diff --git a/docs/api/index.rst b/docs/api/index.rst
index 42e2e565..24ae531b 100644
--- a/docs/api/index.rst
+++ b/docs/api/index.rst
@@ -3,6 +3,21 @@
    You can adapt this file completely to your liking, but it should at least
    contain the root `toctree` directive.
 
+Welcome to HTSinfer Documentation!
+==================================
+
+HTSinfer is a tool for high-throughput sequencing inference.
+
+This documentation will guide you through installation, usage, and the API reference.
+
+HTSinfer Documentation
+=======================
+
+.. toctree::
+   :caption: Contents:
+
+   guides/installation
+
 HTSinfer API docs
 =================
 
diff --git a/docs/guides/installation.rst b/docs/guides/installation.rst
new file mode 100644
index 00000000..63ca4e79
--- /dev/null
+++ b/docs/guides/installation.rst
@@ -0,0 +1,40 @@
+Installation Guide
+==================
+
+This section describes how to install HTSinfer using Conda.
+
+Clone the Repository and Install Dependencies
+---------------------------------------------
+
+To install HTSinfer, first clone the repository and install the dependencies via `Conda`:
+
+.. code-block:: bash
+
+   git clone https://github.com/zavolanlab/htsinfer
+   cd htsinfer
+   conda env create --file environment.yml
+   # Alternatively, to install with development dependencies,
+   # run the following instead
+   conda env create --file environment-dev.yml
+
+.. note::
+
+   Creating the environment may take some time. It is strongly recommended to install `Mamba`_ and replace ``conda`` with ``mamba`` in the previous commands for faster installation.
+
+Activate the Conda Environment
+------------------------------
+
+After the installation is complete, activate the `htsinfer` Conda environment with:
+
+.. code-block:: bash
+
+   conda activate htsinfer
+
+Verify the Installation (Optional)
+----------------------------------
+
+If you have installed the development or testing dependencies, you can verify that HTSinfer was installed correctly by executing the tests shipped with the package:
+
+.. code-block:: bash
+
+   python -m pytest