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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
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<title>:: Home ::</title>
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<h1>Sachin Pundhir, Ph.D.</h1>
<!--p>Post-doc @ University of Copenhagen, Denmark</p-->
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<li><a href="index.html">Home</a></li>
<li><a href="https://scholar.google.com/citations?user=KNHvdX8AAAAJ&hl=en">Publications</a></li>
<li><a href="cv.html">CV</a></li>
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<li><a href="research.html">Research</a></li>
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<h3>Contact</h3>
<p>Room no. 1.3.34, BRIC<br />
University of Copenhagen<br />
Ole Maaløes Vej 5, 4<br />
2200 Copenhagen N<br />
Denmark<br />
Phone (+45) 3532 5666<br />
<a href="">pundhir.cph [the sign] gmail.com</a><br />
<a href="https://spundhir.github.io/">https://spundhir.github.io/</a></p>
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<p style="text-align:justify">Thanks for visiting my home page. I am a working as a Senior Scientist in the research area of computational biology. My current research is focused on to understand the role of two chromatin remodellers, Chd4 and Brg1 in regulating promoter activity during stem cell differentiation. I use multitude of genomics data (RNA-seq, TF-ChIP-seq, Histone-ChIP-seq) to study how the binding of the two remodellers alters the chromatin landscape and activity of promoters.</p>
<p style="text-align:justify">During my post-doctoral work with <a href="https://www.bric.ku.dk/Research/Porse_Group/" target="_blank">Prof. Bo Porse</a>, I studied the role of two transcription factors (TF), PU.1 and CEBPA during differentiation of stem cells into mature blood cells (hematopoiesis). In contrast to our previous understanding, I showed that CEBPA controls PU.1 levels and loss of CEBPA leads to a very early differentiation block during hematopoiesis. I also showed that the formation of granulocytes is driven by a sub-set of enhancers where CEBPA acts a pioneering factor, and are not dependent on PU.1 for their activation [PMID: <a href="https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30745-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124718307459%3Fshowall%3Dtrue" target="_blank">29847803</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/27095194" target="_blank">27095194</a>].</p>
<!--p style="text-align:justify">I did my Ph.D. (computational biology) in 2013 under the supervision of <a href="http://rth.dk/~gorodkin" target="_blank">Prof. Jan Gorodkin</a> at the University of Copenhagen. I developed and used computational and statistical methods to analyze RNA-seq data for the prediction of non-coding RNAs [PMID: <a href="http://www.ncbi.nlm.nih.gov/pubmed/22053076" target="_blank">22053076</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/23874353" target="_blank">23874353</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/24797614" target="_blank">24797614</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/26042150" target="_blank">26042150</a>] and to understand regulation in their post-transcriptional processing [PMID: <a href="http://www.ncbi.nlm.nih.gov/pubmed/26166713" target="_blank">26166713</a>].</p-->
<p>For a complete list of my publications, please click <a href="https://scholar.google.com/citations?user=KNHvdX8AAAAJ&hl=en">here</a>. My CV is available <a href="cv.html">here</a></p>
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