n", + "\n", + "\n", + "\n", + "RARA->THRA\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K10\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "RAC1->MAP3K10\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDC42->MAP3K10\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "RUNX2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EP300->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDK1->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "SMAD3->RUNX2\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RBL2\n", + "\n", + "\n", + "\n", + "\n", + "FOXO3->RBL2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK4->RBL2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK6->RBL2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "GSK3A\n", + "\n", + "\n", + "\n", + "\n", + "PRKCD->GSK3A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKACA->GSK3A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RARB\n", + "\n", + "\n", + "\n", + "\n", + "THRA->RARB\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "NEUROD1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K10->NEUROD1\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "E2F5\n", + "\n", + "\n", + "\n", + "\n", + "RBL2->E2F5\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCL3\n", + "\n", + "\n", + "\n", + "\n", + "GSK3A->BCL3\n", + "\n", + "\n", "\n", "\n", "\n" ], "text/plain": [ - ">" + ">" ] }, "metadata": {}, @@ -5786,7 +2452,7 @@ } ], "source": [ - "a = nc.visualize_graph_simple(shortest_sc_network, sources, measurements, is_sign_consistent=True)\n", + "a = nc.visual.visualize_graph_simple(shortest_sc_network, sources, measurements, is_sign_consistent=True)\n", "style = \"\"\n", "display(HTML(style))\n", "display(a)" @@ -5803,16 +2469,16 @@ }, { "cell_type": "code", - "execution_count": 19, + "execution_count": 23, "metadata": {}, "outputs": [], "source": [ - "all_paths_network, all_paths_list = nc.run_all_paths(graph, sources, measurements, depth_cutoff=4)" + "all_paths_network, all_paths_list = nc.methods.run_all_paths(graph, sources, measurements, depth_cutoff=4)" ] }, { "cell_type": "code", - "execution_count": 20, + "execution_count": 24, "metadata": {}, "outputs": [ { @@ -5833,1639 +2499,1873 @@ "\n", "\n", - "\n", "\n", - "\n", - "\n", - "\n", + "\n", + "\n", + "\n", "\n", "\n", "EGFR\n", - "\n", + "\n", "\n", - "\n", + "\n", "\n", - "GRB2\n", - "\n", + "MAP2K1\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->GRB2\n", - "\n", - "\n", + "EGFR->MAP2K1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "JAK1\n", - "\n", + "ERBB2\n", + "\n", "\n", - "\n", + "\n", "\n", + "EGFR->ERBB2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "ESR1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->ESR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "GRB2\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->GRB2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "JAK1\n", + "\n", + "\n", + "\n", + "\n", "EGFR->JAK1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CRK\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->CRK\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "SHC1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->SHC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "E2F1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->E2F1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PRKDC\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PRKDC\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "MAP2K1\n", - "\n", - "\n", - "\n", - "\n", - "EGFR->MAP2K1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PTPN1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PTPN1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "NCK2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->NCK2\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "ERBB2\n", - "\n", - "\n", - "\n", - "\n", - "EGFR->ERBB2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "NCK1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->NCK1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "GRAP\n", - "\n", + "\n", "\n", "\n", - 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"\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "MAPK14->RUNX2\n", - "\n", - "\n", + "\n", + "\n", + "HDAC4->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RARB\n", + "\n", + "\n", + "\n", + "\n", + "THRA->RARB\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->HIPK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "E2F5\n", + "\n", + "\n", + "\n", + "\n", + "RBL2->E2F5\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "SIAH1->HIPK2\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK14->RUNX2\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "YAP1->RUNX2\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "CDK2->ID3\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "CEBPB->RUNX2\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "CSNK2A1->MAZ\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "SMAD1->RUNX2\n", - "\n", - "\n", + "\n", + "\n", + "BCL3\n", + "\n", "\n", - "\n", - "\n", - "HDAC4->RUNX2\n", - "\n", - "\n", + "\n", + "\n", + "GSK3A->BCL3\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "HDAC5->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "NEUROD1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K10->NEUROD1\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "RARB\n", - "\n", - "\n", - "\n", - "\n", - "THRA->RARB\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", "\n" ], "text/plain": [ - ">" + ">" ] }, "metadata": {}, @@ -7473,7 +4373,7 @@ } ], "source": [ - "a = nc.visualize_graph_simple(all_paths_network, sources, measurements, is_sign_consistent=False)\n", + "a = nc.visual.visualize_graph_simple(all_paths_network, sources, measurements, is_sign_consistent=False)\n", "style = \"\"\n", "display(HTML(style))\n", "display(a)" @@ -7488,16 +4388,16 @@ }, { "cell_type": "code", - "execution_count": 21, + "execution_count": 25, "metadata": {}, "outputs": [], "source": [ - "allpaths_sc_network, allpaths_sc_list = nc.run_sign_consistency(all_paths_network, all_paths_list, sources, measurements)" + "allpaths_sc_network, allpaths_sc_list = nc.methods.run_sign_consistency(all_paths_network, all_paths_list, sources, measurements)" ] }, { "cell_type": "code", - 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"\n", - "\n", + "\n", + "\n", + "PRKACA->GSK3A\n", + "\n", + "\n", "\n", - "\n", - "\n", - "CAMK2A->CEBPB\n", - "\n", - "\n", + "\n", + "\n", + "CSNK2A1->MAZ\n", + "\n", + "\n", "\n", - "\n", - "\n", - "CAMK4->HDAC5\n", - "\n", - "\n", + "\n", + "\n", + "SMAD1->RUNX2\n", + "\n", + "\n", "\n", - "\n", - "\n", - "HDAC4\n", - "\n", + "\n", + "\n", + "RARB\n", + "\n", "\n", - "\n", - "\n", - "CAMK4->HDAC4\n", - "\n", - "\n", + "\n", + "\n", + "THRA->RARB\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K7->HIPK2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "ATM->HIPK2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CASP6->HIPK2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK14->RUNX2\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "ID3\n", - "\n", - "\n", - "\n", - "\n", - "CDK2->ID3\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CEBPB->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "HDAC5->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "MAZ\n", - "\n", + "\n", + "\n", + "BCL3\n", + "\n", "\n", - "\n", - "\n", - "CSNK2A1->MAZ\n", - "\n", - "\n", + "\n", + "\n", + "GSK3A->BCL3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "E2F5\n", + "\n", + "\n", + "\n", + "\n", + "RBL2->E2F5\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "NEUROD1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K10->NEUROD1\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "SMAD1->RUNX2\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "EGR1->ID3\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "HDAC4->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", "\n" ], "text/plain": [ - ">" + ">" ] }, "metadata": {}, @@ -8731,7 +5886,7 @@ } ], "source": [ - "a = nc.visualize_graph_simple(allpaths_sc_network, sources, measurements, is_sign_consistent=True)\n", + "a = nc.visual.visualize_graph_simple(allpaths_sc_network, sources, measurements, is_sign_consistent=True)\n", "style = \"\"\n", "display(HTML(style))\n", "display(a)" @@ -8750,14 +5905,14 @@ }, { "cell_type": "code", - "execution_count": 23, + "execution_count": 27, "metadata": {}, "outputs": [], "source": [ - "ppr_network = nc.add_pagerank_scores(graph, sources, measurements, personalize_for='source')\n", - "ppr_network = nc.add_pagerank_scores(ppr_network, sources, measurements, personalize_for='target')\n", + "ppr_network = nc.methods.add_pagerank_scores(graph, sources, measurements, personalize_for='source')\n", + "ppr_network = nc.methods.add_pagerank_scores(ppr_network, sources, measurements, personalize_for='target')\n", "\n", - "ppr_network = nc.compute_ppr_overlap(ppr_network, percentage=1)" + "ppr_network = nc.methods.compute_ppr_overlap(ppr_network, percentage=1)" ] }, { @@ -8769,16 +5924,16 @@ }, { "cell_type": "code", - "execution_count": 24, + "execution_count": 28, "metadata": {}, "outputs": [], "source": [ - "shortest_ppr_network, shortest_ppr_list = nc.run_shortest_paths(ppr_network, sources, measurements)" + "shortest_ppr_network, shortest_ppr_list = nc.methods.run_shortest_paths(ppr_network, sources, measurements)" ] }, { "cell_type": "code", - "execution_count": 25, + "execution_count": 29, "metadata": {}, "outputs": [ { @@ -8799,357 +5954,502 @@ "\n", "\n", - "\n", "\n", - "\n", - "\n", - "\n", + "\n", + "\n", + "\n", "\n", "\n", "EGFR\n", - "\n", + "\n", "\n", - "\n", + "\n", "\n", - "PTPN1\n", - "\n", + "MAP2K1\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->PTPN1\n", - "\n", - "\n", + "EGFR->MAP2K1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "MAP2K1\n", - "\n", + "PTPN1\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->MAP2K1\n", - "\n", - "\n", + "EGFR->PTPN1\n", + "\n", + "\n", "\n", "\n", "\n", "CALM1\n", - "\n", + "\n", "\n", "\n", "\n", "EGFR->CALM1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", "\n", "CALM3\n", - "\n", + "\n", "\n", "\n", "\n", "EGFR->CALM3\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", "\n", "CALM2\n", - "\n", + "\n", "\n", "\n", "\n", "EGFR->CALM2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", "\n", "PIK3R1\n", - "\n", + "\n", "\n", "\n", "\n", "EGFR->PIK3R1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", "\n", "PTK2\n", - "\n", + "\n", "\n", "\n", "\n", "EGFR->PTK2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", "\n", "VAV2\n", - "\n", + "\n", "\n", "\n", "\n", "EGFR->VAV2\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", - "STAT3\n", - "\n", + "E2F1\n", + "\n", "\n", - "\n", + "\n", "\n", - "EGFR->STAT3\n", - "\n", - "\n", + "EGFR->E2F1\n", + "\n", + "\n", "\n", - "\n", + "\n", "\n", + "PRKDC\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PRKDC\n", + "\n", + "\n", + "\n", + "\n", + "\n", "PCNA\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PCNA\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "ERBB2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->ERBB2\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "ABL1\n", - "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", "\n", - "\n", - "\n", - "PTPN1->ABL1\n", - "\n", - "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SHC1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->SHC1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CCND1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CCND1\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK3\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP2K1->MAPK3\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP2K1->MAPK1\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "ABL1\n", + "\n", + "\n", + "\n", + "\n", + "PTPN1->ABL1\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "RAC1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "CALM1->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CALM3->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CALM2->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PIK3R1->RAC1\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "AKT1\n", + "\n", + "\n", + "\n", + "\n", + "PIK3R1->AKT1\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PTK2->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "VAV2->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "CDC42\n", - "\n", + "\n", + "\n", + "TP53\n", + "\n", "\n", - "\n", - "\n", - "VAV2->CDC42\n", - "\n", - "\n", + "\n", + "\n", + "E2F1->TP53\n", + "\n", + "\n", "\n", - "\n", - "\n", - "EGR1\n", - "\n", + "\n", + "\n", + "PRKDC->AKT1\n", + "\n", + "\n", "\n", - "\n", - "\n", - "STAT3->EGR1\n", - "\n", - "\n", + "\n", + "\n", + "PRKDC->TP53\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "EP300\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "PCNA->EP300\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDK1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "ERBB2->CDK1\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "HIPK2\n", - "\n", + "\n", + "\n", + "FOXO3\n", + "\n", "\n", - "\n", - "\n", - "ABL1->HIPK2\n", - "\n", - "\n", + "\n", + "\n", + "CTNNB1->FOXO3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SHC1->FOXO3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK6\n", + "\n", + "\n", + "\n", + "\n", + "CCND1->CDK6\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK4\n", + "\n", + "\n", + "\n", + "\n", + "CCND1->CDK4\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAZ\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK3->MAZ\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "RUNX2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAPK3->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "NCOA6\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK1->NCOA6\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "HIPK2\n", + "\n", "\n", - "\n", - "\n", - "MAPK1->NCOA6\n", - "\n", - "\n", + "\n", + "\n", + "ABL1->HIPK2\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K10\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "RAC1->MAP3K10\n", - "\n", - "\n", + "\n", + "\n", "\n", - "\n", - "\n", - "CDC42->MAP3K10\n", - "\n", - "\n", + "\n", + "\n", + "GSK3A\n", + "\n", "\n", - "\n", - "\n", - "ID3\n", - "\n", + "\n", + "\n", + "AKT1->GSK3A\n", + "\n", + "\n", "\n", - "\n", - "\n", - "EGR1->ID3\n", - "\n", - "\n", + "\n", + "\n", + "NFYB\n", + "\n", + "\n", + "\n", + "\n", + "TP53->NFYB\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "EP300->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDK1->RUNX2\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RBL2\n", + "\n", + "\n", + "\n", + "\n", + "FOXO3->RBL2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK6->RBL2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK4->RBL2\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "NEUROD1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K10->NEUROD1\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCL3\n", + "\n", + "\n", + "\n", + "\n", + "GSK3A->BCL3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "E2F5\n", + "\n", + "\n", + "\n", + "\n", + "RBL2->E2F5\n", + "\n", + "\n", "\n", "\n", "\n" ], "text/plain": [ - ">" + ">" ] }, "metadata": {}, @@ -9157,7 +6457,7 @@ } ], "source": [ - "a = nc.visualize_graph_simple(shortest_ppr_network, sources, measurements, is_sign_consistent=False)\n", + "a = nc.visual.visualize_graph_simple(shortest_ppr_network, sources, measurements, is_sign_consistent=False)\n", "style = \"\"\n", "display(HTML(style))\n", "display(a)" @@ -9172,16 +6472,16 @@ }, { "cell_type": "code", - "execution_count": 26, + "execution_count": 30, "metadata": {}, "outputs": [], "source": [ - "shortest_sc_ppr_network, shortest_sc_ppr_list = nc.run_sign_consistency(shortest_ppr_network, shortest_ppr_list, sources, measurements)" + "shortest_sc_ppr_network, shortest_sc_ppr_list = nc.methods.run_sign_consistency(shortest_ppr_network, shortest_ppr_list, sources, measurements)" ] }, { "cell_type": "code", - "execution_count": 27, + "execution_count": 31, "metadata": {}, "outputs": [ { @@ -9202,179 +6502,284 @@ "\n", "\n", - "\n", "\n", - "\n", - "\n", - "\n", + "\n", + "\n", + "\n", "\n", "\n", "EGFR\n", - "\n", + "\n", "\n", - "\n", + "\n", "\n", + "MAP2K1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->MAP2K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", "PIK3R1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PIK3R1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PTK2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PTK2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "VAV2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->VAV2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PCNA\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->PCNA\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "ERBB2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EGFR->ERBB2\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SHC1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->SHC1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CCND1\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CCND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3\n", + "\n", + "\n", + "\n", + "\n", + "MAP2K1->MAPK3\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "RAC1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "PIK3R1->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "PTK2->RAC1\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "VAV2->RAC1\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "CDC42\n", - "\n", - "\n", - "\n", - "\n", - "VAV2->CDC42\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "EP300\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "PCNA->EP300\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDK1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "ERBB2->CDK1\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "FOXO3\n", + "\n", + "\n", + "\n", + "\n", + "SHC1->FOXO3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK6\n", + "\n", + "\n", + "\n", + "\n", + "CCND1->CDK6\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK4\n", + "\n", + "\n", + "\n", + "\n", + "CCND1->CDK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAZ\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3->MAZ\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K10\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "RAC1->MAP3K10\n", - "\n", - "\n", - "\n", - "\n", - "\n", - "CDC42->MAP3K10\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "RUNX2\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "EP300->RUNX2\n", - "\n", - "\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "CDK1->RUNX2\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RBL2\n", + "\n", + "\n", + "\n", + "\n", + "FOXO3->RBL2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK6->RBL2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDK4->RBL2\n", + "\n", + "\n", "\n", "\n", - "\n", + "\n", "NEUROD1\n", - "\n", + "\n", "\n", "\n", - "\n", + "\n", "MAP3K10->NEUROD1\n", - "\n", - "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "E2F5\n", + "\n", + "\n", + "\n", + "\n", + "RBL2->E2F5\n", + "\n", + "\n", "\n", "\n", "\n" ], "text/plain": [ - ">" + ">" ] }, "metadata": {}, @@ -9382,11 +6787,115 @@ } ], "source": [ - "a = nc.visualize_graph_simple(shortest_sc_ppr_network, sources, measurements, is_sign_consistent=True)\n", + "a = nc.visual.visualize_graph_simple(shortest_sc_ppr_network, sources, measurements, is_sign_consistent=True)\n", "style = \"\"\n", "display(HTML(style))\n", "display(a)" ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## 3. Evaluation" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "Now that we have the networks inferred using different approaches, we can compare them in terms of size, connectivity or centrality. For this, ``NetworkCommons`` incorporates several functions to retrieve this code:" + ] + }, + { + "cell_type": "code", + "execution_count": 32, + "metadata": {}, + "outputs": [], + "source": [ + "# we include all the networks in a dictionary with custom labels\n", + "networks = {\n", + " 'shortest_path': shortest_path_network,\n", + " 'shortest_path_sc': shortest_sc_network,\n", + " 'all_paths': all_paths_network,\n", + " 'all_paths_sc': allpaths_sc_network,\n", + " 'shortest_ppr_network': shortest_ppr_network,\n", + " 'shortest_ppr_sc_network': shortest_sc_ppr_network,\n", + " 'corneto': corneto_network\n", + "}" + ] + }, + { + "cell_type": "code", + "execution_count": 33, + "metadata": {}, + "outputs": [], + "source": [ + "metrics = nc.eval.get_metrics_from_networks(networks, measurements)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "Now, we can have a look at different topological metrics. For example, we see that networks inferred with the *all paths* method tend to have bigger networks, while Corneto/Carnival and shortest path + sign consistency show the lowest values. " + ] + }, + { + "cell_type": "code", + "execution_count": 34, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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", + "text/plain": [ + "
" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "nc.visual.lollipop_plot(metrics, 'network', 'Number of nodes', orientation='vertical', color_palette='tab10', size=10, linewidth=2, marker='o', title='Mean Degree by Network', render=True)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "However, the Corneto/Carnival graph manages to score high in terms of connected offargets. Despite their bigger size, the *all paths* methods do not show higher connectivity." + ] + }, + { + "cell_type": "code", + "execution_count": 35, + "metadata": {}, + "outputs": [ + { + "data": { + "image/png": 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", + "text/plain": [ + "
" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "nc.visual.lollipop_plot(metrics, 'network', 'Connected targets', orientation='vertical', color_palette='tab10', size=10, linewidth=2, marker='o', title='Mean Degree by Network', render=True)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "Thank you for trying **NetworkCommons**! We hope you found this tutorial helpful. We showcased data imports, methods, visualization and metric extraction features that are already implemented. \n", + "However, this is just the beginning! We aim to expand this collection of tools and methods by incorporating more data sources, methods, and visualizations.\n", + "If you have any questions or feedback, or you would like to contribute, please feel free to reach out to us :)" + ] } ], "metadata": { diff --git a/docs/src/vignettes/2_moon.ipynb b/docs/src/vignettes/2_moon.ipynb index fc0fd6e..a067ceb 100644 --- a/docs/src/vignettes/2_moon.ipynb +++ b/docs/src/vignettes/2_moon.ipynb @@ -18,16 +18,7 @@ "cell_type": "code", "execution_count": 1, "metadata": {}, - "outputs": [ - { - "name": "stderr", - "output_type": "stream", - "text": [ - "/home/victo/.local/lib/python3.10/site-packages/tqdm/auto.py:22: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", - " from .autonotebook import tqdm as notebook_tqdm\n" - ] - } - ], + "outputs": [], "source": [ "import networkcommons as nc\n", "import decoupler as dc\n", @@ -53,9 +44,17 @@ "cell_type": "code", "execution_count": 2, "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "/home/victo/networkcommons/docs/src/vignettes\n" + ] + } + ], "source": [ - "meta_network_df = pd.read_csv('../data/moon/meta_network.sif', sep='\\t')" + "!pwd" ] }, { @@ -63,6 +62,15 @@ "execution_count": 3, "metadata": {}, "outputs": [], + "source": [ + "meta_network_df = pd.read_csv('../../../data/moon/meta_network.sif', sep='\\t')" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "metadata": {}, + "outputs": [], "source": [ "meta_network_df = meta_network_df.drop_duplicates(subset=['source', 'target', 'sign'], keep='first')\n", "meta_network_df = meta_network_df.drop_duplicates(subset=['source', 'target'], keep=False)" @@ -77,20 +85,20 @@ }, { "cell_type": "code", - "execution_count": 4, + "execution_count": 5, "metadata": {}, "outputs": [], "source": [ - "meta_network = nc.network_from_df(meta_network_df, directed=True)" + "meta_network = nc.utils.network_from_df(meta_network_df, directed=True)" ] }, { "cell_type": "code", - "execution_count": 5, + "execution_count": 6, "metadata": {}, "outputs": [], "source": [ - "meta_network = nc.meta_network_cleanup(meta_network) # equals R" + "meta_network = nc.methods.meta_network_cleanup(meta_network) # equals R" ] }, { @@ -102,22 +110,115 @@ }, { "cell_type": "code", - "execution_count": 6, + "execution_count": 7, "metadata": {}, "outputs": [], "source": [ - "moon_data = nc.download_dataset('MOON')" + "moon_data = nc.data.omics.moon()" ] }, { "cell_type": "code", - "execution_count": 7, + "execution_count": 8, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'sig': TF value\n", + " 0 AR 1.156582\n", + " 1 BACH1 2.399881\n", + " 2 CEBPA 3.687354\n", + " 3 CREB1 0.829149\n", + " 4 CTCF 2.914983\n", + " 5 E2F1 4.989779\n", + " 6 E2F4 3.972646\n", + " 7 EGR1 6.337803\n", + " 8 ELK1 0.444149\n", + " 9 EPAS1 4.268129\n", + " 10 ESR1 7.069928\n", + " 11 ETS1 5.957844\n", + " 12 FOS 5.009215\n", + " 13 FOXA1 2.338539\n", + " 14 FOXM1 1.206632\n", + " 15 FOXO3 -0.772054\n", + " 16 FOXP1 0.876896\n", + " 17 GATA2 1.052240\n", + " 18 GATA3 4.433932\n", + " 19 HIF1A 2.503899\n", + " 20 HNF4A 5.230794\n", + " 21 JUN 4.310749\n", + " 22 MITF 4.685015\n", + " 23 MYC 0.761681\n", + " 24 NFKB1 2.386302\n", + " 25 PRDM14 2.602170\n", + " 26 RARA 2.259669\n", + " 27 RELA 3.635926\n", + " 28 RUNX1 1.654963\n", + " 29 SOX2 0.903587\n", + " 30 SP1 2.073969\n", + " 31 SP3 0.190111\n", + " 32 SPI1 5.666462\n", + " 33 SREBF1 1.577459\n", + " 34 STAT1 2.219767\n", + " 35 STAT2 0.092127\n", + " 36 STAT3 1.241225\n", + " 37 TAL1 2.968578\n", + " 38 TFAP2A 0.182564\n", + " 39 TFAP2C 7.987909\n", + " 40 TP53 1.014723\n", + " 41 USF1 2.194528\n", + " 42 VDR 1.545408\n", + " 43 YY1 1.521236\n", + " 44 ZNF263 7.254531,\n", + " 'metab': metab value Unnamed: 2\n", + " 0 HMDB0011747 0.401991 NaN\n", + " 1 HMDB0000755 -0.142718 NaN\n", + " 2 HMDB0000905 -1.244183 NaN\n", + " 3 HMDB0000012 -0.967207 NaN\n", + " 4 HMDB0001191 -0.631035 NaN\n", + " .. ... ... ...\n", + " 133 HMDB0011720 -0.716155 NaN\n", + " 134 HMDB0000883 -0.059923 NaN\n", + " 135 HMDB0000292 -0.772272 NaN\n", + " 136 HMDB0000299 1.132812 NaN\n", + " 137 HMDB0002917 -1.728352 NaN\n", + " \n", + " [138 rows x 3 columns],\n", + " 'rna': gene value\n", + " 0 WASH7P -0.084246\n", + " 1 LINC01128 -0.246712\n", + " 2 NOC2L 0.508906\n", + " 3 KLHL17 -0.001460\n", + " 4 HES4 -0.281146\n", + " ... ... ...\n", + " 8252 CMC4 -0.029409\n", + " 8253 BRCC3 -0.058883\n", + " 8254 VBP1 -0.554804\n", + " 8255 TMLHE -1.095530\n", + " 8256 CD24 0.923448\n", + " \n", + " [8257 rows x 2 columns]}" + ] + }, + "execution_count": 8, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "moon_data" + ] + }, + { + "cell_type": "code", + "execution_count": 9, "metadata": {}, "outputs": [], "source": [ - "sig_input = moon_data['sig_input'].set_index('TF')['value'].to_dict()\n", - "rna_input = moon_data['rna_input'].set_index('gene')['value'].to_dict()\n", - "metab_input = moon_data['metab_input'].set_index('metab')['value'].to_dict()" + "sig_input = moon_data['sig'].set_index('TF')['value'].to_dict()\n", + "rna_input = moon_data['rna'].set_index('gene')['value'].to_dict()\n", + "metab_input = moon_data['metab'].set_index('metab')['value'].to_dict()" ] }, { @@ -129,37 +230,20 @@ }, { "cell_type": "code", - "execution_count": 8, + "execution_count": 10, "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Adding compartment codes.\n" - ] - } - ], + "outputs": [], "source": [ - "metab_input = nc.prepare_metab_inputs(metab_input, [\"c\", \"m\"])" + "metab_input = nc.methods.prepare_metab_inputs(metab_input, [\"c\", \"m\"])" ] }, { "cell_type": "code", - "execution_count": 9, + "execution_count": 11, "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "MOON: removing unexpressed nodes from PKN...\n", - "MOON: 13090 nodes removed\n" - ] - } - ], + "outputs": [], "source": [ - "meta_network = nc.filter_pkn_expressed_genes(rna_input.keys(), meta_network)" + "meta_network = nc.methods.filter_pkn_expressed_genes(rna_input.keys(), meta_network)" ] }, { @@ -171,25 +255,15 @@ }, { "cell_type": "code", - "execution_count": 10, + "execution_count": 12, "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "COSMOS: 17 input/measured nodes are not inPKN anymore: ['AR', 'CEBPA', 'ESR1', 'FOS', 'FOXA1', 'FOXP1', 'GATA2', 'GATA3', 'HNF4A', 'MITF', 'PRDM14', 'SOX2', 'SPI1', 'TAL1', 'TFAP2C', 'VDR', 'ZNF263']\n", - "COSMOS: 154 input/measured nodes are not inPKN anymore: ['Metab__HMDB0011747_c', 'Metab__HMDB0000755_c', 'Metab__HMDB0000355_c', 'Metab__HMDB0000479_c', 'Metab__HMDB0000807_c', 'Metab__HMDB0003464_c', 'Metab__HMDB0000076_c', 'Metab__HMDB0003701_c', 'Metab__HMDB0001494_c', 'Metab__HMDB0000462_c', 'Metab__HMDB0001548_c', 'Metab__HMDB0001893_c', 'Metab__HMDB0000646_c', 'Metab__HMDB0001352_c', 'Metab__HMDB0000902_c', 'Metab__HMDB0000030_c', 'Metab__HMDB0001847_c', 'Metab__HMDB0000062_c', 'Metab__HMDB0000562_c', 'Metab__HMDB0001151_c', 'Metab__HMDB0000283_c', 'Metab__HMDB0000622_c', 'Metab__HMDB0011737_c', 'Metab__HMDB0011741_c', 'Metab__HMDB0000625_c', 'Metab__HMDB0003466_c', 'Metab__HMDB0000130_c', 'Metab__HMDB0000965_c', 'Metab__HMDB0000213_c', 'Metab__HMDB0000715_c', 'Metab__HMDB0004041_c', 'Metab__HMDB0000086_c', 'Metab__HMDB0002320_c', 'Metab__HMDB0000691_c', 'Metab__HMDB0000169_c', 'Metab__HMDB0001078_c', 'Metab__HMDB0001389_c', 'Metab__HMDB0000853_c', 'Metab__HMDB0031018_c', 'Metab__HMDB0001015_c', 'Metab__HMDB0001539_c', 'Metab__HMDB0004825_c', 'Metab__HMDB0000207_c', 'Metab__HMDB0000472_c', 'Metab__HMDB0000210_c', 'Metab__HMDB0001429_c', 'Metab__HMDB0002243_c', 'Metab__HMDB0000245_c', 'Metab__HMDB0001545_c', 'Metab__HMDB0000250_c', 'Metab__HMDB0000232_c', 'Metab__HMDB0000126_c', 'Metab__HMDB0000956_c', 'Metab__HMDB0000251_c', 'Metab__HMDB0002231_c', 'Metab__HMDB0001124_c', 'Metab__HMDB0000306_c', 'Metab__HMDB0011720_c', 'Metab__HMDB0011747_m', 'Metab__HMDB0000755_m', 'Metab__HMDB0000905_m', 'Metab__HMDB0000012_m', 'Metab__HMDB0001294_m', 'Metab__HMDB0000355_m', 'Metab__HMDB0000479_m', 'Metab__HMDB0000807_m', 'Metab__HMDB0000272_m', 'Metab__HMDB0003464_m', 'Metab__HMDB0000267_m', 'Metab__HMDB0001173_m', 'Metab__HMDB0000076_m', 'Metab__HMDB0003701_m', 'Metab__HMDB0001316_m', 'Metab__HMDB0001494_m', 'Metab__HMDB0000034_m', 'Metab__HMDB0000462_m', 'Metab__HMDB0001548_m', 'Metab__HMDB0001893_m', 'Metab__HMDB0001123_m', 'Metab__HMDB0000646_m', 'Metab__HMDB0000052_m', 'Metab__HMDB0001352_m', 'Metab__HMDB0000902_m', 'Metab__HMDB0001847_m', 'Metab__HMDB0000062_m', 'Metab__HMDB0000562_m', 'Metab__HMDB0001151_m', 'Metab__HMDB0000283_m', 'Metab__HMDB0000099_m', 'Metab__HMDB0000742_m', 'Metab__HMDB0001321_m', 'Metab__HMDB0000622_m', 'Metab__HMDB0001049_m', 'Metab__HMDB0011737_m', 'Metab__HMDB0011741_m', 'Metab__HMDB0000625_m', 'Metab__HMDB0001401_m', 'Metab__HMDB0000132_m', 'Metab__HMDB0000133_m', 'Metab__HMDB0001397_m', 'Metab__HMDB0003466_m', 'Metab__HMDB0000177_m', 'Metab__HMDB0000130_m', 'Metab__HMDB0000965_m', 'Metab__HMDB0000157_m', 'Metab__HMDB0000195_m', 'Metab__HMDB0000211_m', 'Metab__HMDB0000213_m', 'Metab__HMDB0000715_m', 'Metab__HMDB0004041_m', 'Metab__HMDB0000086_m', 'Metab__HMDB0001851_m', 'Metab__HMDB0002320_m', 'Metab__HMDB0000691_m', 'Metab__HMDB0000169_m', 'Metab__HMDB0001078_m', 'Metab__HMDB0001389_m', 'Metab__HMDB0000853_m', 'Metab__HMDB0000230_m', 'Metab__HMDB0031018_m', 'Metab__HMDB0001015_m', 'Metab__HMDB0000220_m', 'Metab__HMDB0001325_m', 'Metab__HMDB0001406_m', 'Metab__HMDB0001539_m', 'Metab__HMDB0004825_m', 'Metab__HMDB0000207_m', 'Metab__HMDB0000218_m', 'Metab__HMDB0000472_m', 'Metab__HMDB0000210_m', 'Metab__HMDB0001429_m', 'Metab__HMDB0002243_m', 'Metab__HMDB0000245_m', 'Metab__HMDB0001545_m', 'Metab__HMDB0000250_m', 'Metab__HMDB0000232_m', 'Metab__HMDB0000618_m', 'Metab__HMDB0000126_m', 'Metab__HMDB0000247_m', 'Metab__HMDB0001257_m', 'Metab__HMDB0000956_m', 'Metab__HMDB0000251_m', 'Metab__HMDB0000806_m', 'Metab__HMDB0002231_m', 'Metab__HMDB0001124_m', 'Metab__HMDB0000929_m', 'Metab__HMDB0000306_m', 'Metab__HMDB0000300_m', 'Metab__HMDB0000289_m', 'Metab__HMDB0000296_m', 'Metab__HMDB0011720_m', 'Metab__HMDB0000292_m', 'Metab__HMDB0000299_m', 'Metab__HMDB0002917_m']\n", - "COSMOS: 7 input/measured nodes are not inPKN anymore: ['CTCF', 'ELK1', 'EPAS1', 'ETS1', 'SREBF1', 'TFAP2A', 'USF1']\n" - ] - } - ], + "outputs": [], "source": [ - "sig_input = nc.filter_input_nodes_not_in_pkn(sig_input, meta_network)\n", - "meta_network = nc.keep_controllable_neighbours(sig_input, meta_network)\n", - "metab_input = nc.filter_input_nodes_not_in_pkn(metab_input, meta_network)\n", - "meta_network = nc.keep_observable_neighbours(metab_input, meta_network)\n", - "sig_input = nc.filter_input_nodes_not_in_pkn(sig_input, meta_network)" + "sig_input = nc.methods.filter_input_nodes_not_in_pkn(sig_input, meta_network)\n", + "meta_network = nc.methods.keep_controllable_neighbours(sig_input, meta_network)\n", + "metab_input = nc.methods.filter_input_nodes_not_in_pkn(metab_input, meta_network)\n", + "meta_network = nc.methods.keep_observable_neighbours(metab_input, meta_network)\n", + "sig_input = nc.methods.filter_input_nodes_not_in_pkn(sig_input, meta_network)" ] }, { @@ -236,11 +310,11 @@ }, { "cell_type": "code", - "execution_count": 11, + "execution_count": 13, "metadata": {}, "outputs": [], "source": [ - "meta_network_compressed, signatures, dup_parents = nc.compress_same_children(meta_network, sig_input, metab_input) # equals R" + "meta_network_compressed, signatures, dup_parents = nc.methods.compress_same_children(meta_network, sig_input, metab_input) # equals R" ] }, { @@ -252,11 +326,11 @@ }, { "cell_type": "code", - "execution_count": 12, + "execution_count": 14, "metadata": {}, "outputs": [], "source": [ - "meta_network_compressed = nc.meta_network_cleanup(meta_network_compressed)" + "meta_network_compressed = nc.methods.meta_network_cleanup(meta_network_compressed)" ] }, { @@ -282,148 +356,16 @@ }, { "cell_type": "code", - "execution_count": 13, + "execution_count": 15, "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
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sourceconfidencetargetweight
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3KLF6ALTC4S1.0
4KLF5ANOTCH11.0
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15113 rows × 4 columns

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" - ], - "text/plain": [ - " source confidence target weight\n", - "0 MYC A TERT 1.0\n", - "1 LEF1 A CCL7 1.0\n", - "2 LEF1 A BIRC5 1.0\n", - "3 KLF6 A LTC4S 1.0\n", - "4 KLF5 A NOTCH1 1.0\n", - "... ... ... ... ...\n", - "15108 FOS B CREB5 0.5\n", - "15109 FOS B CRIM1 0.5\n", - "15110 FOS B CRYBG1 0.5\n", - "15111 FOS B CDK6 0.5\n", - "15112 ZNF740 B SETD1B 0.5\n", - "\n", - "[15113 rows x 4 columns]" - ] - }, - "execution_count": 13, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "tf_regn = dc.get_dorothea(levels = ['A', 'B'])" ] }, { "cell_type": "code", - "execution_count": 14, + "execution_count": 16, "metadata": {}, "outputs": [], "source": [ @@ -432,7 +374,7 @@ }, { "cell_type": "code", - "execution_count": 15, + "execution_count": 18, "metadata": {}, "outputs": [ { @@ -462,7 +404,7 @@ } ], "source": [ - "moon_res, moon_network = nc.run_moon(\n", + "moon_res, moon_network = nc.methods.run_moon(\n", " meta_network_compressed,\n", " sig_input,\n", " metab_input,\n", @@ -489,11 +431,11 @@ }, { "cell_type": "code", - "execution_count": 16, + "execution_count": 19, "metadata": {}, "outputs": [], "source": [ - "moon_res_dec = nc.decompress_moon_result(moon_res, signatures, dup_parents, meta_network_compressed)" + "moon_res_dec = nc.methods.decompress_moon_result(moon_res, signatures, dup_parents, meta_network_compressed)" ] }, { @@ -512,11 +454,11 @@ }, { "cell_type": "code", - "execution_count": 17, + "execution_count": 20, "metadata": {}, "outputs": [], "source": [ - "res_network, att = nc.reduce_solution_network(moon_res_dec, meta_network, 1, sig_input, rna_input) # equals R" + "res_network, att = nc.methods.reduce_solution_network(moon_res_dec, meta_network, 1, sig_input, rna_input) # equals R" ] }, { @@ -528,27 +470,27 @@ }, { "cell_type": "code", - "execution_count": 18, + "execution_count": 22, "metadata": {}, "outputs": [], "source": [ - "mapping_dict = pd.read_csv(\"../data/moon/hmdb_mapper_vec.csv\", header=0).set_index('HMDB_id')['name'].to_dict()" + "mapping_dict = pd.read_csv(\"../../../data/moon/hmdb_mapper_vec.csv\", header=0).set_index('HMDB_id')['name'].to_dict()" ] }, { "cell_type": "code", - "execution_count": 19, + "execution_count": 23, "metadata": {}, "outputs": [], "source": [ - "translated_network, att_translated = nc.translate_res(res_network, att, mapping_dict)" + "translated_network, att_translated = nc.methods.translate_res(res_network, att, mapping_dict)" ] }, { "cell_type": "markdown", "metadata": {}, "source": [ - "The resulted network can be used now for visualization purposes. Since the network is quite big, it will not be shown in this notebook." + "The resulted network can be used now for visualization purposes, or further studying of the topology can be conducted, as shown in Vignette 1. Since the network is quite big, it will not be shown in this notebook." ] } ], @@ -568,7 +510,7 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.10.14" + "version": "3.10.12" } }, "nbformat": 4,