diff --git a/Cargo.toml b/Cargo.toml
index d6f4b3f..2bdab7f 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -11,7 +11,7 @@ name = "biobear"
 arrow = { version = "52.0.0", features = ["pyarrow"] }
 datafusion = "39"
 exon = { version = "0.26", features = ["default"] }
-pyo3 = "0.21.2"
+pyo3 = "0.22.0"
 tokio = { version = "1", features = ["rt"] }
 noodles = { version = "0.77", features = ["core"] }