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6 changes: 3 additions & 3 deletions DESCRIPTION
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Package: scarHRD
Type: Package
Title: Estimatig Genomic scars signatures (LST, TAI,LOH)
Title: Estimating Genomic Scars Signatures (LST, TAI, LOH)
Version: 0.1.0
Author: Zsofia Sztupinszki, Nicolaj Birkbak
Author: Zsofia Sztupinszki, Nicolai Birkbak
Maintainer: Zsofia Sztupinszki <zsosupi@bioinformatics.dtu.dk>
Description: This package determines the level of homologous recombination deficiency based on WXS or WGS data. The imput files may be...
Description: This package determines the level of homologous recombination deficiency based on WXS or WGS data. The input files may be...
Depends: R (>= 3.4.2),sequenza,copynumber,data.table
License: GPL-3
Encoding: UTF-8
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2 changes: 1 addition & 1 deletion R/calc.ai_new.R
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#' Determnine Allelic imbalance
#' Determine Allelic imbalance
#'
#' @param seg segmentation data
#' @param chrominfo reference genome version
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2 changes: 1 addition & 1 deletion R/calc.hrd.R
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#' Determnine number of loss-off heterosigosity
#' Determine number of loss of heterozygosity
#'
#' @param seg segmentation data
#' @param nA column number of copy number of A allele
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2 changes: 1 addition & 1 deletion R/calc.lst.R
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#' Determnine large-scale transitions
#' Determine large-scale transitions
#'
#' @param seg segmentation data
#' @param chrominfo reference genome version
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2 changes: 1 addition & 1 deletion R/scar_score.R
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#' Scar score
#'
#' Determining genomic scar score (telomeric allelic imbalance, loss-off heterozigosity, large-scle transitions), signs of homologous recombination deficiency
#' Determining genomic scar score (telomeric allelic imbalance, loss of heterozygosity, large-scale transitions), signs of homologous recombination deficiency
#' @param seg Imput file: either a binned sequenza out file (or any other segmentation file with the following columns: chromosome, position, base.ref, depth.normal, depth.tumor, depth.ratio, Af, Bf, zygosity.normal, GC.percent, good.reads, AB.normal, AB.tumor, tumor.strand) or an allele-specific segmentation file with the following columns: 1st column: sample name, 2nd column: chromosome, 3rd column: segmentation start, 4th column: segmentation end, 5th column: total copynumber, 6th column: copy number of A allele, 7th column: copy number of B allele
#' @param reference: reference genome: either grch38 or grch37. Default is grch38.
#' @param seqz Optional parameter, set to TRUE, if input file is a binned sequenza file.
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2 changes: 1 addition & 1 deletion README.md
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# scarHRD

scarHRD is an R package which determines the levels of homologous recombination deficiency (telomeric allelic imbalance, loss-off heterozigosity, number of large-scale transitions) based on NGS (WES, WGS) data.
scarHRD is an R package which determines the levels of homologous recombination deficiency (telomeric allelic imbalance, loss of heterozygosity, number of large-scale transitions) based on NGS (WES, WGS) data.

## Citation

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