diff --git a/slides/VEP_variantAnnotationPresentation.qmd b/slides/VEP_variantAnnotationPresentation.qmd index 8731304..1f363e5 100644 --- a/slides/VEP_variantAnnotationPresentation.qmd +++ b/slides/VEP_variantAnnotationPresentation.qmd @@ -35,9 +35,9 @@ code-overflow: wrap ## How do mutations appear? -- Mutations occur due to replication errors (1 nucleotide per ~10^4) but with reparation mechanisms (1 error per 10^9 10^10) +- Mutations occur due to replication errors (1 nucleotide per ~10^4) but with reparation mechanisms (1 error per 10^7 - 10^9) - As a consequence of DNA damage (~70,000 nucleotide lesions or modifications per day) - - Exposure to mutagens such as UV, smoking increases the mutations' frequency +- Exposure to mutagens such as UV, smoking increases the mutations' frequency ::: {.fragment .fade-in} ![Example UV damage](https://knowgenetics.org/wp-content/uploads/2012/12/amanda1.png){#fig_uv_damage fig-caption="Germline vs somatic mutations" width="250" height="200"}