Spatiotemporal analysis of F-actin polymerization with micropillar arrays reveals synchronization between adhesion sites
This project is based on the article Spatiotemporal analysis of F-actin polymerization with micropillar arrays reveals synchronization between adhesion sites. The study repurposed micropillar-arrays to quantify spatiotemporal inter-adhesion communication. Following the observation that integrin adhesions formed around pillar tops we relied on the precise repetitive spatial control of the pillars to reliably monitor F-actin dynamics in mouse embryonic fibroblasts as a model for spatiotemporal adhesion-related intracellular signaling.
Data availability: movies of micropillar at height 5.3𝜇m, movies of micropillar at height 13.2𝜇m